Entry
Name
GABAergic synapse - Homo sapiens (human)
Description
Gamma aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the mammalian central nervous system (CNS). When released in the synaptic cleft, GABA binds to three major classes of receptors: GABAA, GABAB, and GABAC receptors. GABAA and GABAC receptors are ionotropic and mediate fast GABA responses by triggering chloride channel openings, while GABAB receptors are metabotropic and mediate slower GABA responses by activating G-proteins and influencing second messenger systems. GABAA receptors, the major sites for fast inhibitory neurotransmission in the CNS, are regulated by phosphorylation mechanisms, affecting both their functional properties and their cell surface mobility and trafficking. GABA release by the presynaptic terminal is negatively regulated by GABAB autoreceptors, and is cleared from the extracellular space by GABA transporters (GATs) located either on the presynaptic terminal or neighboring glial cells.
Class
Organismal Systems; Nervous system
BRITE hierarchy
Pathway map
Ortholog table
Drug
D00058 gamma-Aminobutyric acid (JAN)
D00225 Alprazolam (JP18/USP/INN)
D00241 Baclofen (JP18/USP/INN)
D00267 Chlordiazepoxide (JP18/USP/INN)
D00280 Clonazepam (JP18/USP/INN)
D00293 Diazepam (JP18/USP/INN)
D00304 Divalproex sodium (USP)
D00311 Estazolam (JP18/USP/INN)
D00332 Gabapentin (JAN/USP/INN)
D00365 Lorazepam (JP18/USP/INN)
D00376 Meprobamate (JAN/USP/INN)
D00387 Triazolam (JP18/USP/INN)
D00470 Prazepam (JP18/USAN/INN)
D00499 Pentobarbital (USP/INN)
D00500 Pentobarbital sodium (JAN/USP)
D00506 Phenobarbital (JP18/USP/INN)
D00531 Nitrazepam (JP18/USAN/INN)
D00535 Vigabatrin (JAN/USP/INN)
D00537 Topiramate (JAN/USP/INN)
D00550 Midazolam (JAN/USP/INN)
D00693 Chlordiazepoxide hydrochloride (JAN/USP)
D00694 Clorazepate dipotassium (JP18/USP)
D00695 Flurazepam hydrochloride (USP)
D00696 Midazolam hydrochloride (USAN)
D00697 Flumazenil (JAN/USP/INN)
D00699 Butabarbital sodium (USP)
D00700 Mephobarbital (JAN/USP)
D00701 Phenobarbital sodium (JAN/USP/INN)
D00706 Zolpidem tartrate (JP18/USP)
D00710 Valproate sodium (USAN)
D00713 Thiamylal sodium (JP18)
D00714 Thiopental sodium (JP18/USP/INN)
D01230 Flunitrazepam (JP18/USAN/INN)
D01245 Bromazepam (JP18/USAN/INN)
D01253 Clobazam (JAN/USAN/INN)
D01279 Flutoprazepam (JP18/INN)
D01293 Ethyl loflazepate (JP18/INN)
D01310 Secobarbital sodium (JAN/USP)
D01408 Flurazepam hydrochloride (JP18)
D01564 Rilmazafone hydrochloride hydrate (JP18)
D01657 Lormetazepam (JAN/USAN/INN)
D01744 Brotizolam (JP18/USAN/INN)
D02097 Tiagabine hydrochloride (USP)
D02252 Amobarbital sodium (JAN/USP)
D02253 Pentobarbital calcium (JP18)
D02283 Iomazenil (123I) (JAN/INN)
D02624 Eszopiclone (JAN/USP/INN)
D02771 Adinazolam mesylate (USAN)
D03562 Clorazepate monopotassium (USAN)
D03737 Dextofisopam (USAN/INN)
D04257 Fospropofol disodium (USAN)
D04721 Levotofisopam (USAN/INN)
D04882 Medazepam hydrochloride (USAN)
D05028 Midazolam maleate (USAN)
D07725 Clomethiazole edisilate
D08356 Phenobarbital diethylamine
D08861 Arbaclofen placarbil (USAN/INN)
D09539 Gabapentin enacarbil (JAN/USAN/INN)
D10194 Remimazolam besylate (USAN)
Other DBs
Organism
Homo sapiens (human) [GN:
hsa ]
Gene
81539 SLC38A1; solute carrier family 38 member 1 [KO:K14990 ]
54407 SLC38A2; solute carrier family 38 member 2 [KO:K14207 ]
140679 SLC32A1; solute carrier family 32 member 1 [KO:K15015 ]
2554 GABRA1; gamma-aminobutyric acid type A receptor subunit alpha1 [KO:K05175 ]
2555 GABRA2; gamma-aminobutyric acid type A receptor subunit alpha2 [KO:K05175 ]
2556 GABRA3; gamma-aminobutyric acid type A receptor subunit alpha3 [KO:K05175 ]
2557 GABRA4; gamma-aminobutyric acid type A receptor subunit alpha4 [KO:K05175 ]
2558 GABRA5; gamma-aminobutyric acid type A receptor subunit alpha5 [KO:K05175 ]
2559 GABRA6; gamma-aminobutyric acid type A receptor subunit alpha6 [KO:K05175 ]
2560 GABRB1; gamma-aminobutyric acid type A receptor subunit beta1 [KO:K05181 ]
2562 GABRB3; gamma-aminobutyric acid type A receptor subunit beta3 [KO:K05181 ]
2561 GABRB2; gamma-aminobutyric acid type A receptor subunit beta2 [KO:K05181 ]
2565 GABRG1; gamma-aminobutyric acid type A receptor subunit gamma1 [KO:K05186 ]
2566 GABRG2; gamma-aminobutyric acid type A receptor subunit gamma2 [KO:K05186 ]
2567 GABRG3; gamma-aminobutyric acid type A receptor subunit gamma3 [KO:K05186 ]
2563 GABRD; gamma-aminobutyric acid type A receptor subunit delta [KO:K05184 ]
2564 GABRE; gamma-aminobutyric acid type A receptor subunit epsilon [KO:K05185 ]
55879 GABRQ; gamma-aminobutyric acid type A receptor subunit theta [KO:K05192 ]
2568 GABRP; gamma-aminobutyric acid type A receptor subunit pi [KO:K05189 ]
9001 HAP1; huntingtin associated protein 1 [KO:K04647 ]
11337 GABARAP; GABA type A receptor-associated protein [KO:K08341 ]
23710 GABARAPL1; GABA type A receptor associated protein like 1 [KO:K08341 ]
11345 GABARAPL2; GABA type A receptor associated protein like 2 [KO:K08341 ]
4905 NSF; N-ethylmaleimide sensitive factor, vesicle fusing ATPase [KO:K06027 ] [EC:3.6.4.6 ]
5334 PLCL1; phospholipase C like 1 (inactive) [KO:K15375 ]
57468 SLC12A5; solute carrier family 12 member 5 [KO:K23967 ]
2569 GABRR1; gamma-aminobutyric acid type A receptor subunit rho1 [KO:K05190 ]
2570 GABRR2; gamma-aminobutyric acid type A receptor subunit rho2 [KO:K05190 ]
200959 GABRR3; gamma-aminobutyric acid type A receptor subunit rho3 [KO:K05190 ]
773 CACNA1A; calcium voltage-gated channel subunit alpha1 A [KO:K04344 ]
774 CACNA1B; calcium voltage-gated channel subunit alpha1 B [KO:K04849 ]
775 CACNA1C; calcium voltage-gated channel subunit alpha1 C [KO:K04850 ]
776 CACNA1D; calcium voltage-gated channel subunit alpha1 D [KO:K04851 ]
778 CACNA1F; calcium voltage-gated channel subunit alpha1 F [KO:K04853 ]
779 CACNA1S; calcium voltage-gated channel subunit alpha1 S [KO:K04857 ]
2550 GABBR1; gamma-aminobutyric acid type B receptor subunit 1 [KO:K04615 ]
9568 GABBR2; gamma-aminobutyric acid type B receptor subunit 2 [KO:K04615 ]
2770 GNAI1; G protein subunit alpha i1 [KO:K04630 ]
2773 GNAI3; G protein subunit alpha i3 [KO:K04630 ]
2771 GNAI2; G protein subunit alpha i2 [KO:K04630 ]
2775 GNAO1; G protein subunit alpha o1 [KO:K04534 ]
2790 GNG10; G protein subunit gamma 10 [KO:K04545 ]
2791 GNG11; G protein subunit gamma 11 [KO:K04546 ]
2792 GNGT1; G protein subunit gamma transducin 1 [KO:K04548 ]
2793 GNGT2; G protein subunit gamma transducin 2 [KO:K04549 ]
3763 KCNJ6; potassium inwardly rectifying channel subfamily J member 6 [KO:K05000 ]
6529 SLC6A1; solute carrier family 6 member 1 [KO:K05034 ]
6540 SLC6A13; solute carrier family 6 member 13 [KO:K05046 ]
6538 SLC6A11; solute carrier family 6 member 11 [KO:K05044 ]
6539 SLC6A12; solute carrier family 6 member 12 [KO:K05045 ]
10991 SLC38A3; solute carrier family 38 member 3 [KO:K13576 ]
92745 SLC38A5; solute carrier family 38 member 5 [KO:K14992 ]
Compound
Reference
Authors
Davis KL, Charney D, Coyle JT, Nemeroff C (ed).
Title
Neuropsychopharmacology: The fifth generation of progress
Journal
Reference
Authors
Farrant M, Kaila K
Title
The cellular, molecular and ionic basis of GABA(A) receptor signalling.
Journal
Reference
Authors
Ben-Ari Y, Khazipov R, Leinekugel X, Caillard O, Gaiarsa JL
Title
GABAA, NMDA and AMPA receptors: a developmentally regulated 'menage a trois'.
Journal
Reference
Authors
Pinard A, Seddik R, Bettler B
Title
GABAB receptors: physiological functions and mechanisms of diversity.
Journal
Reference
Authors
Chalifoux JR, Carter AG
Title
GABAB receptor modulation of synaptic function.
Journal
Reference
Authors
Padgett CL, Slesinger PA
Title
GABAB receptor coupling to G-proteins and ion channels.
Journal
Reference
Authors
Emson PC
Title
GABA(B) receptors: structure and function.
Journal
Reference
Authors
Kornau HC
Title
GABA(B) receptors and synaptic modulation.
Journal
Reference
Authors
Jacob TC, Moss SJ, Jurd R
Title
GABA(A) receptor trafficking and its role in the dynamic modulation of neuronal inhibition.
Journal
Reference
Authors
Kneussel M
Title
Dynamic regulation of GABA(A) receptors at synaptic sites.
Journal
Reference
Authors
Luscher B, Fuchs T, Kilpatrick CL
Title
GABAA receptor trafficking-mediated plasticity of inhibitory synapses.
Journal
Reference
Authors
Arancibia-Carcamo IL, Kittler JT
Title
Regulation of GABA(A) receptor membrane trafficking and synaptic localization.
Journal
Reference
Authors
Bak LK, Schousboe A, Waagepetersen HS
Title
The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer.
Journal
Reference
Authors
Conti F, Minelli A, Melone M
Title
GABA transporters in the mammalian cerebral cortex: localization, development and pathological implications.
Journal
Reference
Authors
Brambilla P, Perez J, Barale F, Schettini G, Soares JC
Title
GABAergic dysfunction in mood disorders.
Journal
Reference
Authors
Chebib M, Johnston GA
Title
GABA-Activated ligand gated ion channels: medicinal chemistry and molecular biology.
Journal
Related pathway
hsa00250 Alanine, aspartate and glutamate metabolism
KO pathway
LinkDB
All DBs