KEGG   PATHWAY: cimi04621
Entry
cimi04621                   Pathway                                
Name
NOD-like receptor signaling pathway - Cebus imitator (Panamanian white-faced capuchin)
Description
Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recognition of intracellular ligands. NOD1 and NOD2, two prototypic NLRs, sense the cytosolic presence of the bacterial peptidoglycan fragments that escaped from endosomal compartments, driving the activation of NF-{kappa}B and MAPK, cytokine production and apoptosis. On the other hand, a different set of NLRs induces caspase-1 activation through the assembly of multiprotein complexes called inflammasomes. The activated of caspase-1 regulates maturation of the pro-inflammatory cytokines IL-1B, IL-18 and drives pyroptosis.
Class
Organismal Systems; Immune system
Pathway map
cimi04621  NOD-like receptor signaling pathway
cimi04621

Organism
Cebus imitator (Panamanian white-faced capuchin) [GN:cimi]
Gene
108281215  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
108281284  NLRP1; NACHT, LRR and PYD domains-containing protein 1 isoform X1 [KO:K12798]
108281290  TRPV2; transient receptor potential cation channel subfamily V member 2 isoform X1 [KO:K04971]
108281783  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
108281831  [KO:K04725] [EC:2.3.2.27]
108281919  PKN1; serine/threonine-protein kinase N1 isoform X3 [KO:K06071] [EC:2.7.11.13]
108282127  NLRP12; NACHT, LRR and PYD domains-containing protein 12 isoform X1 [KO:K20865]
108282423  GBP4; guanylate-binding protein 4 [KO:K20899]
108282427  GBP5; guanylate-binding protein 5 [KO:K20898]
108282429  GBP2; guanylate-binding protein 2 isoform X3 [KO:K20899]
108282430  [KO:K20899]
108282451  PANX1; pannexin-1 [KO:K03443]
108283688  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
108283868  CARD8; caspase recruitment domain-containing protein 8 isoform X1 [KO:K12801]
108284042  [KO:K04079]
108284049  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
108284210  [KO:K08341]
108284964  GBP3; guanylate-binding protein 3 [KO:K20899]
108284967  PKN2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691]
108285034  ATG12; ubiquitin-like protein ATG12 [KO:K08336]
108285886  TXN; thioredoxin [KO:K03671]
108286075  IFI16; gamma-interferon-inducible protein 16 isoform X1 [KO:K20914]
108286076  AIM2; interferon-inducible protein AIM2 isoform X2 [KO:K12966]
108286470  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
108286511  MFN2; mitofusin-2 isoform X2 [KO:K06030] [EC:3.6.5.-]
108286678  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
108286781  MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
108286818  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
108286819  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
108287258  TRAF2; TNF receptor-associated factor 2 isoform X2 [KO:K03173] [EC:2.3.2.27]
108287321  CARD9; caspase recruitment domain-containing protein 9 [KO:K12794]
108287389  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
108287565  NEK7; serine/threonine-protein kinase Nek7 isoform X1 [KO:K20876] [EC:2.7.11.34]
108287734  MFN1; mitofusin-1 isoform X1 [KO:K21356] [EC:3.6.5.-]
108287871  NFKBIB; NF-kappa-B inhibitor beta isoform X4 [KO:K02581]
108288162  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
108288399  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
108288787  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
108288822  DNM1L; dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
108288946  CASR; extracellular calcium-sensing receptor [KO:K04612]
108289112  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
108289254  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
108289576  [KO:K03671]
108290619  [KO:K04079]
108290989  MEFV; pyrin [KO:K12803]
108291281  GSDMD; gasdermin-D isoform X1 [KO:K20917]
108291319  [KO:K20894]
108291435  SUGT1; protein SGT1 homolog isoform X1 [KO:K12795]
108292033  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
108292194  [KO:K05505]
108292198  [KO:K05505]
108292201  CXCL8; interleukin-8 [KO:K10030]
108292805  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
108293110  [KO:K21100]
108293111  [KO:K23126]
108293116  [KO:K05230]
108293117  [KO:K21100]
108293123  [KO:K05230]
108293124  [KO:K05230]
108293125  [KO:K05230]
108293471  BCL2L1; bcl-2-like protein 1 [KO:K04570]
108293537  IRGM; LOW QUALITY PROTEIN: immunity-related GTPase family M protein [KO:K14139] [EC:3.6.5.-]
108293666  [KO:K20910]
108293676  RBCK1; ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X2 [KO:K10630] [EC:2.3.2.31]
108293841  NAMPT; nicotinamide phosphoribosyltransferase [KO:K03462] [EC:2.4.2.12]
108293911  PYDC1; pyrin domain-containing protein 1 [KO:K12802]
108293914  PYCARD; apoptosis-associated speck-like protein containing a CARD [KO:K12799]
108294082  [KO:K13916]
108294124  FADD; FAS-associated death domain protein [KO:K02373]
108294364  BRCC3; lys-63-specific deubiquitinase BRCC36 isoform X2 [KO:K11864] [EC:3.4.19.-]
108295228  MAPK9; mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
108295590  TRPM7; transient receptor potential cation channel subfamily M member 7 isoform X1 [KO:K04982] [EC:2.7.11.1]
108296000  PSTPIP1; proline-serine-threonine phosphatase-interacting protein 1 isoform X1 [KO:K12804]
108296146  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
108296165  IFNA21; interferon alpha-21 [KO:K05414]
108296167  [KO:K05414]
108296168  [KO:K05414]
108296169  IFNB1; interferon beta [KO:K05415]
108296180  [KO:K05414]
108296181  [KO:K05414]
108296183  [KO:K05414]
108296184  [KO:K05414]
108296197  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
108296544  TXN2; thioredoxin, mitochondrial [KO:K03671]
108296669  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
108296753  [KO:K04513]
108297062  [KO:K12795]
108297293  [KO:K21421] [EC:1.-.-.-]
108297768  DHX33; ATP-dependent RNA helicase DHX33 isoform X1 [KO:K17820] [EC:5.6.2.6]
108297938  RIPK3; receptor-interacting serine/threonine-protein kinase 3 isoform X1 [KO:K08847] [EC:2.7.11.1]
108298093  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
108298301  NLRP6; NACHT, LRR and PYD domains-containing protein 6 isoform X2 [KO:K20863]
108298392  IRF3; interferon regulatory factor 3 isoform X3 [KO:K05411]
108298912  [KO:K05230]
108298913  [KO:K05230]
108299668  ANTXR1; anthrax toxin receptor 1 isoform X1 [KO:K20909]
108299857  TNF; tumor necrosis factor [KO:K03156]
108300002  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
108300003  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
108300031  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X3 [KO:K04960]
108300504  IL18; interleukin-18 [KO:K05482]
108300590  [KO:K20858]
108300636  NLRX1; NLR family member X1 [KO:K12653]
108300913  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
108300966  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2 [KO:K05858] [EC:3.1.4.11]
108301342  RNASEL; 2-5A-dependent ribonuclease isoform X1 [KO:K01165]
108301897  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
108302141  TRAF5; TNF receptor-associated factor 5 isoform X4 [KO:K09849]
108302441  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
108302508  [KO:K05131]
108303199  IL6; interleukin-6 isoform X1 [KO:K05405]
108303311  NOD1; nucleotide-binding oligomerization domain-containing protein 1 isoform X1 [KO:K08727]
108303675  [KO:K12807]
108304024  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
108304038  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
108304274  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
108304551  [KO:K08336]
108304605  BCL2; apoptosis regulator Bcl-2 isoform X2 [KO:K02161]
108304989  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
108305262  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
108305468  NOD2; nucleotide-binding oligomerization domain-containing protein 2 isoform X1 [KO:K10165]
108305500  ANTXR2; anthrax toxin receptor 2 [KO:K20909]
108305702  TNFAIP3; tumor necrosis factor alpha-induced protein 3 isoform X1 [KO:K11859] [EC:3.4.19.12]
108305750  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
108305814  GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
108306065  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
108306142  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
108306378  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
108306609  [KO:K08341]
108306951  MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
108307148  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
108307639  BIRC3; baculoviral IAP repeat-containing protein 3 isoform X1 [KO:K16060]
108307687  CARD6; caspase recruitment domain-containing protein 6 [KO:K12797]
108307970  TRIP6; thyroid receptor-interacting protein 6 [KO:K12792]
108308410  CCL5; C-C motif chemokine 5 [KO:K12499]
108308445  CCL2; C-C motif chemokine 2 [KO:K14624]
108309779  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
108310070  STING1; stimulator of interferon genes protein isoform X1 [KO:K12654]
108310295  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
108310400  RELA; transcription factor p65 isoform X2 [KO:K04735]
108310465  [KO:K08341]
108310631  ATG16L1; autophagy-related protein 16-1 isoform X1 [KO:K17890]
108310722  ERBIN; erbin isoform X1 [KO:K12796]
108310867  RIPK2; receptor-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K08846] [EC:2.7.11.1]
108311256  TRPM2; transient receptor potential cation channel subfamily M member 2 isoform X4 [KO:K04977] [EC:3.6.1.13]
108311469  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
108312520  CTSB; cathepsin B isoform X2 [KO:K01363] [EC:3.4.22.1]
108312755  [KO:K06630]
108313230  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
108313340  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
108314219  OAS1; 2'-5'-oligoadenylate synthase 1 isoform X1 [KO:K14216] [EC:2.7.7.84]
108314231  OAS3; 2'-5'-oligoadenylate synthase 3 isoform X1 [KO:K14216] [EC:2.7.7.84]
108314247  OAS2; 2'-5'-oligoadenylate synthase 2 isoform X1 [KO:K14216] [EC:2.7.7.84]
108314631  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
108314702  [KO:K08009]
108314738  ATG5; autophagy protein 5 isoform X1 [KO:K08339]
108314896  JUN; transcription factor AP-1 [KO:K04448]
108315122  P2RX7; P2X purinoceptor 7 isoform X1 [KO:K05220]
108315297  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
108315371  RNF31; E3 ubiquitin-protein ligase RNF31 [KO:K11974] [EC:2.3.2.31]
108315378  IRF9; interferon regulatory factor 9 isoform X2 [KO:K04693]
108315419  BIRC2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
108315450  CASP1; caspase-1 isoform X2 [KO:K01370] [EC:3.4.22.36]
108315451  [KO:K04394] [EC:3.4.22.57 3.4.22.64]
108315452  [KO:K12806]
108315453  [KO:K12806]
108315696  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
108315757  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
108315794  NLRP3; NACHT, LRR and PYD domains-containing protein 3 isoform X1 [KO:K12800]
108315802  GABARAPL1; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
108316185  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
108316189  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
108316390  TP53BP1; TP53-binding protein 1 isoform X2 [KO:K20915]
108316598  NLRP7; NACHT, LRR and PYD domains-containing protein 7 [KO:K20864]
108317063  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
108317391  TANK; TRAF family member-associated NF-kappa-B activator isoform X2 [KO:K12650]
108317788  TAB3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1 [KO:K12793]
108318266  GPRC6A; G-protein coupled receptor family C group 6 member A isoform X1 [KO:K04622]
108318634  IL1B; interleukin-1 beta [KO:K04519]
119467639  PYDC5; LOW QUALITY PROTEIN: pyrin domain-containing protein 5 [KO:K20916]
Compound
C00002  ATP
C00076  Calcium cation
C00155  L-Homocysteine
C00238  Potassium cation
C00533  Nitric oxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:23124073
  Authors
Vandenabeele P, Bertrand MJ
  Title
The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling.
  Journal
Nat Rev Immunol 12:833-44 (2012)
DOI:10.1038/nri3325
Reference
PMID:16493424
  Authors
Strober W, Murray PJ, Kitani A, Watanabe T
  Title
Signalling pathways and molecular interactions of NOD1 and NOD2.
  Journal
Nat Rev Immunol 6:9-20 (2006)
DOI:10.1038/nri1747
Reference
PMID:24718315
  Authors
Estornes Y, Bertrand MJ
  Title
IAPs, regulators of innate immunity and inflammation.
  Journal
Semin Cell Dev Biol 39:106-14 (2015)
DOI:10.1016/j.semcdb.2014.03.035
Reference
PMID:24707857
  Authors
Jakopin Z
  Title
Nucleotide-binding oligomerization domain (NOD) inhibitors: a rational approach toward inhibition of NOD signaling pathway.
  Journal
J Med Chem 57:6897-918 (2014)
DOI:10.1021/jm401841p
Reference
PMID:25526305
  Authors
Caruso R, Warner N, Inohara N, Nunez G
  Title
NOD1 and NOD2: signaling, host defense, and inflammatory disease.
  Journal
Immunity 41:898-908 (2014)
DOI:10.1016/j.immuni.2014.12.010
Reference
PMID:19767725
  Authors
Murray PJ
  Title
Beyond peptidoglycan for Nod2.
  Journal
Nat Immunol 10:1053-4 (2009)
DOI:10.1038/ni1009-1053
Reference
PMID:20643110
  Authors
Lecat A, Piette J, Legrand-Poels S
  Title
The protein Nod2: an innate receptor more complex than previously assumed.
  Journal
Biochem Pharmacol 80:2021-31 (2010)
DOI:10.1016/j.bcp.2010.07.016
Reference
PMID:26655628
  Authors
Man SM, Kanneganti TD
  Title
Converging roles of caspases in inflammasome activation, cell death and innate immunity.
  Journal
Nat Rev Immunol 16:7-21 (2016)
DOI:10.1038/nri.2015.7
Reference
PMID:27291964
  Authors
Broz P, Dixit VM
  Title
Inflammasomes: mechanism of assembly, regulation and signalling.
  Journal
Nat Rev Immunol 16:407-20 (2016)
DOI:10.1038/nri.2016.58
Reference
PMID:25879280
  Authors
Man SM, Kanneganti TD
  Title
Regulation of inflammasome activation.
  Journal
Immunol Rev 265:6-21 (2015)
DOI:10.1111/imr.12296
Reference
PMID:26549800
  Authors
Jo EK, Kim JK, Shin DM, Sasakawa C
  Title
Molecular mechanisms regulating NLRP3 inflammasome activation.
  Journal
Cell Mol Immunol 13:148-59 (2016)
DOI:10.1038/cmi.2015.95
Reference
PMID:23846113
  Authors
Broz P, Monack DM
  Title
Newly described pattern recognition receptors team up against intracellular pathogens.
  Journal
Nat Rev Immunol 13:551-65 (2013)
DOI:10.1038/nri3479
Reference
PMID:22430786
  Authors
Rathinam VA, Vanaja SK, Fitzgerald KA
  Title
Regulation of inflammasome signaling.
  Journal
Nat Immunol 13:333-42 (2012)
DOI:10.1038/ni.2237
Reference
PMID:24840700
  Authors
Sutterwala FS, Haasken S, Cassel SL
  Title
Mechanism of NLRP3 inflammasome activation.
  Journal
Ann N Y Acad Sci 1319:82-95 (2014)
DOI:10.1111/nyas.12458
Reference
PMID:23702978
  Authors
Latz E, Xiao TS, Stutz A
  Title
Activation and regulation of the inflammasomes.
  Journal
Nat Rev Immunol 13:397-411 (2013)
DOI:10.1038/nri3452
Reference
PMID:25145756
  Authors
Blander JM
  Title
A long-awaited merger of the pathways mediating host defence and programmed cell death.
  Journal
Nat Rev Immunol 14:601-18 (2014)
DOI:10.1038/nri3720
Reference
PMID:23215645
  Authors
von Moltke J, Ayres JS, Kofoed EM, Chavarria-Smith J, Vance RE
  Title
Recognition of bacteria by inflammasomes.
  Journal
Annu Rev Immunol 31:73-106 (2013)
DOI:10.1146/annurev-immunol-032712-095944
Reference
PMID:25330206
  Authors
Abais JM, Xia M, Zhang Y, Boini KM, Li PL
  Title
Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?
  Journal
Antioxid Redox Signal 22:1111-29 (2015)
DOI:10.1089/ars.2014.5994
Reference
PMID:25879288
  Authors
Storek KM, Monack DM
  Title
Bacterial recognition pathways that lead to inflammasome activation.
  Journal
Immunol Rev 265:112-29 (2015)
DOI:10.1111/imr.12289
Reference
PMID:27012466
  Authors
Hu H, Sun SC
  Title
Ubiquitin signaling in immune responses.
  Journal
Cell Res 26:457-83 (2016)
DOI:10.1038/cr.2016.40
Reference
PMID:26121197
  Authors
Guo H, Callaway JB, Ting JP
  Title
Inflammasomes: mechanism of action, role in disease, and therapeutics.
  Journal
Nat Med 21:677-87 (2015)
DOI:10.1038/nm.3893
Reference
PMID:26482951
  Authors
Man SM, Kanneganti TD
  Title
Gasdermin D: the long-awaited executioner of pyroptosis.
  Journal
Cell Res 25:1183-4 (2015)
DOI:10.1038/cr.2015.124
Reference
PMID:22819539
  Authors
Rathinam VA, Vanaja SK, Waggoner L, Sokolovska A, Becker C, Stuart LM, Leong JM, Fitzgerald KA
  Title
TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.
  Journal
Cell 150:606-19 (2012)
DOI:10.1016/j.cell.2012.07.007
Reference
PMID:21575908
  Authors
Kerur N, Veettil MV, Sharma-Walia N, Bottero V, Sadagopan S, Otageri P, Chandran B
  Title
IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection.
  Journal
Cell Host Microbe 9:363-75 (2011)
DOI:10.1016/j.chom.2011.04.008
Reference
PMID:29148036
  Authors
Heilig R, Broz P
  Title
Function and mechanism of the pyrin inflammasome.
  Journal
Eur J Immunol 48:230-238 (2018)
DOI:10.1002/eji.201746947
Reference
PMID:25816776
  Authors
Chakrabarti A, Banerjee S, Franchi L, Loo YM, Gale M Jr, Nunez G, Silverman RH
  Title
RNase L activates the NLRP3 inflammasome during viral infections.
  Journal
Cell Host Microbe 17:466-77 (2015)
DOI:10.1016/j.chom.2015.02.010
Related
pathway
cimi04010  MAPK signaling pathway
cimi04064  NF-kappa B signaling pathway
cimi04140  Autophagy - animal
cimi04620  Toll-like receptor signaling pathway
KO pathway
ko04621   

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