Entry Name Yersinia infection - Camelus ferus (Wild Bactrian camel)
Description Pathogenic Yersinia injects virulent Yersinia outer proteins (Yops) into the host cell through a type three secretion system (T3SS) to express its pathogenicity. Through inactivation of small GTPases by YopT protease, YopE GTPase-activating protein, and YpkA/YopO sequestration of GDP-bound small GTPases, Yersinia prevents its uptake by phagocytic cells and disrupts the actin cytoskeleton. YopH phosphatase shuts down phagocytosis by dephosphorylating key host proteins as well as suppresses T cell activation. Yersinia induces macrophage pyroptosis via YopB/YopD activation of canonical and noncanonical inflammasomes and YopT/YopE-mediated activation of pyrin. These effects are counteracted by YopK and YopM. YopP/J is a member of an ubiquitin-like protein cysteine protease family and simultaneously targets signaling components of the MAPK and NF-kappaB signaling pathways following activation of Toll-like receptor4 to inhibit production of proinflammatory cytokines.
Class Human Diseases; Infectious disease: bacterialBRITE hierarchy
Pathway map Ortholog table Organism Camelus ferus (Wild Bactrian camel) [GN:
cfr ]
Gene 102522119 BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726 ]
102523792 ELMO1; engulfment and cell motility protein 1 isoform X3 [KO:K12366 ]
102511400 ELMO2; engulfment and cell motility protein 2 isoform X1 [KO:K18985 ]
102514294 DOCK1; LOW QUALITY PROTEIN: dedicator of cytokinesis protein 1 [KO:K13708 ]
102517806 low affinity immunoglobulin gamma Fc region receptor II-like isoform X1 [KO:K06472 ]
102516893 RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
102519112 RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860 ]
102508710 RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861 ]
102504610 WASL; neural Wiskott-Aldrich syndrome protein isoform X1 [KO:K23612 ]
102506683 ACTR3B; LOW QUALITY PROTEIN: actin-related protein 3B [KO:K18584 ]
102517144 ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754 ]
102509395 LOW QUALITY PROTEIN: actin-related protein 2/3 complex subunit 5 [KO:K05754 ]
102524367 WIPF2; WAS/WASL-interacting protein family member 2 isoform X1 [KO:K19475 ]
102513169 BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1 [KO:K05627 ]
102515617 LOW QUALITY PROTEIN: brain-specific angiogenesis inhibitor 1-associated protein 2-like [KO:K05627 ]
102519425 WASF2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748 ]
102518885 ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X1 [KO:K13710 ]
102514486 CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393 ]
102508547 GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634 ]
102524302 ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532 ]
102504201 ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330 ]
102513248 ARHGEF28; rho guanine nucleotide exchange factor 28 isoform X7 [KO:K21072 ]
102504811 SKAP2; src kinase-associated phosphoprotein 2 isoform X1 [KO:K23471 ]
102520415 NLRP3; NACHT, LRR and PYD domains-containing protein 3 [KO:K12800 ]
102524619 NLRC4; LOW QUALITY PROTEIN: NLR family CARD domain-containing protein 4 [KO:K12805 ]
102513340 apoptosis-associated speck-like protein containing a CARD isoform X1 [KO:K12799 ]
102506575 MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729 ]
102508813 TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403 ]
102516031 TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404 ]
102505905 NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580 ]
102523502 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
102518643 PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
102519994 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
102513205 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649 ]
102505690 LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
102520923 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649 ]
102510688 LAT; linker for activation of T-cells family member 1 isoform X2 [KO:K07362 ]
102509705 VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730 ]
102518740 VAV3; LOW QUALITY PROTEIN: guanine nucleotide exchange factor VAV3 [KO:K05730 ]
102524452 PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116 ] [EC:3.1.4.11 ]
102523589 NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446 ]
102521501 NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332 ]
102514634 NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
C04637 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Pha K, Navarro L
Title Yersinia type III effectors perturb host innate immune responses.
Journal Reference Authors Pinaud L, Sansonetti PJ, Phalipon A
Title Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
Journal Reference Authors Huveneers S, Danen EH
Title Adhesion signaling - crosstalk between integrins, Src and Rho.
Journal Reference Authors Angot A, Vergunst A, Genin S, Peeters N
Title Exploitation of eukaryotic ubiquitin signaling pathways by effectors translocated by bacterial type III and type IV secretion systems.
Journal Reference Authors Bliska JB
Title Yop effectors of Yersinia spp. and actin rearrangements.
Journal Reference Authors Gustavsson A, Yuan M, Fallman M
Title Temporal dissection of beta1-integrin signaling indicates a role for p130Cas-Crk in filopodia formation.
Journal Reference Authors Bruce-Staskal PJ, Weidow CL, Gibson JJ, Bouton AH
Title Cas, Fak and Pyk2 function in diverse signaling cascades to promote Yersinia uptake.
Journal J Cell Sci 115:2689-700 (2002)
Reference Authors McGee K, Zettl M, Way M, Fallman M
Title A role for N-WASP in invasin-promoted internalisation.
Journal Reference Authors Pizarro-Cerda J, Cossart P
Title Subversion of phosphoinositide metabolism by intracellular bacterial pathogens.
Journal Reference Authors Chung LK, Park YH, Zheng Y, Brodsky IE, Hearing P, Kastner DL, Chae JJ, Bliska JB
Title The Yersinia Virulence Factor YopM Hijacks Host Kinases to Inhibit Type III Effector-Triggered Activation of the Pyrin Inflammasome.
Journal Reference Authors Schotte P, Denecker G, Van Den Broeke A, Vandenabeele P, Cornelis GR, Beyaert R
Title Targeting Rac1 by the Yersinia effector protein YopE inhibits caspase-1-mediated maturation and release of interleukin-1beta.
Journal Reference Authors Orth K, Palmer LE, Bao ZQ, Stewart S, Rudolph AE, Bliska JB, Dixon JE
Title Inhibition of the mitogen-activated protein kinase kinase superfamily by a Yersinia effector.
Journal Reference Authors Zhou H, Monack DM, Kayagaki N, Wertz I, Yin J, Wolf B, Dixit VM
Title Yersinia virulence factor YopJ acts as a deubiquitinase to inhibit NF-kappa B activation.
Journal Reference Authors Haase R, Richter K, Pfaffinger G, Courtois G, Ruckdeschel K
Title Yersinia outer protein P suppresses TGF-beta-activated kinase-1 activity to impair innate immune signaling in Yersinia enterocolitica-infected cells.
Journal Reference Authors Thiefes A, Wolf A, Doerrie A, Grassl GA, Matsumoto K, Autenrieth I, Bohn E, Sakurai H, Niedenthal R, Resch K, Kracht M
Title The Yersinia enterocolitica effector YopP inhibits host cell signalling by inactivating the protein kinase TAK1 in the IL-1 signalling pathway.
Journal Reference Authors Rosadini CV, Zanoni I, Odendall C, Green ER, Paczosa MK, Philip NH, Brodsky IE, Mecsas J, Kagan JC
Title A Single Bacterial Immune Evasion Strategy Dismantles Both MyD88 and TRIF Signaling Pathways Downstream of TLR4.
Journal Reference Authors Rolan HG, Durand EA, Mecsas J
Title Identifying Yersinia YopH-targeted signal transduction pathways that impair neutrophil responses during in vivo murine infection.
Journal Reference Authors Alonso A, Bottini N, Bruckner S, Rahmouni S, Williams S, Schoenberger SP, Mustelin T
Title Lck dephosphorylation at Tyr-394 and inhibition of T cell antigen receptor signaling by Yersinia phosphatase YopH.
Journal Related cfr04620 Toll-like receptor signaling pathway
cfr04621 NOD-like receptor signaling pathway
cfr04660 T cell receptor signaling pathway
cfr04666 Fc gamma R-mediated phagocytosis
cfr04810 Regulation of actin cytoskeleton
KO pathway LinkDB All DBs
