KEGG   PATHWAY: aful04810
Entry
aful04810                   Pathway                                
Name
Regulation of actin cytoskeleton - Aythya fuligula (tufted duck)
Class
Cellular Processes; Cell motility
Pathway map
aful04810  Regulation of actin cytoskeleton
aful04810

Other DBs
GO: 0030036
Organism
Aythya fuligula (tufted duck) [GN:aful]
Gene
116497433  lysophosphatidic acid receptor 1-B-like [KO:K04289]
116500601  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
116500097  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
116494621  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
116491230  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
116491233  CXCL12; stromal cell-derived factor 1 [KO:K10031]
116490781  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
116490058  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
116500734  F2R; proteinase-activated receptor 1 [KO:K03914]
116489355  INS; insulin [KO:K04526]
116488496  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
116494876  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
116488431  FGF2; fibroblast growth factor 2 [KO:K18497]
116485205  FGF6; fibroblast growth factor 6 [KO:K04358]
116493667  FGF7; fibroblast growth factor 7 [KO:K04358]
116488852  FGF5; LOW QUALITY PROTEIN: fibroblast growth factor 5 [KO:K04358]
116489164  FGF20; fibroblast growth factor 20 [KO:K04358]
116494542  FGF16; fibroblast growth factor 16 [KO:K04358]
116494797  FGF18; fibroblast growth factor 18 [KO:K04358]
116499225  FGF22; fibroblast growth factor 22 [KO:K04358]
116499329  FGF17; fibroblast growth factor 17 [KO:K04358]
116499649  FGF9; fibroblast growth factor 9 [KO:K04358]
116490304  FGF3; fibroblast growth factor 3 [KO:K04358]
116490397  FGF4; fibroblast growth factor 4 [KO:K04358]
116500745  FGF10; fibroblast growth factor 10 isoform X1 [KO:K04358]
116491338  FGF8; fibroblast growth factor 8 [KO:K04358]
116490003  FGF19; fibroblast growth factor 19 [KO:K22603]
116485512  FGF23; fibroblast growth factor 23 [KO:K22428]
116495257  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
116502269  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
116488844  PDGFC; platelet-derived growth factor C [KO:K05450]
116490799  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
116499545  INSRR; insulin receptor-related protein [KO:K05086] [EC:2.7.10.1]
116485864  EGFR; LOW QUALITY PROTEIN: epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
116499369  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
116491246  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
116488690  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
116494777  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
116488453  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
116494711  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
116490459  FN1; fibronectin isoform X1 [KO:K05717]
116500835  ITGA1; integrin alpha-1 [KO:K06480]
116500518  ITGA2; integrin alpha-2 [KO:K06481]
116498331  ITGA2B; integrin alpha-IIb [KO:K06476]
116498573  ITGA3; integrin alpha-3 [KO:K06482]
116490629  ITGA4; integrin alpha-4 [KO:K06483]
116490658  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
116499963  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
116486913  ITGA8; integrin alpha-8 [KO:K06584]
116485489  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
116499570  ITGA10; LOW QUALITY PROTEIN: integrin alpha-10 [KO:K06586]
116493274  ITGA11; integrin alpha-11 [KO:K06587]
116490600  ITGAV; integrin alpha-V [KO:K06487]
116501492  integrin alpha-L-like [KO:K05718]
116497350  ITGAE; integrin alpha-E [KO:K06524]
116485474  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
116490793  ITGB2; integrin beta-2 [KO:K06464]
116498494  ITGB3; integrin beta-3 [KO:K06493]
116496563  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
116490808  ITGB5; integrin beta-5 [KO:K06588]
116490871  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
116486140  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
116492399  KNG1; kininogen-1 [KO:K03898]
116489478  BDKRB1; B1 bradykinin receptor [KO:K03915]
116489944  BDKRB2; B2 bradykinin receptor [KO:K03916]
116501786  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
116487856  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
116489871  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
116489998  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
116496912  C5; complement C5 [KO:K03994]
116501076  C6; complement component C6 [KO:K03995]
116501215  C7; complement component C7 isoform X1 [KO:K03996]
116492170  C8A; complement component C8 alpha chain [KO:K03997]
116492071  C8B; complement component C8 beta chain [KO:K03998]
116496941  C8G; complement component C8 gamma chain [KO:K03999]
116500515  C9; complement component C9 [KO:K04000]
116495096  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
116496726  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
116492131  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 isoform X1 [KO:K04347]
116493008  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 isoform X1 [KO:K05722]
116485476  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
116494114  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
116497176  CRK; adapter molecule crk isoform X1 [KO:K04438]
116496037  CRKL; crk-like protein [KO:K04438]
116491116  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
116495903  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
116487382  SOS1; son of sevenless homolog 1 [KO:K03099]
116489737  SOS2; son of sevenless homolog 2 [KO:K03099]
116490064  HRAS; GTPase HRas [KO:K02833]
116486326  KRAS; LOW QUALITY PROTEIN: GTPase KRas [KO:K07827]
116498924  NRAS; GTPase NRas [KO:K07828]
116490108  RRAS2; ras-related protein R-Ras2 [KO:K07830]
116490883  MRAS; ras-related protein M-Ras [KO:K07831]
116494326  ARHGEF6; rho guanine nucleotide exchange factor 6 isoform X1 [KO:K05729]
116492299  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
116492415  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
116497623  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
116499089  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
116501170  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
116491758  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
116492044  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
116500092  VAV1; proto-oncogene vav [KO:K05730]
116496875  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
116495393  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
116492488  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
116493064  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
116485438  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
116493377  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
116499043  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
116496022  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
116488009  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
116489712  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
116499782  RGCC; regulator of cell cycle RGCC [KO:K26108]
116494443  regulator of cell cycle RGCC-like [KO:K26108]
116497821  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
116501544  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
116492928  RHOA; transforming protein RhoA [KO:K04513]
116495209  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
116496135  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
116496439  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
116497501  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
116492966  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
116492367  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
116494321  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
116501527  PAK4; LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
116488332  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
116490056  PAK6; serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
116502089  ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X1 [KO:K13710]
116497379  GIT1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
116486829  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
116487357  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
116493811  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
116490524  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
116495849  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
116485603  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
116498329  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
116487559  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
116490257  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
116495978  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
116497380  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
116498840  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
116496258  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
116495666  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
116497402  MYL10; myosin regulatory light chain 10 [KO:K12756]
116486339  myosin regulatory light chain 2, smooth muscle minor isoform-like [KO:K12757]
116486483  myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
116502112  MYH9; myosin-9 [KO:K10352]
116495440  MYH11; myosin-11 isoform X1 [KO:K10352]
116496619  MYH10; myosin-10 isoform X1 [KO:K10352]
116494241  DIAPH2; protein diaphanous homolog 2 isoform X1 [KO:K05741]
116498117  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
116499178  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
116499631  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
116501126  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
116498394  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta [KO:K00920] [EC:2.7.1.149]
116485820  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1 [KO:K00920] [EC:2.7.1.149]
116490543  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
116497220  LIMK1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
116496228  LIMK2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
116502344  DIAPH3; protein diaphanous homolog 3 [KO:K05745]
116496617  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1 [KO:K05627]
116487236  ENAH; protein enabled homolog isoform X1 [KO:K05746]
116489706  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
116498089  WASF2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
116502241  CYFIP1; cytoplasmic FMR1-interacting protein 1 [KO:K05749]
116494677  CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
116490516  NCKAP1; nck-associated protein 1 isoform X1 [KO:K05750]
116490442  ABI2; abl interactor 2 isoform X1 [KO:K05751]
116493164  BRK1; protein BRICK1 [KO:K05752]
116488234  WASF1; wiskott-Aldrich syndrome protein family member 1 [KO:K05753]
116487276  ACTR2; actin-related protein 2 [KO:K17260]
116490737  ACTR3; actin-related protein 3 [KO:K18584]
116486488  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
116495249  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
116495252  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
116490863  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
116496156  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
116492994  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
116492083  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
116496853  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
116487373  actin, cytoplasmic 1-like [KO:K05692]
116493419  actin, cytoplasmic type 5 [KO:K05692]
116495117  ACTB; actin, cytoplasmic 1 [KO:K05692]
116496411  ACTG1; actin, cytoplasmic 2 [KO:K05692]
116487442  PFN4; profilin-4 [KO:K05759]
116492569  PFN2; profilin-2 isoform X1 [KO:K05759]
116496331  PXN; paxillin [KO:K05760]
116488122  EZR; ezrin isoform X1 [KO:K08007]
116485929  RDX; radixin isoform X1 [KO:K05762]
116494284  MSN; moesin [KO:K05763]
116501949  TMSB4X; thymosin beta-4 [KO:K05764]
116494776  thymosin beta-12-like [KO:K05764]
116489664  CFL2; cofilin-2 isoform X1 [KO:K05765]
116497448  SSH2; protein phosphatase Slingshot homolog 2 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
116489525  SSH3; protein phosphatase Slingshot homolog 3 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
116495967  SSH1; protein phosphatase Slingshot homolog 1 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
116491085  VCL; vinculin isoform X1 [KO:K05700]
116493615  IQGAP1; ras GTPase-activating-like protein IQGAP1 isoform X1 [KO:K16848]
116499550  IQGAP3; ras GTPase-activating-like protein IQGAP3 [KO:K05767]
116500413  IQGAP2; ras GTPase-activating-like protein IQGAP2 isoform X1 [KO:K05767]
116485555  SCIN; adseverin [KO:K05768]
116496783  GSN; gelsolin isoform X1 [KO:K05768]
116489754  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
116498976  APC2; LOW QUALITY PROTEIN: adenomatous polyposis coli protein 2 [KO:K02085]
116500517  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
116492365  ARHGEF4; rho guanine nucleotide exchange factor 4 isoform X1 [KO:K05769]
116502247  SPATA13; spermatogenesis-associated protein 13 isoform X1 [KO:K05769]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
aful04010  MAPK signaling pathway
aful04510  Focal adhesion
aful04520  Adherens junction
KO pathway
ko04810   
LinkDB

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