Entry Name JAK-STAT signaling pathway - Ovis aries (sheep)
Description The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Other DBs Organism Ovis aries (sheep) [GN:
oas ]
Gene 100294659 STAT3; signal transducer and activator of transcription 3 isoform X10 [KO:K04692 ]
100307049 STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220 ]
100820736 IL12RB2; interleukin-12 receptor subunit beta-2 precursor [KO:K05064 ]
100885760 CNTFR; ciliary neurotrophic factor receptor subunit alpha isoform X1 [KO:K05059 ]
101102134 STAT6; signal transducer and activator of transcription 6 isoform X1 [KO:K11225 ]
101102232 IL27RA; interleukin-27 receptor subunit alpha isoform X1 [KO:K19598 ]
101103369 IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055 ]
101104493 PIAS1; E3 SUMO-protein ligase PIAS1 isoform X2 [KO:K04706 ] [EC:2.3.2.-]
101105948 OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057 ]
101107088 IL2RB; interleukin-2 receptor subunit beta isoform X2 [KO:K05069 ]
101107377 IL15RA; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074 ]
101108025 IL13RA2; interleukin-13 receptor subunit alpha-2 isoform X2 [KO:K05077 ]
101108211 STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221 ]
101108788 CLCF1; cardiotrophin-like cytokine factor 1 isoform X2 [KO:K05421 ]
101109063 IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071 ]
101109759 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
101109893 GRB2; growth factor receptor-bound protein 2 isoform X5 [KO:K04364 ]
101110015 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
101110054 IL12RB1; interleukin-12 receptor subunit beta-1 precursor [KO:K05063 ]
101111126 IL7R; interleukin-7 receptor subunit alpha isoform X3 [KO:K05072 ]
101111214 STAM; signal transducing adapter molecule 1 isoform X1 [KO:K04705 ]
101111546 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X2 [KO:K02649 ]
101111837 IL5RA; interleukin-5 receptor subunit alpha isoform X1 [KO:K05067 ]
101112782 PIAS2; E3 SUMO-protein ligase PIAS2 isoform X2 [KO:K16063 ] [EC:2.3.2.-]
101113034 IL20RB; interleukin-20 receptor subunit beta isoform X2 [KO:K05137 ]
101113991 IL3RA; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737 ]
101116875 PIAS3; E3 SUMO-protein ligase PIAS3 isoform X2 [KO:K16064 ] [EC:2.3.2.-]
101117348 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3 [KO:K00922 ] [EC:2.7.1.153 ]
101117562 STAT4; signal transducer and activator of transcription 4 isoform X2 [KO:K11222 ]
101117649 STAM2; signal transducing adapter molecule 2 isoform X1 [KO:K04705 ]
101118070 CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061 ]
101118168 IL22RA1; interleukin-22 receptor subunit alpha-1 isoform X1 [KO:K05138 ]
101120946 IL10RA; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134 ]
101121455 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649 ]
101122961 STAT5B; signal transducer and activator of transcription 5B isoform X1 [KO:K11224 ]
101123199 CSF2RB; cytokine receptor common subunit beta isoform X1 [KO:K04738 ]
101123247 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
114110564 PDGFA; platelet-derived growth factor subunit A isoform X2 [KO:K04359 ]
443064 IL12A; interleukin-12 subunit alpha precursor [KO:K05406 ]
443126 IFNAR1; interferon alpha/beta receptor 1 precursor [KO:K05130 ]
443220 GFAP; glial fibrillary acidic protein isoform X1 [KO:K05640 ]
443363 IFNAR2; interferon alpha/beta receptor 2 precursor [KO:K05131 ]
443400 CSF2; granulocyte-macrophage colony-stimulating factor precursor [KO:K05427 ]
443419 STAT5A; signal transducer and activator of transcription 5A [KO:K11223 ]
443435 IL2RA; interleukin-2 receptor subunit alpha precursor [KO:K05068 ]
443472 IL12B; interleukin-12 subunit beta precursor [KO:K05425 ]
443518 IL13RA1; interleukin-13 receptor subunit alpha-1 isoform X2 [KO:K05076 ]
443523 CSF3; granulocyte colony-stimulating factor isoform X1 [KO:K05423 ]
443545 PDGFB; platelet-derived growth factor subunit B precursor [KO:K17386 ]
554329 MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539 ]
Reference Authors Harrison DA
Title The Jak/STAT pathway.
Journal Reference Authors Kiu H, Nicholson SE
Title Biology and significance of the JAK/STAT signalling pathways.
Journal Reference Authors Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A, Sanmamed MF, Le Bon A, Melero I
Title Direct effects of type I interferons on cells of the immune system.
Journal Reference Authors Fish EN, Platanias LC
Title Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes.
Journal Reference Authors Ivanenkov YA, Balakin KV, Lavrovsky Y
Title Small molecule inhibitors of NF-kB and JAK/STAT signal transduction pathways as promising anti-inflammatory therapeutics.
Journal Reference Authors O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A
Title The JAK-STAT pathway: impact on human disease and therapeutic intervention.
Journal Reference Authors Zoranovic T, Grmai L, Bach EA
Title Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway.
Journal Reference Authors Ungureanu D, Silvennoinen O
Title SLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling.
Journal Reference Authors Richard AJ, Stephens JM
Title The role of JAK-STAT signaling in adipose tissue function.
Journal Reference Authors Sun Y, Lehmbecker A, Kalkuhl A, Deschl U, Sun W, Rohn K, Tzvetanova ID, Nave KA, Baumgartner W, Ulrich R
Title STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis.
Journal Reference Authors Hirano T, Ishihara K, Hibi M
Title Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors.
Journal Reference Authors Rane SG, Reddy EP
Title Janus kinases: components of multiple signaling pathways.
Journal Reference Authors Heim MH
Title The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus.
Journal Reference Authors Morris R, Kershaw NJ, Babon JJ
Title The molecular details of cytokine signaling via the JAK/STAT pathway.
Journal Reference Authors Tzeng HT, Chyuan IT, Lai JH
Title Targeting the JAK-STAT pathway in autoimmune diseases and cancers: A focus on molecular mechanisms and therapeutic potential.
Journal Reference Authors Salas A, Hernandez-Rocha C, Duijvestein M, Faubion W, McGovern D, Vermeire S, Vetrano S, Vande Casteele N
Title JAK-STAT pathway targeting for the treatment of inflammatory bowel disease.
Journal Related oas04060 Cytokine-cytokine receptor interaction
KO pathway
