KEGG   PATHWAY: myb04024
Entry
myb04024                    Pathway                                
Name
cAMP signaling pathway - Myotis brandtii (Brandt's bat)
Description
cAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands including hormones, neurotransmitters, and other signaling molecules. cAMP regulates pivotal physiologic processes including metabolism, secretion, calcium homeostasis, muscle contraction, cell fate, and gene transcription. cAMP acts directly on three main targets: protein kinase A (PKA), the exchange protein activated by cAMP (Epac), and cyclic nucleotide-gated ion channels (CNGCs). PKA modulates, via phosphorylation, a number of cellular substrates, including transcription factors, ion channels, transporters, exchangers, intracellular Ca2+ -handling proteins, and the contractile machinery. Epac proteins function as guanine nucleotide exchange factors (GEFs) for both Rap1 and Rap2. Various effector proteins, including adaptor proteins implicated in modulation of the actin cytoskeleton, regulators of G proteins of the Rho family, and phospholipases, relay signaling downstream from Rap.
Class
Environmental Information Processing; Signal transduction
Pathway map
myb04024  cAMP signaling pathway
myb04024

Other DBs
GO: 0019933
Organism
Myotis brandtii (Brandt's bat) [GN:myb]
Gene
102254866  VIP; vasoactive intestinal peptide [KO:K05264]
102263423  VIP peptides-like [KO:K05264]
106726504  VIP peptides-like [KO:K05264]
102257606  CRH; corticotropin releasing hormone [KO:K05256]
106724162  corticoliberin-like [KO:K05256]
102239335  CGA; glycoprotein hormones, alpha polypeptide [KO:K08522]
102260259  LHB; luteinizing hormone beta polypeptide [KO:K08521]
102244708  GPHA2; glycoprotein hormone alpha 2 [KO:K25483]
102242895  GPHB5; glycoprotein hormone beta 5 [KO:K25484]
102247015  TSHB; thyroid stimulating hormone beta [KO:K05251]
102240883  GCG; glucagon [KO:K05259]
102251223  GIP; gastric inhibitory polypeptide [KO:K05258]
102244646  FSHB; follicle stimulating hormone beta subunit [KO:K05250]
102245841  NPPA; natriuretic peptide A [KO:K12334]
102256160  ADCYAP1; adenylate cyclase activating polypeptide 1 [KO:K05262]
102258046  ADRB1; adrenoceptor beta 1 [KO:K04141]
102249639  ADRB2; adrenoceptor beta 2 [KO:K04142]
102248577  DRD1; dopamine receptor D1 [KO:K04144]
102243447  DRD5; dopamine receptor D5 [KO:K05840]
102250018  ADORA2A; adenosine A2a receptor [KO:K04266]
102248943  HTR4; 5-hydroxytryptamine receptor 4 [KO:K04160]
102250300  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
102261194  PTGER2; prostaglandin E receptor 2 [KO:K04259]
102261446  ADCYAP1R1; ADCYAP receptor type I [KO:K04587]
102241827  VIPR2; vasoactive intestinal peptide receptor 2 [KO:K04590]
102259439  CRHR1; corticotropin releasing hormone receptor 1 [KO:K04578]
102263180  CRHR2; corticotropin releasing hormone receptor 2 [KO:K04579]
102261272  LHCGR; luteinizing hormone/choriogonadotropin receptor [KO:K04248]
102247607  TSHR; thyroid stimulating hormone receptor [KO:K04249]
102244928  MC2R; melanocortin 2 receptor [KO:K04200]
102244440  GLP1R; glucagon like peptide 1 receptor [KO:K04581]
102247229  GIPR; gastric inhibitory polypeptide receptor [KO:K04580]
102259722  GPR119; G protein-coupled receptor 119 [KO:K08424]
102261565  FSHR; follicle stimulating hormone receptor [KO:K04247]
102249825  NPR1; natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
102252262  guanine nucleotide-binding protein G(s) subunit alpha isoforms short [KO:K04632]
102255448  neuroendocrine secretory protein 55 [KO:K04632]
102263857  EDN1; endothelin 1 [KO:K16366]
102261280  EDN2; endothelin 2 [KO:K16367]
102257082  EDN3; endothelin 3 [KO:K05227]
102242181  SST; somatostatin [KO:K05237]
102263120  NPY; neuropeptide Y [KO:K05232]
102261891  GHRL; ghrelin and obestatin prepropeptide [KO:K05254]
102259622  HTR1D; 5-hydroxytryptamine receptor 1D [KO:K04153]
102240054  HTR1F; 5-hydroxytryptamine receptor 1F [KO:K04153]
102257142  HTR1A; 5-hydroxytryptamine receptor 1A [KO:K04153]
102239028  HTR1E; 5-hydroxytryptamine receptor 1E [KO:K04153]
102246815  HTR1B; 5-hydroxytryptamine receptor 1B [KO:K04153]
102238610  CHRM1; cholinergic receptor muscarinic 1 [KO:K04129]
102244198  CHRM2; cholinergic receptor muscarinic 2 [KO:K04130]
102238602  DRD2; dopamine receptor D2 [KO:K04145]
102254844  GABBR1; gamma-aminobutyric acid type B receptor subunit 1 [KO:K04615]
102256100  GABBR2; gamma-aminobutyric acid type B receptor subunit 2 [KO:K04615]
102242144  ADORA1; adenosine A1 receptor [KO:K04265]
102246345  EDNRA; endothelin receptor type A [KO:K04197]
102243123  NPY1R; neuropeptide Y receptor Y1 [KO:K04204]
102246470  SSTR1; somatostatin receptor 1 [KO:K04217]
102243522  SSTR2; somatostatin receptor 2 [KO:K04218]
102257723  SSTR5; somatostatin receptor 5 [KO:K04221]
106727662  HCAR1; hydroxycarboxylic acid receptor 1 [KO:K08401]
102260135  HCAR3; hydroxycarboxylic acid receptor 2 [KO:K08402]
102250699  FFAR2; free fatty acid receptor 2 [KO:K04328]
102264152  SUCNR1; succinate receptor 1 [KO:K10042]
102247462  PTGER3; prostaglandin E receptor 3 [KO:K04260]
102240455  OXTR; oxytocin receptor [KO:K04229]
102263465  GHSR; growth hormone secretagogue receptor [KO:K04284]
102249318  GNAI2; G protein subunit alpha i2 [KO:K04630]
102239557  GNAI3; G protein subunit alpha i3 [KO:K04630]
102256872  GNAI1; G protein subunit alpha i1 [KO:K04630]
102257679  ADCY1; adenylate cyclase 1 [KO:K08041] [EC:4.6.1.1]
102260356  ADCY2; adenylate cyclase 2 [KO:K08042] [EC:4.6.1.1]
102261014  ADCY3; adenylate cyclase 3 [KO:K08043] [EC:4.6.1.1]
102247996  ADCY4; adenylate cyclase 4 [KO:K08044] [EC:4.6.1.1]
102257731  ADCY5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
102248773  ADCY6; adenylate cyclase 6 [KO:K08046] [EC:4.6.1.1]
102253549  ADCY7; adenylate cyclase 7 [KO:K08047] [EC:4.6.1.1]
102249345  ADCY8; adenylate cyclase 8 [KO:K08048] [EC:4.6.1.1]
102248953  ADCY9; adenylate cyclase 9 [KO:K08049] [EC:4.6.1.1]
102245584  ADCY10; adenylate cyclase 10, soluble [KO:K11265] [EC:4.6.1.1]
102253117  CNGA1; cyclic nucleotide gated channel alpha 1 [KO:K04948]
102247714  CNGA2; cyclic nucleotide gated channel alpha 2 [KO:K04949]
102251375  CNGA3; cyclic nucleotide gated channel alpha 3 [KO:K04950]
102244716  CNGA4; cyclic nucleotide gated channel alpha 4 [KO:K04951]
102248955  CNGB1; cyclic nucleotide gated channel beta 1 [KO:K04952]
102242709  CNGB3; cyclic nucleotide gated channel beta 3 [KO:K04953]
102244216  CALM2; calmodulin 2 [KO:K02183]
102251233  CALM1; calmodulin 1 [KO:K02183]
102253504  CALML3; calmodulin-like protein 3 [KO:K02183]
102253811  CALML5; calmodulin like 5 [KO:K02183]
102240022  CALML6; calmodulin like 6 [KO:K02183]
102251350  CALM3; calmodulin 3 [KO:K02183]
102256865  calmodulin [KO:K02183]
102242522  CALML4; calmodulin like 4 [KO:K02183]
102252254  CAMK2D; calcium/calmodulin dependent protein kinase II delta [KO:K04515] [EC:2.7.11.17]
102262365  CAMK2G; calcium/calmodulin dependent protein kinase II gamma [KO:K04515] [EC:2.7.11.17]
102260966  CAMK2B; calcium/calmodulin dependent protein kinase II beta [KO:K04515] [EC:2.7.11.17]
102257317  CAMK2A; calcium/calmodulin dependent protein kinase II alpha [KO:K04515] [EC:2.7.11.17]
102254489  CAMK4; calcium/calmodulin dependent protein kinase IV [KO:K05869] [EC:2.7.11.17]
102261456  BVES; blood vessel epicardial substance [KO:K21108]
102247392  POPDC2; popeye domain containing 2 [KO:K26206]
102261167  POPDC3; popeye domain containing 3 [KO:K26207]
102263619  potassium channel subfamily K member 2 [KO:K04913]
102253581  HCN2; hyperpolarization activated cyclic nucleotide gated potassium channel 2 [KO:K04955]
102247720  HCN4; hyperpolarization activated cyclic nucleotide gated potassium channel 4 [KO:K04957]
102262345  ABCC4; ATP binding cassette subfamily C member 4 [KO:K05673]
102257237  RAPGEF3; Rap guanine nucleotide exchange factor 3 [KO:K08014]
102262528  RAPGEF4; Rap guanine nucleotide exchange factor 4 [KO:K04351]
102257602  RRAS2; related RAS viral (r-ras) oncogene homolog 2 [KO:K07830]
102264100  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
102239050  PLD1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
102241624  PLCE1; phospholipase C epsilon 1 [KO:K05860] [EC:3.1.4.11]
102259984  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
102263026  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
102246292  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
102258771  RAP1A; RAP1A, member of RAS oncogene family [KO:K04353]
102254910  RAP1B; RAP1B, member of RAS oncogene family [KO:K07836]
102242321  VAV3; vav guanine nucleotide exchange factor 3 [KO:K05730]
102253658  VAV1; vav guanine nucleotide exchange factor 1 [KO:K05730]
102263523  VAV2; vav guanine nucleotide exchange factor 2 [KO:K05730]
102259160  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
102239988  RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
102249503  RAC3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [KO:K07861]
102240321  PAK1; p21 (RAC1) activated kinase 1 [KO:K04409] [EC:2.7.11.1]
102253252  ARAP3; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 [KO:K12490]
102244315  RHOA; ras homolog family member A [KO:K04513]
102243870  AFDN; afadin, adherens junction formation factor [KO:K05702]
102260487  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
102252921  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
102239669  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
102258430  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
102253405  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
102242302  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
102254864  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
102254191  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
102251050  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102260644  BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
102254003  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
102240696  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102245571  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102255250  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102245641  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102244919  PRKACB; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
102252927  PRKACA; protein kinase cAMP-activated catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
102245087  PPP1R1B; protein phosphatase 1 regulatory inhibitor subunit 1B [KO:K15494]
102244214  PPP1CA; protein phosphatase 1 catalytic subunit alpha [KO:K06269] [EC:3.1.3.16]
102253559  serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
102248545  PPP1CB; protein phosphatase 1 catalytic subunit beta [KO:K06269] [EC:3.1.3.16]
102239740  PPP1CC; protein phosphatase 1 catalytic subunit gamma [KO:K06269] [EC:3.1.3.16]
102246867  CREB1; cAMP responsive element binding protein 1 [KO:K05870]
102258024  CREB3L4; cAMP responsive element binding protein 3 like 4 [KO:K09048]
102241829  CREB3; cAMP responsive element binding protein 3 [KO:K09048]
102244833  CREB3L1; cAMP responsive element binding protein 3 like 1 [KO:K09048]
102245296  CREB3L2; cAMP responsive element binding protein 3 like 2 [KO:K09048]
102251355  CREB3L3; cAMP responsive element binding protein 3 like 3 [KO:K09048]
102240701  CREB5; cAMP responsive element binding protein 5 [KO:K09047]
102249541  CREBBP; CREB binding protein [KO:K04498] [EC:2.3.1.48]
102260716  EP300; E1A binding protein p300 [KO:K04498] [EC:2.3.1.48]
102247090  BDNF; brain derived neurotrophic factor [KO:K04355]
102246307  FOS; Fos proto-oncogene, AP-1 transcription factor subunit [KO:K04379]
102260808  JUN; Jun proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
102239811  GLI3; GLI family zinc finger 3 [KO:K06230]
102256246  GLI1; GLI family zinc finger 1 [KO:K16797]
102254605  PTCH1; patched 1 [KO:K06225]
102242947  HHIP; hedgehog interacting protein [KO:K06231]
102256580  NFKBIA; NFKB inhibitor alpha [KO:K04734]
102255251  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
102263790  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
102263578  SOX9; SRY-box 9 [KO:K18435]
102251551  AMH; anti-Mullerian hormone [KO:K04665]
102249818  PPARA; peroxisome proliferator activated receptor alpha [KO:K07294]
102247645  ACOX3; acyl-CoA oxidase 3, pristanoyl [KO:K00232] [EC:1.3.3.6]
102259193  ACOX1; acyl-CoA oxidase 1 [KO:K00232] [EC:1.3.3.6]
102245976  NFATC1; nuclear factor of activated T-cells 1 [KO:K04446]
102249171  F2R; coagulation factor II thrombin receptor [KO:K03914]
102239479  BAD; BCL2 associated agonist of cell death [KO:K02158]
102247234  LIPE; lipase E, hormone sensitive type [KO:K07188] [EC:3.1.1.79]
102252747  ROCK1; Rho associated coiled-coil containing protein kinase 1 [KO:K04514] [EC:2.7.11.1]
102254781  ROCK2; Rho associated coiled-coil containing protein kinase 2 [KO:K17388] [EC:2.7.11.1]
102251394  PPP1R12A; protein phosphatase 1 regulatory subunit 12A [KO:K06270]
102251806  myosin regulatory light polypeptide 9 [KO:K12755]
102253999  MYL9; myosin light chain 9 [KO:K12755]
102243369  myosin regulatory light chain 2, smooth muscle major isoform [KO:K12755]
102247697  PLN; phospholamban [KO:K05852]
102242162  ATP2A1; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 [KO:K05853] [EC:7.2.2.10]
102239308  ATP2A3; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 [KO:K05853] [EC:7.2.2.10]
102263136  ATP2A2; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 [KO:K05853] [EC:7.2.2.10]
102263572  RYR2; ryanodine receptor 2 [KO:K04962]
102240692  GRIN1; glutamate ionotropic receptor NMDA type subunit 1 [KO:K05208]
102245838  GRIN2A; glutamate ionotropic receptor NMDA type subunit 2A [KO:K05209]
102249136  GRIN2B; glutamate ionotropic receptor NMDA type subunit 2B [KO:K05210]
102264015  GRIN2C; glutamate ionotropic receptor NMDA type subunit 2C [KO:K05211]
102257658  GRIN2D; glutamate ionotropic receptor NMDA type subunit 2D [KO:K05212]
102257766  GRIN3A; glutamate ionotropic receptor NMDA type subunit 3A [KO:K05213]
102257196  GRIN3B; glutamate ionotropic receptor NMDA type subunit 3B [KO:K05214]
102242763  GRIA1; glutamate ionotropic receptor AMPA type subunit 1 [KO:K05197]
102247019  GRIA2; glutamate ionotropic receptor AMPA type subunit 2 [KO:K05198]
102245142  GRIA3; glutamate ionotropic receptor AMPA type subunit 3 [KO:K05199]
102254773  GRIA4; glutamate ionotropic receptor AMPA type subunit 4 [KO:K05200]
102257625  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
102243691  ATP1A1; ATPase Na+/K+ transporting subunit alpha 1 [KO:K01539] [EC:7.2.2.13]
102243972  ATP1A4; ATPase Na+/K+ transporting subunit alpha 4 [KO:K01539] [EC:7.2.2.13]
102244267  ATP1A2; ATPase Na+/K+ transporting subunit alpha 2 [KO:K01539] [EC:7.2.2.13]
102242637  ATP1A3; ATPase Na+/K+ transporting subunit alpha 3 [KO:K01539] [EC:7.2.2.13]
102243046  ATP1B4; ATPase Na+/K+ transporting family member beta 4 [KO:K01540]
102244043  ATP1B3; ATPase Na+/K+ transporting subunit beta 3 [KO:K01540]
102245478  ATP1B1; ATPase Na+/K+ transporting subunit beta 1 [KO:K01540]
106723585  FXYD1; FXYD domain containing ion transport regulator 1 [KO:K13360]
102260344  SLC9A1; solute carrier family 9 member A1 [KO:K05742]
102253522  ORAI1; ORAI calcium release-activated calcium modulator 1 [KO:K16056]
102254169  plasma membrane calcium-transporting ATPase 4 [KO:K05850] [EC:7.2.2.10]
102239691  ATP2B3; ATPase plasma membrane Ca2+ transporting 3 [KO:K05850] [EC:7.2.2.10]
102259512  ATP2B2; ATPase plasma membrane Ca2+ transporting 2 [KO:K05850] [EC:7.2.2.10]
102259346  ATP2B4; ATPase plasma membrane Ca2+ transporting 4 [KO:K05850] [EC:7.2.2.10]
102257503  ATP2B1; ATPase plasma membrane Ca2+ transporting 1 [KO:K05850] [EC:7.2.2.10]
102240225  CACNA1C; calcium voltage-gated channel subunit alpha1 C [KO:K04850]
102259218  CACNA1D; calcium voltage-gated channel subunit alpha1 D [KO:K04851]
102260789  CACNA1F; calcium voltage-gated channel subunit alpha1 F [KO:K04853]
102243265  CACNA1S; calcium voltage-gated channel subunit alpha1 S [KO:K04857]
102255698  PDE3A; phosphodiesterase 3A [KO:K19021] [EC:3.1.4.17]
102259206  PDE3B; phosphodiesterase 3B [KO:K13296] [EC:3.1.4.17]
102246891  PDE4A; phosphodiesterase 4A [KO:K13293] [EC:3.1.4.53]
102262904  PDE4B; phosphodiesterase 4B [KO:K13293] [EC:3.1.4.53]
102250580  PDE4D; phosphodiesterase 4D [KO:K13293] [EC:3.1.4.53]
102263025  PDE4C; phosphodiesterase 4C [KO:K13293] [EC:3.1.4.53]
102239433  PDE10A; phosphodiesterase 10A [KO:K18438] [EC:3.1.4.17 3.1.4.35]
Compound
C00020  AMP
C00042  Succinate
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00186  (S)-Lactate
C00212  Adenosine
C00238  Potassium cation
C00288  HCO3-
C00334  4-Aminobutanoate
C00416  Phosphatidate
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00698  Cl-
C00780  Serotonin
C00788  L-Adrenaline
C01089  (R)-3-Hydroxybutanoate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01312  Prostaglandin I2
C01330  Sodium cation
C01996  Acetylcholine
C03758  Dopamine
C20792  Oleoylethanolamide
C20793  3-Hydroxyoctanoate
Reference
PMID:11493633
  Authors
Fimia GM, Sassone-Corsi P
  Title
Cyclic AMP signalling.
  Journal
J Cell Sci 114:1971-2 (2001)
Reference
PMID:18323530
  Authors
Serezani CH, Ballinger MN, Aronoff DM, Peters-Golden M
  Title
Cyclic AMP: master regulator of innate immune cell function.
  Journal
Am J Respir Cell Mol Biol 39:127-32 (2008)
DOI:10.1165/rcmb.2008-0091TR
Reference
PMID:24281338
  Authors
Oldenburger A, Maarsingh H, Schmidt M
  Title
Multiple facets of cAMP signalling and physiological impact: cAMP compartmentalization in the lung.
  Journal
Pharmaceuticals (Basel) 5:1291-331 (2012)
DOI:10.3390/ph5121291
Reference
PMID:24613710
  Authors
Ahuja M, Jha A, Maleth J, Park S, Muallem S
  Title
cAMP and Ca signaling in secretory epithelia: Crosstalk and synergism.
  Journal
Cell Calcium 55:385-393 (2014)
DOI:10.1016/j.ceca.2014.01.006
Reference
PMID:22082266
  Authors
Shirshev SV
  Title
Role of Epac proteins in mechanisms of cAMP-dependent immunoregulation.
  Journal
Biochemistry (Mosc) 76:981-98 (2011)
DOI:10.1134/S000629791109001X
Reference
PMID:18176800
  Authors
Roscioni SS, Elzinga CR, Schmidt M
  Title
Epac: effectors and biological functions.
  Journal
Naunyn Schmiedebergs Arch Pharmacol 377:345-57 (2008)
DOI:10.1007/s00210-007-0246-7
Reference
PMID:24450633
  Authors
Roberts OL, Dart C
  Title
cAMP signalling in the vasculature: the role of Epac (exchange protein directly activated by cAMP).
  Journal
Biochem Soc Trans 42:89-97 (2014)
DOI:10.1042/BST20130253
Reference
PMID:16765984
  Authors
Schaub MC, Hefti MA, Zaugg M
  Title
Integration of calcium with the signaling network in cardiac myocytes.
  Journal
J Mol Cell Cardiol 41:183-214 (2006)
DOI:10.1016/j.yjmcc.2006.04.005
Reference
PMID:19874988
  Authors
Triposkiadis F, Karayannis G, Giamouzis G, Skoularigis J, Louridas G, Butler J
  Title
The sympathetic nervous system in heart failure physiology, pathophysiology, and clinical implications.
  Journal
J Am Coll Cardiol 54:1747-62 (2009)
DOI:10.1016/j.jacc.2009.05.015
Reference
PMID:15142747
  Authors
Saucerman JJ, McCulloch AD
  Title
Mechanistic systems models of cell signaling networks: a case study of myocyte adrenergic regulation.
  Journal
Prog Biophys Mol Biol 85:261-78 (2004)
DOI:10.1016/j.pbiomolbio.2004.01.005
Reference
PMID:21212391
  Authors
Yang JH, Saucerman JJ
  Title
Computational models reduce complexity and accelerate insight into cardiac signaling networks.
  Journal
Circ Res 108:85-97 (2011)
DOI:10.1161/CIRCRESAHA.110.223602
Reference
PMID:22022314
  Authors
Taggart P, Boyett MR, Logantha S, Lambiase PD
  Title
Anger, emotion, and arrhythmias: from brain to heart.
  Journal
Front Physiol 2:67 (2011)
DOI:10.3389/fphys.2011.00067
Reference
PMID:21852968
  Authors
Bozzi Y, Dunleavy M, Henshall DC
  Title
Cell signaling underlying epileptic behavior.
  Journal
Front Behav Neurosci 5:45 (2011)
DOI:10.3389/fnbeh.2011.00045
Reference
PMID:10880354
  Authors
Lizcano JM, Morrice N, Cohen P
  Title
Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155.
  Journal
Biochem J 349:547-57 (2000)
DOI:10.1042/bj3490547
Reference
PMID:21744067
  Authors
Gerlo S, Kooijman R, Beck IM, Kolmus K, Spooren A, Haegeman G
  Title
Cyclic AMP: a selective modulator of NF-kappaB action.
  Journal
Cell Mol Life Sci 68:3823-41 (2011)
DOI:10.1007/s00018-011-0757-8
Reference
PMID:7688165
  Authors
Lauder JM
  Title
Neurotransmitters as growth regulatory signals: role of receptors and second messengers.
  Journal
Trends Neurosci 16:233-40 (1993)
DOI:10.1016/0166-2236(93)90162-F
Reference
PMID:17077866
  Authors
Voglis G, Tavernarakis N
  Title
The role of synaptic ion channels in synaptic plasticity.
  Journal
EMBO Rep 7:1104-10 (2006)
DOI:10.1038/sj.embor.7400830
Reference
PMID:21346730
  Authors
Altarejos JY, Montminy M
  Title
CREB and the CRTC co-activators: sensors for hormonal and metabolic signals.
  Journal
Nat Rev Mol Cell Biol 12:141-51 (2011)
DOI:10.1038/nrm3072
Reference
PMID:24062645
  Authors
Bozzi Y, Borrelli E
  Title
The role of dopamine signaling in epileptogenesis.
  Journal
Front Cell Neurosci 7:157 (2013)
DOI:10.3389/fncel.2013.00157
Reference
PMID:14715909
  Authors
Ceulemans H, Bollen M
  Title
Functional diversity of protein phosphatase-1, a cellular economizer and reset button.
  Journal
Physiol Rev 84:1-39 (2004)
DOI:10.1152/physrev.00013.2003
Reference
PMID:16571352
  Authors
Lipinski RJ, Gipp JJ, Zhang J, Doles JD, Bushman W
  Title
Unique and complimentary activities of the Gli transcription factors in Hedgehog signaling.
  Journal
Exp Cell Res 312:1925-38 (2006)
DOI:10.1016/j.yexcr.2006.02.019
Reference
PMID:21693691
  Authors
Lasala C, Schteingart HF, Arouche N, Bedecarras P, Grinspon RP, Picard JY, Josso N, di Clemente N, Rey RA
  Title
SOX9 and SF1 are involved in cyclic AMP-mediated upregulation of anti-Mullerian gene expression in the testicular prepubertal Sertoli cell line SMAT1.
  Journal
Am J Physiol Endocrinol Metab 301:E539-47 (2011)
DOI:10.1152/ajpendo.00187.2011
Reference
PMID:19460777
  Authors
Rosenkranz AC, Rauch BH, Freidel K, Schror K
  Title
Regulation of protease-activated receptor-1 by vasodilatory prostaglandins via NFAT.
  Journal
Cardiovasc Res 83:778-84 (2009)
DOI:10.1093/cvr/cvp163
Reference
PMID:11117527
  Authors
Lazennec G, Canaple L, Saugy D, Wahli W
  Title
Activation of peroxisome proliferator-activated receptors (PPARs) by their ligands and protein kinase A activators.
  Journal
Mol Endocrinol 14:1962-75 (2000)
DOI:10.1210/mend.14.12.0575
Reference
PMID:16460276
  Authors
Murthy KS
  Title
Signaling for contraction and relaxation in smooth muscle of the gut.
  Journal
Annu Rev Physiol 68:345-74 (2006)
DOI:10.1146/annurev.physiol.68.040504.094707
Reference
PMID:18064650
  Authors
Birukova AA, Zagranichnaya T, Alekseeva E, Bokoch GM, Birukov KG
  Title
Epac/Rap and PKA are novel mechanisms of ANP-induced Rac-mediated pulmonary endothelial barrier protection.
  Journal
J Cell Physiol 215:715-24 (2008)
DOI:10.1002/jcp.21354
Reference
PMID:9204709
  Authors
Houslay MD, Milligan G
  Title
Tailoring cAMP-signalling responses through isoform multiplicity.
  Journal
Trends Biochem Sci 22:217-24 (1997)
DOI:10.1016/S0968-0004(97)01050-5
Related
pathway
myb00071  Fatty acid degradation
myb04015  Rap1 signaling pathway
myb04020  Calcium signaling pathway
myb04151  PI3K-Akt signaling pathway
myb04210  Apoptosis
myb04260  Cardiac muscle contraction
myb04340  Hedgehog signaling pathway
myb04720  Long-term potentiation
myb04740  Olfactory transduction
myb04972  Pancreatic secretion
myb04976  Bile secretion
KO pathway
ko04024   
LinkDB

DBGET integrated database retrieval system