KEGG   PATHWAY: cmao04210
Entry
cmao04210                   Pathway                                
Name
Apoptosis - Colossoma macropomum (tambaqui)
Description
Apoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled by numerous interrelating processes. The 'extrinsic' pathway involves stimulation of members of the tumor necrosis factor (TNF) receptor subfamily, such as TNFRI, CD95/Fas or TRAILR (death receptors), located at the cell surface, by their specific ligands, such as TNF-alpha, FasL or TRAIL, respectively. The 'intrinsic' pathway is activated mainly by non-receptor stimuli, such as DNA damage, ER stress, metabolic stress, UV radiation or growth-factor deprivation. The central event in the 'intrinsic' pathway is the mitochondrial outer membrane permeabilization (MOMP), which leads to the release of cytochrome c. These two pathways converge at the level of effector caspases, such as caspase-3 and caspase-7. The third major pathway is initiated by the constituents of cytotoxic granules (e.g. Perforin and Granzyme B) that are released by CTLs (cytotoxic T-cells) and NK (natural killer) cells. Granzyme B, similarly to the caspases, cleaves its substrates after aspartic acid residues, suggesting that this protease has the ability to activate members of the caspase family directly. It is the balance between the pro-apoptotic and anti-apoptotic signals that eventually determines whether cells will undergo apoptosis, survive or proliferate. TNF family of ligands activates anti-apoptotic or cell-survival signals as well as apoptotic signals. NGF and Interleukin-3 promotes the survival, proliferation and differentiation of neurons or hematopoietic cells, respectively. Withdrawal of these growth factors leads to cell death, as described above.
Class
Cellular Processes; Cell growth and death
Pathway map
cmao04210  Apoptosis
cmao04210

Other DBs
GO: 0006915
Organism
Colossoma macropomum (tambaqui) [GN:cmao]
Gene
118798701  tnfsf10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
118827384  hdr; hematopoietic death receptor isoform X1 [KO:K04722]
118816146  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
118823507  tumor necrosis factor receptor superfamily member 6-like [KO:K04390]
118823508  tumor necrosis factor receptor superfamily member 6-like isoform X1 [KO:K04390]
118819390  fadd; protein FADD [KO:K02373]
118805034  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
118817653  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
118818639  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
118812213  CASP8 and FADD-like apoptosis regulator [KO:K04724]
118803815  cflara; CASP8 and FADD-like apoptosis regulator a [KO:K04724]
118805906  casp10; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
118807777  casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
118797027  casp22; caspase-22 [KO:K04398] [EC:3.4.22.61]
118809985  caspase-6-like [KO:K04396] [EC:3.4.22.59]
118809990  caspase-6-like isoform X1 [KO:K04396] [EC:3.4.22.59]
118810794  caspase-6-like isoform X1 [KO:K04396] [EC:3.4.22.59]
118810851  caspase-6-like [KO:K04396] [EC:3.4.22.59]
118810853  caspase-6-like [KO:K04396] [EC:3.4.22.59]
118810890  caspase-6-like [KO:K04396] [EC:3.4.22.59]
118817001  LOW QUALITY PROTEIN: caspase-3-like [KO:K02187] [EC:3.4.22.56]
118806926  caspase-3-like [KO:K02187] [EC:3.4.22.56]
118806927  caspase-3-like [KO:K02187] [EC:3.4.22.56]
118809408  casp7; caspase-7 [KO:K04397] [EC:3.4.22.60]
118817734  bida; BH3 interacting domain death agonist [KO:K04726]
118819120  zgc:153993; apoptosis regulator BAX [KO:K02159]
118821229  baxa; BCL2 associated X, apoptosis regulator a [KO:K02159]
118799288  diabloa; diablo, IAP-binding mitochondrial protein a isoform X1 [KO:K10522]
118820425  diablob; diablo, IAP-binding mitochondrial protein b [KO:K10522]
118797416  sept4b; LOW QUALITY PROTEIN: septin 4b [KO:K16943]
118819893  sept4a; septin 4a [KO:K16943]
118820574  septin-5-like [KO:K16943]
118810305  LOW QUALITY PROTEIN: serine protease HTRA2, mitochondrial-like [KO:K08669] [EC:3.4.21.108]
118807813  cytochrome c [KO:K08738]
118812026  apaf1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
118822627  casp9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
118822366  perforin-1-like [KO:K07818]
118814044  prf1.5; perforin 1.5 [KO:K07818]
118804848  perforin-1-like [KO:K07818]
118804849  perforin-1-like [KO:K07818]
118804850  perforin-1-like [KO:K07818]
118804851  perforin-1-like [KO:K07818]
118804857  perforin-1-like [KO:K07818]
118804860  perforin-1-like [KO:K07818]
118821235  LOW QUALITY PROTEIN: perforin-1-like [KO:K07818]
118805012  perforin-1-like [KO:K07818]
118805013  perforin-1-like [KO:K07818]
118805014  perforin-1-like [KO:K07818]
118805194  prf1.3; perforin-1.3 [KO:K07818]
118805255  perforin-1-like isoform X1 [KO:K07818]
118821822  prf1.1; perforin-1.1 [KO:K07818]
118809904  granzyme B-like [KO:K01353] [EC:3.4.21.79]
118810605  granzyme B-like [KO:K01353] [EC:3.4.21.79]
118810674  granzyme B(G,H)-like isoform X1 [KO:K01353] [EC:3.4.21.79]
118811274  granzyme B-like isoform X1 [KO:K01353] [EC:3.4.21.79]
118822125  tuba1a; tubulin alpha-1A chain [KO:K07374]
118822126  tubulin alpha-1C chain-like [KO:K07374]
118806183  tubulin alpha-8 chain-like [KO:K07374]
118799305  tubulin alpha-1B chain [KO:K07374]
118799306  tubulin alpha-1A chain-like [KO:K07374]
118799307  tubulin alpha-1C chain [KO:K07374]
118806949  tubulin alpha chain [KO:K07374]
118806958  tubulin alpha-4A chain-like [KO:K07374]
118806979  tubulin alpha chain-like [KO:K07374]
118824432  tuba7l; tubulin, alpha 7 like [KO:K07374]
118813414  tuba5; tubulin alpha 5 [KO:K07374]
118802950  tubulin alpha-8 chain-like [KO:K07374]
118808075  tubulin alpha chain-like [KO:K07374]
118808077  tubulin alpha-1A chain-like [KO:K07374]
118803534  tuba8l2; tubulin, alpha 8 like 2 [KO:K07374]
118822038  tuba1c; tubulin alpha-1C chain [KO:K07374]
118817515  mcl1b; induced myeloid leukemia cell differentiation protein Mcl-1b [KO:K02539]
118812804  induced myeloid leukemia cell differentiation protein Mcl-1 homolog [KO:K02539]
118812809  induced myeloid leukemia cell differentiation protein Mcl-1 homolog [KO:K02539]
118805712  actb2; actin, cytoplasmic 2 [KO:K05692]
118798271  actb1; actin, cytoplasmic 1 [KO:K05692]
118820059  sptan1; LOW QUALITY PROTEIN: spectrin alpha chain, non-erythrocytic 1 [KO:K06114]
118817359  lmna; lamin [KO:K12641]
118819082  lmnb2; lamin-B2 [KO:K07611]
118824915  lmnb1; lamin-B1 [KO:K07611]
118819400  lmnl3; lamin L3 isoform X1 [KO:K07611]
118815724  parp1; poly [ADP-ribose] polymerase 1 [KO:K24070] [EC:2.4.2.30]
118801254  parp4; protein mono-ADP-ribosyltransferase PARP4 isoform X1 [KO:K10798] [EC:2.4.2.30]
118825577  parp2; poly [ADP-ribose] polymerase 2 isoform X1 [KO:K10798] [EC:2.4.2.30]
118808354  parp3; protein mono-ADP-ribosyltransferase PARP3 [KO:K10798] [EC:2.4.2.30]
118821952  dffa; DNA fragmentation factor subunit alpha [KO:K02310]
118813674  dffb; DNA fragmentation factor subunit beta [KO:K02311] [EC:3.-.-.-]
118813831  endog; endonuclease G, mitochondrial [KO:K01173]
118814412  aifm1; LOW QUALITY PROTEIN: apoptosis-inducing factor 1, mitochondrial [KO:K04727] [EC:1.-.-.-]
118802151  ern2; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
118821186  ern1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
118814555  traf2b; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
118827146  traf2a; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
118799312  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
118808278  itpr1a; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
118818001  itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
118813746  itpr3; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
118810903  capn1a; calpain 1, (mu/I) large subunit a [KO:K01367] [EC:3.4.22.52]
118801737  capn1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
118801767  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
118820023  si:dkeyp-50d11.2; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
118804576  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
118804658  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
118810905  capn2a; calpain 2, (m/II) large subunit a [KO:K03853] [EC:3.4.22.53]
118804562  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
118804578  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
118804588  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
118804589  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
118804595  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
118804599  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
118804628  calpain-2 catalytic subunit-like isoform X1 [KO:K03853] [EC:3.4.22.53]
118810293  eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
118823923  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
118815824  eif2s1b; eukaryotic translation initiation factor 2 subunit 1b [KO:K03237]
118807890  atf4a; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
118808477  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
118803181  ctsba; cathepsin B [KO:K01363] [EC:3.4.22.1]
118815880  ctsbb; cathepsin Bb [KO:K01363] [EC:3.4.22.1]
118800560  ctsc; dipeptidyl peptidase 1 [KO:K01275] [EC:3.4.14.1]
118817746  ctsd; cathepsin D [KO:K01379] [EC:3.4.23.5]
118805373  napsa; napsin-A [KO:K01379] [EC:3.4.23.5]
118806838  ctsf; cathepsin F [KO:K01373] [EC:3.4.22.41]
118801415  ctsh; pro-cathepsin H [KO:K01366] [EC:3.4.22.16]
118817493  ctsk; cathepsin K [KO:K01371] [EC:3.4.22.38]
118812790  ctss1; cathepsin S, ortholog 1 [KO:K01371] [EC:3.4.22.38]
118823535  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
118823536  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
118823537  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
118823538  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
118823540  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
118823541  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
118823542  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
118823544  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
118823545  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
118823547  cathepsin L1-like isoform X1 [KO:K01365] [EC:3.4.22.15]
118823548  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
118823549  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
118823550  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
118823551  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
118823554  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
118823556  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
118823557  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
118823558  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
118823559  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
118823560  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
118823569  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
118823866  digestive cysteine proteinase 3-like [KO:K01365] [EC:3.4.22.15]
118800990  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
118818887  cts12; cathepsin L1 [KO:K01365] [EC:3.4.22.15]
118819270  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
118819913  cathepsin L1-like isoform X1 [KO:K01365] [EC:3.4.22.15]
118819914  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
118819915  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
118819916  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
118814996  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
118827549  ctsla; cathepsin La [KO:K01365] [EC:3.4.22.15]
118807302  ctso; cathepsin O [KO:K01374] [EC:3.4.22.42]
118817502  ctss2.1; cathepsin S, ortholog2, tandem duplicate 1 [KO:K01368] [EC:3.4.22.27]
118808735  ctsz; cathepsin Z [KO:K08568] [EC:3.4.18.1]
118797262  cathepsin Z [KO:K08568] [EC:3.4.18.1]
118820703  birc2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
118806894  E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
118822764  birc5b; baculoviral IAP repeat-containing protein 5b [KO:K08731]
118809371  birc5a; baculoviral IAP repeat-containing protein 5a [KO:K08731]
118821318  baculoviral IAP repeat-containing protein 5.2-like [KO:K08731]
118810097  bcl2l11; bcl-2-like protein 11 [KO:K16341]
118822077  bcl2l1; bcl-2-like protein 1 [KO:K04570]
118798671  bcl2a; apoptosis regulator Bcl-2a [KO:K02161]
118826264  bcl2b; apoptosis regulator Bcl-2 [KO:K02161]
118805918  daxx; death domain-associated protein 6 isoform X1 [KO:K02308]
118825895  ripk1l; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
118813830  dab2ipa; disabled homolog 2-interacting protein isoform X1 [KO:K19901]
118814356  dab2ipb; DAB2 interacting protein b isoform X1 [KO:K19901]
118800999  mitogen-activated protein kinase kinase kinase 5-like [KO:K04426] [EC:2.7.11.25]
118819190  si:ch211-1i11.3; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
118810413  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
118820022  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
118820354  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
118809785  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
118826580  badb; BCL2 associated agonist of cell death b isoform X1 [KO:K02158]
118820664  bada; bcl2-associated agonist of cell death [KO:K02158]
118814879  june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
118815433  jun; transcription factor AP-1 [KO:K04448]
118816011  fosab; v-fos FBJ murine osteosarcoma viral oncogene homolog Ab [KO:K04379]
118816012  si:ch211-153j24.3; proto-oncogene c-Fos isoform X1 [KO:K04379]
118823609  fosaa; proto-oncogene c-Fos [KO:K04379]
118826251  cellular tumor antigen p53-like [KO:K04451]
118814925  tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
118822540  uncharacterized protein LOC118822540 isoform X1 [KO:K04466] [EC:2.7.11.25]
118821145  map3k14a; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
118810516  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
118810719  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
118813511  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
118822022  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
118815986  nfkbiaa; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a [KO:K04734]
118823828  nfkbiab; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b [KO:K04734]
118821638  nfkb1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
118816672  rela; transcription factor p65 [KO:K04735]
118819807  ptpn13; LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 13 [KO:K02374]
118818878  gadd45ba; growth arrest and DNA-damage-inducible, beta a isoform X1 [KO:K04402]
118813019  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
118807727  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
118820040  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
118825864  gadd45bb; growth arrest and DNA-damage-inducible, beta b [KO:K04402]
118797223  gadd45aa; growth arrest and DNA-damage-inducible, alpha, a [KO:K04402]
118813828  traf1; TNF receptor-associated factor 1 [KO:K03172]
118796987  atm; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
118811912  pidd1; p53-induced death domain-containing protein 1 isoform X1 [KO:K10130]
118825109  pmaip1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
118817839  casp2; caspase-2 isoform X1 [KO:K02186] [EC:3.4.22.55]
118823119  ngfa; neurotrophin-7 [KO:K02582]
118807564  ngfb; nerve growth factor [KO:K02582]
118798677  ntrk1; LOW QUALITY PROTEIN: high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
118821449  csf2rb; cytokine receptor common subunit beta isoform X1 [KO:K04738]
118822140  zgc:158659; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
118822617  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
118818810  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118801967  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118808170  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
118814571  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
118805760  pdpk1a; 3-phosphoinositide-dependent protein kinase 1a [KO:K06276] [EC:2.7.11.1]
118822345  pdpk1b; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
118810240  akt3a; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118815953  LOW QUALITY PROTEIN: RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
118798278  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118823237  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118818017  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118817540  hrasb; HRas proto-oncogene, GTPase b isoform X1 [KO:K02833]
118811525  hrasa; HRas proto-oncogene, GTPase a [KO:K02833]
118811569  kras; GTPase KRas isoform X1 [KO:K07827]
118821270  zgc:55558; GTPase HRas [KO:K07827]
118813822  nras; GTPase NRas [KO:K07828]
118822149  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
118799451  raf1b; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
118818240  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
118818647  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
118797185  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
118820974  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
118827508  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00319  Sphingosine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
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Related
pathway
cmao04010  MAPK signaling pathway
cmao04020  Calcium signaling pathway
cmao04115  p53 signaling pathway
cmao04141  Protein processing in endoplasmic reticulum
KO pathway
ko04210   
LinkDB

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