Entry
Name
Cytokine-cytokine receptor interaction - Mastomys coucha (southern multimammate mouse)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
mcoc04060 Cytokine-cytokine receptor interaction
Organism
Mastomys coucha (southern multimammate mouse) [GN:
mcoc ]
Gene
116068892 Tnfsf13b; tumor necrosis factor ligand superfamily member 13B isoform X1 [KO:K05476 ]
116069495 Il12rb1; interleukin-12 receptor subunit beta-1 isoform X1 [KO:K05063 ]
116070781 Tnfsf4; tumor necrosis factor ligand superfamily member 4 [KO:K05469 ]
116070785 Faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
116072998 Il20rb; interleukin-20 receptor subunit beta isoform X1 [KO:K05137 ]
116074341 Tnfrsf21; tumor necrosis factor receptor superfamily member 21 isoform X1 [KO:K05157 ]
116074815 Tnfsf14; tumor necrosis factor ligand superfamily member 14 isoform X1 [KO:K05477 ]
116075145 Edar; tumor necrosis factor receptor superfamily member EDAR [KO:K05162 ]
116075222 Tnfsf9; tumor necrosis factor ligand superfamily member 9 [KO:K05472 ]
116076945 Csf2; granulocyte-macrophage colony-stimulating factor [KO:K05427 ]
116077677 Tnfrsf12a; tumor necrosis factor receptor superfamily member 12A isoform X1 [KO:K05149 ]
116078356 Ngfr; tumor necrosis factor receptor superfamily member 16 [KO:K02583 ]
116078412 Tnfrsf13b; tumor necrosis factor receptor superfamily member 13B [KO:K05150 ]
116078657 Gdf9; LOW QUALITY PROTEIN: growth/differentiation factor 9 [KO:K22673 ]
116079091 Tnfsf12; tumor necrosis factor ligand superfamily member 12 isoform X1 [KO:K05474 ]
116081618 Tnfrsf13c; tumor necrosis factor receptor superfamily member 13C isoform X1 [KO:K05151 ]
116081769 Tnfrsf11b; tumor necrosis factor receptor superfamily member 11B [KO:K05148 ]
116082267 Il15ra; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074 ]
116082367 Il2ra; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068 ]
116083573 Osmr; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057 ]
116083598 Il31ra; interleukin-31 receptor subunit alpha isoform X1 [KO:K22630 ]
116083943 Il6st; interleukin-6 receptor subunit beta isoform X1 [KO:K05060 ]
116084439 Tnfsf11; tumor necrosis factor ligand superfamily member 11 isoform X1 [KO:K05473 ]
116085337 Tnfrsf17; tumor necrosis factor receptor superfamily member 17 isoform X1 [KO:K05153 ]
116085382 Tnfrsf19; tumor necrosis factor receptor superfamily member 19 [KO:K05155 ]
116085769 Il1rap; interleukin-1 receptor accessory protein isoform X1 [KO:K04723 ]
116086125 Il10rb; interleukin-10 receptor subunit beta isoform X1 [KO:K05135 ]
116087001 Eda2r; tumor necrosis factor receptor superfamily member 27 isoform X1 [KO:K05163 ]
116087170 Il2rg; cytokine receptor common subunit gamma isoform X1 [KO:K05070 ]
116089782 Il1rn; interleukin-1 receptor antagonist protein isoform X1 [KO:K05481 ]
116091386 Cd40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160 ]
116093191 Il6r; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055 ]
116093601 Csf1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453 ]
116095017 Tnfsf10; tumor necrosis factor ligand superfamily member 10 [KO:K04721 ]
116095346 Tnfsf15; tumor necrosis factor ligand superfamily member 15 [KO:K05478 ]
116095669 Tnfrsf8; tumor necrosis factor receptor superfamily member 8 [KO:K05145 ]
116095690 Tnfrsf9; tumor necrosis factor receptor superfamily member 9 [KO:K05146 ]
116095716 Tnfrsf18; tumor necrosis factor receptor superfamily member 18 [KO:K05154 ]
116095849 Cntfr; ciliary neurotrophic factor receptor subunit alpha isoform X1 [KO:K05059 ]
116095856 Il11ra; interleukin-11 receptor subunit alpha isoform X1 [KO:K05056 ]
116096133 Tnfsf8; tumor necrosis factor ligand superfamily member 8 [KO:K05471 ]
116096625 Csf3r; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061 ]
116096996 Tnfrsf1b; tumor necrosis factor receptor superfamily member 1B isoform X1 [KO:K05141 ]
116097089 Tnfrsf25; tumor necrosis factor receptor superfamily member 25 isoform X1 [KO:K05160 ]
116097128 Tnfrsf14; tumor necrosis factor receptor superfamily member 14 isoform X1 [KO:K05152 ]
116097162 Tnfrsf11a; tumor necrosis factor receptor superfamily member 11A [KO:K05147 ]
116097169 Tnfrsf4; tumor necrosis factor receptor superfamily member 4 [KO:K05142 ]
116097809 Il20ra; interleukin-20 receptor subunit alpha isoform X1 [KO:K05136 ]
116099025 Il12rb2; interleukin-12 receptor subunit beta-2 isoform X1 [KO:K05064 ]
116099354 Il5ra; interleukin-5 receptor subunit alpha isoform X1 [KO:K05067 ]
116099612 Ltbr; tumor necrosis factor receptor superfamily member 3 [KO:K03159 ]
116099614 Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
116102406 Tnfsf18; LOW QUALITY PROTEIN: tumor necrosis factor ligand superfamily member 18 [KO:K05479 ]
116102655 Relt; tumor necrosis factor receptor superfamily member 19L isoform X1 [KO:K05156 ]
116102932 Il4r; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071 ]
116103327 Clcf1; cardiotrophin-like cytokine factor 1 isoform X1 [KO:K05421 ]
116103761 Fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390 ]
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Reference
Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
Journal
Reference
Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
Journal
Reference
Authors
Boulanger MJ, Garcia KC
Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
Journal
Reference
Authors
Allan SM, Tyrrell PJ, Rothwell NJ
Title
Interleukin-1 and neuronal injury.
Journal
Reference
Authors
Lopetuso LR, Chowdhry S, Pizarro TT
Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
Journal
Reference
Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
Title
Functional specialization of interleukin-17 family members.
Journal
Reference
Authors
Fischer P, Hilfiker-Kleiner D
Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
Journal
Reference
Authors
Richards CD
Title
The enigmatic cytokine oncostatin m and roles in disease.
Journal
Reference
Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
Title
Structures and biological functions of IL-31 and IL-31 receptors.
Journal
Reference
Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
Journal
Reference
Authors
de Weerd NA, Nguyen T
Title
The interferons and their receptors--distribution and regulation.
Journal
Reference
Authors
Aggarwal BB
Title
Signalling pathways of the TNF superfamily: a double-edged sword.
Journal
Reference
Authors
Ashkenazi A
Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
Journal
Reference
Authors
Seeger P, Musso T, Sozzani S
Title
The TGF-beta superfamily in dendritic cell biology.
Journal
Reference
Authors
Wakefield LM, Hill CS
Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
Journal
Reference
Authors
Mueller TD, Nickel J
Title
Promiscuity and specificity in BMP receptor activation.
Journal
KO pathway