Entry
Name
Cytokine-cytokine receptor interaction - Ictidomys tridecemlineatus (thirteen-lined ground squirrel)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
iti04060 Cytokine-cytokine receptor interaction
Organism
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) [GN:
iti ]
Gene
101956762 Il10ra; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134 ]
101957188 Tnfrsf12a; tumor necrosis factor receptor superfamily member 12A [KO:K05149 ]
101957786 Il6st; interleukin-6 receptor subunit beta isoform X1 [KO:K05060 ]
101957838 Tnfsf10; tumor necrosis factor ligand superfamily member 10 isoform X1 [KO:K04721 ]
101958576 Osmr; oncostatin-M-specific receptor subunit beta isoform X2 [KO:K05057 ]
101958873 Tnfsf9; tumor necrosis factor ligand superfamily member 9 [KO:K05472 ]
101959099 Tnfrsf1b; tumor necrosis factor receptor superfamily member 1B [KO:K05141 ]
101960256 Il17ra; LOW QUALITY PROTEIN: interleukin-17 receptor A [KO:K05164 ]
101960446 Il1rn; interleukin-1 receptor antagonist protein isoform X1 [KO:K05481 ]
101960630 Fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390 ]
101960857 Tnfrsf13c; tumor necrosis factor receptor superfamily member 13C [KO:K05151 ]
101961679 Il2rg; LOW QUALITY PROTEIN: cytokine receptor common subunit gamma [KO:K05070 ]
101961736 Tnfsf14; tumor necrosis factor ligand superfamily member 14 [KO:K05477 ]
101962148 Il1rl2; LOW QUALITY PROTEIN: interleukin-1 receptor-like 2 [KO:K05172 ]
101962509 Tnfrsf25; tumor necrosis factor receptor superfamily member 25 isoform X1 [KO:K05160 ]
101964509 Tnfsf11; tumor necrosis factor ligand superfamily member 11 [KO:K05473 ]
101964811 Tnfsf4; tumor necrosis factor ligand superfamily member 4 [KO:K05469 ]
101964911 Tnfrsf8; tumor necrosis factor receptor superfamily member 8 [KO:K05145 ]
101965093 Ltbr; tumor necrosis factor receptor superfamily member 3 isoform X1 [KO:K03159 ]
101965108 Faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
101965485 Tnfsf13b; tumor necrosis factor ligand superfamily member 13B isoform X1 [KO:K05476 ]
101965683 Tnfrsf4; tumor necrosis factor receptor superfamily member 4 isoform X2 [KO:K05142 ]
101965886 Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A isoform X3 [KO:K03158 ]
101965980 Tnfrsf18; tumor necrosis factor receptor superfamily member 18 [KO:K05154 ]
101966565 Csf3r; granulocyte colony-stimulating factor receptor [KO:K05061 ]
101966977 Ngfr; tumor necrosis factor receptor superfamily member 16 [KO:K02583 ]
101967599 Tgfb2; transforming growth factor beta-2 proprotein isoform X2 [KO:K13376 ]
101967668 Cntfr; ciliary neurotrophic factor receptor subunit alpha isoform X4 [KO:K05059 ]
101968296 Tnfsf18; LOW QUALITY PROTEIN: tumor necrosis factor ligand superfamily member 18 [KO:K05479 ]
101968440 Il20ra; interleukin-20 receptor subunit alpha isoform X4 [KO:K05136 ]
101968804 Bmp15; LOW QUALITY PROTEIN: bone morphogenetic protein 15 [KO:K05498 ]
101968821 Cd40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160 ]
101969837 Tnfrsf14; tumor necrosis factor receptor superfamily member 14 [KO:K05152 ]
101970011 Tnfrsf21; tumor necrosis factor receptor superfamily member 21 [KO:K05157 ]
101970043 Tnfrsf11a; tumor necrosis factor receptor superfamily member 11A [KO:K05147 ]
101970320 Csf3; granulocyte colony-stimulating factor isoform X2 [KO:K05423 ]
101970743 Il11ra; interleukin-11 receptor subunit alpha isoform X1 [KO:K05056 ]
101971170 Tnfrsf13b; tumor necrosis factor receptor superfamily member 13B [KO:K05150 ]
101971532 Eda2r; tumor necrosis factor receptor superfamily member 27 isoform X1 [KO:K05163 ]
101971743 Tnfrsf11b; tumor necrosis factor receptor superfamily member 11B [KO:K05148 ]
101971785 Relt; tumor necrosis factor receptor superfamily member 19L isoform X1 [KO:K05156 ]
101972747 Tnfsf15; tumor necrosis factor ligand superfamily member 15 [KO:K05478 ]
101973978 Edar; tumor necrosis factor receptor superfamily member EDAR [KO:K05162 ]
101974504 Tnfrsf9; tumor necrosis factor receptor superfamily member 9 [KO:K05146 ]
101974602 Tnfrsf19; tumor necrosis factor receptor superfamily member 19 isoform X1 [KO:K05155 ]
101974686 Clcf1; cardiotrophin-like cytokine factor 1 isoform X1 [KO:K05421 ]
101976851 Csf2; granulocyte-macrophage colony-stimulating factor [KO:K05427 ]
101977305 Il12rb2; interleukin-12 receptor subunit beta-2 isoform X2 [KO:K05064 ]
101977938 Tnfsf13; tumor necrosis factor ligand superfamily member 13 [KO:K05475 ]
101977985 Tnfsf8; tumor necrosis factor ligand superfamily member 8 [KO:K05471 ]
110597992 Tnfrsf17; tumor necrosis factor receptor superfamily member 17 isoform X1 [KO:K05153 ]
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Reference
Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
Journal
Reference
Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
Journal
Reference
Authors
Boulanger MJ, Garcia KC
Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
Journal
Reference
Authors
Allan SM, Tyrrell PJ, Rothwell NJ
Title
Interleukin-1 and neuronal injury.
Journal
Reference
Authors
Lopetuso LR, Chowdhry S, Pizarro TT
Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
Journal
Reference
Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
Title
Functional specialization of interleukin-17 family members.
Journal
Reference
Authors
Fischer P, Hilfiker-Kleiner D
Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
Journal
Reference
Authors
Richards CD
Title
The enigmatic cytokine oncostatin m and roles in disease.
Journal
Reference
Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
Title
Structures and biological functions of IL-31 and IL-31 receptors.
Journal
Reference
Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
Journal
Reference
Authors
de Weerd NA, Nguyen T
Title
The interferons and their receptors--distribution and regulation.
Journal
Reference
Authors
Aggarwal BB
Title
Signalling pathways of the TNF superfamily: a double-edged sword.
Journal
Reference
Authors
Ashkenazi A
Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
Journal
Reference
Authors
Seeger P, Musso T, Sozzani S
Title
The TGF-beta superfamily in dendritic cell biology.
Journal
Reference
Authors
Wakefield LM, Hill CS
Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
Journal
Reference
Authors
Mueller TD, Nickel J
Title
Promiscuity and specificity in BMP receptor activation.
Journal
KO pathway