KEGG   PATHWAY: cjc04210
Entry
cjc04210                    Pathway                                
Name
Apoptosis - Callithrix jacchus (white-tufted-ear marmoset)
Description
Apoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled by numerous interrelating processes. The 'extrinsic' pathway involves stimulation of members of the tumor necrosis factor (TNF) receptor subfamily, such as TNFRI, CD95/Fas or TRAILR (death receptors), located at the cell surface, by their specific ligands, such as TNF-alpha, FasL or TRAIL, respectively. The 'intrinsic' pathway is activated mainly by non-receptor stimuli, such as DNA damage, ER stress, metabolic stress, UV radiation or growth-factor deprivation. The central event in the 'intrinsic' pathway is the mitochondrial outer membrane permeabilization (MOMP), which leads to the release of cytochrome c. These two pathways converge at the level of effector caspases, such as caspase-3 and caspase-7. The third major pathway is initiated by the constituents of cytotoxic granules (e.g. Perforin and Granzyme B) that are released by CTLs (cytotoxic T-cells) and NK (natural killer) cells. Granzyme B, similarly to the caspases, cleaves its substrates after aspartic acid residues, suggesting that this protease has the ability to activate members of the caspase family directly. It is the balance between the pro-apoptotic and anti-apoptotic signals that eventually determines whether cells will undergo apoptosis, survive or proliferate. TNF family of ligands activates anti-apoptotic or cell-survival signals as well as apoptotic signals. NGF and Interleukin-3 promotes the survival, proliferation and differentiation of neurons or hematopoietic cells, respectively. Withdrawal of these growth factors leads to cell death, as described above.
Class
Cellular Processes; Cell growth and death
Pathway map
cjc04210  Apoptosis
cjc04210

Other DBs
GO: 0006915
Organism
Callithrix jacchus (white-tufted-ear marmoset) [GN:cjc]
Gene
100396000  TNFSF10; tumor necrosis factor ligand superfamily member 10 isoform X1 [KO:K04721]
100395977  TNFRSF10A; tumor necrosis factor receptor superfamily member 10A isoform X1 [KO:K04722]
100397442  TNFRSF10B; tumor necrosis factor receptor superfamily member 10B isoform X2 [KO:K04722]
100397065  LOW QUALITY PROTEIN: uncharacterized protein LOC100397065 [KO:K04722]
100404850  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
100397803  FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
100410616  FADD; FAS-associated death domain protein [KO:K02373]
100397484  TNF; tumor necrosis factor [KO:K03156]
100397418  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
100401347  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X3 [KO:K03171]
100393782  CFLAR; CASP8 and FADD-like apoptosis regulator isoform X1 [KO:K04724]
100395220  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
100394139  CASP10; caspase-10 [KO:K04400] [EC:3.4.22.63]
100394331  PLA2G12A; group XIIA secretory phospholipase A2 isoform X2 [KO:K04396] [EC:3.4.22.59]
100387570  CASP3; caspase-3 isoform X2 [KO:K02187] [EC:3.4.22.56]
100386577  CASP7; caspase-7 [KO:K04397] [EC:3.4.22.60]
100403496  BID; BH3-interacting domain death agonist isoform X2 [KO:K04726]
100391322  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
100387945  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
100403222  DIABLO; diablo IAP-binding mitochondrial protein isoform X1 [KO:K10522]
100410707  septin-4 isoform X1 [KO:K16943]
100388347  LOW QUALITY PROTEIN: septin-4 [KO:K16943]
100391596  septin-4-like isoform X1 [KO:K16943]
100403563  septin-4 isoform X1 [KO:K16943]
100415727  HAP1; LOW QUALITY PROTEIN: huntingtin-associated protein 1 [KO:K16943]
100385512  HTRA2; serine protease HTRA2, mitochondrial isoform X2 [KO:K08669] [EC:3.4.21.108]
108593648  cytochrome c-like [KO:K08738]
108593819  cytochrome c-like [KO:K08738]
108593835  cytochrome c-like [KO:K08738]
108588095  cytochrome c-like [KO:K08738]
100406761  cytochrome c-like [KO:K08738]
100401718  cytochrome c [KO:K08738]
100413276  cytochrome c-like [KO:K08738]
108591937  cytochrome c-like [KO:K08738]
108592162  cytochrome c-like [KO:K08738]
108591932  cytochrome c, somatic-like [KO:K08738]
100403825  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
100409028  CASP9; caspase-9 isoform X3 [KO:K04399] [EC:3.4.22.62]
100404817  PRF1; perforin-1 precursor [KO:K07818]
100389206  GZMB; granzyme B precursor [KO:K01353] [EC:3.4.21.79]
100404055  tubulin alpha-3 chain [KO:K07374]
100403861  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
100410702  tubulin alpha-4A chain-like [KO:K07374]
100400294  TUBA4A; tubulin alpha-4A chain isoform X3 [KO:K07374]
100410466  TUBAL3; tubulin alpha chain-like 3 isoform X1 [KO:K07374]
100392817  tubulin alpha-1A chain [KO:K07374]
100409161  TUBA1C; tubulin alpha-1C chain isoform X1 [KO:K07374]
100392213  tubulin alpha-1B chain [KO:K07374]
100390144  LOW QUALITY PROTEIN: tubulin alpha-3 chain [KO:K07374]
118147191  tubulin alpha-3 chain [KO:K07374]
100406790  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
100398645  actin, cytoplasmic 2-like [KO:K05692]
100404409  actin, cytoplasmic 1-like [KO:K05692]
100406907  actin, cytoplasmic 2-like [KO:K05692]
100410882  actin, cytoplasmic 2-like [KO:K05692]
100412618  actin, cytoplasmic 1 [KO:K05692]
100409006  ACTG1; actin, cytoplasmic 2 [KO:K05692]
100388094  actin, cytoplasmic 2 [KO:K05692]
100406296  ACTB; actin, cytoplasmic 1 [KO:K05692]
100401391  actin, cytoplasmic 2-like [KO:K05692]
118150586  actin, cytoplasmic 2-like [KO:K05692]
100408104  SPTAN1; spectrin alpha chain, non-erythrocytic 1 isoform X1 [KO:K06114]
100401580  LMNA; lamin [KO:K12641]
100410429  LMNB2; lamin-B2 [KO:K07611]
100395999  LMNB1; lamin-B1 [KO:K07611]
100403519  PARP1; poly [ADP-ribose] polymerase 1 [KO:K24070] [EC:2.4.2.30]
100388484  PARP2; poly [ADP-ribose] polymerase 2 isoform X1 [KO:K10798] [EC:2.4.2.30]
100411001  PARP3; protein mono-ADP-ribosyltransferase PARP3 isoform X2 [KO:K10798] [EC:2.4.2.30]
100386757  PARP4; protein mono-ADP-ribosyltransferase PARP4 isoform X1 [KO:K10798] [EC:2.4.2.30]
100402847  DFFA; DNA fragmentation factor subunit alpha [KO:K02310]
100400538  DFFB; DNA fragmentation factor subunit beta isoform X1 [KO:K02311] [EC:3.-.-.-]
100410999  ENDOG; endonuclease G, mitochondrial [KO:K01173]
100387002  AIFM1; apoptosis-inducing factor 1, mitochondrial isoform X1 [KO:K04727] [EC:1.-.-.-]
100414862  ERN1; LOW QUALITY PROTEIN: serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
100404226  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
100385763  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
118144170  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
100390843  inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
100411931  CAPN1; calpain-1 catalytic subunit isoform X1 [KO:K01367] [EC:3.4.22.52]
100405215  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
100394186  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
100399114  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
100392193  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
103794361  DNA damage-inducible transcript 3 protein [KO:K04452]
100385367  DDIT3; DNA damage-inducible transcript 3 protein isoform X3 [KO:K04452]
100389833  CTSB; cathepsin B isoform X1 [KO:K01363] [EC:3.4.22.1]
100400437  CTSC; dipeptidyl peptidase 1 isoform X1 [KO:K01275] [EC:3.4.14.1]
100397061  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
100398631  CTSF; cathepsin F isoform X1 [KO:K01373] [EC:3.4.22.41]
100413104  CTSH; pro-cathepsin H isoform X1 [KO:K01366] [EC:3.4.22.16]
100410169  CTSK; cathepsin K [KO:K01371] [EC:3.4.22.38]
100412536  CTSL; procathepsin L isoform X2 [KO:K01365] [EC:3.4.22.15]
100410974  LOW QUALITY PROTEIN: procathepsin L-like [KO:K01365] [EC:3.4.22.15]
100388522  CTSO; cathepsin O [KO:K01374] [EC:3.4.22.42]
100409214  CTSS; cathepsin S isoform X2 [KO:K01368] [EC:3.4.22.27]
100411470  CTSV; cathepsin L2 [KO:K01375] [EC:3.4.22.43]
100388606  CTSW; cathepsin W isoform X1 [KO:K08569] [EC:3.4.22.-]
100409242  CTSZ; cathepsin Z [KO:K08568] [EC:3.4.18.1]
100394418  BIRC2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
100399118  BIRC3; baculoviral IAP repeat-containing protein 3 isoform X1 [KO:K16060]
100402341  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
100398121  BIRC5; baculoviral IAP repeat-containing protein 5 isoform X2 [KO:K08731]
100399968  BCL2L11; bcl-2-like protein 11 isoform X16 [KO:K16341]
100401978  BCL2L1; bcl-2-like protein 1 [KO:K04570]
100408947  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
100401218  DAXX; death domain-associated protein 6 [KO:K02308]
100415562  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
100391271  DAB2IP; disabled homolog 2-interacting protein isoform X1 [KO:K19901]
100406322  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X2 [KO:K04426] [EC:2.7.11.25]
100392721  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100387686  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100390109  MAPK10; mitogen-activated protein kinase 10 isoform X7 [KO:K04440] [EC:2.7.11.24]
100412880  BAD; bcl2-associated agonist of cell death isoform X2 [KO:K02158]
100400411  JUN; transcription factor Jun [KO:K04448]
100390054  FOS; protein c-Fos [KO:K04379]
100415710  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
100398384  HRK; activator of apoptosis harakiri [KO:K02512]
100401112  MAP3K14; mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
100393096  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2 [KO:K07209] [EC:2.7.11.10]
100390258  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
100402266  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
100415321  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100388493  RELA; transcription factor p65 isoform X1 [KO:K04735]
100389019  PTPN13; tyrosine-protein phosphatase non-receptor type 13 isoform X2 [KO:K02374]
100412572  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
100405303  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
100394399  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
100389116  TRAF1; TNF receptor-associated factor 1 [KO:K03172]
100410695  BCL2A1; bcl-2-related protein A1 [KO:K02162]
100402387  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
100402158  PIDD1; p53-induced death domain-containing protein 1 isoform X4 [KO:K10130]
100387604  BBC3; LOW QUALITY PROTEIN: bcl-2-binding component 3 [KO:K10132]
100404690  PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
100402493  CASP2; caspase-2 isoform X1 [KO:K02186] [EC:3.4.22.55]
100391837  NGF; beta-nerve growth factor isoform X2 [KO:K02582]
103789024  NTRK1; LOW QUALITY PROTEIN: high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
100405472  interleukin-3 receptor subunit alpha isoform X1 [KO:K04737]
100393477  CSF2RB; cytokine receptor common subunit beta isoform X1 [KO:K04738]
100403494  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100391655  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
100398849  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100406689  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100392639  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
100414659  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
100389944  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X4 [KO:K06276] [EC:2.7.11.1]
100404447  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100399039  AKT3; RAC-gamma serine/threonine-protein kinase isoform X6 [KO:K04456] [EC:2.7.11.1]
100388080  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100406017  HRAS; GTPase HRas [KO:K02833]
118144179  KRAS; GTPase KRas isoform X2 [KO:K07827]
100414782  NRAS; GTPase NRas isoform X2 [KO:K07828]
108591807  GTPase NRas-like [KO:K07828]
100415300  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100387394  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
100393991  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100400700  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100404815  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00319  Sphingosine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:26615431
  Authors
Savitskaya MA, Onishchenko GE
  Title
Mechanisms of Apoptosis.
  Journal
Biochemistry (Mosc) 80:1393-417 (2015)
DOI:10.1134/S0006297915110012
Reference
PMID:23803157
  Authors
Schleich K, Lavrik IN
  Title
Mathematical modeling of apoptosis.
  Journal
Cell Commun Signal 11:44 (2013)
DOI:10.1186/1478-811X-11-44
Reference
PMID:15654015
  Authors
Lavrik I, Golks A, Krammer PH
  Title
Death receptor signaling.
  Journal
J Cell Sci 118:265-7 (2005)
DOI:10.1242/jcs.01610
Reference
PMID:15725726
  Authors
Jin Z, El-Deiry WS
  Title
Overview of cell death signaling pathways.
  Journal
Cancer Biol Ther 4:139-63 (2005)
DOI:10.4161/cbt.4.2.1508
Reference
PMID:15322527
  Authors
Benn SC, Woolf CJ
  Title
Adult neuron survival strategies--slamming on the brakes.
  Journal
Nat Rev Neurosci 5:686-700 (2004)
DOI:10.1038/nrn1477
Reference
PMID:12838338
  Authors
Orrenius S, Zhivotovsky B, Nicotera P
  Title
Regulation of cell death: the calcium-apoptosis link.
  Journal
Nat Rev Mol Cell Biol 4:552-65 (2003)
DOI:10.1038/nrm1150
Reference
PMID:19148180
  Authors
Clarke P, Tyler KL
  Title
Apoptosis in animal models of virus-induced disease.
  Journal
Nat Rev Microbiol 7:144-55 (2009)
DOI:10.1038/nrmicro2071
Reference
PMID:22429822
  Authors
Wen X, Lin ZQ, Liu B, Wei YQ
  Title
Caspase-mediated programmed cell death pathways as potential therapeutic targets in cancer.
  Journal
Cell Prolif 45:217-24 (2012)
DOI:10.1111/j.1365-2184.2012.00814.x
Reference
PMID:25526085
  Authors
Shalini S, Dorstyn L, Dawar S, Kumar S
  Title
Old, new and emerging functions of caspases.
  Journal
Cell Death Differ 22:526-39 (2015)
DOI:10.1038/cdd.2014.216
Reference
PMID:15601572
  Authors
Philchenkov A
  Title
Caspases: potential targets for regulating cell death.
  Journal
J Cell Mol Med 8:432-44 (2004)
DOI:10.1111/j.1582-4934.2004.tb00468.x
Reference
PMID:9894605
  Authors
Stroh C, Schulze-Osthoff K
  Title
Death by a thousand cuts: an ever increasing list of caspase substrates.
  Journal
Cell Death Differ 5:997-1000 (1998)
DOI:10.1038/sj.cdd.4400451
Reference
PMID:23070002
  Authors
Safa AR
  Title
c-FLIP, a master anti-apoptotic regulator.
  Journal
Exp Oncol 34:176-84 (2012)
Reference
PMID:18304445
  Authors
Jeong SY, Seol DW
  Title
The role of mitochondria in apoptosis.
  Journal
BMB Rep 41:11-22 (2008)
DOI:10.5483/bmbrep.2008.41.1.011
Reference
PMID:20533903
  Authors
Parsons MJ, Green DR
  Title
Mitochondria in cell death.
  Journal
Essays Biochem 47:99-114 (2010)
DOI:10.1042/bse0470099
Reference
PMID:15719025
  Authors
Strasser A
  Title
The role of BH3-only proteins in the immune system.
  Journal
Nat Rev Immunol 5:189-200 (2005)
DOI:10.1038/nri1568
Reference
PMID:24278747
  Authors
Schonthal AH
  Title
Endoplasmic reticulum stress: its role in disease and novel prospects for therapy.
  Journal
Scientifica (Cairo) 2012:857516 (2012)
DOI:10.6064/2012/857516
Reference
PMID:21145844
  Authors
Malhi H, Kaufman RJ
  Title
Endoplasmic reticulum stress in liver disease.
  Journal
J Hepatol 54:795-809 (2011)
DOI:10.1016/j.jhep.2010.11.005
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:16397578
  Authors
Wu J, Kaufman RJ
  Title
From acute ER stress to physiological roles of the Unfolded Protein Response.
  Journal
Cell Death Differ 13:374-84 (2006)
DOI:10.1038/sj.cdd.4401840
Reference
PMID:21914490
  Authors
Repnik U, Stoka V, Turk V, Turk B
  Title
Lysosomes and lysosomal cathepsins in cell death.
  Journal
Biochim Biophys Acta 1824:22-33 (2012)
DOI:10.1016/j.bbapap.2011.08.016
Reference
PMID:22465226
  Authors
Cesen MH, Pegan K, Spes A, Turk B
  Title
Lysosomal pathways to cell death and their therapeutic applications.
  Journal
Exp Cell Res 318:1245-51 (2012)
DOI:10.1016/j.yexcr.2012.03.005
Reference
PMID:26231733
  Authors
Dashzeveg N, Yoshida K
  Title
Cell death decision by p53 via control of the mitochondrial membrane.
  Journal
Cancer Lett 367:108-12 (2015)
DOI:10.1016/j.canlet.2015.07.019
Reference
PMID:22075987
  Authors
Bouchier-Hayes L, Green DR
  Title
Caspase-2: the orphan caspase.
  Journal
Cell Death Differ 19:51-7 (2012)
DOI:10.1038/cdd.2011.157
Reference
PMID:18238895
  Authors
Baptiste-Okoh N, Barsotti AM, Prives C
  Title
A role for caspase 2 and PIDD in the process of p53-mediated apoptosis.
  Journal
Proc Natl Acad Sci U S A 105:1937-42 (2008)
DOI:10.1073/pnas.0711800105
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:14737178
  Authors
Steelman LS, Pohnert SC, Shelton JG, Franklin RA, Bertrand FE, McCubrey JA.
  Title
JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis.
  Journal
Leukemia 18:189-218 (2004)
DOI:10.1038/sj.leu.2403241
Reference
PMID:9916983
  Authors
Dragovich T, Rudin CM, Thompson CB
  Title
Signal transduction pathways that regulate cell survival and cell death.
  Journal
Oncogene 17:3207-13 (1998)
DOI:10.1038/sj.onc.1202587
Reference
PMID:11520933
  Authors
Sofroniew MV, Howe CL, Mobley WC
  Title
Nerve growth factor signaling, neuroprotection, and neural repair.
  Journal
Annu Rev Neurosci 24:1217-81 (2001)
DOI:10.1146/annurev.neuro.24.1.1217
Reference
PMID:24769728
  Authors
Kristiansen M, Ham J
  Title
Programmed cell death during neuronal development: the sympathetic neuron model.
  Journal
Cell Death Differ 21:1025-35 (2014)
DOI:10.1038/cdd.2014.47
Reference
PMID:18208375
  Authors
Logue SE, Martin SJ
  Title
Caspase activation cascades in apoptosis.
  Journal
Biochem Soc Trans 36:1-9 (2008)
DOI:10.1042/BST0360001
Reference
PMID:19770840
  Authors
Boivin WA, Cooper DM, Hiebert PR, Granville DJ
  Title
Intracellular versus extracellular granzyme B in immunity and disease: challenging the dogma.
  Journal
Lab Invest 89:1195-220 (2009)
DOI:10.1038/labinvest.2009.91
Reference
PMID:20075940
  Authors
Cullen SP, Brunet M, Martin SJ
  Title
Granzymes in cancer and immunity.
  Journal
Cell Death Differ 17:616-23 (2010)
DOI:10.1038/cdd.2009.206
Related
pathway
cjc04010  MAPK signaling pathway
cjc04020  Calcium signaling pathway
cjc04064  NF-kappa B signaling pathway
cjc04115  p53 signaling pathway
cjc04141  Protein processing in endoplasmic reticulum
cjc04151  PI3K-Akt signaling pathway
cjc04650  Natural killer cell mediated cytotoxicity
cjc04668  TNF signaling pathway
KO pathway
ko04210   
LinkDB

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