KEGG   PATHWAY: mpuf04510
Entry
mpuf04510                   Pathway                                
Name
Focal adhesion - Mustela putorius furo (domestic ferret)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
mpuf04510  Focal adhesion
mpuf04510

Other DBs
GO: 0005925
Organism
Mustela putorius furo (domestic ferret) [GN:mpuf]
Gene
101669936  ITGA9; integrin alpha-9 [KO:K06585]
101670064  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
101670225  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
101670448  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
101670844  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
101670896  EMP2; epithelial membrane protein 2 [KO:K26256]
101670913  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
101671073  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101671154  XIAP; E3 ubiquitin-protein ligase XIAP isoform X1 [KO:K04725] [EC:2.3.2.27]
101671302  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
101671328  VEGFC; vascular endothelial growth factor C [KO:K05449]
101671478  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
101671536  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
101671594  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
101671893  ITGB5; integrin beta-5 [KO:K06588]
101671970  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
101671999  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
101672072  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101672159  ITGA11; integrin alpha-11 [KO:K06587]
101672160  FIGF; vascular endothelial growth factor D [KO:K05449]
101672161  COL6A5; collagen alpha-5(VI) chain isoform X2 [KO:K06238]
101672230  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
101672384  LAMC1; laminin subunit gamma-1 [KO:K05635]
101672605  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
101672620  SPP1; osteopontin [KO:K06250]
101673012  [KO:K06238]
101673394  IBSP; bone sialoprotein 2 [KO:K06253]
101673442  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
101673580  THBS3; thrombospondin-3 [KO:K04659]
101673644  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
101673926  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
101673993  LAMA1; laminin subunit alpha-1 [KO:K05637]
101674061  FLT4; vascular endothelial growth factor receptor 3 isoform X8 [KO:K05097] [EC:2.7.10.1]
101674077  LAMB4; laminin subunit beta-4 isoform X1 [KO:K06245]
101674249  ILK; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
101674350  TNN; tenascin-N isoform X1 [KO:K06252]
101674562  DIAPH1; protein diaphanous homolog 1 isoform X5 [KO:K05740]
101674626  ACTN1; alpha-actinin-1 isoform X3 [KO:K05699]
101674914  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
101674942  TNR; tenascin-R isoform X2 [KO:K06252]
101674947  LAMB1; laminin subunit beta-1 [KO:K05636]
101675046  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X2 [KO:K04349]
101675244  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
101675655  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
101675667  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
101675757  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
101675802  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
101675945  VEGFA; vascular endothelial growth factor A [KO:K05448]
101675955  CAV1; caveolin-1 isoform X1 [KO:K06278]
101676004  PXN; paxillin isoform X1 [KO:K05760]
101676005  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
101676109  SHC3; SHC-transforming protein 3 isoform X2 [KO:K17448]
101676197  KDR; vascular endothelial growth factor receptor 2 isoform X2 [KO:K05098] [EC:2.7.10.1]
101676200  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
101676423  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101676559  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
101676567  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101676645  CAV2; caveolin-2 isoform X2 [KO:K12958]
101676685  ZYX; zyxin isoform X1 [KO:K06273]
101676758  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
101676895  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101676920  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
101676957  PAK2; serine/threonine-protein kinase PAK 2 isoform X1 [KO:K04410] [EC:2.7.11.1]
101677155  VWF; von Willebrand factor [KO:K03900]
101677536  COL6A3; collagen alpha-3(VI) chain isoform X2 [KO:K06238]
101677610  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
101677753  ARHGAP5; rho GTPase-activating protein 5 isoform X1 [KO:K13709]
101677795  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
101678224  ITGA2B; integrin alpha-IIb isoform X2 [KO:K06476]
101678420  THBS4; thrombospondin-4 [KO:K04659]
101678913  CRKL; crk-like protein [KO:K04438]
101678969  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
101679039  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
101679339  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
101679540  ACTG1; actin, cytoplasmic 2 [KO:K05692]
101679631  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
101679725  VCL; vinculin isoform X1 [KO:K05700]
101679748  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101679776  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101679813  LAMA3; laminin subunit alpha-3 isoform X2 [KO:K06240]
101679891  RHOA; transforming protein RhoA [KO:K04513]
101680348  JUN; transcription factor AP-1 [KO:K04448]
101680372  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101680399  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101680463  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
101680746  COL4A1; collagen alpha-1(IV) chain isoform X3 [KO:K06237]
101680880  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
101680922  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
101680975  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
101681141  PAK7; serine/threonine-protein kinase PAK 7 [KO:K05736] [EC:2.7.11.1]
101681217  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
101681308  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
101681349  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101681355  HRAS; GTPase HRas isoform X1 [KO:K02833]
101681396  ITGA4; integrin alpha-4 [KO:K06483]
101681427  MYLK4; myosin light chain kinase family member 4 isoform X2 [KO:K00907] [EC:2.7.11.18]
101681503  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
101681544  FLNB; filamin-B isoform X1 [KO:K27392]
101681626  ITGAV; integrin alpha-V [KO:K06487]
101681650  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101681759  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
101681860  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
101681879  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
101681935  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
101682257  TLN1; talin-1 isoform X2 [KO:K06271]
101682299  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
101682530  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
101682951  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
101683021  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
101683143  PARVG; gamma-parvin isoform X3 [KO:K06275]
101683440  PARVB; beta-parvin isoform X2 [KO:K06275]
101683594  [KO:K02649]
101683710  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101683736  CRK; adapter molecule crk isoform X1 [KO:K04438]
101683751  ITGB3; integrin beta-3 [KO:K06493]
101683828  LAMC2; laminin subunit gamma-2 [KO:K06246]
101683865  EMP1; epithelial membrane protein 1 [KO:K26255]
101684180  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
101684232  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
101684358  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
101684361  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
101684443  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101684479  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101684525  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
101684587  RAP1A; ras-related protein Rap-1A [KO:K04353]
101684840  CAV3; caveolin-3 [KO:K12959]
101684983  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
101685180  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
101685186  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
101685370  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
101685630  LAMB2; laminin subunit beta-2 [KO:K06243]
101685685  ITGB7; integrin beta-7 [KO:K06590]
101685824  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
101686072  PARVA; alpha-parvin isoform X1 [KO:K06275]
101686096  ITGA10; integrin alpha-10 isoform X4 [KO:K06586]
101686268  ACTB; actin, cytoplasmic 1 [KO:K05692]
101686312  MYL7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
101686427  BAD; bcl2-associated agonist of cell death [KO:K02158]
101686447  ITGA5; integrin alpha-5 [KO:K06484]
101686513  [KO:K12757]
101686744  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
101686788  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
101686980  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
101686987  [KO:K12757]
101686988  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
101687213  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
101687324  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101687362  LAMA2; laminin subunit alpha-2 [KO:K05637]
101687579  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
101687682  TNC; tenascin isoform X1 [KO:K06252]
101687739  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
101688005  LAMA5; laminin subunit alpha-5 [KO:K06240]
101688258  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
101688760  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
101689143  VAV2; guanine nucleotide exchange factor VAV2 isoform X3 [KO:K05730]
101689165  PGF; placenta growth factor isoform X1 [KO:K16859]
101689202  SHC4; SHC-transforming protein 4 [KO:K17449]
101689297  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
101689432  TLN2; talin-2 isoform X1 [KO:K06271]
101689502  CTNNB1; catenin beta-1 [KO:K02105]
101689515  FLNA; filamin-A isoform X1 [KO:K04437]
101689940  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
101690124  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
101690142  VASP; vasodilator-stimulated phosphoprotein isoform X2 [KO:K06274]
101690170  LAMB3; laminin subunit beta-3 [KO:K06244]
101690226  VTN; vitronectin [KO:K06251]
101690329  COL1A2; collagen alpha-2(I) chain [KO:K06236]
101690344  MYL5; myosin light chain 5 [KO:K12753]
101690463  COL6A2; collagen alpha-2(VI) chain isoform X2 [KO:K06238]
101690482  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
101690600  CHAD; chondroadherin [KO:K06248]
101690880  [KO:K06487]
101690894  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
101691130  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
101691164  MYL10; myosin regulatory light chain 10 [KO:K12756]
101691404  RAP1B; ras-related protein Rap-1b [KO:K07836]
101691421  LAMC3; laminin subunit gamma-3 [KO:K06247]
101691499  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
101691556  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X2 [KO:K00889] [EC:2.7.1.68]
101691743  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
101691821  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
101691865  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
101691926  THBS2; thrombospondin-2 [KO:K04659]
101691976  TNXB; tenascin-X [KO:K06252]
101692148  COL4A3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
101692284  [KO:K12757]
101692293  [KO:K16060]
101692343  SHC2; SHC-transforming protein 2 isoform X1 [KO:K17447]
101692352  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
101692402  FN1; fibronectin isoform X2 [KO:K05717]
101692429  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
101692568  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
101692696  ITGA7; integrin alpha-7 isoform X2 [KO:K06583]
101692829  ITGA8; integrin alpha-8 [KO:K06584]
101692999  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
101693248  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
101693834  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
101693911  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
101694049  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
101694197  THBS1; thrombospondin-1 [KO:K16857]
101694423  COMP; cartilage oligomeric matrix protein [KO:K04659]
106003286  [KO:K06238]
106003305  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
mpuf04010  MAPK signaling pathway
mpuf04060  Cytokine-cytokine receptor interaction
mpuf04070  Phosphatidylinositol signaling system
mpuf04110  Cell cycle
mpuf04151  PI3K-Akt signaling pathway
mpuf04310  Wnt signaling pathway
mpuf04512  ECM-receptor interaction
mpuf04810  Regulation of actin cytoskeleton
KO pathway
ko04510   

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