KEGG   PATHWAY: pcad04148
Entry
pcad04148                   Pathway                                
Name
Efferocytosis - Physeter macrocephalus (sperm whale)
Class
Cellular Processes; Transport and catabolism
Pathway map
pcad04148  Efferocytosis
pcad04148

Organism
Physeter macrocephalus (sperm whale) [GN:pcad]
Gene
102973123  XKR8; XK-related protein 8 [KO:K26813]
102973277  RAB5B; ras-related protein Rab-5B [KO:K07888]
102973323  [KO:K06259]
102973376  C1QA; complement C1q subcomponent subunit A [KO:K03986]
102973585  IL10; interleukin-10 [KO:K05443]
102973652  C1QC; complement C1q subcomponent subunit C [KO:K03988]
102974187  CASP7; caspase-7 [KO:K04397] [EC:3.4.22.60]
102974200  ATP8A1; phospholipid-transporting ATPase IA [KO:K14802] [EC:7.6.2.1]
102974304  AXL; tyrosine-protein kinase receptor UFO isoform X1 [KO:K05115] [EC:2.7.10.1]
102974346  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
102974359  [KO:K06259]
102974582  ODC1; ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
102974657  ADAM9; disintegrin and metalloproteinase domain-containing protein 9 isoform X1 [KO:K06834] [EC:3.4.24.-]
102974736  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X3 [KO:K05726]
102975188  ADAM10; disintegrin and metalloproteinase domain-containing protein 10 isoform X1 [KO:K06704] [EC:3.4.24.81]
102975405  [KO:K06259]
102975454  [KO:K26935]
102975517  NR1H2; oxysterols receptor LXR-beta isoform X1 [KO:K08535]
102975547  XKR9; XK-related protein 9 [KO:K26814]
102975643  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
102975832  CEBPB; CCAAT/enhancer-binding protein beta [KO:K10048]
102976074  AGER; LOW QUALITY PROTEIN: advanced glycosylation end product-specific receptor [KO:K19722]
102976852  [KO:K08057]
102976905  RAB7A; ras-related protein Rab-7a [KO:K07897]
102977165  [KO:K19501]
102977531  MAPK12; mitogen-activated protein kinase 12 isoform X3 [KO:K04441] [EC:2.7.11.24]
102977692  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
102977867  RAB14; ras-related protein Rab-14 [KO:K07881]
102977900  ANO9; anoctamin-9 [KO:K19503]
102977994  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
102978494  TYRO3; tyrosine-protein kinase receptor TYRO3 isoform X1 [KO:K05116] [EC:2.7.10.1]
102978565  ADAM17; disintegrin and metalloproteinase domain-containing protein 17 isoform X1 [KO:K06059] [EC:3.4.24.86]
102978574  HIF1A; hypoxia-inducible factor 1-alpha [KO:K08268]
102978811  JAK2; tyrosine-protein kinase JAK2 isoform X2 [KO:K04447] [EC:2.7.10.2]
102978873  C1QB; complement C1q subcomponent subunit B [KO:K03987]
102978874  MEGF11; multiple epidermal growth factor-like domains protein 11 isoform X2 [KO:K24068]
102978918  SLC66A1; lysosomal amino acid transporter 1 homolog [KO:K23678]
102979072  MEGF10; multiple epidermal growth factor-like domains protein 10 isoform X1 [KO:K24068]
102979195  [KO:K04392]
102979224  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
102979428  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102979498  TGFBRAP1; transforming growth factor-beta receptor-associated protein 1 isoform X4 [KO:K20177]
102979499  ANO3; LOW QUALITY PROTEIN: anoctamin-3 [KO:K19498]
102979840  TMEM30A; cell cycle control protein 50A [KO:K26935]
102979902  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102979910  ABCA1; phospholipid-transporting ATPase ABCA1 isoform X3 [KO:K05641]
102979922  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
102980301  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102980451  EPOR; erythropoietin receptor [KO:K05079]
102980504  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform isoform X2 [KO:K19523] [EC:2.3.1.21]
102980540  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
102980846  ARNT; aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
102980851  ITGAV; integrin alpha-V [KO:K06487]
102980906  PECAM1; platelet endothelial cell adhesion molecule isoform X1 [KO:K06471]
102981108  P2RY2; P2Y purinoceptor 2 [KO:K04269]
102981198  ATP11A; phospholipid-transporting ATPase IH isoform X3 [KO:K26934]
102981387  P2RY6; P2Y purinoceptor 6 [KO:K04272]
102981472  XKR6; XK-related protein 6 [KO:K26811]
102981495  GPR132; probable G-protein coupled receptor 132 [KO:K08426]
102981762  EPO; erythropoietin [KO:K05437]
102981826  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
102982110  CASP1; caspase-1 [KO:K01370] [EC:3.4.22.36]
102982170  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102982223  MERTK; tyrosine-protein kinase Mer [KO:K05117] [EC:2.7.10.1]
102982229  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
102982708  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
102982799  SIGLEC10; sialic acid-binding Ig-like lectin 10 [KO:K06749]
102982871  VPS16; vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
102982912  SPHK1; LOW QUALITY PROTEIN: sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
102983198  PBX1; pre-B-cell leukemia transcription factor 1 isoform X2 [KO:K09355]
102983592  XKR4; XK-related protein 4 [KO:K26811]
102983593  PLA2G15; phospholipase A2 group XV isoform X1 [KO:K06129] [EC:3.1.1.5]
102983772  ADGRB1; adhesion G protein-coupled receptor B1 isoform X2 [KO:K04596]
102983951  VPS39; vam6/Vps39-like protein [KO:K20183]
102984161  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
102984254  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
102984305  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102984345  LIPA; lysosomal acid lipase/cholesteryl ester hydrolase [KO:K01052] [EC:3.1.1.13]
102984481  RAB5A; ras-related protein Rab-5A isoform X1 [KO:K07887]
102984693  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102984755  VPS41; vacuolar protein sorting-associated protein 41 homolog isoform X2 [KO:K20184]
102984806  CH25H; cholesterol 25-hydroxylase [KO:K10223] [EC:1.14.99.38]
102984866  RAB5C; ras-related protein Rab-5C [KO:K07889]
102985019  LRP1; prolow-density lipoprotein receptor-related protein 1 [KO:K04550]
102985121  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
102985261  [KO:K08179]
102985343  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
102985462  GULP1; PTB domain-containing engulfment adapter protein 1 isoform X3 [KO:K23285]
102985552  CX3CR1; LOW QUALITY PROTEIN: CX3C chemokine receptor 1 [KO:K04192]
102985575  XKR7; XK-related protein 7 [KO:K26811]
102985657  ANO4; anoctamin-4 isoform X1 [KO:K19499]
102985728  PTGER4; prostaglandin E2 receptor EP4 subtype isoform X1 [KO:K04261]
102985798  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102985848  ARG1; arginase-1 [KO:K01476] [EC:3.5.3.1]
102985852  ATP11C; phospholipid-transporting ATPase IG isoform X2 [KO:K26934]
102986376  RAB17; ras-related protein Rab-17 [KO:K07909]
102986457  ALOX15; LOW QUALITY PROTEIN: polyunsaturated fatty acid lipoxygenase ALOX15 [KO:K00460] [EC:1.13.11.33]
102986529  PPARG; peroxisome proliferator-activated receptor gamma isoform X3 [KO:K08530]
102986976  DNMT3A; DNA (cytosine-5)-methyltransferase 3A isoform X3 [KO:K17398] [EC:2.1.1.37]
102987109  PPARD; peroxisome proliferator-activated receptor delta [KO:K04504]
102987197  [KO:K05853] [EC:7.2.2.10]
102987433  STAB1; stabilin-1 isoform X2 [KO:K19020]
102987463  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
102987506  [KO:K07293] [EC:3.1.3.48]
102987672  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
102987975  ALOX5; polyunsaturated fatty acid 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
102988344  [KO:K04446]
102988534  CPT1C; carnitine O-palmitoyltransferase 1, brain isoform [KO:K19524] [EC:2.3.1.21]
102988740  ITGB3; integrin beta-3 isoform X2 [KO:K06493]
102988892  TMEM30B; cell cycle control protein 50B [KO:K26935]
102988954  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X25 [KO:K04515] [EC:2.7.11.17]
102989074  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102989082  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
102989111  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
102989442  ANO5; anoctamin-5 isoform X1 [KO:K19480]
102989859  SLC16A1; monocarboxylate transporter 1 [KO:K08179]
102989876  PROS1; vitamin K-dependent protein S [KO:K03908]
102989908  PTPN6; tyrosine-protein phosphatase non-receptor type 6 isoform X1 [KO:K05697] [EC:3.1.3.48]
102990100  CRKL; crk-like protein [KO:K04438]
102990276  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X2 [KO:K04392]
102990302  MAPK13; mitogen-activated protein kinase 13 isoform X3 [KO:K04441] [EC:2.7.11.24]
102990513  [KO:K00411] [EC:7.1.1.8]
102990694  VPS11; vacuolar protein sorting-associated protein 11 homolog isoform X1 [KO:K20179]
102991387  STAB2; stabilin-2 [KO:K19013]
102991878  P2RY12; P2Y purinoceptor 12 [KO:K04298]
102992191  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102992378  [KO:K08765] [EC:2.3.1.21]
102992401  RXRA; retinoic acid receptor RXR-alpha [KO:K08524]
102992483  CX3CL1; fractalkine isoform X2 [KO:K05508]
102992683  RAB7B; ras-related protein Rab-7b isoform X3 [KO:K07898]
102992783  MFGE8; lactadherin [KO:K17253]
102993007  PANX1; pannexin-1 [KO:K03443]
102993268  ARG2; arginase-2, mitochondrial [KO:K01476] [EC:3.5.3.1]
102993364  SIRT1; NAD-dependent protein deacetylase sirtuin-1 isoform X3 [KO:K11411] [EC:2.3.1.286]
102993512  VPS18; vacuolar protein sorting-associated protein 18 homolog isoform X2 [KO:K20181]
102993698  NR1H3; oxysterols receptor LXR-alpha isoform X1 [KO:K08536]
102993777  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X5 [KO:K17332]
102993934  SCARF1; scavenger receptor class F member 1 isoform X3 [KO:K24318]
102994150  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102994214  CRK; adapter molecule crk isoform X1 [KO:K04438]
102994282  ELMO1; engulfment and cell motility protein 1 isoform X1 [KO:K12366]
102994529  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
102994554  GAS6; growth arrest-specific protein 6 isoform X1 [KO:K05464]
102994643  ANO6; anoctamin-6 isoform X1 [KO:K19500]
102994737  [KO:K14802] [EC:7.6.2.1]
102994812  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X2 [KO:K04515] [EC:2.7.11.17]
102994865  ATP11B; phospholipid-transporting ATPase IF isoform X1 [KO:K26934]
102995187  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
102995205  ITGB5; integrin beta-5 [KO:K06588]
102995293  CD47; leukocyte surface antigen CD47 isoform X1 [KO:K06266]
102995337  VPS8; vacuolar protein sorting-associated protein 8 homolog isoform X4 [KO:K20178]
102995420  THBS1; thrombospondin-1 [KO:K16857]
102996061  HAVCR2; hepatitis A virus cellular receptor 2 [KO:K20414]
102996228  [KO:K06551]
102996287  VPS33A; vacuolar protein sorting-associated protein 33A isoform X2 [KO:K20182]
102996337  TIMD4; T-cell immunoglobulin and mucin domain-containing protein 4 [KO:K26936]
102996620  HAVCR1; hepatitis A virus cellular receptor 1 [KO:K20413]
102996858  BSG; basigin isoform X1 [KO:K06535]
102996910  CALR; calreticulin [KO:K08057]
102996942  S1PR1; sphingosine 1-phosphate receptor 1 [KO:K04288]
112062100  CD24; signal transducer CD24 [KO:K06469]
112065033  [KO:K13302] [EC:2.7.11.1]
112066203  [KO:K06551]
114484431  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
114485528  [KO:K00461] [EC:1.13.11.34]
114486503  [KO:K06469]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
pcad00010  Glycolysis / Gluconeogenesis
pcad04140  Autophagy - animal
pcad04145  Phagosome
KO pathway
ko04148   

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