KEGG   PATHWAY: ecb05208
Entry
ecb05208                    Pathway                                
Name
Chemical carcinogenesis - reactive oxygen species - Equus caballus (horse)
Description
It is well established that cancer is a multi-step process which involves initiation, promotion and progression. Chemical carcinogens can alter any of these processes to induce their carcinogenic effects. In the majority of instances, chemical carcinogens, directly or after xenobiotic metabolism, induce DNA damage and act in a 'genotoxic' manner. There is, however, a group of carcinogens that induce cancer via nongenotoxic mechanisms. The biochemical modes of action for nongenotoxic carcinogens are diverse, one example of which is induction of oxidative stress. Trace metals and organic xenobiotics are typical classes of environmental pollutants with prooxidant effects. Trace metals generate reactive oxygen species (ROS) depending on their ability to lose electrons and catalyze Haber Weiss and Fenton reactions. ROS are also generated due to induction of various cytochrome P450 isoenzymes during detoxification of chemical carcinogens. Increased ROS generation often has been linked to DNA damage that can lead to mutations and may, therefore, play an important role in the initiation and progression of multistage carcinogenesis. Besides causing DNA damage, ROS further induce multiple intracellular signaling pathways, notably NF-kappa B, JNK/SAPK/p38, as well as Erk/MAPK. These signaling routes can lead to transcriptional induction of target genes that could promote proliferation or confer apoptosis resistance to exposed cells.
Class
Human Diseases; Cancer: overview
Pathway map
ecb05208  Chemical carcinogenesis - reactive oxygen species
ecb05208

Organism
Equus caballus (horse) [GN:ecb]
Gene
100033839  VEGFA; vascular endothelial growth factor A precursor [KO:K05448]
100033855  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
100034141  SLC26A2; sulfate transporter [KO:K14701]
100034223  SOD2; superoxide dismutase [Mn], mitochondrial precursor [KO:K04564] [EC:1.15.1.1]
100034244  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
100049843  CYBA; cytochrome b-245 light chain isoform X1 [KO:K08009]
100049848  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
100050036  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
100050091  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
100050140  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
100050167  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
100050227  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
100050321  NOX4; NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
100050322  [KO:K00799] [EC:2.5.1.18]
100050390  [KO:K00799] [EC:2.5.1.18]
100050693  SLC26A9; solute carrier family 26 member 9 isoform X1 [KO:K14706]
100050762  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
100051110  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100051249  COX6B1; cytochrome c oxidase subunit 6B1 [KO:K02267]
100051333  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
100051391  COX5A; cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
100051504  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
100051576  EPHX4; epoxide hydrolase 4 [KO:K22369] [EC:3.3.-.-]
100051623  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100051632  FOS; proto-oncogene c-Fos [KO:K04379]
100051753  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
100051785  [KO:K07827]
100051787  NCF2; neutrophil cytosol factor 2 [KO:K08010]
100051798  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100051866  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100051878  [KO:K00416]
100052066  PTPN1; tyrosine-protein phosphatase non-receptor type 1 [KO:K05696] [EC:3.1.3.48]
100052122  [KO:K02649]
100052131  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
100052169  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
100052170  ATP5PD; ATP synthase subunit d, mitochondrial isoform X2 [KO:K02138]
100052360  AKR1A1; alcohol dehydrogenase [NADP(+)] [KO:K00002] [EC:1.1.1.2]
100052608  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
100052985  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
100053033  ABL2; Abelson tyrosine-protein kinase 2 isoform X2 [KO:K08887] [EC:2.7.10.2]
100053178  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
100053347  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
100053392  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
100053420  COX6A1; cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
100053468  [KO:K00799] [EC:2.5.1.18]
100053548  COX4I2; cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
100053634  [KO:K00411] [EC:7.1.1.8]
100053736  COX7A2L; cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
100053786  UQCRC1; cytochrome b-c1 complex subunit 1, mitochondrial isoform X2 [KO:K00414]
100053889  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100054187  PRKD3; serine/threonine-protein kinase D3 [KO:K06070] [EC:2.7.11.13]
100054269  EPHX1; epoxide hydrolase 1 [KO:K01253] [EC:3.3.2.9]
100054377  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
100054445  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
100054611  [KO:K09093]
100054961  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100054964  PRKD1; serine/threonine-protein kinase D1 isoform X1 [KO:K06070] [EC:2.7.11.13]
100055128  KEAP1; kelch-like ECH-associated protein 1 [KO:K10456]
100055447  BAD; bcl2-associated agonist of cell death [KO:K02158]
100055481  HRAS; GTPase HRas isoform X1 [KO:K02833]
100055813  [KO:K02268]
100056013  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
100056171  COX4I1; cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
100056239  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
100056278  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
100056332  GSTA1; glutathione S-transferase alpha 1 [KO:K00799] [EC:2.5.1.18]
100056418  GSTA3; glutathione S-transferase A3 [KO:K00799] [EC:2.5.1.18]
100056462  [KO:K00799] [EC:2.5.1.18]
100056506  [KO:K00799] [EC:2.5.1.18]
100056597  GSTA4; glutathione S-transferase A4 isoform X1 [KO:K00799] [EC:2.5.1.18]
100056857  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
100056877  LPO; lactoperoxidase [KO:K12550] [EC:1.11.1.7]
100057212  [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
100057251  [KO:K00037] [EC:1.1.1.50 1.1.1.357 1.1.1.225]
100057408  ACP1; low molecular weight phosphotyrosine protein phosphatase isoform X1 [KO:K14394] [EC:3.1.3.2 3.1.3.48]
100057483  RELA; transcription factor p65 [KO:K04735]
100057623  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
100057691  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X4 [KO:K03944]
100057698  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X1 [KO:K03954]
100057701  MAPK1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
100057774  PLD1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
100057847  UQCRC2; cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
100057961  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100058000  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
100058141  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100058223  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial isoform X1 [KO:K03936] [EC:7.1.1.2]
100058245  PTK2; focal adhesion kinase 1 isoform X12 [KO:K05725] [EC:2.7.10.2]
100058290  [KO:K00799] [EC:2.5.1.18]
100058329  [KO:K00799] [EC:2.5.1.18]
100058402  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
100058432  IKBKG; NF-kappa-B essential modulator [KO:K07210]
100058514  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
100058689  PTPRJ; receptor-type tyrosine-protein phosphatase eta isoform X1 [KO:K05698] [EC:3.1.3.48]
100058835  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
100058893  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
100059103  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
100059178  ARNT; aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
100059469  NRAS; GTPase NRas [KO:K07828]
100059569  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
100059627  UQCRB; cytochrome b-c1 complex subunit 7 [KO:K00417]
100059825  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
100060414  EPHX2; bifunctional epoxide hydrolase 2 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
100060451  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
100060647  CAT; catalase isoform X1 [KO:K03781] [EC:1.11.1.6]
100060719  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
100061130  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100061166  HIF1A; hypoxia-inducible factor 1-alpha [KO:K08268]
100061212  ARAF; serine/threonine-protein kinase A-Raf isoform X2 [KO:K08845] [EC:2.7.11.1]
100061592  [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
100061622  [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
100061690  [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
100061732  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
100061761  [KO:K00799] [EC:2.5.1.18]
100061787  [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
100061811  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
100061826  GSTM3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
100061973  COX5B; cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
100062244  CYP1A2; cytochrome P450 1A2 isoform X2 [KO:K07409] [EC:1.14.14.1]
100062285  CYP1A1; cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
100062388  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100062974  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
100063124  EPHX3; epoxide hydrolase 3 [KO:K22368] [EC:3.3.2.10]
100063168  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X1 [KO:K03937]
100063190  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100063197  COX6A2; cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
100063532  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
100064102  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
100064131  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
100064276  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
100064473  KRAS; GTPase KRas isoform X1 [KO:K07827]
100064671  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100064695  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
100064796  [KO:K00799] [EC:2.5.1.18]
100064992  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 isoform X2 [KO:K03963]
100065070  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
100065553  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
100065760  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
100065866  PRKD2; serine/threonine-protein kinase D2 [KO:K06070] [EC:2.7.11.13]
100065940  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X3 [KO:K00236]
100065996  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
100066089  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
100066173  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100066186  AHR; aryl hydrocarbon receptor [KO:K09093]
100066282  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
100066330  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X2 [KO:K03934] [EC:7.1.1.2]
100066379  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
100066422  CYP2E1; cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
100066558  FOXO3; forkhead box protein O3 [KO:K09408]
100066816  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X2 [KO:K05638]
100066991  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
100067237  NQO1; NAD(P)H dehydrogenase [quinone] 1 [KO:K00355] [EC:1.6.5.2]
100067469  JUN; transcription factor AP-1 [KO:K04448]
100067562  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
100067755  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100067894  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X4 [KO:K02580]
100067936  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
100068315  CYP2F1; cytochrome P450 2F5 isoform X1 [KO:K07416] [EC:1.14.14.1]
100068334  [KO:K07416] [EC:1.14.14.1]
100068855  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
100069058  HMOX1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
100069079  NDUFAB1; acyl carrier protein, mitochondrial isoform X1 [KO:K03955]
100069298  [KO:K00799] [EC:2.5.1.18]
100069318  [KO:K00799] [EC:2.5.1.18]
100069523  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
100069628  GSTO2; glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
100069640  GSTO1; glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
100069715  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
100069819  AS3MT; arsenite methyltransferase [KO:K07755] [EC:2.1.1.137]
100069870  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
100069978  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X3 [KO:K02136]
100070088  CYP1B1; cytochrome P450 1B1 [KO:K07410] [EC:1.14.14.1]
100070393  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100070491  [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
100070501  [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
100070509  [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
100070570  [KO:K00212] [EC:1.1.1.149 1.1.1.357 1.3.1.20]
100070616  [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
100070815  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
100071532  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
100071879  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
100071908  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
100072863  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
100073016  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
100073094  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
100073186  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
100146128  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
100146191  [KO:K07293] [EC:3.1.3.48]
100146253  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
100146315  [KO:K00799] [EC:2.5.1.18]
100146348  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100146522  NCF1; neutrophil cytosol factor 1 [KO:K08011]
100146668  CYC1; cytochrome c1, heme protein, mitochondrial [KO:K00413]
100146804  [KO:K00799] [EC:2.5.1.18]
100146850  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
100146916  NOX1; NADPH oxidase 1 [KO:K08008]
100147230  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
100147519  [KO:K00420]
100271875  [KO:K00799] [EC:2.5.1.18]
100629332  COX7B2; cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
100629334  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
100629515  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
100629609  [KO:K00799] [EC:2.5.1.18]
100630209  [KO:K02270]
100630340  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
100630425  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
100630549  [KO:K02272]
100630562  MGST2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
100630568  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
100630657  [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
100630736  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
100630758  [KO:K02271]
100630846  [KO:K00419]
100630892  [KO:K03968]
102148919  SLC26A1; sulfate anion transporter 1 [KO:K14700]
102149678  [KO:K02267]
106782100  [KO:K02270]
106782258  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
106782874  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
106783042  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
111767785  [KO:K03946]
111767790  [KO:K03946]
111767815  [KO:K00418]
111768337  SLC26A6; solute carrier family 26 member 6 isoform X1 [KO:K14704]
111770393  [KO:K02273]
111771771  [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
111771772  [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
111771846  [KO:K05698] [EC:3.1.3.48]
111772123  [KO:K03946]
111775907  [KO:K05698] [EC:3.1.3.48]
111775959  [KO:K02273]
807844  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
807845  COX2; cytochrome c oxidase subunit II [KO:K02261]
807846  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
807847  CYTB; cytochrome b [KO:K00412]
807848  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
807849  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
807850  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
807851  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
807852  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
807853  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
807854  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
807855  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
807856  COX3; cytochrome c oxidase subunit III [KO:K02262]
Compound
C00001  H2O
C00003  NAD+
C00005  NADPH
C00006  NADP+
C00007  Oxygen
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00023  Iron
C00027  Hydrogen peroxide
C00051  Glutathione
C00070  Copper
C00084  Acetaldehyde
C00127  Glutathione disulfide
C00146  Phenol
C00291  Nickel
C00469  Ethanol
C00472  p-Benzoquinone
C00530  Hydroquinone
C00704  Superoxide
C00951  Estradiol-17beta
C01407  Benzene
C01413  Cadmium
C01782  Benzene oxide
C02389  p-Benzosemiquinone
C02575  Pentachlorophenol
C02814  Benzene-1,2,4-triol
C03434  Tetrachlorohydroquinone
C03622  N-Hydroxy-4-aminobiphenyl
C04623  DDT
C05301  2-Hydroxyestradiol
C05309  Semiquinone
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06268  Chromium
C06269  Arsenic
C06696  Lead
C07294  Methylarsonate
C07295  Methanearsonous acid
C07308  Cacodylate
C07535  Benzo[a]pyrene
C07557  2,3,7,8-Tetrachlorodibenzodioxin
C10998  4-Aminobiphenyl
C14209  4-Hydroxy-17beta-estradiol
C14850  Benzo[a]pyrene-7,8-oxide
C14852  Benzo[a]pyrene-7,8-dihydrodiol
C16038  2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
C16844  Hydroxyl radical
C18205  2,2',4,4'-Tetrabromodiphenyl ether
C18933  Chloranil
C19171  Cobalt
C20300  Dimethylarsinous acid
C20316  4-Nitrosobiphenyl
C20319  Hydronitroxide radical
C22355  Benzo[a]pyrene-7,8-diol
C22356  Benzo[a]pyrene-7,8-dione
C22357  17beta-Estradiol-2,3-quinone
C22381  Reactive oxygen species
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Related
pathway
ecb00190  Oxidative phosphorylation
ecb00980  Metabolism of xenobiotics by cytochrome P450
ecb04010  MAPK signaling pathway
ecb04064  NF-kappa B signaling pathway
ecb04066  HIF-1 signaling pathway
ecb04151  PI3K-Akt signaling pathway
ecb04370  VEGF signaling pathway
ecb05207  Chemical carcinogenesis - receptor activation
ecb05211  Renal cell carcinoma
ecb05215  Prostate cancer
ecb05219  Bladder cancer
ecb05221  Acute myeloid leukemia
ecb05222  Small cell lung cancer
ecb05223  Non-small cell lung cancer
ecb05224  Breast cancer
ecb05225  Hepatocellular carcinoma
KO pathway
ko05208   

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