Entry
Name
Cytokine-cytokine receptor interaction - Rhinolophus ferrumequinum (greater horseshoe bat)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
rfq04060 Cytokine-cytokine receptor interaction
Ortholog table
Organism
Rhinolophus ferrumequinum (greater horseshoe bat) [GN:
rfq ]
Gene
117021908 alveolar macrophage chemotactic factor-like isoform X1 [KO:K05506 ]
117022233 CXCL11; LOW QUALITY PROTEIN: C-X-C motif chemokine 11 [KO:K12672 ]
117017067 CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427 ]
117029942 CLCF1; cardiotrophin-like cytokine factor 1 isoform X1 [KO:K05421 ]
117019343 IL1RN; interleukin-1 receptor antagonist protein isoform X1 [KO:K05481 ]
117019266 IL36RN; LOW QUALITY PROTEIN: interleukin-36 receptor antagonist protein [KO:K05483 ]
117014994 CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453 ]
117038021 TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477 ]
117014309 FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
117012422 TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721 ]
117021430 TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473 ]
117013812 TNFSF12; tumor necrosis factor ligand superfamily member 12 isoform X1 [KO:K05474 ]
117031616 TNFSF8; tumor necrosis factor ligand superfamily member 8 [KO:K05471 ]
117038092 TNFSF9; tumor necrosis factor ligand superfamily member 9 [KO:K05472 ]
117014869 TNFSF4; tumor necrosis factor ligand superfamily member 4 [KO:K05469 ]
117014871 TNFSF18; tumor necrosis factor ligand superfamily member 18 [KO:K05479 ]
117013811 tumor necrosis factor ligand superfamily member 13 isoform X1 [KO:K05475 ]
117021465 TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476 ]
117018527 TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376 ]
117029472 IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069 ]
117019653 IL4R; LOW QUALITY PROTEIN: interleukin-4 receptor subunit alpha [KO:K05071 ]
117019208 IL15RA; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074 ]
117029540 IL3RA; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737 ]
117028020 LOW QUALITY PROTEIN: cytokine receptor common subunit beta-like [KO:K04738 ]
117029211 cytokine receptor common subunit beta-like isoform X1 [KO:K04738 ]
117028565 granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like isoform X1 [KO:K05066 ]
117027656 CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061 ]
117014426 IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055 ]
117024735 IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060 ]
117032099 IL11RA; interleukin-11 receptor subunit alpha isoform X1 [KO:K05056 ]
117038178 IL27RA; interleukin-27 receptor subunit alpha isoform X1 [KO:K19598 ]
117031925 CNTFR; ciliary neurotrophic factor receptor subunit alpha [KO:K05059 ]
117025195 OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057 ]
117030829 IL10RA; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134 ]
117020734 IL20RA; interleukin-20 receptor subunit alpha isoform X1 [KO:K05136 ]
117026844 IL22RA1; interleukin-22 receptor subunit alpha-1 isoform X1 [KO:K05138 ]
117036159 IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723 ]
117033296 IL1RL2; LOW QUALITY PROTEIN: interleukin-1 receptor-like 2 [KO:K05172 ]
117032651 IL18RAP; LOW QUALITY PROTEIN: interleukin-18 receptor accessory protein [KO:K05174 ]
117028184 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
117027578 TNFRSF1B; tumor necrosis factor receptor superfamily member 1B [KO:K05141 ]
117028187 LTBR; tumor necrosis factor receptor superfamily member 3 [KO:K03159 ]
117026964 TNFRSF14; tumor necrosis factor receptor superfamily member 14 isoform X1 [KO:K05152 ]
117016318 TNFRSF6B; tumor necrosis factor receptor superfamily member 6B [KO:K05143 ]
117035725 FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390 ]
117027168 TNFRSF25; tumor necrosis factor receptor superfamily member 25 isoform X1 [KO:K05160 ]
117038097 tumor necrosis factor receptor superfamily member 10B-like [KO:K04722 ]
117038099 tumor necrosis factor receptor superfamily member 10A-like isoform X1 [KO:K04722 ]
117019569 TNFRSF21; tumor necrosis factor receptor superfamily member 21 [KO:K05157 ]
117032662 EDAR; tumor necrosis factor receptor superfamily member EDAR isoform X1 [KO:K05162 ]
117024165 EDA2R; tumor necrosis factor receptor superfamily member 27 isoform X1 [KO:K05163 ]
117013914 NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583 ]
117033796 TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148 ]
117038716 TNFRSF11A; tumor necrosis factor receptor superfamily member 11A isoform X1 [KO:K05147 ]
117019451 TNFRSF12A; tumor necrosis factor receptor superfamily member 12A [KO:K05149 ]
117026756 TNFRSF8; tumor necrosis factor receptor superfamily member 8 [KO:K05145 ]
117015694 CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160 ]
117027456 TNFRSF9; tumor necrosis factor receptor superfamily member 9 isoform X1 [KO:K05146 ]
117027341 TNFRSF4; tumor necrosis factor receptor superfamily member 4 isoform X1 [KO:K05142 ]
117027263 TNFRSF18; tumor necrosis factor receptor superfamily member 18 [KO:K05154 ]
117019461 TNFRSF17; tumor necrosis factor receptor superfamily member 17 [KO:K05153 ]
117012821 TNFRSF13B; tumor necrosis factor receptor superfamily member 13B [KO:K05150 ]
117028003 TNFRSF13C; tumor necrosis factor receptor superfamily member 13C isoform X1 [KO:K05151 ]
117021711 TNFRSF19; tumor necrosis factor receptor superfamily member 19 isoform X1 [KO:K05155 ]
117031170 RELT; tumor necrosis factor receptor superfamily member 19L [KO:K05156 ]
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Reference
Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
Journal
Reference
Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
Journal
Reference
Authors
Boulanger MJ, Garcia KC
Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
Journal
Reference
Authors
Allan SM, Tyrrell PJ, Rothwell NJ
Title
Interleukin-1 and neuronal injury.
Journal
Reference
Authors
Lopetuso LR, Chowdhry S, Pizarro TT
Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
Journal
Reference
Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
Title
Functional specialization of interleukin-17 family members.
Journal
Reference
Authors
Fischer P, Hilfiker-Kleiner D
Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
Journal
Reference
Authors
Richards CD
Title
The enigmatic cytokine oncostatin m and roles in disease.
Journal
Reference
Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
Title
Structures and biological functions of IL-31 and IL-31 receptors.
Journal
Reference
Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
Journal
Reference
Authors
de Weerd NA, Nguyen T
Title
The interferons and their receptors--distribution and regulation.
Journal
Reference
Authors
Aggarwal BB
Title
Signalling pathways of the TNF superfamily: a double-edged sword.
Journal
Reference
Authors
Ashkenazi A
Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
Journal
Reference
Authors
Seeger P, Musso T, Sozzani S
Title
The TGF-beta superfamily in dendritic cell biology.
Journal
Reference
Authors
Wakefield LM, Hill CS
Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
Journal
Reference
Authors
Mueller TD, Nickel J
Title
Promiscuity and specificity in BMP receptor activation.
Journal
KO pathway
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