KEGG   PATHWAY: vun03040
Entry
vun03040                    Pathway                                
Name
Spliceosome - Vigna unguiculata (cowpea)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
vun03040  Spliceosome
vun03040

Other DBs
GO: 0005681
Organism
Vigna unguiculata (cowpea) [GN:vun]
Gene
114164902  U1 spliceosomal RNA [KO:K14276]
114189268  U1 spliceosomal RNA [KO:K14276]
114195712  U1 spliceosomal RNA [KO:K14276]
114189344  U1 spliceosomal RNA [KO:K14276]
114189335  U1 spliceosomal RNA [KO:K14276]
114192830  U1 spliceosomal RNA [KO:K14276]
114170862  U1 spliceosomal RNA [KO:K14276]
114189345  U1 spliceosomal RNA [KO:K14276]
114170867  U2 spliceosomal RNA [KO:K14277]
114170866  U2 spliceosomal RNA [KO:K14277]
114189289  U2 spliceosomal RNA [KO:K14277]
114192853  U2 spliceosomal RNA [KO:K14277]
114180019  U2 spliceosomal RNA [KO:K14277]
114170873  U2 spliceosomal RNA [KO:K14277]
114170880  U2 spliceosomal RNA [KO:K14277]
114165488  U2 spliceosomal RNA [KO:K14277]
114170886  U2 spliceosomal RNA [KO:K14277]
114170870  U2 spliceosomal RNA [KO:K14277]
114186398  U4 spliceosomal RNA [KO:K14278]
114189290  U4 spliceosomal RNA [KO:K14278]
114192833  U4 spliceosomal RNA [KO:K14278]
114170895  U4 spliceosomal RNA [KO:K14278]
114186399  U4 spliceosomal RNA [KO:K14278]
114186402  U4 spliceosomal RNA [KO:K14278]
114164903  U5 spliceosomal RNA [KO:K14279]
114174754  U5 spliceosomal RNA [KO:K14279]
114165476  U6 spliceosomal RNA [KO:K14280]
114165530  U6 spliceosomal RNA [KO:K14280]
114167710  DEAD-box ATP-dependent RNA helicase 42 [KO:K12811] [EC:5.6.2.7]
114195616  DEAD-box ATP-dependent RNA helicase 56-like [KO:K12812] [EC:5.6.2.7]
114162444  DEAD-box ATP-dependent RNA helicase 56-like isoform X1 [KO:K12812] [EC:5.6.2.7]
114166673  DEAD-box ATP-dependent RNA helicase 56 isoform X1 [KO:K12812] [EC:5.6.2.7]
114164620  pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH1 isoform X1 [KO:K12813] [EC:5.6.2.6]
114184772  LOW QUALITY PROTEIN: pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH7-like [KO:K12815] [EC:5.6.2.6]
114182984  pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH7 [KO:K12815] [EC:5.6.2.6]
114191939  pre-mRNA-processing factor 17 isoform X1 [KO:K12816]
114187325  pre-mRNA-splicing factor 18 [KO:K12817]
114194750  probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH5 [KO:K12818] [EC:5.6.2.6]
114193294  ATP-dependent RNA helicase DEAH12, chloroplastic-like [KO:K12818] [EC:5.6.2.6]
114187076  probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH5 [KO:K12818] [EC:5.6.2.6]
114173628  pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH10 [KO:K12818] [EC:5.6.2.6]
114178479  probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH4 [KO:K12818] [EC:5.6.2.6]
114189069  pre-mRNA-splicing factor SLU7-A-like [KO:K12819]
114163908  pre-mRNA-splicing factor SLU7-A-like [KO:K12819]
114190616  probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH2 isoform X1 [KO:K12820] [EC:5.6.2.6]
114185316  LOW QUALITY PROTEIN: probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH2 [KO:K12820] [EC:5.6.2.6]
114195286  small nuclear ribonucleoprotein-associated protein B [KO:K11086]
114176034  small nuclear ribonucleoprotein SmD1a-like [KO:K11087]
114186353  small nuclear ribonucleoprotein SmD1a [KO:K11087]
114176409  small nuclear ribonucleoprotein Sm D2-like [KO:K11096]
114168762  small nuclear ribonucleoprotein Sm D2-like [KO:K11096]
114176564  small nuclear ribonucleoprotein SmD3b-like [KO:K11088]
114183869  small nuclear ribonucleoprotein E-like [KO:K11097]
114176797  small nuclear ribonucleoprotein E-like [KO:K11097]
114163611  small nuclear ribonucleoprotein E-like [KO:K11097]
114176547  probable small nuclear ribonucleoprotein F [KO:K11098]
114162609  probable small nuclear ribonucleoprotein F isoform X1 [KO:K11098]
114173978  probable small nuclear ribonucleoprotein G [KO:K11099]
114167409  LOW QUALITY PROTEIN: U1 small nuclear ribonucleoprotein 70 kDa [KO:K11093]
114186787  U1 small nuclear ribonucleoprotein A [KO:K11091]
114189804  U1 small nuclear ribonucleoprotein C-like [KO:K11095]
114190178  U1 small nuclear ribonucleoprotein C-like [KO:K11095]
114194145  pre-mRNA-processing protein 40A [KO:K12821]
114190951  pre-mRNA-processing protein 40A-like isoform X1 [KO:K12821]
114173719  RNA-binding protein 25 isoform X1 [KO:K12822]
114188719  DEAD-box ATP-dependent RNA helicase 20-like isoform X1 [KO:K12823] [EC:5.6.2.7]
114181511  DEAD-box ATP-dependent RNA helicase 46 [KO:K12823] [EC:5.6.2.7]
114176819  DEAD-box ATP-dependent RNA helicase 20-like isoform X1 [KO:K12823] [EC:5.6.2.7]
114186763  DEAD-box ATP-dependent RNA helicase 40 [KO:K12823] [EC:5.6.2.7]
114167267  DEAD-box ATP-dependent RNA helicase 20 [KO:K12823] [EC:5.6.2.7]
114169353  pre-mRNA-processing protein 40C isoform X1 [KO:K12824]
114195227  transcription initiation factor TFIID subunit 15b-like [KO:K13098]
114187555  transcription initiation factor TFIID subunit 15b isoform X1 [KO:K13098]
114168335  U2 small nuclear ribonucleoprotein A' [KO:K11092]
114193338  U2 small nuclear ribonucleoprotein B'' 2-like [KO:K11094]
114192445  probable splicing factor 3A subunit 1 [KO:K12825]
114182940  splicing factor 3A subunit 2 [KO:K12826]
114164521  splicing factor SF3a60 homolog [KO:K12827]
114187929  splicing factor 3B subunit 1 [KO:K12828]
114188214  splicing factor 3B subunit 2 [KO:K12829]
114189934  spliceosome-associated protein 130 A [KO:K12830]
114163540  LOW QUALITY PROTEIN: splicing factor 3B subunit 3 [KO:K12830]
114189922  splicing factor 3B subunit 4 [KO:K12831]
114170046  splicing factor 3B subunit 4 [KO:K12831]
114166073  uncharacterized protein At4g14342-like isoform X1 [KO:K12832]
114176572  uncharacterized protein At4g14342 isoform X1 [KO:K12832]
114195222  splicing factor 3B subunit 6-like protein [KO:K12833]
114187143  PHD finger-like domain-containing protein 5B [KO:K12834]
114184407  DEAD-box ATP-dependent RNA helicase 24 [KO:K12835] [EC:5.6.2.7]
114185273  splicing factor U2af small subunit B-like [KO:K12836]
114173314  splicing factor U2af small subunit A-like [KO:K12836]
114185952  splicing factor U2af small subunit B-like [KO:K12836]
114190482  splicing factor U2af large subunit B [KO:K12837]
114177937  LOW QUALITY PROTEIN: splicing factor U2af large subunit B-like [KO:K12837]
114178149  survival of motor neuron-related-splicing factor 30 [KO:K12839]
114179168  DNA-damage-repair/toleration protein DRT111, chloroplastic [KO:K12840]
114176495  protein RRC1 isoform X1 [KO:K12842]
114174428  sm-like protein LSM2 [KO:K12621]
114174434  sm-like protein LSM2 [KO:K12621]
114181805  sm-like protein LSM3A [KO:K12622]
114190372  probable U6 snRNA-associated Sm-like protein LSm4 isoform X1 [KO:K12623]
114176619  probable U6 snRNA-associated Sm-like protein LSm4 isoform X1 [KO:K12623]
114177088  sm-like protein LSM5 [KO:K12624]
114183860  sm-like protein LSM6A [KO:K12625]
114176544  sm-like protein LSM7 [KO:K12626]
114194343  sm-like protein LSM8 [KO:K12627]
114190805  protein RDM16-like isoform X1 [KO:K12843]
114172970  protein RDM16-like isoform X1 [KO:K12843]
114190624  U4/U6 small nuclear ribonucleoprotein PRP4-like protein [KO:K12662]
114168312  peptidyl-prolyl cis-trans isomerase CYP22 [KO:K09567] [EC:5.2.1.8]
114185464  U4/U6 small nuclear ribonucleoprotein Prp31 homolog [KO:K12844]
114182286  U4/U6 small nuclear ribonucleoprotein Prp31 homolog isoform X1 [KO:K12844]
114193466  NHP2-like protein 1 [KO:K12845]
114177103  NHP2-like protein 1 [KO:K12845]
114179751  RNA-binding protein 25 [KO:K12846]
114194703  U4/U6.U5 tri-snRNP-associated protein 2-like [KO:K12847]
114170686  SART-1 family protein DOT2-like [KO:K11984]
114169921  SART-1 family protein DOT2-like [KO:K11984]
114169941  SART-1 family protein DOT2-like [KO:K11984]
114175652  zinc finger matrin-type protein 2 [KO:K12848]
114191489  pre-mRNA-splicing factor 38 [KO:K12849]
114193447  pre-mRNA splicing factor SR-like 1 isoform X1 [KO:K12850]
114177725  110 kDa U5 small nuclear ribonucleoprotein component CLO [KO:K12852]
114163584  DExH-box ATP-dependent RNA helicase DExH12 [KO:K12854] [EC:5.6.2.6]
114184916  protein STABILIZED1 [KO:K12855]
114185872  pre-mRNA-processing-splicing factor 8A [KO:K12856]
114193019  U5 small nuclear ribonucleoprotein 40 kDa protein [KO:K12857]
114175945  DEAD-box ATP-dependent RNA helicase 21 [KO:K12858] [EC:5.6.2.7]
114168141  thioredoxin-like protein YLS8 [KO:K12859]
114174285  thioredoxin-like protein YLS8 [KO:K12859]
114191988  pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
114181535  cell division cycle 5-like protein [KO:K12860]
114176130  pre-mRNA-splicing factor SPF27 homolog [KO:K12861]
114164644  protein pleiotropic regulatory locus 1 [KO:K12862]
114175949  protein CWC15 homolog [KO:K12863]
114187343  beta-catenin-like protein 1 isoform X1 [KO:K12864]
114191738  heat shock cognate 70 kDa protein 2-like [KO:K03283]
114185895  probable mediator of RNA polymerase II transcription subunit 37c [KO:K03283]
114186878  probable mediator of RNA polymerase II transcription subunit 37c [KO:K03283]
114166970  probable mediator of RNA polymerase II transcription subunit 37c [KO:K03283]
114176677  heat shock 70 kDa protein [KO:K03283]
114165904  heat shock 70 kDa protein-like [KO:K03283]
114167046  heat shock 70 kDa protein 18-like isoform X1 [KO:K03283]
114173338  probable mediator of RNA polymerase II transcription subunit 37c isoform X1 [KO:K03283]
114186949  stromal 70 kDa heat shock-related protein, chloroplastic [KO:K03283]
114187275  probable mediator of RNA polymerase II transcription subunit 37c [KO:K03283]
114187276  probable mediator of RNA polymerase II transcription subunit 37c [KO:K03283]
114187590  heat shock 70 kDa protein-like [KO:K03283]
114187591  heat shock 70 kDa protein-like [KO:K03283]
114169933  heat shock cognate 70 kDa protein 2 [KO:K03283]
114173774  heat shock cognate 70 kDa protein 2-like [KO:K03283]
114183522  probable mediator of RNA polymerase II transcription subunit 37c [KO:K03283]
114184936  heat shock cognate 70 kDa protein 2-like [KO:K03283]
114185030  probable mediator of RNA polymerase II transcription subunit 37c [KO:K03283]
114185031  heat shock cognate 70 kDa protein-like [KO:K03283]
114185579  heat shock cognate 70 kDa protein 2-like [KO:K03283]
114185580  heat shock cognate 70 kDa protein-like [KO:K03283]
114167130  uncharacterized protein LOC114167130 isoform X1 [KO:K12865]
114169174  SNW/SKI-interacting protein A-like [KO:K06063]
114181842  SNW/SKI-interacting protein A-like [KO:K06063]
114187836  pre-mRNA-splicing factor SYF1 [KO:K12867]
114192367  pre-mRNA-splicing factor syf2 [KO:K12868]
114173693  crooked neck-like protein 1 [KO:K12869]
114193345  pre-mRNA-splicing factor ISY1 homolog [KO:K12870]
114172931  peptidyl-prolyl cis-trans isomerase CYP18-2 [KO:K12733] [EC:5.2.1.8]
114190389  coiled-coil domain-containing protein 12 [KO:K12871]
114194485  zinc finger CCCH domain-containing protein 40-like [KO:K12872]
114187868  zinc finger CCCH domain-containing protein 40-like [KO:K12872]
114193281  protein BUD31 homolog 2 [KO:K12873]
114181743  protein BUD31 homolog 2 isoform X1 [KO:K12873]
114173784  RNA helicase aquarius [KO:K12874]
114175829  apoptotic chromatin condensation inducer in the nucleus [KO:K12875]
114163956  eukaryotic initiation factor 4A-3 [KO:K13025] [EC:5.6.2.7]
114173816  RNA-binding protein Y14 [KO:K12876]
114165059  protein mago nashi homolog [KO:K12877]
114187136  protein mago nashi homolog [KO:K12877]
114188485  THO complex subunit 1 [KO:K12878]
114177081  THO complex subunit 2 [KO:K12879]
114188712  THO complex subunit 3 [KO:K12880]
114184878  THO complex subunit 4A [KO:K12881]
114185115  THO complex subunit 4D [KO:K12881]
114184140  THO complex subunit 4B-like [KO:K12881]
114184971  nuclear cap-binding protein subunit 1 [KO:K12882]
114183033  nuclear cap-binding protein subunit 2 [KO:K12883]
114195263  UBP1-associated protein 2B-like [KO:K12741]
114192743  UBP1-associated protein 2C-like [KO:K12741]
114194561  UBP1-associated protein 2A [KO:K12741]
114185608  glycine-rich RNA-binding protein 3, mitochondrial [KO:K12741]
114187270  heterogeneous nuclear ribonucleoprotein A3 [KO:K12741]
114182964  glycine-rich RNA-binding protein 2, mitochondrial-like [KO:K12741]
114181908  UBP1-associated protein 2A-like [KO:K12741]
114185305  heterogeneous nuclear ribonucleoprotein 1 [KO:K12741]
114169313  UBP1-associated protein 2C [KO:K12741]
114178575  glycine-rich RNA-binding protein 2, mitochondrial-like [KO:K12741]
114178441  UBP1-associated protein 2C-like [KO:K12741]
114192643  serine/arginine-rich splicing factor SR30-like [KO:K12890]
114164586  serine/arginine-rich splicing factor SR34A [KO:K12890]
114180327  LOW QUALITY PROTEIN: serine/arginine-rich-splicing factor SR34-like [KO:K12890]
114178194  serine/arginine-rich splicing factor SC35 [KO:K12891]
114191098  serine/arginine-rich splicing factor RS40-like isoform X1 [KO:K12893]
114166850  serine/arginine-rich splicing factor RS31 isoform X1 [KO:K12893]
114167180  serine/arginine-rich splicing factor RS41-like isoform X1 [KO:K12893]
114194644  serine/arginine-rich splicing factor RSZ22 isoform X1 [KO:K12896]
114186147  serine/arginine-rich splicing factor RS2Z32-like isoform X1 [KO:K12896]
114187240  LOW QUALITY PROTEIN: serine/arginine-rich splicing factor RS2Z32-like [KO:K12896]
114173898  serine/arginine-rich splicing factor SR45a [KO:K12897]
114195556  serine/arginine-rich SC35-like splicing factor SCL30 [KO:K12900]
114193463  serine/arginine-rich SC35-like splicing factor SCL33 isoform X1 [KO:K12900]
114189599  serine/arginine-rich SC35-like splicing factor SCL33 isoform X1 [KO:K12900]
114178646  serine/arginine-rich SC35-like splicing factor SCL28 [KO:K12900]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   
LinkDB

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