KEGG   PATHWAY: pdic04630
Entry
pdic04630                   Pathway                                
Name
JAK-STAT signaling pathway - Phyllostomus discolor (pale spear-nosed bat)
Description
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
Class
Environmental Information Processing; Signal transduction
Pathway map
pdic04630  JAK-STAT signaling pathway
pdic04630

Other DBs
GO: 0007259
Organism
Phyllostomus discolor (pale spear-nosed bat) [GN:pdic]
Gene
114502552  IL2; interleukin-2 [KO:K05429]
114510341  IL4; interleukin-4 [KO:K05430]
114501947  IL7; LOW QUALITY PROTEIN: interleukin-7 [KO:K05431]
114510338  IL9; interleukin-9 [KO:K05432]
114503576  IL15; interleukin-15 [KO:K05433]
114502310  IL21; interleukin-21 [KO:K05434]
114491940  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
114513750  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
114504996  IL2RG; cytokine receptor common subunit gamma isoform X2 [KO:K05070]
114512581  interleukin-4 receptor subunit alpha-like isoform X1 [KO:K05071]
114512758  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
114506652  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
114507683  interleukin-9 receptor [KO:K05073]
114491942  IL15RA; LOW QUALITY PROTEIN: interleukin-15 receptor subunit alpha [KO:K05074]
114506477  IL21R; interleukin-21 receptor [KO:K05075]
114489877  CRLF2; cytokine receptor-like factor 2 [KO:K05078]
114510347  IL3; interleukin-3 [KO:K04736]
114510343  IL5; LOW QUALITY PROTEIN: interleukin-5 [KO:K05428]
114510130  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
114489875  IL3RA; interleukin-3 receptor subunit alpha [KO:K04737]
114501812  IL5RA; interleukin-5 receptor subunit alpha [KO:K05067]
114513933  CSF2RB; cytokine receptor common subunit beta isoform X1 [KO:K04738]
114508090  IL6; interleukin-6 isoform X1 [KO:K05405]
114510716  IL11; interleukin-11 [KO:K05417]
114510342  IL13; interleukin-13 [KO:K05435]
114507042  IL27; interleukin-27 subunit alpha isoform X1 [KO:K22629]
114509353  IL31; interleukin-31 [KO:K22631]
114510381  OSM; oncostatin-M [KO:K05418]
114510082  LIF; leukemia inhibitory factor [KO:K05419]
114500666  CNTF; ciliary neurotrophic factor [KO:K05420]
114508584  CTF1; cardiotrophin-1 [KO:K05422]
114506516  cardiotrophin-2-like [KO:K24382]
114500925  CLCF1; cardiotrophin-like cytokine factor 1 isoform X2 [KO:K05421]
114489094  IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
114502072  IL6ST; interleukin-6 receptor subunit beta [KO:K05060]
114504790  IL13RA1; interleukin-13 receptor subunit alpha-1 [KO:K05076]
114505166  IL13RA2; interleukin-13 receptor subunit alpha-2 [KO:K05077]
114503389  IL27RA; interleukin-27 receptor subunit alpha isoform X1 [KO:K19598]
114507034  IL31RA; interleukin-31 receptor subunit alpha [KO:K22630]
114511461  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
114507436  LIFR; leukemia inhibitory factor receptor [KO:K05058]
114507589  CNTFR; ciliary neurotrophic factor receptor subunit alpha [KO:K05059]
114511966  IL10; interleukin-10 [KO:K05443]
114512176  IL19; interleukin-19 [KO:K05444]
114512617  IL22; interleukin-22 [KO:K05445]
114512103  IL20; interleukin-20 [KO:K22667]
114512105  IL24; LOW QUALITY PROTEIN: interleukin-24 [KO:K22668]
114512636  IL26; interleukin-26 [KO:K05446]
114500775  IL10RA; interleukin-10 receptor subunit alpha isoform X2 [KO:K05134]
114490059  IL10RB; interleukin-10 receptor subunit beta [KO:K05135]
114494604  IL20RA; interleukin-20 receptor subunit alpha isoform X2 [KO:K05136]
114502017  IL20RB; interleukin-20 receptor subunit beta [KO:K05137]
114498142  IL22RA1; interleukin-22 receptor subunit alpha-1 [KO:K05138]
114495669  IL22RA2; interleukin-22 receptor subunit alpha-2 [KO:K05139]
114491057  IL12A; interleukin-12 subunit alpha [KO:K05406]
114510060  IL12B; interleukin-12 subunit beta [KO:K05425]
114513716  IL23A; interleukin-23 subunit alpha [KO:K05426]
114503736  IL12RB1; interleukin-12 receptor subunit beta-1 [KO:K05063]
114496738  IL12RB2; interleukin-12 receptor subunit beta-2 [KO:K05064]
114498060  IL23R; interleukin-23 receptor [KO:K05065]
114506763  EPO; erythropoietin [KO:K05437]
114502866  somatotropin [KO:K05438]
114497751  PRL; prolactin [KO:K05439]
114490884  THPO; thrombopoietin isoform X2 [KO:K06854]
114503848  CSF3; granulocyte colony-stimulating factor [KO:K05423]
114508146  leptin isoform X1 [KO:K05424]
114503014  EPOR; LOW QUALITY PROTEIN: erythropoietin receptor [KO:K05079]
114510955  GHR; growth hormone receptor [KO:K05080]
114509172  PRLR; prolactin receptor isoform X1 [KO:K05081]
114497536  MPL; thrombopoietin receptor [KO:K05082]
114497355  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
114497664  LEPR; leptin receptor isoform X2 [KO:K05062]
114502765  interferon alpha-4-like [KO:K05414]
114502773  interferon alpha-4-like [KO:K05414]
114503306  interferon alpha-4-like [KO:K05414]
114490854  interferon alpha-4-like [KO:K05414]
114490401  interferon alpha-4-like [KO:K05414]
114512515  IFNB1; interferon beta [KO:K05415]
114491882  IFNE; LOW QUALITY PROTEIN: interferon epsilon [KO:K05442]
114508085  IFNK; interferon kappa [KO:K05441]
114511308  LOW QUALITY PROTEIN: interferon lambda-1-like [KO:K05447]
114511582  interferon lambda-1-like [KO:K05447]
114511283  interferon lambda-3-like [KO:K22669]
114511290  interferon lambda-3-like [KO:K22669]
114511294  interferon lambda-3-like [KO:K22669]
114511296  interferon lambda-3-like [KO:K22669]
114490402  interferon omega-2-like [KO:K05440]
114511668  interferon omega-2-like [KO:K05440]
114507612  interferon omega-2-like [KO:K05440]
114508694  interferon omega-2-like [KO:K05440]
114509253  interferon omega-2-like [KO:K05440]
114490062  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
114490003  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
114497871  IFNLR1; interferon lambda receptor 1 [KO:K05140]
114514094  IFNG; interferon gamma [KO:K04687]
114495155  IFNGR1; interferon gamma receptor 1 [KO:K05132]
118498608  IFNGR2; interferon gamma receptor 2 [KO:K05133]
114492590  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
114510403  PDGFA; platelet-derived growth factor subunit A isoform X2 [KO:K04359]
114514158  PDGFB; platelet-derived growth factor subunit B isoform X2 [KO:K17386]
114507607  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
114493180  PDGFRA; platelet-derived growth factor receptor alpha isoform X2 [KO:K04363] [EC:2.7.10.1]
114509632  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
114498103  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
114496018  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
114503157  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
114502963  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X2 [KO:K11219] [EC:2.7.10.2]
114494120  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
114513273  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
114502756  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
114494417  STAT4; signal transducer and activator of transcription 4 [KO:K11222]
114503056  signal transducer and activator of transcription 5A isoform X1 [KO:K11223]
114502991  STAT5B; signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
114512701  STAT6; signal transducer and activator of transcription 6 isoform X3 [KO:K11225]
114492081  IRF9; LOW QUALITY PROTEIN: interferon regulatory factor 9 [KO:K04693]
114501715  CISH; cytokine-inducible SH2-containing protein [KO:K04701]
114500939  SOCS1; suppressor of cytokine signaling 1 [KO:K04694]
114510311  suppressor of cytokine signaling 2-like [KO:K04695]
114513532  SOCS2; suppressor of cytokine signaling 2 [KO:K04695]
114503090  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
114491820  SOCS4; LOW QUALITY PROTEIN: suppressor of cytokine signaling 4 [KO:K04697]
114498655  SOCS5; suppressor of cytokine signaling 5 isoform X2 [KO:K04698]
114503379  SOCS7; suppressor of cytokine signaling 7 isoform X1 [KO:K04699]
114506406  SOCS6; suppressor of cytokine signaling 6 [KO:K04699]
114507071  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
114488771  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539]
114506927  BCL2L1; bcl-2-like protein 1 [KO:K04570]
114494328  PIM1; serine/threonine-protein kinase pim-1 [KO:K04702] [EC:2.7.11.1]
114514698  MYC; myc proto-oncogene protein [KO:K04377]
114500683  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
114514087  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
114494075  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
114494317  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
114495389  aldehyde oxidase isoform X1 [KO:K00157] [EC:1.2.3.1]
114494690  aldehyde oxidase 2 [KO:K00157] [EC:1.2.3.1]
114503017  glial fibrillary acidic protein isoform X1 [KO:K05640]
114491677  STAM; signal transducing adapter molecule 1 isoform X2 [KO:K04705]
114494587  STAM2; signal transducing adapter molecule 2 isoform X1 [KO:K04705]
114506294  PTPN2; tyrosine-protein phosphatase non-receptor type 2 isoform X2 [KO:K18026] [EC:3.1.3.48]
114513480  PTPN6; tyrosine-protein phosphatase non-receptor type 6 isoform X1 [KO:K05697] [EC:3.1.3.48]
114512901  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
114495032  CREB-binding protein [KO:K04498] [EC:2.3.1.48]
114493041  PIAS1; E3 SUMO-protein ligase PIAS1 isoform X2 [KO:K04706] [EC:2.3.2.-]
114506232  PIAS2; E3 SUMO-protein ligase PIAS2 isoform X2 [KO:K16063] [EC:2.3.2.-]
114488802  PIAS3; E3 SUMO-protein ligase PIAS3 isoform X1 [KO:K16064] [EC:2.3.2.-]
114502266  PIAS4; E3 SUMO-protein ligase PIAS4 isoform X1 [KO:K16065] [EC:2.3.2.27]
114504645  FHL1; four and a half LIM domains protein 1 isoform X2 [KO:K14365]
114492948  four and a half LIM domains protein 1-like [KO:K14365]
114509670  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X2 [KO:K07293] [EC:3.1.3.48]
114503433  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
114499241  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
114493440  SOS2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
114499504  HRAS; GTPase HRas isoform X2 [KO:K02833]
114501905  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
114497407  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
114490993  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
114501452  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
114496100  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
114502559  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
114501063  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
114510957  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114512350  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114492688  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114496034  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
Reference
PMID:22383755
  Authors
Harrison DA
  Title
The Jak/STAT pathway.
  Journal
Cold Spring Harb Perspect Biol 4:a011205 (2012)
DOI:10.1101/cshperspect.a011205
Reference
PMID:22339650
  Authors
Kiu H, Nicholson SE
  Title
Biology and significance of the JAK/STAT signalling pathways.
  Journal
Growth Factors 30:88-106 (2012)
DOI:10.3109/08977194.2012.660936
Reference
PMID:21372217
  Authors
Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A, Sanmamed MF, Le Bon A, Melero I
  Title
Direct effects of type I interferons on cells of the immune system.
  Journal
Clin Cancer Res 17:2619-27 (2011)
DOI:10.1158/1078-0432.CCR-10-1114
Reference
PMID:25217450
  Authors
Fish EN, Platanias LC
  Title
Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes.
  Journal
Mol Cancer Res 12:1691-703 (2014)
DOI:10.1158/1541-7786.MCR-14-0450
Reference
PMID:21034406
  Authors
Ivanenkov YA, Balakin KV, Lavrovsky Y
  Title
Small molecule inhibitors of NF-kB and JAK/STAT signal transduction pathways as promising anti-inflammatory therapeutics.
  Journal
Mini Rev Med Chem 11:55-78 (2011)
DOI:10.2174/138955711793564079
Reference
PMID:25587654
  Authors
O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A
  Title
The JAK-STAT pathway: impact on human disease and therapeutic intervention.
  Journal
Annu Rev Med 66:311-28 (2015)
DOI:10.1146/annurev-med-051113-024537
Reference
PMID:24069565
  Authors
Zoranovic T, Grmai L, Bach EA
  Title
Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway.
  Journal
JAKSTAT 2:e25408 (2013)
DOI:10.4161/jkst.25408
Reference
PMID:16204702
  Authors
Ungureanu D, Silvennoinen O
  Title
SLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling.
  Journal
Sci STKE 2005:pe49 (2005)
DOI:10.1126/stke.3042005pe49
Reference
PMID:23735217
  Authors
Richard AJ, Stephens JM
  Title
The role of JAK-STAT signaling in adipose tissue function.
  Journal
Biochim Biophys Acta 1842:431-9 (2014)
DOI:10.1016/j.bbadis.2013.05.030
Reference
PMID:24606160
  Authors
Sun Y, Lehmbecker A, Kalkuhl A, Deschl U, Sun W, Rohn K, Tzvetanova ID, Nave KA, Baumgartner W, Ulrich R
  Title
STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis.
  Journal
Neuropathol Appl Neurobiol 41:347-70 (2015)
DOI:10.1111/nan.12133
Reference
PMID:10851053
  Authors
Hirano T, Ishihara K, Hibi M
  Title
Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors.
  Journal
Oncogene 19:2548-56 (2000)
DOI:10.1038/sj.onc.1203551
Reference
PMID:11114747
  Authors
Rane SG, Reddy EP
  Title
Janus kinases: components of multiple signaling pathways.
  Journal
Oncogene 19:5662-79 (2000)
DOI:10.1038/sj.onc.1203925
Reference
PMID:8682149
  Authors
Heim MH
  Title
The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus.
  Journal
Eur J Clin Invest 26:1-12 (1996)
DOI:10.1046/j.1365-2362.1996.103248.x
Reference
PMID:30267440
  Authors
Morris R, Kershaw NJ, Babon JJ
  Title
The molecular details of cytokine signaling via the JAK/STAT pathway.
  Journal
Protein Sci 27:1984-2009 (2018)
DOI:10.1002/pro.3519
Reference
PMID:34492272
  Authors
Tzeng HT, Chyuan IT, Lai JH
  Title
Targeting the JAK-STAT pathway in autoimmune diseases and cancers: A focus on molecular mechanisms and therapeutic potential.
  Journal
Biochem Pharmacol 193:114760 (2021)
DOI:10.1016/j.bcp.2021.114760
Reference
PMID:32203403
  Authors
Salas A, Hernandez-Rocha C, Duijvestein M, Faubion W, McGovern D, Vermeire S, Vetrano S, Vande Casteele N
  Title
JAK-STAT pathway targeting for the treatment of inflammatory bowel disease.
  Journal
Nat Rev Gastroenterol Hepatol 17:323-337 (2020)
DOI:10.1038/s41575-020-0273-0
Related
pathway
pdic04010  MAPK signaling pathway
pdic04060  Cytokine-cytokine receptor interaction
pdic04110  Cell cycle
pdic04120  Ubiquitin mediated proteolysis
pdic04151  PI3K-Akt signaling pathway
pdic04210  Apoptosis
KO pathway
ko04630   
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