KEGG   PATHWAY: etf04810
Entry
etf04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Echinops telfairi (small Madagascar hedgehog)
Class
Cellular Processes; Cell motility
Pathway map
etf04810  Regulation of actin cytoskeleton
etf04810

Other DBs
GO: 0030036
Organism
Echinops telfairi (small Madagascar hedgehog) [GN:etf]
Gene
101638933  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
101656485  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
101648748  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
101660253  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
101643882  CXCL12; stromal cell-derived factor 1 [KO:K10031]
101658890  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
101644470  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
101652507  F2R; proteinase-activated receptor 1 [KO:K03914]
101641705  INS; insulin [KO:K04526]
101645300  EGF; pro-epidermal growth factor [KO:K04357]
101654974  FGF1; fibroblast growth factor 1 [KO:K18496]
101640090  FGF2; fibroblast growth factor 2 [KO:K18497]
101657384  FGF6; fibroblast growth factor 6 [KO:K04358]
101655892  FGF7; fibroblast growth factor 7 [KO:K04358]
101645725  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
101658407  FGF3; fibroblast growth factor 3 [KO:K04358]
101654224  FGF20; fibroblast growth factor 20 [KO:K04358]
101659774  FGF18; fibroblast growth factor 18 [KO:K04358]
101641057  FGF9; fibroblast growth factor 9 [KO:K04358]
101645168  FGF16; fibroblast growth factor 16 [KO:K04358]
101649614  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
101656763  FGF22; fibroblast growth factor 22 [KO:K04358]
101644233  FGF8; fibroblast growth factor 8 [KO:K04358]
101657770  FGF19; fibroblast growth factor 19 [KO:K22603]
101645758  FGF21; fibroblast growth factor 21 [KO:K22429]
101659280  FGF23; fibroblast growth factor 23 [KO:K22428]
101657212  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
101642424  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
101647643  PDGFC; platelet-derived growth factor C [KO:K05450]
101654830  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
101646846  INSRR; insulin receptor-related protein isoform X1 [KO:K05086] [EC:2.7.10.1]
101652848  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
101650479  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
101658234  FGFR2; fibroblast growth factor receptor 2 isoform X4 [KO:K05093] [EC:2.7.10.1]
101644525  FGFR3; LOW QUALITY PROTEIN: fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
101644075  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
101663213  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101650381  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
101653760  FN1; fibronectin [KO:K05717]
101651763  ITGA1; integrin alpha-1 [KO:K06480]
101651459  ITGA2; integrin alpha-2 [KO:K06481]
101644908  ITGA2B; LOW QUALITY PROTEIN: integrin alpha-IIb [KO:K06476]
101648576  ITGA3; LOW QUALITY PROTEIN: integrin alpha-3 [KO:K06482]
101640152  ITGA4; integrin alpha-4 [KO:K06483]
101640652  ITGA5; integrin alpha-5 [KO:K06484]
101663608  ITGA6; integrin alpha-6 [KO:K06485]
101639933  ITGA7; integrin alpha-7 isoform X2 [KO:K06583]
101659770  ITGA8; integrin alpha-8 [KO:K06584]
101653341  ITGA9; integrin alpha-9 [KO:K06585]
101654263  ITGA10; integrin alpha-10 [KO:K06586]
101653494  ITGA11; integrin alpha-11 [KO:K06587]
101643277  ITGAV; integrin alpha-V [KO:K06487]
101663621  ITGAL; integrin alpha-L [KO:K05718]
101657619  ITGAM; integrin alpha-M [KO:K06461]
101657313  integrin alpha-X [KO:K06462]
101657004  ITGAD; integrin alpha-D [KO:K06594]
101662305  ITGAE; integrin alpha-E [KO:K06524]
101652501  ITGB1; integrin beta-1 isoform X2 [KO:K05719]
101642606  ITGB2; integrin beta-2 [KO:K06464]
101653361  ITGB3; integrin beta-3 [KO:K06493]
101660073  ITGB4; integrin beta-4 [KO:K06525]
101645557  ITGB5; LOW QUALITY PROTEIN: integrin beta-5 [KO:K06588]
101653236  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
101660910  ITGB7; integrin beta-7 [KO:K06590]
101662870  ITGB8; integrin beta-8 [KO:K06591]
101650277  KNG1; kininogen-1 isoform X1 [KO:K03898]
101657267  BDKRB1; B1 bradykinin receptor [KO:K03915]
101662833  BDKRB2; B2 bradykinin receptor [KO:K03916]
101641566  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
101644587  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
101641017  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
101641746  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
101649961  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
101651201  C5; complement C5 [KO:K03994]
101654690  C6; complement component C6 [KO:K03995]
101654065  C7; complement component C7 [KO:K03996]
101647811  C8A; complement component C8 alpha chain [KO:K03997]
101659081  C8B; complement component C8 beta chain [KO:K03998]
101643242  C8G; complement component C8 gamma chain [KO:K03999]
101656856  C9; complement component C9 [KO:K04000]
101637962  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
101645418  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
115869515  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
115870155  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
115872073  putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
101653711  FGD1; FYVE, RhoGEF and PH domain-containing protein 1 [KO:K05720]
101647889  PTK2; focal adhesion kinase 1 isoform X12 [KO:K05725] [EC:2.7.10.2]
101642973  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X2 [KO:K05726]
101644047  CRK; adapter molecule crk [KO:K04438]
101660211  CRKL; crk-like protein [KO:K04438]
101664536  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
101640115  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
101649001  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
101646109  SOS2; son of sevenless homolog 2 [KO:K03099]
101663997  HRAS; GTPase HRas isoform X1 [KO:K02833]
101639926  KRAS; GTPase KRas isoform X3 [KO:K07827]
101649328  GTPase NRas-like [KO:K07828]
101653520  NRAS; GTPase NRas [KO:K07828]
101657858  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
101655065  MRAS; ras-related protein M-Ras [KO:K07831]
101653287  ARHGEF6; rho guanine nucleotide exchange factor 6 isoform X1 [KO:K05729]
101641853  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101654217  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101640675  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
101655654  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101659995  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101657368  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101638863  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
101639268  VAV1; proto-oncogene vav [KO:K05730]
101656425  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
101647656  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
101648298  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
101657046  BRAF; serine/threonine-protein kinase B-raf isoform X3 [KO:K04365] [EC:2.7.11.1]
101656360  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X3 [KO:K04366] [EC:2.7.11.1]
101644945  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
101650474  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101643986  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101648971  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101661786  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101643102  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101649881  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101655315  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101646828  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
101639130  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
101662299  RHOA; transforming protein RhoA [KO:K04513]
101644576  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101656762  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
101660384  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
101644037  cell division control protein 42 homolog [KO:K04393]
101647533  CDC42; cell division control protein 42 homolog [KO:K04393]
101645746  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
101655687  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
101657127  PAK3; serine/threonine-protein kinase PAK 3 isoform X3 [KO:K05733] [EC:2.7.11.1]
101640920  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
101646840  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
101658717  serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
101642244  ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X1 [KO:K13710]
101649412  GIT1; ARF GTPase-activating protein GIT1 [KO:K05737]
101642345  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
101646611  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
101654866  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
101647217  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
101660330  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
101647140  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
101653184  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
101663948  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
101656573  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase PP1-gamma catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
101638709  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
101646224  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X5 [KO:K06270]
101662729  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X2 [KO:K12329]
101648322  PPP1R12C; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
101663637  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351]
101650809  MYL5; myosin light chain 5 [KO:K12753]
101642992  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
101664182  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
101641625  MYL10; myosin regulatory light chain 10 [KO:K12756]
101664547  myosin regulatory light chain 12B [KO:K12757]
101648460  myosin regulatory light chain 12B-like [KO:K12757]
101662723  myosin regulatory light chain 12B-like [KO:K12757]
101641066  myosin regulatory light chain 12B-like isoform X1 [KO:K12757]
101657522  myosin regulatory light chain 12B-like [KO:K12757]
101641841  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
101661114  MYH14; myosin-14 [KO:K10352]
101664374  MYH10; myosin-10 isoform X1 [KO:K10352]
101644258  MYH11; myosin-11 [KO:K10352]
101640459  MYH9; myosin-9 [KO:K10352]
101651608  DIAPH1; protein diaphanous homolog 1 [KO:K05740]
101657440  DIAPH2; protein diaphanous homolog 2 isoform X1 [KO:K05741]
101656593  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
101663584  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
101658099  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [KO:K00889] [EC:2.7.1.68]
101661139  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
101653379  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X2 [KO:K00920] [EC:2.7.1.149]
101650106  PIP4K2C; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X1 [KO:K00920] [EC:2.7.1.149]
101661197  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta [KO:K00920] [EC:2.7.1.149]
101650012  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase [KO:K00921] [EC:2.7.1.150]
101652935  LIMK1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
101646862  LIMK2; LIM domain kinase 2 [KO:K05744] [EC:2.7.11.1]
101655992  DIAPH3; protein diaphanous homolog 3 [KO:K05745]
101649303  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1 [KO:K05627]
101650620  ENAH; LOW QUALITY PROTEIN: protein enabled homolog [KO:K05746]
101656077  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
101654813  WASF2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
101659897  CYFIP1; cytoplasmic FMR1-interacting protein 1 [KO:K05749]
101663558  CYFIP2; cytoplasmic FMR1-interacting protein 2 [KO:K05749]
101641711  NCKAP1; nck-associated protein 1 isoform X1 [KO:K05750]
101648440  NCKAP1L; nck-associated protein 1-like [KO:K05750]
101640348  ABI2; abl interactor 2 isoform X1 [KO:K05751]
101639841  BRK1; protein BRICK1 [KO:K05752]
101661292  WASF1; wiskott-Aldrich syndrome protein family member 1 isoform X1 [KO:K05753]
101663740  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
101638364  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
101658709  ACTR3; actin-related protein 3 [KO:K18584]
101662442  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
101662763  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
101646513  actin-related protein 2/3 complex subunit 1A-like [KO:K05757]
101659096  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
101659331  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
101642236  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
101659744  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
101656758  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
101659333  LOW QUALITY PROTEIN: actin, cytoplasmic 2-like [KO:K05692]
123522265  PFN2; profilin-2 [KO:K05759]
101655472  PFN4; profilin-4 [KO:K05759]
101645984  PFN3; profilin-3 [KO:K05759]
101645144  profilin-1-like [KO:K05759]
101652786  profilin-1-like [KO:K05759]
101652580  PFN1; profilin-1 [KO:K05759]
101653688  PXN; paxillin [KO:K05760]
101658452  EZR; ezrin [KO:K08007]
101647335  RDX; radixin [KO:K05762]
101646749  MSN; moesin [KO:K05763]
101644072  TMSB4X; thymosin beta-4 [KO:K05764]
105979637  thymosin beta-4-like [KO:K05764]
101653954  cofilin-1-like [KO:K05765]
123521884  cofilin-1-like [KO:K05765]
101640726  CFL1; cofilin-1 [KO:K05765]
101652781  CFL2; cofilin-2 [KO:K05765]
101660056  cofilin-1-like [KO:K05765]
101651174  SSH2; protein phosphatase Slingshot homolog 2 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
101662904  SSH1; protein phosphatase Slingshot homolog 1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
101645889  SSH3; protein phosphatase Slingshot homolog 3 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
101645821  VCL; vinculin isoform X2 [KO:K05700]
101651283  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
101645084  IQGAP2; LOW QUALITY PROTEIN: ras GTPase-activating-like protein IQGAP2 [KO:K05767]
101644633  IQGAP3; ras GTPase-activating-like protein IQGAP3 [KO:K05767]
101638512  GSN; gelsolin [KO:K05768]
101655969  SCIN; adseverin [KO:K05768]
101649676  ACTN4; alpha-actinin-4 isoform X5 [KO:K05699]
101641688  ACTN1; alpha-actinin-1 [KO:K05699]
101656287  APC; adenomatous polyposis coli protein isoform X3 [KO:K02085]
101640142  APC2; adenomatous polyposis coli protein 2 isoform X4 [KO:K02085]
101650086  SPATA13; spermatogenesis-associated protein 13 [KO:K05769]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
etf04010  MAPK signaling pathway
etf04510  Focal adhesion
etf04520  Adherens junction
KO pathway
ko04810   
LinkDB

DBGET integrated database retrieval system