KEGG   PATHWAY: clum04530
Entry
clum04530                   Pathway                                
Name
Tight junction - Cyclopterus lumpus (lumpfish)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
clum04530  Tight junction
clum04530

Other DBs
GO: 0005923
Organism
Cyclopterus lumpus (lumpfish) [GN:clum]
Gene
117725282  actn1; alpha-actinin-1 isoform X1 [KO:K05699]
117725305  si:dkey-221l4.11; claudin-23 [KO:K06087]
117725441  ezra; ezrin a [KO:K08007]
117726071  hcls1; hematopoietic lineage cell-specific protein isoform X1 [KO:K06106]
117727038  map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
117727106  afdna; afadin isoform X1 [KO:K05702]
117727147  [KO:K06087]
117727194  ezrb; ezrin b isoform X1 [KO:K08007]
117727250  [KO:K07374]
117727344  mpp5b; MAGUK p55 subfamily member 5b [KO:K06091]
117727345  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
117727468  gata4; transcription factor GATA-4 [KO:K09183]
117727562  [KO:K17388] [EC:2.7.11.39]
117727973  [KO:K05699]
117728168  bves; blood vessel epicardial substance [KO:K21108]
117728826  [KO:K06106]
117729101  prkacab; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
117729130  amotl2a; angiomotin-like 2a isoform X1 [KO:K06104]
117729142  patj; inaD-like protein isoform X1 [KO:K06092]
117729237  arhgef18b; rho guanine nucleotide exchange factor 18 isoform X1 [KO:K21066]
117729339  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
117729446  si:ch211-191a24.4; MARVEL domain-containing protein 3 [KO:K21099]
117729574  [KO:K12076]
117729622  arpc5b; actin-related protein 2/3 complex subunit 5b [KO:K05754]
117729712  [KO:K06087]
117729746  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
117729761  [KO:K07901]
117729781  tjp3; tight junction protein ZO-3 [KO:K06097]
117729798  si:ch73-61d6.3; occludin [KO:K06088]
117729814  [KO:K06087]
117729855  [KO:K06087]
117730016  cldn34a; claudin-34 [KO:K06087]
117730244  [KO:K10352]
117730294  cdc42; cell division control protein 42 homolog [KO:K04393]
117730340  [KO:K04353]
117730446  arpc1b; actin-related protein 2/3 complex subunit 1B [KO:K05757]
117730481  [KO:K04851]
117730594  cdk4; LOW QUALITY PROTEIN: cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
117730638  [KO:K05631]
117730678  [KO:K04513]
117730842  [KO:K04513]
117731012  cldn19; claudin-19 [KO:K06087]
117731092  [KO:K07374]
117731160  prkag1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
117731253  [KO:K05755]
117731319  [KO:K05704] [EC:2.7.10.2]
117731324  myl6; myosin light polypeptide 6 [KO:K12751]
117731387  [KO:K12755]
117731390  arpc4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
117731947  cftr; LOW QUALITY PROTEIN: cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
117731987  [KO:K21110]
117732189  tjp1b; tight junction protein ZO-1 isoform X1 [KO:K05701]
117732710  [KO:K04503]
117732893  pard6a; partitioning defective 6 homolog alpha [KO:K06093]
117732969  tuba1c; tubulin alpha-1C chain [KO:K07374]
117732983  [KO:K04393]
117733013  actr2a; actin-related protein 2-A [KO:K17260]
117733112  src; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
117733118  [KO:K07374]
117733119  [KO:K07374]
117733120  [KO:K07374]
117733121  [KO:K07374]
117733122  [KO:K07374]
117733123  [KO:K07374]
117733217  cacna1db; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
117733283  zgc:153867; myosin light polypeptide 6 isoform X1 [KO:K12751]
117733290  [KO:K07374]
117733308  rap1aa; RAP1A, member of RAS oncogene family a [KO:K04353]
117733363  ppp2r2ca; protein phosphatase 2, regulatory subunit B, gamma a [KO:K04354]
117733369  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
117733461  [KO:K04513]
117733462  [KO:K04513]
117733503  pard6b; partitioning defective 6 homolog beta [KO:K06093]
117733567  [KO:K06087]
117733603  arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]
117733748  prkcz; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
117733892  tuba5; LOW QUALITY PROTEIN: tubulin alpha 5 [KO:K07374]
117733905  rhoaa; rho-related GTP-binding protein RhoA-A [KO:K04513]
117733925  [KO:K05631]
117734166  [KO:K05747]
117734495  [KO:K04392]
117734517  cldnk; claudin k [KO:K06087]
117734597  actb2; actin, cytoplasmic 2 [KO:K05692]
117734611  [KO:K10352]
117734640  cldni; claudin i [KO:K06087]
117734821  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a [KO:K04345] [EC:2.7.11.11]
117734855  [KO:K10352]
117734876  crb3a; LOW QUALITY PROTEIN: protein crumbs homolog 3a [KO:K06090]
117734941  llgl1; lethal(2) giant larvae protein homolog 1 [KO:K06094]
117734996  micall2a; MICAL-like protein 2a [KO:K21068]
117735046  [KO:K13365]
117735279  [KO:K10352]
117735363  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
117735400  arhgap17b; rho GTPase-activating protein 17b isoform X1 [KO:K20638]
117735682  zgc:86896; actin-related protein 2/3 complex subunit 1A-A [KO:K05757]
117735761  marveld2b; MARVEL domain-containing protein 2b [KO:K17291]
117736034  [KO:K05692]
117736035  [KO:K05692]
117736039  [KO:K04382] [EC:3.1.3.16]
117736120  myl2b; myosin, light chain 2b, regulatory, cardiac, slow [KO:K10351]
117736251  ppp2r2aa; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
117736700  pcna; proliferating cell nuclear antigen [KO:K04802]
117736768  si:dkey-98f17.3; putative claudin-24 [KO:K06087]
117736777  nf2a; neurofibromin 2a (merlin) [KO:K16684]
117736939  oclnb; occludin b [KO:K06088]
117736940  prkab1b; 5'-AMP-activated protein kinase subunit beta-1b [KO:K07199]
117736947  cldn5a; claudin 5a [KO:K06087]
117737011  [KO:K06098]
117737175  rap2c; ras-related protein Rap-2c [KO:K07839]
117737180  dlg3; disks large homolog 3 isoform X1 [KO:K21098]
117737267  rapgef2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
117737331  [KO:K05763]
117737350  ppp2r2ba; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
117737372  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
117737407  hspa4b; heat shock 70 kDa protein 4b [KO:K09489]
117737713  [KO:K04382] [EC:3.1.3.16]
117737758  [KO:K04354]
117737876  [KO:K21112]
117738805  [KO:K04393]
117739043  pard6gb; par-6 family cell polarity regulator gamma b isoform X1 [KO:K06093]
117739164  si:dkey-92j12.5; LOW QUALITY PROTEIN: multiple PDZ domain protein [KO:K06095]
117739169  actb1; actin, cytoplasmic 1 [KO:K05692]
117739443  [KO:K10352]
117739444  cgnb; cingulin isoform X1 [KO:K06102]
117739460  [KO:K06087]
117739496  arhgef1a; rho guanine nucleotide exchange factor 1a isoform X1 [KO:K12791]
117740127  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
117740137  arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
117740334  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
117740352  cldn10a; claudin-10a [KO:K06087]
117740363  cldn5b; claudin-5b [KO:K06087]
117740441  ppp2r2ab; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
117740450  marveld2a; MARVEL domain-containing protein 2 [KO:K17291]
117740509  cldn23a; claudin-23 [KO:K06087]
117740563  tjp2a; tight junction protein ZO-2a isoform X1 [KO:K06098]
117740649  june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
117740813  prkab1a; 5'-AMP-activated protein kinase subunit beta-1a [KO:K07199]
117740814  nedd4l; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
117740940  oclna; occludin [KO:K06088]
117741211  vaspb; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
117741228  ppp2r1bb; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
117741290  [KO:K06087]
117741301  [KO:K06087]
117741325  cldnf; claudin f [KO:K06087]
117741345  [KO:K06087]
117741392  tiam1b; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
117741393  [KO:K06087]
117741394  [KO:K06087]
117741511  zgc:110333; claudin-8 [KO:K06087]
117741556  cldnj; claudin j [KO:K06087]
117741565  [KO:K06087]
117741584  jam3a; junctional adhesion molecule 3B [KO:K06785]
117741697  [KO:K06087]
117741926  [KO:K06087]
117741939  [KO:K06087]
117741990  igsf5b; immunoglobulin superfamily member 5 isoform X1 [KO:K06786]
117741999  cldn8; claudin-8 [KO:K06087]
117742161  [KO:K07374]
117742299  hspa4a; heat shock 70 kDa protein 4a [KO:K09489]
117742310  [KO:K05763]
117742340  [KO:K05731]
117742354  [KO:K07374]
117742415  rapgef6; rap guanine nucleotide exchange factor 6 [KO:K08020]
117742427  [KO:K06087]
117742458  amot; angiomotin isoform X1 [KO:K16819]
117742522  [KO:K06087]
117742523  [KO:K06087]
117742525  [KO:K06087]
117742534  [KO:K06087]
117742545  nf2b; neurofibromin 2b (merlin) isoform X1 [KO:K16684]
117742558  [KO:K06087]
117742858  arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
117742883  ppp2cab; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
117742901  igsf5a; immunoglobulin superfamily member 5 [KO:K06786]
117742911  [KO:K12075]
117742980  [KO:K06087]
117743008  [KO:K06087]
117743009  [KO:K06087]
117743140  jam3b; junctional adhesion molecule 3B [KO:K06785]
117743143  [KO:K06087]
117743195  [KO:K06087]
117743223  [KO:K06087]
117743273  cldn2; claudin-2 [KO:K06087]
117743294  f11r.1; F11 receptor, tandem duplicate 1 [KO:K06089]
117743669  [KO:K05762]
117743747  prkag3a; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
117743777  [KO:K17260]
117743825  tjap1; tight junction-associated protein 1 [KO:K06105]
117743832  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
117743861  [KO:K18050] [EC:2.7.11.13]
117743924  ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
117744016  mpp4b; MAGUK p55 subfamily member 4 isoform X1 [KO:K21109]
117744932  si:ch211-181l5.2; claudin-10 [KO:K06087]
117744948  [KO:K06087]
117745039  jam2a; junctional adhesion molecule 2a isoform X1 [KO:K06735]
117745215  cldn12; claudin-12 [KO:K06087]
117745308  epb41l4b; band 4.1-like protein 4B [KO:K21111]
117745495  cdc42l; cell division cycle 42, like [KO:K04393]
117745538  [KO:K06102]
117745575  arhgef2; rho guanine nucleotide exchange factor 2 isoform X1 [KO:K12791]
117745611  si:ch211-114n24.6; tubulin alpha-1A chain [KO:K07374]
117745684  rab13; ras-related protein Rab-13 [KO:K06109]
117745695  si:ch211-1i11.3; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
117745730  [KO:K18584]
117745972  arhgef18a; rho guanine nucleotide exchange factor 18a isoform X1 [KO:K21066]
117745983  cldn18; claudin-18 [KO:K06087]
117746088  [KO:K07200]
117746128  [KO:K05719]
117746238  [KO:K04237]
117746256  [KO:K07199]
117746316  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b isoform X1 [KO:K04345] [EC:2.7.11.11]
117746364  runx1; runt-related transcription factor 1 isoform X1 [KO:K08367]
117746426  dlg1l; discs large homolog 1-like protein isoform X1 [KO:K12076]
117746529  [KO:K07901]
117746571  ocel1; occludin/ELL domain-containing protein 1 [KO:K17291]
117746575  [KO:K06087]
117746578  jun; transcription factor AP-1 [KO:K04448]
117746583  [KO:K06087]
117746624  myl12.2; myosin, light chain 12, genome duplicate 2 [KO:K12757]
117746638  cldn1; claudin-1 [KO:K06087]
117746803  zgc:154006; occludin [KO:K06088]
117746807  cldn15la; claudin 15-like a [KO:K06087]
117746832  amotl2b; angiomotin-like protein 2b [KO:K06104]
117746953  [KO:K05754]
117747046  prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
117747050  stk11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
117747655  zgc:101810; actin-related protein 2 [KO:K17260]
117747817  cldn7a; claudin-7-A [KO:K06087]
117747858  cldn15a; claudin-15a [KO:K06087]
117747975  nedd4a; E3 ubiquitin-protein ligase NEDD4a [KO:K10591] [EC:2.3.2.26]
117747995  [KO:K06095]
117748308  [KO:K20479]
117748413  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
117748414  marveld3; MARVEL domain-containing protein 3 [KO:K21099]
117748497  slc9a3r1a; Na(+)/H(+) exchange regulatory cofactor NHE-RF1a [KO:K13365]
117748531  tjp1a; LOW QUALITY PROTEIN: tight junction protein ZO-1 [KO:K05701]
117748655  llgl2; LLGL scribble cell polarity complex component 2 isoform X1 [KO:K06094]
117748690  [KO:K04392]
117748961  prkcea; protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
117749018  erbb2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
117749169  micall2b; protein-methionine sulfoxide oxidase mical2b isoform X1 [KO:K21068]
117749200  arhgap17a; rho GTPase-activating protein 17a isoform X1 [KO:K20638]
117749298  scrib; protein scribble homolog isoform X1 [KO:K16175]
117749405  [KO:K07200]
117749655  myl12.1; myosin, light chain 12, genome duplicate 1 [KO:K12757]
117749660  [KO:K04237]
117749744  cldn11b; claudin-11b [KO:K06087]
117749806  itgb1a; integrin beta-1a [KO:K05719]
117750093  sympk; symplekin [KO:K06100]
117750133  [KO:K18584]
117750169  [KO:K06087]
117750339  prkag3b; 5'-AMP-activated protein kinase subunit gamma-3b [KO:K07200]
117750486  [KO:K06087]
117750552  jam2b; junctional adhesion molecule 2b [KO:K06735]
117750609  [KO:K21109]
117750611  cgnl1; cingulin-like protein 1 isoform X1 [KO:K21110]
117750636  [KO:K06087]
117750659  [KO:K06087]
117751049  [KO:K07374]
117751050  [KO:K07374]
117751051  [KO:K07374]
117751143  cldn11a; claudin-11a [KO:K06087]
117751367  rock2a; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
117751388  mpp5a; MAGUK p55 subfamily member 5-A [KO:K06091]
117751606  [KO:K05702]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
clum04520  Adherens junction
clum04810  Regulation of actin cytoskeleton
KO pathway
ko04530   

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