KEGG   PATHWAY: pvp05206
Entry
pvp05206                    Pathway                                
Name
MicroRNAs in cancer - Pteropus vampyrus (large flying fox)
Description
MicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or the inhibition of protein translation. Using high-throughput profiling, dysregulation of miRNAs has been widely observed in different stages of cancer. The upregulation (overexpression) of specific miRNAs could lead to the repression of tumor suppressor gene expression, and conversely the downregulation of specific miRNAs could result in an increase of oncogene expression; both these situations induce subsequent malignant effects on cell proliferation, differentiation, and apoptosis that lead to tumor growth and progress. The miRNA signatures of cancer observed in various studies differ significantly. These inconsistencies occur due to the differences in the study populations and methodologies used. This pathway map shows the summarized results from various studies in 9 cancers, each of which is presented in a review article.
Class
Human Diseases; Cancer: overview
Pathway map
pvp05206  MicroRNAs in cancer
pvp05206

Organism
Pteropus vampyrus (large flying fox) [GN:pvp]
Gene
105288268  TIMP3; metalloproteinase inhibitor 3 [KO:K16866]
105288326  ZEB2; zinc finger E-box-binding homeobox 2 isoform X1 [KO:K23560]
105288383  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
105288389  PIM1; serine/threonine-protein kinase pim-1 [KO:K04702] [EC:2.7.11.1]
105288488  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
105288620  THBS1; thrombospondin-1 [KO:K16857]
105288625  BMF; bcl-2-modifying factor isoform X3 [KO:K17460]
105288811  SHC4; SHC-transforming protein 4 [KO:K17449]
105288832  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
105288867  PLAU; urokinase-type plasminogen activator [KO:K01348] [EC:3.4.21.73]
105289003  SPRY2; protein sprouty homolog 2 [KO:K17383]
105289311  CRKL; crk-like protein [KO:K04438]
105289319  GLS; glutaminase kidney isoform, mitochondrial isoform X2 [KO:K01425] [EC:3.5.1.2]
105289326  MAPK1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
105289809  DNMT3A; DNA (cytosine-5)-methyltransferase 3A [KO:K17398] [EC:2.1.1.37]
105289863  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
105289888  CCNG1; cyclin-G1 [KO:K10145]
105289974  CD44; CD44 antigen isoform X2 [KO:K06256]
105290137  HOXD10; homeobox protein Hox-D10 [KO:K09295]
105290449  E2F2; transcription factor E2F2 isoform X1 [KO:K09389]
105290479  STMN1; stathmin [KO:K04381]
105290575  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
105290926  SOCS1; suppressor of cytokine signaling 1 [KO:K04694]
105290974  ABCC1; multidrug resistance-associated protein 1 [KO:K05665] [EC:7.6.2.3]
105291004  FOXP1; forkhead box protein P1 isoform X1 [KO:K23582]
105291226  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
105291313  MAPK7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
105291512  FZD3; frizzled-3 isoform X1 [KO:K02329]
105291866  CRK; adapter molecule crk isoform X1 [KO:K04438]
105292096  SLC7A1; high affinity cationic amino acid transporter 1 isoform X1 [KO:K13863]
105292284  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
105292561  MYC; myc proto-oncogene protein [KO:K04377]
105292688  TNC; tenascin [KO:K06252]
105292715  SERPINB5; serpin B5 [KO:K10139]
105292717  BCL2; apoptosis regulator Bcl-2 isoform X2 [KO:K02161]
105292894  TNR; tenascin-R [KO:K06252]
105292895  TNN; tenascin-N [KO:K06252]
105292949  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
105292959  [KO:K07410] [EC:1.14.14.1]
105292973  PRKCE; protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
105293029  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
105293112  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X2 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
105293261  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
105293353  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
105293527  TRIM71; E3 ubiquitin-protein ligase TRIM71 [KO:K12035] [EC:2.3.2.27]
105293614  CDC25C; M-phase inducer phosphatase 3 isoform X2 [KO:K05867] [EC:3.1.3.48]
105293808  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
105293923  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
105294059  KRAS; GTPase KRas isoform X2 [KO:K07827]
105294261  TPM1; tropomyosin alpha-1 chain isoform X1 [KO:K10373]
105294429  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
105294446  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
105294516  PDCD4; programmed cell death protein 4 isoform X1 [KO:K16865]
105294593  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
105294612  FSCN1; fascin [KO:K23551]
105294710  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
105294748  IRS1; insulin receptor substrate 1 [KO:K16172]
105294787  ABCB1; multidrug resistance protein 1 isoform X1 [KO:K05658] [EC:7.6.2.2]
105294910  VIM; vimentin [KO:K07606]
105294927  BMI1; polycomb complex protein BMI-1 [KO:K11459]
105295029  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
105295145  RASSF1; ras association domain-containing protein 1 isoform X1 [KO:K09850]
105295257  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
105295466  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
105295478  APC; adenomatous polyposis coli protein isoform X3 [KO:K02085]
105295655  RDX; radixin [KO:K05762]
105295713  EZH2; histone-lysine N-methyltransferase EZH2 isoform X4 [KO:K11430] [EC:2.1.1.356]
105296033  [KO:K07436] [EC:1.14.15.16]
105296163  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
105296273  RECK; reversion-inducing cysteine-rich protein with Kazal motifs [KO:K17461]
105296373  EFNA1; ephrin-A1 [KO:K05462]
105296374  EFNA4; ephrin-A4 [KO:K05462]
105296379  SHC1; SHC-transforming protein 1 isoform X3 [KO:K06279]
105296443  EFNA3; ephrin-A3 [KO:K05462]
105296521  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
105296550  NRAS; GTPase NRas isoform X1 [KO:K07828]
105296605  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105297140  [KO:K02649]
105297463  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
105297702  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
105297815  NOTCH2; neurogenic locus notch homolog protein 2 [KO:K20994]
105297873  [KO:K17390]
105298051  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
105298078  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
105298112  BMPR2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
105298192  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
105298302  ZFPM2; zinc finger protein ZFPM2 isoform X1 [KO:K17442]
105298312  ZEB1; zinc finger E-box-binding homeobox 1 isoform X1 [KO:K09299]
105298511  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
105298625  NOTCH1; neurogenic locus notch homolog protein 1 [KO:K02599]
105298669  ABL1; tyrosine-protein kinase ABL1 [KO:K06619] [EC:2.7.10.2]
105299021  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105299371  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
105299436  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
105299958  WNT3A; protein Wnt-3a [KO:K00312]
105300036  HNRNPK; heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886]
105300174  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
105300269  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
105300541  [KO:K02163]
105300662  SLC45A3; solute carrier family 45 member 3 [KO:K15379]
105300677  MDM4; protein Mdm4 isoform X1 [KO:K10127]
105300805  RPS6KA5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
105301000  [KO:K14021]
105301022  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
105301186  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
105301202  HMGA2; high mobility group protein HMGI-C isoform X1 [KO:K09283]
105301327  IRS2; insulin receptor substrate 2 isoform X1 [KO:K07187]
105301329  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
105301705  SIRT1; NAD-dependent protein deacetylase sirtuin-1 isoform X1 [KO:K11411] [EC:2.3.1.286]
105301871  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
105302235  EFNA2; ephrin-A2 [KO:K05462]
105302259  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
105302354  CDC25A; M-phase inducer phosphatase 1 isoform X1 [KO:K06645] [EC:3.1.3.48]
105302383  RHOA; transforming protein RhoA [KO:K04513]
105302571  GLS2; glutaminase liver isoform, mitochondrial [KO:K01425] [EC:3.5.1.2]
105302594  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
105302702  ITGA5; integrin alpha-5 [KO:K06484]
105302792  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
105302922  ST14; suppressor of tumorigenicity 14 protein [KO:K08670] [EC:3.4.21.109]
105302989  EZR; ezrin [KO:K08007]
105303098  CREBBP; CREB-binding protein [KO:K04498] [EC:2.3.1.48]
105303293  UBE2I; SUMO-conjugating enzyme UBC9 [KO:K10577]
105303446  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
105303453  WNT3; proto-oncogene Wnt-3 [KO:K00312]
105303496  HDAC5; histone deacetylase 5 isoform X1 [KO:K11406] [EC:3.5.1.98]
105303816  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
105303970  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
105304277  E2F1; transcription factor E2F1 [KO:K17454]
105304323  DNMT3B; DNA (cytosine-5)-methyltransferase 3B [KO:K17399] [EC:2.1.1.37]
105304566  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
105305150  DICER1; endoribonuclease Dicer [KO:K11592] [EC:3.1.26.-]
105305213  [KO:K11406] [EC:3.5.1.98]
105305275  NOTCH4; neurogenic locus notch homolog protein 4 isoform X3 [KO:K20996]
105305336  TNXB; LOW QUALITY PROTEIN: tenascin-X [KO:K06252]
105305586  DNMT1; DNA (cytosine-5)-methyltransferase 1 isoform X1 [KO:K00558] [EC:2.1.1.37]
105305933  HRAS; GTPase HRas isoform X1 [KO:K02833]
105306141  [KO:K04361] [EC:2.7.10.1]
105306256  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
105306294  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
105306495  SOX4; transcription factor SOX-4 [KO:K23581]
105306509  TP63; tumor protein 63 isoform X1 [KO:K10149]
105306744  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
105307128  [KO:K04503]
105307215  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105307238  IGF2BP1; insulin-like growth factor 2 mRNA-binding protein 1 isoform X1 [KO:K17391]
105307498  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
105307575  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105308251  NOTCH3; neurogenic locus notch homolog protein 3 [KO:K20995]
105308799  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
105308818  [KO:K19662] [EC:2.7.11.13]
105308956  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
105309462  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
105309535  SOS2; son of sevenless homolog 2 [KO:K03099]
105309593  KIF23; kinesin-like protein KIF23 isoform X1 [KO:K17387]
105309827  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
105311175  HMOX1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
111728746  [KO:K14021]
Reference
PMID:18817506
  Authors
Lee YS, Dutta A
  Title
MicroRNAs in cancer.
  Journal
Annu Rev Pathol 4:199-227 (2009)
DOI:10.1146/annurev.pathol.4.110807.092222
Reference
PMID:21402473
  Authors
Babashah S, Soleimani M
  Title
The oncogenic and tumour suppressive roles of microRNAs in cancer and apoptosis.
  Journal
Eur J Cancer 47:1127-37 (2011)
DOI:10.1016/j.ejca.2011.02.008
Reference
PMID:19630570
  Authors
Garzon R, Calin GA, Croce CM
  Title
MicroRNAs in Cancer.
  Journal
Annu Rev Med 60:167-79 (2009)
DOI:10.1146/annurev.med.59.053006.104707
Reference
PMID:23075324
  Authors
Chen PS, Su JL, Hung MC
  Title
Dysregulation of microRNAs in cancer.
  Journal
J Biomed Sci 19:90 (2012)
DOI:10.1186/1423-0127-19-90
Reference
PMID:22035854
  Authors
Ling H, Zhang W, Calin GA
  Title
Principles of microRNA involvement in human cancers.
  Journal
Chin J Cancer 30:739-48 (2011)
DOI:10.5732/cjc.011.10243
Reference
PMID:22351564
  Authors
Iorio MV, Croce CM
  Title
MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review.
  Journal
EMBO Mol Med 4:143-59 (2012)
DOI:10.1002/emmm.201100209
Reference
PMID:21742789
  Authors
Sayed D, Abdellatif M
  Title
MicroRNAs in development and disease.
  Journal
Physiol Rev 91:827-87 (2011)
DOI:10.1152/physrev.00006.2010
Reference
PMID:22345301
  Authors
Wang Q, Wang S, Wang H, Li P, Ma Z
  Title
MicroRNAs: novel biomarkers for lung cancer diagnosis, prediction and treatment.
  Journal
Exp Biol Med (Maywood) 237:227-35 (2012)
DOI:10.1258/ebm.2011.011192
Reference
PMID:22580099
  Authors
Song JH, Meltzer SJ
  Title
MicroRNAs in pathogenesis, diagnosis, and treatment of gastroesophageal cancers.
  Journal
Gastroenterology 143:35-47.e2 (2012)
DOI:10.1053/j.gastro.2012.05.003
Reference
PMID:23462054
  Authors
Chu Y, Zhu H, Lv L, Zhou Y, Huo J
  Title
MiRNA s in oesophageal squamous cancer.
  Journal
Neth J Med 71:69-75 (2013)
Reference
PMID:19773200
  Authors
Kan T, Meltzer SJ
  Title
MicroRNAs in Barrett's esophagus and esophageal adenocarcinoma.
  Journal
Curr Opin Pharmacol 9:727-32 (2009)
DOI:10.1016/j.coph.2009.08.009
Reference
PMID:20128019
  Authors
Smith CM, Watson DI, Michael MZ, Hussey DJ
  Title
MicroRNAs, development of Barrett's esophagus, and progression to esophageal adenocarcinoma.
  Journal
World J Gastroenterol 16:531-7 (2010)
DOI:10.3748/wjg.v16.i5.531
Reference
PMID:23165235
  Authors
Song S, Ajani JA
  Title
The role of microRNAs in cancers of the upper gastrointestinal tract.
  Journal
Nat Rev Gastroenterol Hepatol 10:109-18 (2013)
DOI:10.1038/nrgastro.2012.210
Reference
PMID:21565290
  Authors
Liu WH, Yeh SH, Chen PJ
  Title
Role of microRNAs in hepatitis B virus replication and pathogenesis.
  Journal
Biochim Biophys Acta 1809:678-85 (2011)
DOI:10.1016/j.bbagrm.2011.04.008
Reference
PMID:23091478
  Authors
Hrasovec S, Glavac D
  Title
MicroRNAs as Novel Biomarkers in Colorectal Cancer.
  Journal
Front Genet 3:180 (2012)
DOI:10.3389/fgene.2012.00180
Reference
PMID:22926415
  Authors
Liu H
  Title
MicroRNAs in breast cancer initiation and progression.
  Journal
Cell Mol Life Sci 69:3587-99 (2012)
DOI:10.1007/s00018-012-1128-9
Reference
PMID:20345848
  Authors
Li SD, Zhang JR, Wang YQ, Wan XP
  Title
The role of microRNAs in ovarian cancer initiation and progression.
  Journal
J Cell Mol Med 14:2240-9 (2010)
DOI:10.1111/j.1582-4934.2010.01058.x
Reference
PMID:23316212
  Authors
Zabolotneva AA, Zhavoronkov A, Garazha AV, Roumiantsev SA, Buzdin AA
  Title
Characteristic patterns of microRNA expression in human bladder cancer.
  Journal
Front Genet 3:310 (2012)
DOI:10.3389/fgene.2012.00310
Reference
PMID:20221895
  Authors
Saini S, Majid S, Dahiya R
  Title
Diet, microRNAs and prostate cancer.
  Journal
Pharm Res 27:1014-26 (2010)
DOI:10.1007/s11095-010-0086-x
Related
pathway
pvp05210  Colorectal cancer
pvp05214  Glioma
pvp05215  Prostate cancer
pvp05219  Bladder cancer
pvp05222  Small cell lung cancer
pvp05223  Non-small cell lung cancer
KO pathway
ko05206   

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