KEGG   PATHWAY: mpuf04810
Entry
mpuf04810                   Pathway                                
Name
Regulation of actin cytoskeleton - Mustela putorius furo (domestic ferret)
Class
Cellular Processes; Cell motility
Pathway map
mpuf04810  Regulation of actin cytoskeleton
mpuf04810

Other DBs
GO: 0030036
Organism
Mustela putorius furo (domestic ferret) [GN:mpuf]
Gene
101669888  RRAS; ras-related protein R-Ras [KO:K07829]
101669936  ITGA9; integrin alpha-9 [KO:K06585]
101670225  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
101670448  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
101670490  KNG1; kininogen-1 isoform X1 [KO:K03898]
101670591  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
101670647  CYFIP1; cytoplasmic FMR1-interacting protein 1 [KO:K05749]
101670723  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
101670913  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
101671073  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101671259  C9; complement component C9 [KO:K04000]
101671335  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
101671349  FGF19; fibroblast growth factor 19 [KO:K22603]
101671364  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
101671559  PFN1; profilin-1 [KO:K05759]
101671594  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
101671663  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
101671736  FGF20; fibroblast growth factor 20 [KO:K04358]
101671799  FGF2; fibroblast growth factor 2 isoform X2 [KO:K18497]
101671893  ITGB5; integrin beta-5 [KO:K06588]
101671970  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
101671999  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
101672159  ITGA11; integrin alpha-11 [KO:K06587]
101672230  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
101672455  ITGAE; integrin alpha-E [KO:K06524]
101672605  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
101672634  FGF18; fibroblast growth factor 18 [KO:K04358]
101672877  CFL2; cofilin-2 [KO:K05765]
101673283  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
101673442  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
101673618  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
101673644  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
101673919  CFL1; cofilin-1 isoform X1 [KO:K05765]
101673926  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
101673953  FGF16; fibroblast growth factor 16 [KO:K04358]
101674120  ITGAD; integrin alpha-D [KO:K06594]
101674359  [KO:K05764]
101674382  ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X1 [KO:K13710]
101674562  DIAPH1; protein diaphanous homolog 1 isoform X5 [KO:K05740]
101674626  ACTN1; alpha-actinin-1 isoform X3 [KO:K05699]
101674688  [KO:K06462]
101674914  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
101674995  ITGAM; integrin alpha-M [KO:K06461]
101675302  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
101675516  IQGAP3; ras GTPase-activating-like protein IQGAP3 [KO:K05767]
101675530  FGF4; fibroblast growth factor 4 [KO:K04358]
101675667  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
101675757  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
101675802  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
101675837  FGF3; fibroblast growth factor 3 [KO:K04358]
101675997  FGF9; fibroblast growth factor 9 [KO:K04358]
101676004  PXN; paxillin isoform X1 [KO:K05760]
101676161  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
101676192  C8A; complement component C8 alpha chain [KO:K03997]
101676200  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
101676288  DIAPH3; protein diaphanous homolog 3 isoform X3 [KO:K05745]
101676491  C8B; complement component C8 beta chain [KO:K03998]
101676559  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
101676567  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101676758  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
101676878  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
101676895  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101676920  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
101676957  PAK2; serine/threonine-protein kinase PAK 2 isoform X1 [KO:K04410] [EC:2.7.11.1]
101677319  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
101677488  FGD1; FYVE, RhoGEF and PH domain-containing protein 1 [KO:K05720]
101677577  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
101677725  NCKAP1; LOW QUALITY PROTEIN: nck-associated protein 1 [KO:K05750]
101677743  ACTR3; actin-related protein 3 [KO:K18584]
101677769  SSH1; protein phosphatase Slingshot homolog 1 isoform X2 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
101677795  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
101677962  PFN2; profilin-2 isoform X1 [KO:K05759]
101678224  ITGA2B; integrin alpha-IIb isoform X2 [KO:K06476]
101678743  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101678762  GSN; gelsolin isoform X1 [KO:K05768]
101678913  CRKL; crk-like protein [KO:K04438]
101678969  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
101679448  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
101679540  ACTG1; actin, cytoplasmic 2 [KO:K05692]
101679596  BRK1; protein BRICK1 [KO:K05752]
101679631  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
101679725  VCL; vinculin isoform X1 [KO:K05700]
101679748  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101679776  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101679836  EZR; ezrin isoform X1 [KO:K08007]
101679891  RHOA; transforming protein RhoA [KO:K04513]
101680306  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
101680399  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101680552  RDX; radixin isoform X1 [KO:K05762]
101680665  ARHGEF6; rho guanine nucleotide exchange factor 6 isoform X1 [KO:K05729]
101680761  SPATA13; spermatogenesis-associated protein 13 isoform X2 [KO:K05769]
101680767  C5; complement C5 [KO:K03994]
101680856  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
101680871  FGF5; fibroblast growth factor 5 [KO:K04358]
101680975  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
101681080  FGF10; fibroblast growth factor 10 [KO:K04358]
101681141  PAK7; serine/threonine-protein kinase PAK 7 [KO:K05736] [EC:2.7.11.1]
101681312  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
101681333  KRAS; GTPase KRas isoform X3 [KO:K07827]
101681355  HRAS; GTPase HRas isoform X1 [KO:K02833]
101681396  ITGA4; integrin alpha-4 [KO:K06483]
101681427  MYLK4; myosin light chain kinase family member 4 isoform X2 [KO:K00907] [EC:2.7.11.18]
101681456  CYFIP2; cytoplasmic FMR1-interacting protein 2 [KO:K05749]
101681503  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
101681531  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [KO:K00920] [EC:2.7.1.149]
101681626  ITGAV; integrin alpha-V [KO:K06487]
101681650  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101681759  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
101681860  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
101681879  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
101681946  ENAH; protein enabled homolog isoform X1 [KO:K05746]
101682055  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta [KO:K00920] [EC:2.7.1.149]
101682419  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
101682467  MYH11; myosin-11 [KO:K10352]
101682530  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
101682635  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
101682916  LIMK1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
101682926  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
101682951  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
101683021  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
101683038  NRAS; GTPase NRas [KO:K07828]
101683115  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
101683168  FGF6; fibroblast growth factor 6 [KO:K04358]
101683212  ACTR2; actin-related protein 2 [KO:K17260]
101683248  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
101683344  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X4 [KO:K05627]
101683475  FGF23; fibroblast growth factor 23 [KO:K22428]
101683594  [KO:K02649]
101683710  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101683736  CRK; adapter molecule crk isoform X1 [KO:K04438]
101683751  ITGB3; integrin beta-3 [KO:K06493]
101684180  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
101684232  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
101684361  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
101684443  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101684479  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101684485  LIMK2; LIM domain kinase 2 isoform X2 [KO:K05744] [EC:2.7.11.1]
101684528  INSRR; insulin receptor-related protein [KO:K05086] [EC:2.7.10.1]
101684598  NCKAP1L; nck-associated protein 1-like [KO:K05750]
101684928  INS; insulin [KO:K04526]
101684930  MYH10; myosin-10 [KO:K10352]
101684983  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
101685044  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 isoform X1 [KO:K05722]
101685180  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
101685186  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
101685307  MSN; moesin [KO:K05763]
101685560  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
101685685  ITGB7; integrin beta-7 [KO:K06590]
101685824  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
101686096  ITGA10; integrin alpha-10 isoform X4 [KO:K06586]
101686122  MRAS; ras-related protein M-Ras [KO:K07831]
101686268  ACTB; actin, cytoplasmic 1 [KO:K05692]
101686312  MYL7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
101686447  ITGA5; integrin alpha-5 [KO:K06484]
101686475  TMSB4X; thymosin beta-4 [KO:K05764]
101686513  [KO:K12757]
101686744  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
101686785  ABI2; abl interactor 2 [KO:K05751]
101686980  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
101686987  [KO:K12757]
101687089  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
101687256  PFN3; profilin-3 [KO:K05759]
101687324  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101687579  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
101687635  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
101687722  RGCC; regulator of cell cycle RGCC [KO:K26108]
101687739  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
101687799  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
101688252  GIT1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
101688258  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
101688519  MYH14; LOW QUALITY PROTEIN: myosin-14 [KO:K10352]
101688833  CXCL12; stromal cell-derived factor 1 isoform X2 [KO:K10031]
101689018  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
101689143  VAV2; guanine nucleotide exchange factor VAV2 isoform X3 [KO:K05730]
101689541  CHRM2; muscarinic acetylcholine receptor M2 isoform X2 [KO:K04130]
101689568  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
101689712  FGF22; fibroblast growth factor 22 isoform X2 [KO:K04358]
101689861  FGF1; fibroblast growth factor 1 [KO:K18496]
101690316  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
101690321  F2R; proteinase-activated receptor 1 [KO:K03914]
101690344  MYL5; myosin light chain 5 [KO:K12753]
101690482  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
101690515  PFN4; profilin-4 [KO:K05759]
101690551  DIAPH2; protein diaphanous homolog 2 isoform X5 [KO:K05741]
101690742  C8G; complement component C8 gamma chain [KO:K03999]
101690825  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
101690880  [KO:K06487]
101690894  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
101690896  IQGAP2; ras GTPase-activating-like protein IQGAP2 isoform X2 [KO:K05767]
101690974  ITGB2; integrin beta-2 [KO:K06464]
101691130  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
101691149  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
101691164  MYL10; myosin regulatory light chain 10 [KO:K12756]
101691181  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
101691216  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
101691432  SSH3; protein phosphatase Slingshot homolog 3 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
101691462  FAM49B; protein FAM49B isoform X1 [KO:K27976]
101691499  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
101691556  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X2 [KO:K00889] [EC:2.7.1.68]
101691659  FGFR3; fibroblast growth factor receptor 3 isoform X10 [KO:K05094] [EC:2.7.10.1]
101691664  PIP4K2C; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma [KO:K00920] [EC:2.7.1.149]
101691862  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
101691913  SCIN; adseverin [KO:K05768]
101692153  ARHGEF4; rho guanine nucleotide exchange factor 4 isoform X2 [KO:K05769]
101692284  [KO:K12757]
101692402  FN1; fibronectin isoform X2 [KO:K05717]
101692429  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
101692433  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
101692447  BDKRB2; B2 bradykinin receptor isoform X1 [KO:K03915]
101692696  ITGA7; integrin alpha-7 isoform X2 [KO:K06583]
101692760  [KO:K10352]
101692803  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
101692829  ITGA8; integrin alpha-8 [KO:K06584]
101692938  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
101692941  C6; complement component C6 [KO:K03995]
101693039  C7; complement component C7 [KO:K03996]
101693053  WASF2; LOW QUALITY PROTEIN: wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
101693424  FGF21; fibroblast growth factor 21 [KO:K22429]
101693463  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
101693628  SSH2; protein phosphatase Slingshot homolog 2 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
101693718  FAM49A; protein FAM49A isoform X1 [KO:K27976]
101693834  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
101693839  WASF1; wiskott-Aldrich syndrome protein family member 1 isoform X1 [KO:K05753]
101693911  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
101693913  FGF8; fibroblast growth factor 8 [KO:K04358]
101693934  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
101694049  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
106003305  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
mpuf04010  MAPK signaling pathway
mpuf04510  Focal adhesion
mpuf04520  Adherens junction
KO pathway
ko04810   

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