Network variation - Human T-cell leukemia virus 1 (HTLV-1)
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ENTRY
nt06160
Name
Human T-cell leukemia virus 1 (HTLV-1)
Category
Disease view; Viral infection
Pathway
hsa05166
Human T-cell leukemia virus 1 infection
Genome
T40003
Disease
H00009
Adult T-cell leukemia
Display
drug-target relation
disease type
PI3K signaling
N00390
EGF
→
EGFR
→
PI3K
→
PIP3
→
AKT
→
IKK
→
NFKBIA
→
NFKB
N00501
TAX
→
PI3K
N00220
PTEN
⊣
PIP3
→
AKT
N00502
TAX
⊣
DLG1
→
PTEN
TGFB signaling
N00063
TGFB
→
(TGFBR2+TGFBR1)
→
(SMAD2,SMAD3)
=
SMAD4
N00507
TAX
⊣
(
SMAD2
,
SMAD3
)
JAK-STAT signaling
N00053
Cytokine
→
Receptor
→
JAK
→
STAT
⇒
PIM1
N00491
P12
→
IL2RB/G
→
JAK1/3
→
STAT5
⇒
IL2
Calcium signaling
N00487
IGH
→
(LYN,SYK)
→
(BTK,BLNK)
→
PLCG2
→
IP3
→
Ca2+
→
CALM
=
CN
→
NFAT
N00490
P12
=
(
CALR
,
CANX
)
→
Ca2+
TNF signaling
N00446
TNF
→
TNFRSF1A
→
(RIPK1+TRADD+TRAF2..
→
(TAK1+TAB1/2)
→
MKK4/7
→
JNK
→
AP1
N00503
TAX
→
(
MAPK8
,
MAPK9
,
MAPK1..
→
JUN
⇒
MMP7
N00151
TNF
→
TNFRSF1A
→
(RIPK1+TRADD+TRAF2..
→
(TAB1/2/3+TAK1)
→
IKK
→
NFKBIA
→
NFKB
N00504
TAX
→
IKK
→
NFKBIA
→
NFKB
N00505
CD40LG
→
CD40
→
(TRAF2+TRAF3)
→
NIK
→
IKKA
→
(NFKB2+RELB)
N00506
TAX
=
IKBKG
→
IKKA
→
(
NFKB2
+
RELB
)
MHC presentation
N00363
TAP1/2
=
TAPBP
=
(PDIA3+CALR)
→
(MHCI+B2M)
N00492
P12
⊣
(
MHCI
+
B2M
)
Cell cycle
N00069
CDKN2A
⊣
(CCND+CDK4/6)
→
RB1
⌿
E2F
N00494
TAX
⊣
CDKN2A
N00090
(MYC+MAX)
⊣
ZBTB17
⇒
CDKN2B
⊣
(CCND+CDK4/6)
→
RB1
⌿
E2F
N00495
TAX
⊣
CDKN2B
N00499
(ATM,ATR)
→
CHEK1
→
TP53
⇒
CDKN1A
⊣
(CDK1+CCNB)
N00500
TAX
⊣
CHEK1
N00493
MAD1L1
→
(MAD2L1/2+BUB1B+BU..
⊣
(ANAPC+CDC20)
⊣
PTTG
⊣
ESPL1
N00222
TAX
⊣
MAD1L1
N00221
TAX
→
(
ANAPC
+
CDC20
)
⊣
PTTG
⊣
ESPL1
Transcription
N00489
P30II
→
(
MYC
+
TRRAP
+
KAT5
)
⇒
CCND2
N00497
TAX
⊣
TP53
⇒
CDKN1A
⊣
(
CDK2
+
CCNE
)
→
RB1
⌿
E2F
N00498
TAX
⊣
CDKN1A
⊣
(
CDK2
+
CCNE
)
→
RB1
⌿
E2F
N00508
TAX
→
NFYB
⇒
MHCII
N00509
TAX
→
SRF
⇒
(
FOS
,
FOSL1
,
EGR1
,
EG..
N00510
TAX
→
CREB3
⇒
CCND1
N00511
TAX
⊣
E47
⇒
(
POLB
,
LCK
,
BAX
,
CDKN..
N00512
TAX
⊣
MYC
⇒
TERT