KEGG   PATHWAY: btax04510
Entry
btax04510                   Pathway                                
Name
Focal adhesion - Budorcas taxicolor (takin)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
btax04510  Focal adhesion
btax04510

Other DBs
GO: 0005925
Organism
Budorcas taxicolor (takin) [GN:btax]
Gene
128065257  COL1A1; collagen alpha-1(I) chain [KO:K06236]
128046458  COL1A2; collagen alpha-2(I) chain [KO:K06236]
128048030  COL2A1; collagen alpha-1(II) chain [KO:K19719]
128069713  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
128070154  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
128070152  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
128057793  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
128057845  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
128071532  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
128050602  COL6A6; LOW QUALITY PROTEIN: collagen alpha-6(VI) chain [KO:K06238]
128057689  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
128045507  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
128060926  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
128048315  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
128044990  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
128058571  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
128059283  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
128053075  LAMA2; laminin subunit alpha-2 [KO:K05637]
128067370  LAMA1; laminin subunit alpha-1 [KO:K05637]
128058740  LAMA5; laminin subunit alpha-5 [KO:K06240]
128067291  LAMA3; laminin subunit alpha-3 [KO:K06240]
128053220  LAMA4; laminin subunit alpha-4 [KO:K06241]
128046398  LAMB1; laminin subunit beta-1 [KO:K05636]
128045013  LOW QUALITY PROTEIN: laminin subunit beta-2-like [KO:K06243]
128053060  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
128061642  LAMB3; laminin subunit beta-3 [KO:K06244]
128046270  LAMB4; LOW QUALITY PROTEIN: laminin subunit beta-4 [KO:K06245]
128061859  LAMC1; laminin subunit gamma-1 [KO:K05635]
128061574  LAMC2; laminin subunit gamma-2 [KO:K06246]
128056135  LAMC3; laminin subunit gamma-3 [KO:K06247]
128064700  CHAD; chondroadherin [KO:K06248]
128046249  RELN; reelin [KO:K06249] [EC:3.4.21.-]
128054540  THBS1; thrombospondin-1 isoform X1 [KO:K16857]
128050621  COMP; cartilage oligomeric matrix protein [KO:K04659]
128045667  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
128053041  THBS2; thrombospondin-2 [KO:K04659]
128054588  THBS4; thrombospondin-4 [KO:K04659]
128071425  fibronectin-like [KO:K05717]
128068063  FN1; fibronectin isoform X1 [KO:K05717]
128049806  SPP1; osteopontin [KO:K06250]
128065568  VTN; vitronectin [KO:K06251]
128056428  TNXB; LOW QUALITY PROTEIN: tenascin-X [KO:K06252]
128052187  TNC; tenascin isoform X1 [KO:K06252]
128061587  TNR; tenascin-R [KO:K06252]
128061818  TNN; tenascin-N [KO:K06252]
128048587  VWF; von Willebrand factor [KO:K03900]
128049743  IBSP; bone sialoprotein 2 [KO:K06253]
128065939  ITGA1; integrin alpha-1 [KO:K06480]
128066170  ITGA2; integrin alpha-2 [KO:K06481]
128065265  ITGA2B; integrin alpha-IIb [KO:K06476]
128065072  ITGA3; integrin alpha-3 [KO:K06482]
128043513  ITGA4; integrin alpha-4 [KO:K06483]
128048841  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
128063440  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
128048509  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
128058543  ITGA8; integrin alpha-8 [KO:K06584]
128046826  ITGA9; integrin alpha-9 [KO:K06585]
128044498  ITGA10; integrin alpha-10 [KO:K06586]
128054246  ITGA11; integrin alpha-11 [KO:K06587]
128061467  ITGAV; integrin alpha-V [KO:K06487]
128058839  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
128064875  ITGB3; integrin beta-3 [KO:K06493]
128064497  ITGB4; integrin beta-4 [KO:K06525]
128061565  ITGB5; integrin beta-5 [KO:K06588]
128068538  ITGB6; integrin beta-6 [KO:K06589]
128048309  ITGB7; LOW QUALITY PROTEIN: integrin beta-7 [KO:K06590]
128046829  ITGB8; integrin beta-8 [KO:K06591]
128068476  EMP2; epithelial membrane protein 2 [KO:K26256]
128065733  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
128047817  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
128060743  PDGFD; platelet-derived growth factor D [KO:K05450]
128062428  PDGFC; platelet-derived growth factor C [KO:K05450]
128050008  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
128048032  IGF1; insulin-like growth factor I [KO:K05459]
128055613  VEGFA; vascular endothelial growth factor A [KO:K05448]
128068711  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
128054318  PGF; placenta growth factor [KO:K16859]
128070311  VEGFD; vascular endothelial growth factor D [KO:K05449]
128068325  VEGFC; vascular endothelial growth factor C [KO:K05449]
128046678  HGF; hepatocyte growth factor [KO:K05460]
128049579  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
128050429  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
128066571  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
128049477  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
128051614  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
128057485  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
128050341  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
128046469  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
128064538  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
128048603  EMP1; epithelial membrane protein 1 [KO:K26255]
128058174  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
128064183  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
128066877  ARHGAP5; rho GTPase-activating protein 5 [KO:K13709]
128044567  RHOA; transforming protein RhoA [KO:K04513]
128051121  DIAPH1; protein diaphanous homolog 1 [KO:K05740]
128067328  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
128055373  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
128062159  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351]
128046447  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
128058295  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
128071534  MYL10; myosin regulatory light chain 10 [KO:K12756]
128067326  myosin regulatory light polypeptide 9 isoform X1 [KO:K12757]
128063455  MYL11; myosin regulatory light chain 11 [KO:K12758]
128055125  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
128062181  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
128068503  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
128047405  PPP1R12A; protein phosphatase 1 regulatory subunit 12A [KO:K06270]
128061235  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
128063185  PPP1R12C; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
128056971  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
128045701  MYLK; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
128058891  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
128062797  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
128051310  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
128045470  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
128052473  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
128043956  ACTB; actin, cytoplasmic 1 [KO:K05692]
128064385  ACTG1; actin, cytoplasmic 2 [KO:K05692]
128066726  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
128061180  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
128063664  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
128053759  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
128052212  TLN1; talin-1 [KO:K06271]
128054345  TLN2; talin-2 isoform X1 [KO:K06271]
128070229  FLNA; filamin-A isoform X1 [KO:K04437]
128055103  FLNB; filamin-B isoform X1 [KO:K27392]
128062630  PXN; paxillin isoform X1 [KO:K05760]
128061035  ILK; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
128046505  ZYX; zyxin [KO:K06273]
128063285  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
128047281  VCL; vinculin isoform X1 [KO:K05700]
128060108  PARVA; alpha-parvin [KO:K06275]
128047330  PARVB; beta-parvin [KO:K06275]
128048484  PARVG; gamma-parvin [KO:K06275]
128060129  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
128063870  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
128067048  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
128061491  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
128043889  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
128058237  CTNNB1; catenin beta-1 [KO:K02105]
128065393  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
128066420  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
128063096  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
128059235  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
128045803  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
128061813  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
128068699  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
128050540  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
128044474  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
128066235  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
128068055  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
128050828  VAV1; proto-oncogene vav [KO:K05730]
128044678  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
128055501  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
128043471  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
128047644  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
128065663  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
128068496  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
128057235  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
128069841  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
128062878  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
128058601  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
128054088  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
128066401  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
128062963  BCAR1; LOW QUALITY PROTEIN: breast cancer anti-estrogen resistance protein 1 [KO:K05726]
128064843  CRK; adapter molecule crk isoform X1 [KO:K04438]
128062501  CRKL; crk-like protein [KO:K04438]
128067963  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
128056845  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
128044450  RAP1A; ras-related protein Rap-1A [KO:K04353]
128061218  LOW QUALITY PROTEIN: ras-related protein Rap-1A-like [KO:K04353]
128047462  RAP1B; ras-related protein Rap-1b [KO:K07836]
128051495  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
128047244  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
128049619  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
128044447  JUN; transcription factor Jun [KO:K04448]
128046969  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
128046440  CAV1; caveolin-1 isoform X1 [KO:K06278]
128046728  CAV2; caveolin-2 [KO:K12958]
128046664  CAV3; caveolin-3 [KO:K12959]
128053552  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
128044445  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
128051196  SHC2; SHC-transforming protein 2 [KO:K17447]
128052614  SHC3; SHC-transforming protein 3 [KO:K17448]
128054009  SHC4; SHC-transforming protein 4 [KO:K17449]
128064562  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
128053892  SOS2; son of sevenless homolog 2 [KO:K03099]
128055374  SOS1; son of sevenless homolog 1 [KO:K03099]
128068689  HRAS; GTPase HRas isoform X1 [KO:K02833]
128043403  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
128054045  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
128043958  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
128062160  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
128070470  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
128069030  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
128048410  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
128055411  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
128060118  BIRC2; LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 2 [KO:K16060]
128060491  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
128070186  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
128068977  BAD; bcl2-associated agonist of cell death [KO:K02158]
128067358  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
btax04010  MAPK signaling pathway
btax04060  Cytokine-cytokine receptor interaction
btax04070  Phosphatidylinositol signaling system
btax04110  Cell cycle
btax04151  PI3K-Akt signaling pathway
btax04310  Wnt signaling pathway
btax04512  ECM-receptor interaction
btax04810  Regulation of actin cytoskeleton
KO pathway
ko04510   
LinkDB

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