Entry
Name
Cytokine-cytokine receptor interaction - Arvicola amphibius (Eurasian water vole)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
aamp04060 Cytokine-cytokine receptor interaction
Organism
Arvicola amphibius (Eurasian water vole) [GN:
aamp ]
Gene
119799817 Tnfrsf19; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 19 [KO:K05155 ]
119800481 Tnfsf11; tumor necrosis factor ligand superfamily member 11 [KO:K05473 ]
119800734 Il6r; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055 ]
119801389 Csf1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453 ]
119801760 Tnfsf14; tumor necrosis factor ligand superfamily member 14 [KO:K05477 ]
119804936 Fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390 ]
119805318 Eda2r; tumor necrosis factor receptor superfamily member 27 [KO:K05163 ]
119806758 Gdf7; LOW QUALITY PROTEIN: growth/differentiation factor 7 [KO:K20013 ]
119807140 Il17re; LOW QUALITY PROTEIN: interleukin-17 receptor E [KO:K05168 ]
119807799 Ltbr; tumor necrosis factor receptor superfamily member 3 isoform X1 [KO:K03159 ]
119808154 Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158 ]
119808804 Il6st; interleukin-6 receptor subunit beta isoform X1 [KO:K05060 ]
119808913 Lifr; LOW QUALITY PROTEIN: leukemia inhibitory factor receptor [KO:K05058 ]
119810678 Il10ra; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134 ]
119811345 Tnfsf13; tumor necrosis factor ligand superfamily member 13 isoform X1 [KO:K05475 ]
119811471 Tnfrsf13b; tumor necrosis factor receptor superfamily member 13B [KO:K05150 ]
119811560 Tnfrsf17; tumor necrosis factor receptor superfamily member 17 [KO:K05153 ]
119811898 Tnfrsf12a; tumor necrosis factor receptor superfamily member 12A [KO:K05149 ]
119812353 Ngfr; tumor necrosis factor receptor superfamily member 16 [KO:K02583 ]
119813021 Tnfsf13b; tumor necrosis factor ligand superfamily member 13B [KO:K05476 ]
119813538 Il12rb1; LOW QUALITY PROTEIN: interleukin-12 receptor subunit beta-1 [KO:K05063 ]
119813675 Tnfsf9; tumor necrosis factor ligand superfamily member 9 [KO:K05472 ]
119813689 Csf2; granulocyte-macrophage colony-stimulating factor isoform X1 [KO:K05427 ]
119814659 Cd40; tumor necrosis factor receptor superfamily member 5 [KO:K03160 ]
119816863 Csf3r; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061 ]
119816939 Tnfrsf25; tumor necrosis factor receptor superfamily member 25 [KO:K05160 ]
119817165 Tnfrsf8; tumor necrosis factor receptor superfamily member 8 [KO:K05145 ]
119817423 Il15ra; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074 ]
119817538 Tnfsf15; tumor necrosis factor ligand superfamily member 15 isoform X1 [KO:K05478 ]
119817669 Tnfrsf9; tumor necrosis factor receptor superfamily member 9 isoform X1 [KO:K05146 ]
119817700 Tnfsf8; tumor necrosis factor ligand superfamily member 8 [KO:K05471 ]
119817747 Tnfrsf18; tumor necrosis factor receptor superfamily member 18 [KO:K05154 ]
119817816 Tnfrsf14; tumor necrosis factor receptor superfamily member 14 isoform X1 [KO:K05152 ]
119817843 Tnfrsf1b; tumor necrosis factor receptor superfamily member 1B [KO:K05141 ]
119817941 Tnfrsf4; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 4 [KO:K05142 ]
119818952 Il1rn; interleukin-1 receptor antagonist protein isoform X1 [KO:K05481 ]
119820251 Ccr6; LOW QUALITY PROTEIN: C-C chemokine receptor type 6 [KO:K04181 ]
119821456 Tgfb1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375 ]
119822395 Relt; tumor necrosis factor receptor superfamily member 19L [KO:K05156 ]
119822935 Tnfrsf21; tumor necrosis factor receptor superfamily member 21 [KO:K05157 ]
119822991 Tnfrsf11b; tumor necrosis factor receptor superfamily member 11B [KO:K05148 ]
119823951 Edar; tumor necrosis factor receptor superfamily member EDAR [KO:K05162 ]
119823993 Tnfrsf13c; tumor necrosis factor receptor superfamily member 13C [KO:K05151 ]
119826351 Il27; LOW QUALITY PROTEIN: interleukin-27 subunit alpha [KO:K22629 ]
119826387 Tnfsf10; tumor necrosis factor ligand superfamily member 10 [KO:K04721 ]
119826408 Cntfr; ciliary neurotrophic factor receptor subunit alpha [KO:K05059 ]
119826707 Il11ra; interleukin-11 receptor subunit alpha isoform X1 [KO:K05056 ]
119827013 Tnfsf4; tumor necrosis factor ligand superfamily member 4 [KO:K05469 ]
119827125 Tnfsf18; tumor necrosis factor ligand superfamily member 18 [KO:K05479 ]
119827432 Tgfb2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376 ]
119827881 Faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
119828067 Tnfrsf11a; tumor necrosis factor receptor superfamily member 11A isoform X1 [KO:K05147 ]
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
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Evolutionary divergence and functions of the human interleukin (IL) gene family.
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Reference
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Title
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Reference
Authors
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Title
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Title
Interleukin-1 and neuronal injury.
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Authors
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Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
Journal
Reference
Authors
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Title
Functional specialization of interleukin-17 family members.
Journal
Reference
Authors
Fischer P, Hilfiker-Kleiner D
Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
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Authors
Richards CD
Title
The enigmatic cytokine oncostatin m and roles in disease.
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Authors
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Title
Structures and biological functions of IL-31 and IL-31 receptors.
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Authors
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Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
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Title
The interferons and their receptors--distribution and regulation.
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Authors
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Title
Signalling pathways of the TNF superfamily: a double-edged sword.
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Authors
Ashkenazi A
Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
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Authors
Seeger P, Musso T, Sozzani S
Title
The TGF-beta superfamily in dendritic cell biology.
Journal
Reference
Authors
Wakefield LM, Hill CS
Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
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Reference
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Mueller TD, Nickel J
Title
Promiscuity and specificity in BMP receptor activation.
Journal
KO pathway