KEGG   PATHWAY: pguu04010
Entry
pguu04010                   Pathway                                
Name
MAPK signaling pathway - Pterocles gutturalis (yellow-throated sandgrouse)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
pguu04010  MAPK signaling pathway
pguu04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Pterocles gutturalis (yellow-throated sandgrouse) [GN:pguu]
Gene
104457452  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
104457773  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
104457893  FGF20; fibroblast growth factor 20 [KO:K04358]
104458055  [KO:K04386]
104458276  [KO:K04348] [EC:3.1.3.16]
104458308  PTPN7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
104458343  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
104458403  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
104458456  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
104458504  RAPGEF2; rap guanine nucleotide exchange factor 2 [KO:K08018]
104458563  [KO:K16342] [EC:3.1.1.4]
104458606  [KO:K20216] [EC:3.1.3.16 3.1.3.48]
104458624  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
104458661  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104458667  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
104458724  [KO:K04348] [EC:3.1.3.16]
104458847  [KO:K04373] [EC:2.7.11.1]
104458907  [KO:K04441] [EC:2.7.11.24]
104458988  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
104459028  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
104459084  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
104459242  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104459262  SRF; serum response factor [KO:K04378]
104459355  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
104459366  [KO:K02833]
104459398  [KO:K04368] [EC:2.7.12.2]
104459630  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
104459746  MEF2C; myocyte-specific enhancer factor 2C [KO:K04454]
104459760  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
104459907  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
104459924  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
104460010  [KO:K04353]
104460275  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104460286  AREG; amphiregulin [KO:K09782]
104460730  [KO:K04358]
104460976  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
104461007  CACNA1G; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
104461023  [KO:K04733] [EC:2.7.11.1]
104461128  [KO:K04439]
104461274  [KO:K03099]
104461293  NTF3; neurotrophin-3 [KO:K04356]
104461336  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
104461448  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
104461654  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
104461660  TAB2; LOW QUALITY PROTEIN: TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
104461678  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
104461685  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104462031  NGF; beta-nerve growth factor [KO:K02582]
104462033  JUN; transcription factor AP-1 [KO:K04448]
104462096  [KO:K16342] [EC:3.1.1.4]
104462148  NRAS; GTPase NRas [KO:K07828]
104462233  [KO:K17534] [EC:2.7.11.25]
104462640  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
104462711  [KO:K04373] [EC:2.7.11.1]
104462723  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
104462853  [KO:K04358]
104463010  [KO:K07861]
104463112  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
104463181  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
104463273  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
104463385  [KO:K04441] [EC:2.7.11.24]
104463386  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
104463458  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
104463504  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
104463508  KRAS; GTPase KRas isoform X1 [KO:K07827]
104463524  FLT4; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
104463528  [KO:K02677] [EC:2.7.11.13]
104463631  IGF1; insulin-like growth factor I [KO:K05459]
104463634  FGF6; fibroblast growth factor 6 [KO:K04358]
104463635  [KO:K22428]
104463687  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
104463775  FGF7; fibroblast growth factor 7 [KO:K04358]
104463785  PDGFRB; LOW QUALITY PROTEIN: platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
104463786  CSF1R; LOW QUALITY PROTEIN: macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
104463869  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
104463925  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104463958  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
104464009  [KO:K04421] [EC:2.7.11.25]
104464060  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
104464183  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
104464214  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
104464244  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
104464263  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
104464393  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
104464465  [KO:K05095] [EC:2.7.10.1]
104464467  CRK; adapter molecule crk [KO:K04438]
104464723  [KO:K04358]
104464756  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
104464783  FGF3; fibroblast growth factor 3 [KO:K04358]
104464818  [KO:K04433] [EC:2.7.12.2]
104464864  TAOK1; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
104464895  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
104465091  [KO:K04849]
104465343  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104465418  [KO:K03173] [EC:2.3.2.27]
104465447  [KO:K04424] [EC:2.7.11.25]
104465484  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
104465541  CACNA1S; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
104465736  [KO:K04380]
104465790  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 [KO:K04407] [EC:2.7.11.1]
104465903  [KO:K04365] [EC:2.7.11.1]
104465991  RAP1B; ras-related protein Rap-1b [KO:K07836]
104466045  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
104466139  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
104466194  PTPN5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
104466291  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
104466443  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
104466524  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
104466773  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
104466797  FGF8; fibroblast growth factor 8 [KO:K04358]
104466815  TEK; LOW QUALITY PROTEIN: angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
104466900  PDGFC; platelet-derived growth factor C [KO:K05450]
104466902  TGFB3; transforming growth factor beta-3 [KO:K13377]
104466977  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
104466982  ANGPT1; angiopoietin-1 [KO:K05465]
104467019  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
104467079  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
104467124  VEGFA; vascular endothelial growth factor A [KO:K05448]
104467130  MECOM; MDS1 and EVI1 complex locus protein EVI1 isoform X1 [KO:K04462] [EC:2.1.1.367]
104467138  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
104467259  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
104467317  FGF18; fibroblast growth factor 18 [KO:K04358]
104467326  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
104467336  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
104467350  RRAS2; ras-related protein R-Ras2 [KO:K07830]
104467493  [KO:K04358]
104467504  [KO:K03099]
104467542  [KO:K04390]
104467681  IL1B; LOW QUALITY PROTEIN: interleukin-1 beta [KO:K04519]
104467711  RPS6KA3; ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
104467752  ELK4; ETS domain-containing protein Elk-4 isoform X1 [KO:K04376]
104467799  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
104468015  CRKL; crk-like protein [KO:K04438]
104468054  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
104468061  RPS6KA1; LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
104468104  [KO:K04369] [EC:2.7.12.2]
104468147  [KO:K09784]
104468256  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
104468292  STK4; serine/threonine-protein kinase 4 [KO:K04411]
104468306  [KO:K04869]
104468340  [KO:K04440] [EC:2.7.11.24]
104468353  RASA2; ras GTPase-activating protein 2 [KO:K08053]
104468357  [KO:K04867]
104468437  [KO:K04861]
104468568  VEGFC; vascular endothelial growth factor C [KO:K05449]
104468649  RASA1; ras GTPase-activating protein 1 [KO:K04352]
104468698  MAP3K9; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
104468762  IL1RAP; LOW QUALITY PROTEIN: interleukin-1 receptor accessory protein [KO:K04723]
104468784  INSR; LOW QUALITY PROTEIN: insulin receptor [KO:K04527] [EC:2.7.10.1]
104468818  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
104468870  [KO:K04348] [EC:3.1.3.16]
104468872  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
104468942  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
104469010  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
104469126  [KO:K04865]
104469173  PAK2; serine/threonine-protein kinase PAK 2 isoform X1 [KO:K04410] [EC:2.7.11.1]
104469186  STMN1; stathmin [KO:K04381]
104469192  [KO:K04407] [EC:2.7.11.1]
104469256  PTPRR; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
104469276  RPS6KA5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
104469338  [KO:K05452]
104469630  [KO:K02580]
104469721  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
104469727  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
104469827  [KO:K04850]
104469831  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
104469844  FGF1; fibroblast growth factor 1 [KO:K18496]
104469878  [KO:K05462]
104469888  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
104469889  [KO:K04345] [EC:2.7.11.11]
104469937  STK3; serine/threonine-protein kinase 3 [KO:K04412]
104469988  [KO:K04856]
104470023  TGFB2; transforming growth factor beta-2 [KO:K13376]
104470036  HSPA8; heat shock cognate 71 kDa protein isoform X1 [KO:K03283]
104470295  [KO:K04456] [EC:2.7.11.1]
104470440  [KO:K02580]
104470488  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104470588  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
104470657  FIGF; vascular endothelial growth factor D [KO:K05449]
104470702  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 [KO:K04406] [EC:2.7.11.1]
104470715  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
104470846  MRAS; ras-related protein M-Ras [KO:K07831]
104471146  KITLG; kit ligand [KO:K05461]
104471272  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 [KO:K04863]
104471291  [KO:K04358]
104471371  [KO:K05093] [EC:2.7.10.1]
104471657  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
104471768  [KO:K04388] [EC:2.7.11.30]
104471784  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
104471785  [KO:K16342] [EC:3.1.1.4]
104471787  [KO:K16342] [EC:3.1.1.4]
104471789  [KO:K16342] [EC:3.1.1.4]
104471790  [KO:K16342] [EC:3.1.1.4]
104471791  [KO:K16342] [EC:3.1.1.4]
104471889  FGF16; fibroblast growth factor 16 [KO:K04358]
104471930  [KO:K04357]
104472048  BDNF; brain-derived neurotrophic factor [KO:K04355]
104472084  NF1; LOW QUALITY PROTEIN: neurofibromin [KO:K08052]
104472141  INS; insulin [KO:K04526]
104472166  [KO:K05096] [EC:2.7.10.1]
104472227  MAP3K1; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
104472245  [KO:K04441] [EC:2.7.11.24]
104472257  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
104472391  [KO:K05466]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
pguu04070  Phosphatidylinositol signaling system
pguu04110  Cell cycle
pguu04115  p53 signaling pathway
pguu04210  Apoptosis
pguu04310  Wnt signaling pathway
KO pathway
ko04010   

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