KEGG   PATHWAY: dle04630
dle04630                    Pathway                                

JAK-STAT signaling pathway - Delphinapterus leucas (beluga whale)
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
Environmental Information Processing; Signal transduction
Pathway map
dle04630  JAK-STAT signaling pathway

Other DBs
GO: 0007259
Delphinapterus leucas (beluga whale) [GN:dle]
111186150  IL2; interleukin-2 [KO:K05429]
111182348  interleukin-3-like [KO:K04736]
111182418  IL4; interleukin-4 [KO:K05430]
111182417  IL5; interleukin-5 [KO:K05428]
111181978  IL6; interleukin-6 [KO:K05405]
111164935  IL7; interleukin-7 isoform X1 [KO:K05431]
111182469  IL9; interleukin-9 [KO:K05432]
111184748  IL10; interleukin-10 [KO:K05443]
111181029  IL11; interleukin-11 [KO:K05417]
111174517  IL12A; interleukin-12 subunit alpha [KO:K05406]
111170635  IL12B; interleukin-12 subunit beta [KO:K05425]
111182419  IL13; interleukin-13 [KO:K05435]
111187740  IL15; interleukin-15 isoform X1 [KO:K05433]
111175147  IL17D; interleukin-17D [KO:K05492]
111184612  IL19; interleukin-19 [KO:K05444]
111184604  IL20; LOW QUALITY PROTEIN: interleukin-20 [KO:K22667]
111186103  IL21; interleukin-21 [KO:K05434]
111173651  IL22; interleukin-22 [KO:K05445]
111173709  IL23A; interleukin-23 subunit alpha [KO:K05426]
111184747  IL24; interleukin-24 isoform X1 [KO:K22668]
111171121  interferon alpha-1-like [KO:K05414]
111171122  interferon alpha-1-like isoform X1 [KO:K05414]
111163101  LOW QUALITY PROTEIN: interferon alpha-8-like [KO:K05414]
111163130  interferon alpha-1-like [KO:K05414]
111174560  IFNB1; interferon beta [KO:K05415]
111173770  IFNG; interferon gamma [KO:K04687]
111163105  IFNE; interferon epsilon [KO:K05442]
111163127  IFNK; interferon kappa [KO:K05441]
111180531  interferon lambda-3-like [KO:K22669]
111180533  interferon lambda-3-like [KO:K22669]
111171093  interferon omega-1-like [KO:K05440]
111163129  interferon omega-1-like [KO:K05440]
111162704  OSM; oncostatin-M [KO:K05418]
111162806  LIF; leukemia inhibitory factor [KO:K05419]
111182131  CTF1; cardiotrophin-1 isoform X1 [KO:K05422]
111182135  cardiotrophin-2 [KO:K24382]
111182406  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
111183926  CNTF; ciliary neurotrophic factor [KO:K05420]
111166403  CSF3; granulocyte colony-stimulating factor [KO:K05423]
111182312  EPO; erythropoietin [KO:K05437]
111182618  somatotropin isoform X1 [KO:K05438]
111182801  LEP; leptin isoform X1 [KO:K05424]
111173147  THPO; thrombopoietin isoform X1 [KO:K06854]
111181274  PRL; prolactin isoform X1 [KO:K05439]
111186135  EGF; pro-epidermal growth factor [KO:K04357]
111169371  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
111186344  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
111177977  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
111186349  IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
111167807  IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070]
111168262  IL3RA; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737]
111182213  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
111174176  IL5RA; interleukin-5 receptor subunit alpha isoform X1 [KO:K05067]
111167075  IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
111187554  IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072]
111185080  IL9R; interleukin-9 receptor [KO:K05073]
111166949  IL10RA; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134]
111163875  IL10RB; interleukin-10 receptor subunit beta isoform X1 [KO:K05135]
111163143  IL11RA; interleukin-11 receptor subunit alpha isoform X1 [KO:K05056]
111166653  IL12RB1; interleukin-12 receptor subunit beta-1 isoform X1 [KO:K05063]
111178439  IL12RB2; interleukin-12 receptor subunit beta-2 isoform X1 [KO:K05064]
111169041  IL13RA1; interleukin-13 receptor subunit alpha-1 [KO:K05076]
111165769  IL13RA2; interleukin-13 receptor subunit alpha-2 [KO:K05077]
111177976  IL15RA; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074]
111166190  IL20RA; interleukin-20 receptor subunit alpha isoform X2 [KO:K05136]
111179218  IL20RB; interleukin-20 receptor subunit beta isoform X1 [KO:K05137]
111182214  IL21R; interleukin-21 receptor isoform X2 [KO:K05075]
111163429  IL22RA1; interleukin-22 receptor subunit alpha-1 [KO:K05138]
111168305  IL22RA2; interleukin-22 receptor subunit alpha-2 [KO:K05139]
111178441  IL23R; interleukin-23 receptor [KO:K05065]
111166637  IL27RA; interleukin-27 receptor subunit alpha isoform X1 [KO:K19598]
111186578  IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
111163780  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
111163874  IFNAR2; interferon alpha/beta receptor 2 isoform X3 [KO:K05131]
111166198  IFNGR1; interferon gamma receptor 1 [KO:K05132]
111163885  IFNGR2; interferon gamma receptor 2 [KO:K05133]
111163318  IFNLR1; interferon lambda receptor 1 isoform X1 [KO:K05140]
111187296  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
111187327  LIFR; leukemia inhibitory factor receptor isoform X1 [KO:K05058]
111168275  CRLF2; cytokine receptor-like factor 2 [KO:K05078]
111163128  CNTFR; ciliary neurotrophic factor receptor subunit alpha isoform X1 [KO:K05059]
111168273  CSF2RA; granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1 [KO:K05066]
111186251  CSF2RB; cytokine receptor common subunit beta [KO:K04738]
111175589  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
111166139  erythropoietin receptor [KO:K05079]
111165942  erythropoietin receptor [KO:K05079]
111187036  GHR; growth hormone receptor isoform X1 [KO:K05080]
111178451  LEPR; leptin receptor isoform X1 [KO:K05062]
111175412  MPL; thrombopoietin receptor [KO:K05082]
111187584  PRLR; prolactin receptor isoform X1 [KO:K05081]
111184548  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:]
111169692  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:]
111183086  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:]
111178461  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:]
111174651  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:]
111166590  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:]
111166017  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:]
111171663  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
111173869  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
111166491  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
111171668  STAT4; signal transducer and activator of transcription 4 isoform X1 [KO:K11222]
111166337  signal transducer and activator of transcription 5A isoform X1 [KO:K11223]
111166483  signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
111173850  STAT6; signal transducer and activator of transcription 6 isoform X4 [KO:K11225]
111174349  CISH; cytokine-inducible SH2-containing protein isoform X1 [KO:K04701]
111163537  SOCS1; suppressor of cytokine signaling 1 [KO:K04694]
111163600  SOCS2; suppressor of cytokine signaling 2 [KO:K04695]
111182757  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
111173136  SOCS4; suppressor of cytokine signaling 4 [KO:K04697]
111174797  SOCS5; suppressor of cytokine signaling 5 [KO:K04698]
111166263  SOCS7; suppressor of cytokine signaling 7 isoform X1 [KO:K04699]
111180175  SOCS6; suppressor of cytokine signaling 6 [KO:K04699]
111180199  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
111169732  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539]
111184326  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
111178754  PIM1; serine/threonine-protein kinase pim-1 isoform X1 [KO:K04702] [EC:]
111186679  LOW QUALITY PROTEIN: serine/threonine-protein kinase pim-1-like [KO:K04702] [EC:]
111164391  MYC; myc proto-oncogene protein [KO:K04377]
111183632  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
111176638  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
111178811  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
111178743  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
111171714  aldehyde oxidase 1 isoform X1 [KO:K00157] [EC:]
111170230  GFAP; glial fibrillary acidic protein isoform X1 [KO:K05640]
111172761  STAM2; signal transducing adapter molecule 2 isoform X1 [KO:K04705]
111178113  STAM; signal transducing adapter molecule 1 [KO:K04705]
111163085  PTPN2; tyrosine-protein phosphatase non-receptor type 2 isoform X1 [KO:K18026] [EC:]
111176702  PTPN6; tyrosine-protein phosphatase non-receptor type 6 isoform X1 [KO:K05697] [EC:]
111164116  IRF9; LOW QUALITY PROTEIN: interferon regulatory factor 9 [KO:K04693]
111185248  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:]
111186470  EP300; histone acetyltransferase p300 [KO:K04498] [EC:]
111177755  PIAS1; E3 SUMO-protein ligase PIAS1 isoform X1 [KO:K04706] [EC:2.3.2.-]
111168224  PIAS2; E3 SUMO-protein ligase PIAS2 isoform X1 [KO:K16063] [EC:2.3.2.-]
111179937  PIAS3; E3 SUMO-protein ligase PIAS3 isoform X1 [KO:K16064] [EC:2.3.2.-]
111166027  PIAS4; E3 SUMO-protein ligase PIAS4 isoform X1 [KO:K16065] [EC:]
111164535  FHL1; four and a half LIM domains protein 1 isoform X1 [KO:K14365]
111188123  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:]
111187198  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:]
111182833  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
111174855  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
111173177  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
111170340  HRAS; GTPase HRas isoform X1 [KO:K02833]
111168973  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:]
111173839  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:]
111179235  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:]
111187262  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:]
111166652  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
111185984  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
111175760  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
111177559  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:]
111176008  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:]
111180855  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:]
111187265  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:]
Harrison DA
The Jak/STAT pathway.
Cold Spring Harb Perspect Biol 4:a011205 (2012)
Kiu H, Nicholson SE
Biology and significance of the JAK/STAT signalling pathways.
Growth Factors 30:88-106 (2012)
Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A, Sanmamed MF, Le Bon A, Melero I
Direct effects of type I interferons on cells of the immune system.
Clin Cancer Res 17:2619-27 (2011)
Fish EN, Platanias LC
Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes.
Mol Cancer Res 12:1691-703 (2014)
Ivanenkov YA, Balakin KV, Lavrovsky Y
Small molecule inhibitors of NF-kB and JAK/STAT signal transduction pathways as promising anti-inflammatory therapeutics.
Mini Rev Med Chem 11:55-78 (2011)
O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A
The JAK-STAT pathway: impact on human disease and therapeutic intervention.
Annu Rev Med 66:311-28 (2015)
Zoranovic T, Grmai L, Bach EA
Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway.
JAKSTAT 2:e25408 (2013)
Ungureanu D, Silvennoinen O
SLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling.
Sci STKE 2005:pe49 (2005)
Richard AJ, Stephens JM
The role of JAK-STAT signaling in adipose tissue function.
Biochim Biophys Acta 1842:431-9 (2014)
Sun Y, Lehmbecker A, Kalkuhl A, Deschl U, Sun W, Rohn K, Tzvetanova ID, Nave KA, Baumgartner W, Ulrich R
STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis.
Neuropathol Appl Neurobiol 41:347-70 (2015)
Hirano T, Ishihara K, Hibi M
Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors.
Oncogene 19:2548-56 (2000)
Rane SG, Reddy EP
Janus kinases: components of multiple signaling pathways.
Oncogene 19:5662-79 (2000)
Heim MH
The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus.
Eur J Clin Invest 26:1-12 (1996)
dle04010  MAPK signaling pathway
dle04060  Cytokine-cytokine receptor interaction
dle04110  Cell cycle
dle04120  Ubiquitin mediated proteolysis
dle04151  PI3K-Akt signaling pathway
dle04210  Apoptosis
KO pathway

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