KEGG   PATHWAY: avit04010
Entry
avit04010                   Pathway                                
Name
MAPK signaling pathway - Apaloderma vittatum (bar-tailed trogon)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
avit04010  MAPK signaling pathway
avit04010

Other DBs
GO: 0000165
Organism
Apaloderma vittatum (bar-tailed trogon) [GN:avit]
Gene
104278438  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
104270141  CACNA1D; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
104278821  LOW QUALITY PROTEIN: voltage-dependent R-type calcium channel subunit alpha-1E-like [KO:K04852]
104272151  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
104279458  LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1I-like [KO:K04856]
104278023  voltage-dependent L-type calcium channel subunit alpha-1S-like [KO:K04857]
104279527  voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
104278457  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
104274539  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 [KO:K04863]
104274722  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
104273210  LOW QUALITY PROTEIN: voltage-dependent calcium channel gamma-3 subunit-like [KO:K04868]
104274723  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
104275139  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
104272387  cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
104276351  protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
104276755  protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
104269513  GNA12; LOW QUALITY PROTEIN: guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
104270838  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
104269130  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
104277086  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
104273974  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
104280397  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
104279759  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
104267216  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
104268376  ras guanyl-releasing protein 3 [KO:K12362]
104271158  RAPGEF2; rap guanine nucleotide exchange factor 2 [KO:K08018]
104270475  neurofibromin [KO:K08052]
104268010  RASA1; ras GTPase-activating protein 1 [KO:K04352]
104267625  RASA2; ras GTPase-activating protein 2 [KO:K08053]
104277180  RAP1A; ras-related protein Rap-1A [KO:K04353]
104270664  RAP1B; ras-related protein Rap-1b [KO:K07836]
104274119  EGF; pro-epidermal growth factor [KO:K04357]
104276082  EREG; proepiregulin [KO:K09784]
104275600  AREG; amphiregulin [KO:K09782]
104279017  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
104269814  FGF16; fibroblast growth factor 16 [KO:K04358]
104272621  FGF3; fibroblast growth factor 3 [KO:K04358]
104280434  FGF6; fibroblast growth factor 6 [KO:K04358]
104269595  FGF9; fibroblast growth factor 9 [KO:K04358]
104277324  FGF7; fibroblast growth factor 7 [KO:K04358]
104280925  FGF8; fibroblast growth factor 8 [KO:K04358]
104267441  FGF20; fibroblast growth factor 20 [KO:K04358]
104273928  FGF18; fibroblast growth factor 18 [KO:K04358]
104279451  FGF19; fibroblast growth factor 19 [KO:K22603]
104280433  FGF23; fibroblast growth factor 23 [KO:K22428]
104271852  NGF; beta-nerve growth factor [KO:K02582]
104279718  BDNF; brain-derived neurotrophic factor [KO:K04355]
104275434  NTF3; neurotrophin-3 [KO:K04356]
104279700  INS; insulin [KO:K04526]
104277162  IGF1; insulin-like growth factor I [KO:K05459]
104269103  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
104281023  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
104279482  PDGFC; platelet-derived growth factor C [KO:K05450]
104279528  PDGFD; platelet-derived growth factor D [KO:K05450]
104278085  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
104273242  KITLG; kit ligand isoform X1 [KO:K05461]
104277471  VEGFA; vascular endothelial growth factor A [KO:K05448]
104280187  PGF; placenta growth factor [KO:K16859]
104271649  VEGFC; vascular endothelial growth factor C [KO:K05449]
104276536  FIGF; vascular endothelial growth factor D [KO:K05449]
104271212  HGF; hepatocyte growth factor [KO:K05460]
104278570  ANGPT1; angiopoietin-1 [KO:K05465]
104270659  ANGPT2; angiopoietin-2 [KO:K05466]
104276940  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
104276524  EGFR; LOW QUALITY PROTEIN: epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
104273952  FGFR2; LOW QUALITY PROTEIN: fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
104278693  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
104272312  FGFR4; LOW QUALITY PROTEIN: fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
104273657  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
104273942  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
104276794  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
104276793  CSF1R; LOW QUALITY PROTEIN: macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
104276022  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
104267561  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
104280341  vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
104273441  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
104279041  FLT4; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
104278517  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
104271276  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
104270152  TEK; LOW QUALITY PROTEIN: angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
104276495  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
104278576  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
104275361  LOW QUALITY PROTEIN: son of sevenless homolog 2-like [KO:K03099]
104273089  SOS1; son of sevenless homolog 1 [KO:K03099]
104273878  GTPase HRas [KO:K02833]
104273514  KRAS; GTPase KRas isoform X1 [KO:K07827]
104276512  NRAS; GTPase NRas [KO:K07828]
104278236  RRAS2; ras-related protein R-Ras2 [KO:K07830]
104269292  MRAS; ras-related protein M-Ras [KO:K07831]
104273141  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
104274018  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
104270203  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
104281173  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
104274698  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
104274457  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
104270791  MKNK1; LOW QUALITY PROTEIN: MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
104275098  RPS6KA1; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
104272029  ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
104280064  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
104278110  ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
104269231  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
104277429  ELK4; LOW QUALITY PROTEIN: ETS domain-containing protein Elk-4 [KO:K04376]
104275194  SRF; serum response factor [KO:K04378]
104273465  STMN1; stathmin [KO:K04381]
104270504  LOW QUALITY PROTEIN: cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
104270513  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
104270595  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
104271203  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
104275261  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
104273500  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
104277600  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
104277601  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
104277602  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
104269667  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
104272583  IL1B; LOW QUALITY PROTEIN: interleukin-1 beta [KO:K04519]
104275881  TGFB2; transforming growth factor beta-2 [KO:K13376]
104277249  TGFB3; transforming growth factor beta-3 [KO:K13377]
104267410  tumor necrosis factor receptor superfamily member 1A-like [KO:K03158]
104267686  interleukin-1 receptor type 1-like [KO:K04386]
104274619  IL1RAP; LOW QUALITY PROTEIN: interleukin-1 receptor accessory protein [KO:K04723]
104276039  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
104281295  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
104277934  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
104268369  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
104270294  tumor necrosis factor receptor superfamily member 6-like [KO:K04390]
104269434  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
104272744  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
104269613  ras-related C3 botulinum toxin substrate 3 [KO:K07861]
104273286  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
104276141  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
104271283  LOW QUALITY PROTEIN: caspase-3-like [KO:K02187] [EC:3.4.22.56]
104271225  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
104278766  MYD88; LOW QUALITY PROTEIN: myeloid differentiation primary response protein MyD88 [KO:K04729]
104270762  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
104277489  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
104275827  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
104276537  TAB2; LOW QUALITY PROTEIN: TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
104279690  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 [KO:K04406] [EC:2.7.11.1]
104279778  mitogen-activated protein kinase kinase kinase kinase 4-like [KO:K04407] [EC:2.7.11.1]
104276764  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 [KO:K04407] [EC:2.7.11.1]
104267246  serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
104281441  PAK2; serine/threonine-protein kinase PAK 2 isoform X1 [KO:K04410] [EC:2.7.11.1]
104269941  STK4; serine/threonine-protein kinase 4 [KO:K04411]
104273317  serine/threonine-protein kinase 3-like [KO:K04412]
104275816  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
104267069  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
104275935  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
104270669  mitogen-activated protein kinase kinase kinase 3-like [KO:K04421] [EC:2.7.11.25]
104278271  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
104277951  mitogen-activated protein kinase kinase kinase MLK4 [KO:K17534] [EC:2.7.11.25]
104276006  LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 13-like [KO:K04422] [EC:2.7.11.25]
104271310  LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase MLT-like [KO:K04424] [EC:2.7.11.25]
104270448  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
104280973  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
104271444  MAP3K4; mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
104277929  TAOK1; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
104272771  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
104270947  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
104279348  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
104273886  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
104268676  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 [KO:K04436]
104269842  CRK; adapter molecule crk [KO:K04438]
104274413  CRKL; crk-like protein [KO:K04438]
104278019  beta-arrestin-1 [KO:K04439]
104270528  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
104273048  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
104276958  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
104279040  mitogen-activated protein kinase 11-like [KO:K04441] [EC:2.7.11.24]
104275886  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
104279490  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
104279806  mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
104274453  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
104280146  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
104274487  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
104273823  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
104271778  RPS6KA5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
104271384  nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
104268247  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
104275215  JUN; transcription factor AP-1 [KO:K04448]
104271266  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
104278971  MEF2C; myocyte-specific enhancer factor 2C [KO:K04454]
104279847  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104281165  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
104278856  PPM1A; LOW QUALITY PROTEIN: protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
104271242  PTPN5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
104273162  PTPN7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
104280282  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
104270861  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104269621  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104276475  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104280158  DUSP4; LOW QUALITY PROTEIN: dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104269641  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
104275375  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
104279788  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
104269343  protein phosphatase 1B [KO:K04461] [EC:3.1.3.16]
104274203  HSPA8; heat shock cognate 71 kDa protein isoform X1 [KO:K03283]
104271549  MECOM; MDS1 and EVI1 complex locus protein EVI1 isoform X1 [KO:K04462] [EC:2.1.1.367]
104278454  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
104267618  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
104274892  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
104270954  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
104278479  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
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Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
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PMID:22296764
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Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
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Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
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Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
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Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
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Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
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Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
avit04070  Phosphatidylinositol signaling system
avit04110  Cell cycle
avit04115  p53 signaling pathway
avit04210  Apoptosis
avit04310  Wnt signaling pathway
KO pathway
ko04010   
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