KEGG   PATHWAY: aful04010
Entry
aful04010                   Pathway                                
Name
MAPK signaling pathway - Aythya fuligula (tufted duck)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
aful04010  MAPK signaling pathway
aful04010

Other DBs
GO: 0000165
Organism
Aythya fuligula (tufted duck) [GN:aful]
Gene
116496971  voltage-dependent N-type calcium channel subunit alpha-1B-like isoform X1 [KO:K04849]
116489537  CACNA1C; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
116493152  CACNA1D; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
116492019  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
116501486  voltage-dependent L-type calcium channel subunit alpha-1F-like [KO:K04853]
116496468  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
116495203  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
116493711  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
116498683  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
116490704  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
116492948  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
116492912  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
116487287  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
116498268  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 [KO:K04862]
116485907  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
116499912  CACNB3; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit beta-3 [KO:K04864]
116490515  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
116496383  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
116494746  CACNG2; voltage-dependent calcium channel gamma-2 subunit isoform X1 [KO:K04867]
116495225  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
116496591  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
116496651  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
116491750  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
116496571  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
116495441  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
116495096  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
116492131  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 isoform X1 [KO:K04347]
116488423  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
116499431  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
116491585  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
116487412  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
116493607  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
116500532  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
116490271  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
116488345  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
116488451  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
116497144  NF1; neurofibromin isoform X1 [KO:K08052]
116500446  RASA1; ras GTPase-activating protein 1 [KO:K04352]
116501401  ras GTPase-activating protein 1-like [KO:K04352]
116492435  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
116498770  RAP1A; ras-related protein Rap-1A [KO:K04353]
116487830  RAP1B; ras-related protein Rap-1b [KO:K07836]
116488496  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
116499458  TGFA; protransforming growth factor alpha [KO:K08774]
116489068  EREG; proepiregulin [KO:K09784]
116489036  AREG; amphiregulin [KO:K09782]
116494876  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
116488431  FGF2; fibroblast growth factor 2 [KO:K18497]
116485205  FGF6; fibroblast growth factor 6 [KO:K04358]
116493667  FGF7; fibroblast growth factor 7 [KO:K04358]
116488852  FGF5; LOW QUALITY PROTEIN: fibroblast growth factor 5 [KO:K04358]
116489164  FGF20; fibroblast growth factor 20 [KO:K04358]
116494542  FGF16; fibroblast growth factor 16 [KO:K04358]
116494797  FGF18; fibroblast growth factor 18 [KO:K04358]
116499225  FGF22; fibroblast growth factor 22 [KO:K04358]
116499329  FGF17; fibroblast growth factor 17 [KO:K04358]
116499649  FGF9; fibroblast growth factor 9 [KO:K04358]
116490304  FGF3; fibroblast growth factor 3 [KO:K04358]
116490397  FGF4; fibroblast growth factor 4 [KO:K04358]
116500745  FGF10; fibroblast growth factor 10 isoform X1 [KO:K04358]
116491338  FGF8; fibroblast growth factor 8 [KO:K04358]
116490003  FGF19; fibroblast growth factor 19 [KO:K22603]
116485512  FGF23; fibroblast growth factor 23 [KO:K22428]
116498715  NGF; beta-nerve growth factor isoform X1 [KO:K02582]
116490119  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
116498912  NTF3; neurotrophin-3 [KO:K04356]
116489355  INS; insulin [KO:K04526]
116494460  IGF1; insulin-like growth factor I [KO:K05459]
116490287  IGF2; insulin-like growth factor II [KO:K13769]
116495257  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
116502269  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
116488844  PDGFC; platelet-derived growth factor C [KO:K05450]
116490799  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
116498783  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
116489625  KITLG; kit ligand [KO:K05461]
116488296  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
116490346  PGF; placenta growth factor [KO:K16859]
116502060  VEGFD; vascular endothelial growth factor D [KO:K05449]
116488843  VEGFC; LOW QUALITY PROTEIN: vascular endothelial growth factor C [KO:K05449]
116497145  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
116486877  ANGPT1; angiopoietin-1 [KO:K05465]
116487432  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
116495702  ANGPT4; angiopoietin-4 [KO:K05467]
116498975  EFNA2; ephrin-A2 [KO:K05462]
116499509  EFNA1; ephrin-A1 [KO:K05462]
116499510  EFNA3; ephrin-A3 [KO:K05462]
116499511  EFNA4; ephrin-A4 [KO:K05462]
116501092  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
116501148  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
116499213  NRTN; neurturin [KO:K25414]
116491736  ARTN; artemin [KO:K25415]
116485864  EGFR; LOW QUALITY PROTEIN: epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
116498599  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
116500019  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
116490568  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
116499369  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
116491246  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
116488690  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
116494777  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
116486809  tumor necrosis factor receptor superfamily member 16-like [KO:K02583]
116498422  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
116499797  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
116500354  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
116499030  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
116493472  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
116488453  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
116494711  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
116494881  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
116488883  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
116501572  FLT3; LOW QUALITY PROTEIN: receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
116492016  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
116494267  vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
116494987  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
116489139  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
116486260  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
116501135  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
116497732  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
116491283  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
116496483  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
116487382  SOS1; son of sevenless homolog 1 [KO:K03099]
116489737  SOS2; son of sevenless homolog 2 [KO:K03099]
116490064  HRAS; GTPase HRas [KO:K02833]
116486326  KRAS; LOW QUALITY PROTEIN: GTPase KRas [KO:K07827]
116498924  NRAS; GTPase NRas [KO:K07828]
116490108  RRAS2; ras-related protein R-Ras2 [KO:K07830]
116490883  MRAS; ras-related protein M-Ras [KO:K07831]
116492488  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
116493064  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
116493377  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
116499043  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
116489209  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
116496022  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
116492042  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
116499138  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
116487113  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
116498096  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
116494263  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
116495404  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
116501070  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
116498727  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
116486166  MYC; myc proto-oncogene protein [KO:K04377]
116487758  SRF; serum response factor [KO:K04378]
116489845  FOS; proto-oncogene c-Fos [KO:K04379]
116498375  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
116498070  STMN1; stathmin [KO:K04381]
116491943  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
116498294  PLA2G4C; cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
116489567  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
116489876  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
116489886  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
116489887  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
116489921  cytosolic phospholipase A2 beta-like [KO:K16342] [EC:3.1.1.4]
116489997  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
116490054  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
116490067  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
116499453  interleukin-1 receptor antagonist protein-like [KO:K04519]
116488326  TGFB2; LOW QUALITY PROTEIN: transforming growth factor beta-2 proprotein [KO:K13376]
116490182  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
116495970  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
116492687  interleukin-1 receptor type 1-like [KO:K04386]
116492383  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
116485537  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
116490458  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
116486426  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
116491691  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
116491656  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
116495209  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
116496135  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
116496439  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
116497501  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
116494058  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
116489142  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
116496858  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
116486798  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
116502253  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
116489674  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
116492040  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
116500801  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
116486860  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
116487122  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
116500093  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
116487180  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
116494271  NRK; nik-related protein kinase isoform X1 [KO:K04407] [EC:2.7.11.1]
116496507  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
116492966  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
116492367  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
116495676  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
116485467  STK3; serine/threonine-protein kinase 3 [KO:K04412]
116486568  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
116501197  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
116501286  LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 1-like [KO:K04416] [EC:2.7.11.25]
116490728  MAP3K2; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
116486750  mitogen-activated protein kinase kinase kinase 3-like isoform X1 [KO:K04421] [EC:2.7.11.25]
116498376  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
116489929  MAP3K9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
116487188  MAP3K21; mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
116492442  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
116490553  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
116498207  MAP3K6; mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
116487197  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
116487158  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
116487327  MAP3K4; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
116497165  TAOK1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
116495998  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
116496474  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
116495505  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
116496466  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
116489982  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
116497366  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435]
116495268  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
116497176  CRK; adapter molecule crk isoform X1 [KO:K04438]
116496037  CRKL; crk-like protein [KO:K04438]
116501894  ARRB1; beta-arrestin-1 [KO:K04439]
116489162  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
116495022  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
116491194  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
116498684  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
116489834  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
116489843  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
116496123  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
116498743  MAPKAPK2; LOW QUALITY PROTEIN: MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
116493128  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
116489656  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
116485856  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
116493842  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
116492142  JUN; transcription factor AP-1 [KO:K04448]
116499037  JUND; transcription factor jun-D [KO:K04449]
116490508  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
116500031  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
116490171  MAX; protein max isoform X1 [KO:K04453]
116500432  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
116497214  HSPB1; heat shock protein beta-1 [KO:K04455]
116488009  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
116489712  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
116490365  PPM1A; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
116490216  PTPRR; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
116490382  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
116498848  PTPN7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
116495021  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
116487417  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
116492999  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
116489022  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
116489698  DUSP8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
116491395  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
116502329  DUSP6; dual specificity protein phosphatase 6 isoform X1 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
116487739  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
116498432  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
116487204  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
116497840  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
116492753  MECOM; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
116493410  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
116499970  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
116498521  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
116491240  CHUK; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
116499350  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
116497142  NLK; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
116488446  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
116491307  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
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Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
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Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
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Reference
PMID:22367796
  Authors
Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
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Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
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Trends Immunol 34:307-16 (2013)
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Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
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Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
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Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
aful04070  Phosphatidylinositol signaling system
aful04110  Cell cycle
aful04115  p53 signaling pathway
aful04210  Apoptosis
aful04310  Wnt signaling pathway
KO pathway
ko04010   
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