Entry |
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Name |
JAK-STAT signaling pathway - Delphinapterus leucas (beluga whale)
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Description |
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
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Class |
Environmental Information Processing; Signal transduction
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Pathway map |

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Other DBs |
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Organism |
Delphinapterus leucas (beluga whale) [GN: dle]
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Gene |
111182406 | CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427] |
111186344 | PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386] |
111186349 | IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069] |
111167807 | IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070] |
111168262 | IL3RA; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737] |
111182213 | IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071] |
111174176 | IL5RA; interleukin-5 receptor subunit alpha isoform X1 [KO:K05067] |
111167075 | IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055] |
111187554 | IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072] |
111166949 | IL10RA; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134] |
111163875 | IL10RB; interleukin-10 receptor subunit beta isoform X1 [KO:K05135] |
111163143 | IL11RA; interleukin-11 receptor subunit alpha isoform X1 [KO:K05056] |
111166653 | IL12RB1; interleukin-12 receptor subunit beta-1 isoform X1 [KO:K05063] |
111178439 | IL12RB2; interleukin-12 receptor subunit beta-2 isoform X1 [KO:K05064] |
111177976 | IL15RA; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074] |
111166190 | IL20RA; interleukin-20 receptor subunit alpha isoform X2 [KO:K05136] |
111179218 | IL20RB; interleukin-20 receptor subunit beta isoform X1 [KO:K05137] |
111166637 | IL27RA; interleukin-27 receptor subunit alpha isoform X1 [KO:K19598] |
111186578 | IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060] |
111187296 | OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057] |
111163128 | CNTFR; ciliary neurotrophic factor receptor subunit alpha isoform X1 [KO:K05059] |
111168273 | CSF2RA; granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1 [KO:K05066] |
111175589 | CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061] |
111171663 | STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220] |
111173869 | STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221] |
111166491 | STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692] |
111171668 | STAT4; signal transducer and activator of transcription 4 isoform X1 [KO:K11222] |
111166337 | signal transducer and activator of transcription 5A isoform X1 [KO:K11223] |
111166483 | signal transducer and activator of transcription 5B isoform X1 [KO:K11224] |
111173850 | STAT6; signal transducer and activator of transcription 6 isoform X4 [KO:K11225] |
111174349 | CISH; cytokine-inducible SH2-containing protein isoform X1 [KO:K04701] |
111169732 | MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539] |
111172761 | STAM2; signal transducing adapter molecule 2 isoform X1 [KO:K04705] |
111164116 | IRF9; LOW QUALITY PROTEIN: interferon regulatory factor 9 [KO:K04693] |
111177755 | PIAS1; E3 SUMO-protein ligase PIAS1 isoform X1 [KO:K04706] [EC:2.3.2.-] |
111168224 | PIAS2; E3 SUMO-protein ligase PIAS2 isoform X1 [KO:K16063] [EC:2.3.2.-] |
111179937 | PIAS3; E3 SUMO-protein ligase PIAS3 isoform X1 [KO:K16064] [EC:2.3.2.-] |
111164535 | FHL1; four and a half LIM domains protein 1 isoform X1 [KO:K14365] |
111173839 | PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153] |
111179235 | PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153] |
111187262 | PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153] |
111166652 | PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649] |
111185984 | PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649] |
111175760 | phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649] |
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Reference |
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Authors |
Harrison DA |
Title |
The Jak/STAT pathway. |
Journal |
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Reference |
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Authors |
Kiu H, Nicholson SE |
Title |
Biology and significance of the JAK/STAT signalling pathways. |
Journal |
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Reference |
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Authors |
Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A, Sanmamed MF, Le Bon A, Melero I |
Title |
Direct effects of type I interferons on cells of the immune system. |
Journal |
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Reference |
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Authors |
Fish EN, Platanias LC |
Title |
Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes. |
Journal |
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Reference |
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Authors |
Ivanenkov YA, Balakin KV, Lavrovsky Y |
Title |
Small molecule inhibitors of NF-kB and JAK/STAT signal transduction pathways as promising anti-inflammatory therapeutics. |
Journal |
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Reference |
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Authors |
O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A |
Title |
The JAK-STAT pathway: impact on human disease and therapeutic intervention. |
Journal |
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Reference |
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Authors |
Zoranovic T, Grmai L, Bach EA |
Title |
Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway. |
Journal |
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Reference |
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Authors |
Ungureanu D, Silvennoinen O |
Title |
SLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling. |
Journal |
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Reference |
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Authors |
Richard AJ, Stephens JM |
Title |
The role of JAK-STAT signaling in adipose tissue function. |
Journal |
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Reference |
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Authors |
Sun Y, Lehmbecker A, Kalkuhl A, Deschl U, Sun W, Rohn K, Tzvetanova ID, Nave KA, Baumgartner W, Ulrich R |
Title |
STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis. |
Journal |
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Reference |
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Authors |
Hirano T, Ishihara K, Hibi M |
Title |
Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors. |
Journal |
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Reference |
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Authors |
Rane SG, Reddy EP |
Title |
Janus kinases: components of multiple signaling pathways. |
Journal |
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Reference |
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Authors |
Heim MH |
Title |
The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus. |
Journal |
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Related pathway |
dle04060 | Cytokine-cytokine receptor interaction |
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KO pathway |
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LinkDB |
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