KEGG   PATHWAY: pdic04010
Entry
pdic04010                   Pathway                                
Name
MAPK signaling pathway - Phyllostomus discolor (pale spear-nosed bat)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
pdic04010  MAPK signaling pathway
pdic04010

Other DBs
GO: 0000165
Organism
Phyllostomus discolor (pale spear-nosed bat) [GN:pdic]
Gene
114502598  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
114494895  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X10 [KO:K04849]
114512949  CACNA1C; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
114501473  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X11 [KO:K04851]
114511888  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
114505705  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
114504331  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X2 [KO:K04854]
114499037  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X2 [KO:K04855]
114513940  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
114512262  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
114507533  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X2 [KO:K04858]
114501400  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X5 [KO:K04859]
114502043  CACNA2D3; LOW QUALITY PROTEIN: voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
114514017  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X3 [KO:K04861]
114503277  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X2 [KO:K04862]
114491704  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X2 [KO:K04863]
114512933  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
114494364  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
114504328  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
114506960  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
114502968  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
114504057  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
114511736  CACNG6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
114511394  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
114510655  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
114502442  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
114496184  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
114502829  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
114494685  PRKCB; LOW QUALITY PROTEIN: protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
114511158  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
114509149  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
114497469  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
114503935  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 isoform X2 [KO:K04347]
114503003  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
114497754  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
114492341  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
114512239  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
114498589  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
114488654  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X2 [KO:K04349]
114512995  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X2 [KO:K12326]
114505747  LOW QUALITY PROTEIN: RAS guanyl-releasing protein 1-like [KO:K04350]
114492677  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
114500603  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
114500279  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
114511084  RASGRP4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
114503947  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X6 [KO:K08018]
114502466  NF1; neurofibromin isoform X5 [KO:K08052]
114509984  RASA1; ras GTPase-activating protein 1 [KO:K04352]
114501324  RASA2; LOW QUALITY PROTEIN: ras GTPase-activating protein 2 [KO:K08053]
114488957  RAP1A; ras-related protein Rap-1A [KO:K04353]
114512692  RAP1B; ras-related protein Rap-1b [KO:K07836]
114492590  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
114498679  TGFA; protransforming growth factor alpha [KO:K08774]
114491881  EREG; proepiregulin [KO:K09784]
114491364  AREG; amphiregulin [KO:K09782]
114510422  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
114502553  FGF2; fibroblast growth factor 2 [KO:K18497]
114509809  FGF18; fibroblast growth factor 18 [KO:K04358]
114496691  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
114503602  FGF22; LOW QUALITY PROTEIN: fibroblast growth factor 22 [KO:K04358]
114504014  FGF17; fibroblast growth factor 17 [KO:K04358]
114512610  FGF6; fibroblast growth factor 6 [KO:K04358]
114491712  FGF7; fibroblast growth factor 7 [KO:K04358]
114499168  FGF3; fibroblast growth factor 3 [KO:K04358]
114505270  FGF16; fibroblast growth factor 16 [KO:K04358]
114514054  FGF9; fibroblast growth factor 9 [KO:K04358]
114493120  FGF5; fibroblast growth factor 5 [KO:K04358]
114500857  FGF4; fibroblast growth factor 4 [KO:K04358]
114501717  FGF10; fibroblast growth factor 10 [KO:K04358]
114508944  FGF20; fibroblast growth factor 20 [KO:K04358]
114499167  FGF19; fibroblast growth factor 19 [KO:K22603]
114510830  FGF21; fibroblast growth factor 21 [KO:K22429]
114514005  FGF23; fibroblast growth factor 23 [KO:K22428]
114488932  NGF; beta-nerve growth factor [KO:K02582]
114500881  BDNF; brain-derived neurotrophic factor [KO:K04355]
114513165  NTF3; neurotrophin-3 [KO:K04356]
114511572  NTF4; neurotrophin-4 [KO:K12457]
114500824  INS; insulin [KO:K04526]
114513472  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
114500628  IGF2; insulin-like growth factor II isoform X2 [KO:K13769]
114510403  PDGFA; platelet-derived growth factor subunit A isoform X2 [KO:K04359]
114514158  PDGFB; platelet-derived growth factor subunit B isoform X2 [KO:K17386]
114504215  PDGFC; platelet-derived growth factor C [KO:K05450]
114500653  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
114489238  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
114512953  KITLG; kit ligand isoform X1 [KO:K05461]
114511215  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
114494974  VEGFA; vascular endothelial growth factor A [KO:K05448]
114499451  VEGFB; vascular endothelial growth factor B isoform X2 [KO:K16858]
114492659  PGF; placenta growth factor isoform X1 [KO:K16859]
114505353  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
114508695  VEGFC; vascular endothelial growth factor C isoform X2 [KO:K05449]
114507737  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
114514762  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
114508628  ANGPT2; LOW QUALITY PROTEIN: angiopoietin-2 [KO:K05466]
114506095  ANGPT4; angiopoietin-4 isoform X2 [KO:K05467]
114488819  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
114489065  EFNA1; ephrin-A1 [KO:K05462]
114489207  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
114504216  EFNA2; ephrin-A2 [KO:K05462]
114493256  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
114506691  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
114504302  NRTN; neurturin isoform X2 [KO:K25414]
114497958  ARTN; artemin isoform X2 [KO:K25415]
114502312  PSPN; persephin [KO:K25416]
114507607  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
114502459  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
114512713  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
114494770  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
114508370  FGFR1; fibroblast growth factor receptor 1 isoform X5 [KO:K04362] [EC:2.7.10.1]
114496712  FGFR2; fibroblast growth factor receptor 2 isoform X8 [KO:K05093] [EC:2.7.10.1]
114489924  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
114509287  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
114504180  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
114489015  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
114492084  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
114509225  INSR; LOW QUALITY PROTEIN: insulin receptor [KO:K04527] [EC:2.7.10.1]
114488551  IGF1R; insulin-like growth factor 1 receptor isoform X2 [KO:K05087] [EC:2.7.10.1]
114493180  PDGFRA; platelet-derived growth factor receptor alpha isoform X2 [KO:K04363] [EC:2.7.10.1]
114509632  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
114509447  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
114491666  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
114489000  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
114489006  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
114505286  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
114509396  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
114492293  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
114507559  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
114498561  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
114497190  EPHA2; ephrin type-A receptor 2 isoform X2 [KO:K05103] [EC:2.7.10.1]
114497427  RET; LOW QUALITY PROTEIN: proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
114503433  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
114499241  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
114493440  SOS2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
114499504  HRAS; GTPase HRas isoform X2 [KO:K02833]
114512682  KRAS; GTPase KRas isoform X1 [KO:K07827]
114489186  NRAS; GTPase NRas [KO:K07828]
114511018  RRAS; ras-related protein R-Ras [KO:K07829]
114500321  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
114501811  MRAS; ras-related protein M-Ras [KO:K07831]
114504860  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
114507230  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
114501905  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
114491735  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
114503388  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
114493217  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
114510156  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
114496946  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
114502525  MKNK2; LOW QUALITY PROTEIN: MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
114497719  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
114496354  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X2 [KO:K04373] [EC:2.7.11.1]
114490089  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X2 [KO:K04373] [EC:2.7.11.1]
114505116  RPS6KA6; LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
114505441  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
114512782  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
114504781  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
114512050  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
114514698  MYC; myc proto-oncogene protein [KO:K04377]
114493927  SRF; serum response factor [KO:K04378]
114493153  FOS; proto-oncogene c-Fos [KO:K04379]
114503143  MAPT; microtubule-associated protein tau isoform X8 [KO:K04380]
114497356  STMN1; stathmin [KO:K04381]
114512046  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
114492224  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
114492506  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
114492507  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
114492921  PLA2G4B; cytosolic phospholipase A2 beta isoform X3 [KO:K16342] [EC:3.1.1.4]
114495334  TNF; tumor necrosis factor isoform X1 [KO:K03156]
114499978  IL1A; interleukin-1 alpha [KO:K04383]
114500536  IL1B; interleukin-1 beta isoform X2 [KO:K04519]
114510965  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
114512425  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
114492736  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
114514124  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
114499425  IL1R1; interleukin-1 receptor type 1 isoform X2 [KO:K04386]
114490986  interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
114499676  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
114501577  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
114512032  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
114497076  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
114510320  CD14; monocyte differentiation antigen CD14 [KO:K04391]
114509515  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
114513229  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
114503040  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
114496144  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
114507316  LOW QUALITY PROTEIN: cell division control protein 42 homolog [KO:K04393]
114488446  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
114508735  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
114504307  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
114493976  DAXX; death domain-associated protein 6 [KO:K02308]
114501591  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
114505021  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X3 [KO:K04730] [EC:2.7.11.1]
114514079  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
114500758  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
114497596  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
114504094  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
114512579  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
114513395  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X2 [KO:K04403]
114495234  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X2 [KO:K04404]
114502488  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
114498649  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
114499282  MAP4K4; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase kinase 4 [KO:K04407] [EC:2.7.11.1]
114511644  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 isoform X1 [KO:K04408] [EC:2.7.11.1]
114505396  serine/threonine-protein kinase PAK 1-like [KO:K04409] [EC:2.7.11.1]
114498660  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
114491113  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
114506375  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
114514493  STK3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
114500332  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
114491904  MAP3K8; mitogen-activated protein kinase kinase kinase 8 isoform X2 [KO:K04415] [EC:2.7.11.25]
114512339  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
114499399  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
114494679  MAP3K2; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
114502262  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X3 [KO:K04421] [EC:2.7.11.25]
114493139  MAP3K9; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
114511012  MAP3K10; mitogen-activated protein kinase kinase kinase 10 isoform X2 [KO:K04418] [EC:2.7.11.25]
114512449  MAP3K21; mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
114513734  MAP3K12; mitogen-activated protein kinase kinase kinase 12 isoform X2 [KO:K04423] [EC:2.7.11.25]
114490458  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
114494252  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
114497665  MAP3K6; mitogen-activated protein kinase kinase kinase 6 isoform X1 [KO:K04425] [EC:2.7.11.25]
114494013  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X2 [KO:K04426] [EC:2.7.11.25]
114493958  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
114490085  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
114502475  TAOK1; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
114509224  TAOK3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
114497676  TAOK2; serine/threonine-protein kinase TAO2 isoform X2 [KO:K04429] [EC:2.7.11.1]
114514974  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
114515070  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
114515272  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
114503069  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X2 [KO:K04433] [EC:2.7.12.2]
114499926  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
114513445  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
114509502  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
114504617  FLNA; filamin-A isoform X2 [KO:K04437]
114502362  CRK; adapter molecule crk isoform X1 [KO:K04438]
114509191  CRKL; crk-like protein [KO:K04438]
114499574  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
114515025  ARRB2; beta-arrestin-2 isoform X3 [KO:K04439]
114509631  MAPK9; mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
114496029  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
114492422  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
114513098  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
114513304  MAPK11; mitogen-activated protein kinase 11 isoform X2 [KO:K04441] [EC:2.7.11.24]
114493876  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
114493878  MAPK13; mitogen-activated protein kinase 13 isoform X2 [KO:K04441] [EC:2.7.11.24]
114509429  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
114511988  MAPKAPK2; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
114501585  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
114493110  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
114499985  RPS6KA4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
114506760  CDC25B; M-phase inducer phosphatase 2 isoform X2 [KO:K05866] [EC:3.1.3.48]
114506388  NFATC1; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
114488255  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
114496428  JUN; transcription factor AP-1 [KO:K04448]
114502564  JUND; transcription factor jun-D [KO:K04449]
114495679  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
114515376  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
114512688  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
114491606  MAX; protein max isoform X1 [KO:K04453]
114510558  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
114498858  HSPB1; heat shock protein beta-1 [KO:K04455]
114510957  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114512350  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114492688  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114491722  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
114513240  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
114500541  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
114512251  PTPN7; tyrosine-protein phosphatase non-receptor type 7 isoform X2 [KO:K18019] [EC:3.1.3.48]
114510076  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
114502056  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
114497881  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
114499334  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
114514176  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
114508845  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
114512759  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
114504992  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
114512468  DUSP10; dual specificity protein phosphatase 10 isoform X1 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
114504064  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
114511087  serine/threonine-protein phosphatase 5 isoform X1 [KO:K04460] [EC:3.1.3.16]
114500211  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
114510108  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
114493937  heat shock 70 kDa protein 1 [KO:K03283]
114495179  heat shock 70 kDa protein 1-like [KO:K03283]
114490488  MECOM; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
114491548  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X6 [KO:K04463] [EC:2.7.12.2]
114515026  MAPK7; mitogen-activated protein kinase 7 isoform X2 [KO:K04464] [EC:2.7.11.24]
114513257  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
114502860  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
114496345  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
114508493  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
114504586  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
114502295  NLK; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
114492465  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X3 [KO:K02580]
114496439  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X4 [KO:K04469]
114499888  RELA; transcription factor p65 [KO:K04735]
114511323  RELB; transcription factor RelB [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
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PMID:12676795
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Annu Rev Biochem 72:609-42 (2003)
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PMID:11369511
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Harper SJ, LoGrasso P.
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
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PMID:12390245
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Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
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Genes Cells 7:1099-111 (2002)
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
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Neurosignals 11:270-81 (2002)
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Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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Cell 141:1117-34 (2010)
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Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
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Methods Mol Biol 846:1-12 (2012)
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Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
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Newton K, Dixit VM
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Signaling in innate immunity and inflammation.
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Cold Spring Harb Perspect Biol 4:a006049 (2012)
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Reference
PMID:19483709
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Gaestel M, Kotlyarov A, Kracht M
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Targeting innate immunity protein kinase signalling in inflammation.
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Nat Rev Drug Discov 8:480-99 (2009)
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Ajibade AA, Wang HY, Wang RF
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Cell type-specific function of TAK1 in innate immune signaling.
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Trends Immunol 34:307-16 (2013)
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Biochim Biophys Acta 1843:2563-2582 (2014)
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Related
pathway
pdic04070  Phosphatidylinositol signaling system
pdic04110  Cell cycle
pdic04115  p53 signaling pathway
pdic04210  Apoptosis
pdic04310  Wnt signaling pathway
pdic04668  TNF signaling pathway
KO pathway
ko04010   
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