KEGG   PATHWAY: etf05168
Entry
etf05168                    Pathway                                
Name
Herpes simplex virus 1 infection - Echinops telfairi (small Madagascar hedgehog)
Description
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class
Human Diseases; Infectious disease: viral
Pathway map
etf05168  Herpes simplex virus 1 infection
etf05168

Organism
Echinops telfairi (small Madagascar hedgehog) [GN:etf]
Gene
101654325  LTA; lymphotoxin-alpha [KO:K05468]
101661569  TNFSF14; tumor necrosis factor ligand superfamily member 14 isoform X1 [KO:K05477]
101643556  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
101655200  TRAF5; TNF receptor-associated factor 5 [KO:K09849]
101657011  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
101649582  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
101648136  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
101656238  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
101662652  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101663870  RELA; transcription factor p65 [KO:K04735]
101655890  baculoviral IAP repeat-containing protein 3 [KO:K16060]
101659133  baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
115869468  baculoviral IAP repeat-containing protein 2 [KO:K16060]
101641002  C-C motif chemokine 2-like isoform X1 [KO:K14624]
101662141  monocyte chemotactic protein 1B-like [KO:K14624]
101656725  NECTIN1; nectin-1 [KO:K06081]
101659021  NECTIN2; nectin-2 isoform X1 [KO:K06531]
101642693  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
101640652  ITGA5; integrin alpha-5 [KO:K06484]
101653361  ITGB3; integrin beta-3 [KO:K06493]
101640115  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
101654763  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
101651114  CARD9; caspase recruitment domain-containing protein 9 isoform X1 [KO:K12794]
101651495  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
101650550  IFNB1; interferon beta [KO:K05415]
101647784  LOW QUALITY PROTEIN: cellular tumor antigen p53-like [KO:K04451]
101656530  TP53; cellular tumor antigen p53 [KO:K04451]
101661246  C3; complement C3 [KO:K03990]
101651201  C5; complement C5 [KO:K03994]
101642915  properdin [KO:K15412]
101643417  TLR2; toll-like receptor 2 isoform X1 [KO:K10159]
115872044  TLR9; toll-like receptor 9 [KO:K10161]
101644448  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
101647709  IRF7; interferon regulatory factor 7 [KO:K09447]
101647976  TLR3; toll-like receptor 3 [KO:K05401]
101649346  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
115873309  LOW QUALITY PROTEIN: TIR domain-containing adapter molecule 1-like [KO:K05842]
101643108  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X2 [KO:K04733] [EC:2.7.11.1]
101652271  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
101658809  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
101647452  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
101649684  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
101642439  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
101639333  IL1B; interleukin-1 beta [KO:K04519]
101645531  CCL5; C-C motif chemokine 5 [KO:K12499]
123522712  interleukin-6-like [KO:K05405]
101644240  IL6; interleukin-6 [KO:K05405]
101654642  TNF; tumor necrosis factor [KO:K03156]
101641618  IL12A; interleukin-12 subunit alpha [KO:K05406]
101650484  IL12B; interleukin-12 subunit beta [KO:K05425]
101649079  IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
101663462  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
101663779  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
101647812  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
101649686  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
101650862  interferon alpha-2-like [KO:K05414]
101644613  CGAS; cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
101649228  STING1; stimulator of interferon genes protein [KO:K12654]
101653184  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
101663948  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
101656573  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase PP1-gamma catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
101638709  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
101645846  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 [KO:K16194] [EC:2.7.11.1]
101640829  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
101641434  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
101657758  EIF2AK4; eIF-2-alpha kinase GCN2 [KO:K16196] [EC:2.7.11.1]
101639489  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
101650561  EIF2B1; translation initiation factor eIF-2B subunit alpha isoform X2 [KO:K03239]
101640636  EIF2B2; translation initiation factor eIF-2B subunit beta [KO:K03754]
101661897  EIF2B3; translation initiation factor eIF-2B subunit gamma isoform X3 [KO:K03241]
101649743  EIF2B4; translation initiation factor eIF-2B subunit delta isoform X1 [KO:K03680]
101647154  EIF2B5; translation initiation factor eIF-2B subunit epsilon [KO:K03240]
101643318  2'-5'-oligoadenylate synthase 3 [KO:K14216] [EC:2.7.7.84]
101643629  OAS2; 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
101662447  RNASEL; 2-5A-dependent ribonuclease [KO:K01165]
101652914  HCFC1; host cell factor 1 isoform X5 [KO:K14966]
101642220  HCFC2; host cell factor 2 [KO:K27390]
101652544  POU2F2; POU domain, class 2, transcription factor 2 [KO:K09364]
101648095  POU2F3; POU domain, class 2, transcription factor 3 [KO:K09364]
101657008  POU2F1; POU domain, class 2, transcription factor 1 isoform X1 [KO:K09364]
101640204  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
101639566  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
101653170  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
101664197  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
101663486  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
101650838  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
101661602  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
101663983  IRF9; LOW QUALITY PROTEIN: interferon regulatory factor 9 [KO:K04693]
101663115  zinc finger protein 343-like [KO:K09228]
101660482  ZNF473; zinc finger protein 473 [KO:K09228]
101650793  LOW QUALITY PROTEIN: zinc finger protein 33B-like [KO:K09228]
101649621  ZNF286A; zinc finger protein 286A [KO:K09228]
115870737  ZFP90; zinc finger protein 90 homolog isoform X1 [KO:K09228]
101654606  ZNF23; zinc finger protein 23 isoform X1 [KO:K09228]
123522103  ZNF19; zinc finger protein 19 [KO:K09228]
101639173  zinc finger protein 883-like isoform X1 [KO:K09228]
123522124  zinc finger protein OZF-like [KO:K09228]
101638541  zinc finger protein 699-like [KO:K09228]
123522125  zinc finger protein 699-like isoform X1 [KO:K09228]
123522126  zinc finger protein 239-like [KO:K09228]
123522127  zinc finger protein 426-like [KO:K09228]
123522138  zinc finger protein 564-like [KO:K09228]
123522193  zinc finger protein OZF-like [KO:K09228]
123522260  ZNF662; zinc finger protein 662 isoform X1 [KO:K09228]
123522267  zinc finger protein 432-like [KO:K09228]
101647006  ZNF621; zinc finger protein 621 [KO:K09228]
101653410  zinc finger protein 343-like isoform X1 [KO:K09228]
101653096  zinc finger protein 343-like isoform X1 [KO:K09228]
101652143  zinc finger protein 343-like isoform X1 [KO:K09228]
123522290  zinc finger protein 343-like [KO:K09228]
101642927  zinc finger protein 343-like isoform X1 [KO:K09228]
101642620  zinc finger protein 343-like [KO:K09228]
101643243  zinc finger protein 343-like [KO:K09228]
101642307  zinc finger protein 343-like isoform X1 [KO:K09228]
101653726  zinc finger protein 343-like isoform X1 [KO:K09228]
101652779  zinc finger protein 343-like isoform X1 [KO:K09228]
101650606  zinc finger protein 337 [KO:K09228]
101640379  zinc finger protein 613-like [KO:K09228]
123522401  LOW QUALITY PROTEIN: zinc finger protein 615-like [KO:K09228]
101637984  ZFP37; zinc finger protein 37 homolog [KO:K09228]
123522447  zinc finger protein 345-like [KO:K09228]
115871923  zinc finger protein 883-like [KO:K09228]
101658817  zinc finger protein 883-like isoform X1 [KO:K09228]
101655369  zinc finger protein 84 isoform X1 [KO:K09228]
101651380  ZNF10; zinc finger protein 10 isoform X1 [KO:K09228]
123522455  ZNF891; zinc finger protein 891 [KO:K09228]
105979260  ZNF140; zinc finger protein 140 isoform X1 [KO:K09228]
101657850  zinc finger protein 883-like [KO:K09228]
101658235  ZNF311; zinc finger protein 311 [KO:K09228]
101645632  zinc finger protein 709-like [KO:K09228]
123522771  zinc finger protein 91-like [KO:K09228]
101662736  zinc finger protein 700-like isoform X1 [KO:K09228]
105978216  zinc finger protein 239-like [KO:K09228]
123520889  zinc finger protein 77-like [KO:K09228]
101664076  zinc finger protein 555-like [KO:K09228]
123522782  zinc finger protein 11-like [KO:K09228]
123522783  zinc finger protein 85-like [KO:K09228]
101642305  zinc finger protein 345-like isoform X1 [KO:K09228]
115873054  zinc finger protein 345-like [KO:K09228]
101664306  zinc finger protein 699 [KO:K09228]
123522787  zinc finger protein 501-like isoform X1 [KO:K09228]
101663770  zinc finger protein 14-like [KO:K09228]
101662189  zinc finger protein 345-like [KO:K09228]
101663996  zinc finger protein 420-like [KO:K09228]
123522789  zinc finger protein 345-like [KO:K09228]
101662293  ZNF317; zinc finger protein 317 [KO:K09228]
123522790  zinc finger protein 77-like [KO:K09228]
123522791  zinc finger protein 883-like isoform X1 [KO:K09228]
123522793  zinc finger protein 345-like isoform X1 [KO:K09228]
101653195  zinc finger protein 14-like isoform X1 [KO:K09228]
101661571  zinc finger protein 239-like isoform X1 [KO:K09228]
101659585  zinc finger protein 2 homolog [KO:K09228]
123522797  zinc finger protein 501-like [KO:K09228]
123522800  zinc finger protein 432-like [KO:K09228]
101642233  gastrula zinc finger protein XlCGF17.1-like [KO:K09228]
101659783  ZNF623; zinc finger protein 623 [KO:K09228]
101642819  ZNF510; zinc finger protein 510 isoform X1 [KO:K09228]
123521623  ZNF74; zinc finger protein 74 [KO:K09228]
123521625  zinc finger protein 596-like isoform X1 [KO:K09228]
123521634  zinc finger protein 420-like [KO:K09228]
123521635  zinc finger protein OZF-like isoform X1 [KO:K09228]
123521637  ZNF333; zinc finger protein 333 [KO:K09228]
101640236  zinc finger protein OZF-like [KO:K09228]
101650219  zinc finger protein 343-like [KO:K09228]
101647918  ZNF248; zinc finger protein 248 [KO:K09228]
101654890  ZNF266; zinc finger protein 266 isoform X1 [KO:K09228]
123521684  ZNF557; zinc finger protein 557 isoform X1 [KO:K09228]
101640765  zinc finger protein 791 [KO:K09228]
101639824  zinc finger protein 699 isoform X1 [KO:K09228]
101641079  zinc finger protein OZF-like isoform X1 [KO:K09228]
123521700  zinc finger protein 615-like [KO:K09228]
101656977  zinc finger protein 615-like [KO:K09228]
123521728  zinc finger protein 615-like [KO:K09228]
123521755  zinc finger protein 883-like isoform X1 [KO:K09228]
123521774  zinc finger protein 343-like [KO:K09228]
123521792  zinc finger protein 699-like [KO:K09228]
123521793  zinc finger protein 883-like isoform X1 [KO:K09228]
105978857  ZNF684; zinc finger protein 684 [KO:K09228]
101659282  LOW QUALITY PROTEIN: zinc finger protein 84-like [KO:K09228]
101662743  zinc finger protein 84-like [KO:K09228]
105979253  ZNF26; LOW QUALITY PROTEIN: zinc finger protein 26 [KO:K09228]
101647872  ZNF175; zinc finger protein 175 [KO:K09228]
123521916  zinc finger protein 343-like isoform X1 [KO:K09228]
101639446  zinc finger protein 343-like isoform X1 [KO:K09228]
101639131  LOW QUALITY PROTEIN: zinc finger protein 268-like [KO:K09228]
101638811  zinc finger protein 345-like [KO:K09228]
101664678  zinc finger protein 343 isoform X1 [KO:K09228]
123521924  ZNF606; zinc finger protein 606 isoform X1 [KO:K09228]
101661779  zinc finger protein 805-like isoform X1 [KO:K09228]
105979782  zinc finger protein 543-like isoform X1 [KO:K09228]
105979785  zinc finger protein 304-like isoform X1 [KO:K09228]
123521925  ZNF304; zinc finger protein 304 isoform X1 [KO:K09228]
105979786  histone-lysine N-methyltransferase PRDM9 [KO:K09228]
101657988  zinc finger protein 583-like [KO:K09228]
101642830  zinc finger protein 324A isoform X1 [KO:K09228]
101639063  zinc finger protein 551-like isoform X1 [KO:K09228]
115870325  zinc finger protein 551-like [KO:K09228]
101641268  ZNF135; zinc finger protein 135 [KO:K09228]
123521926  endothelial zinc finger protein induced by tumor necrosis factor alpha-like [KO:K09228]
115870324  zinc finger protein 551-like [KO:K09228]
123521927  zinc finger protein 543-like [KO:K09228]
123521943  zinc finger protein OZF-like [KO:K09228]
101664155  zinc finger protein 234-like isoform X1 [KO:K09228]
123521952  zinc finger protein 227-like isoform X1 [KO:K09228]
123521953  zinc finger protein 234-like [KO:K09228]
101663230  zinc finger protein 234-like [KO:K09228]
105979331  zinc finger protein 234-like isoform X1 [KO:K09228]
101650989  LOW QUALITY PROTEIN: zinc finger protein 613-like [KO:K09228]
101664360  zinc finger protein 420-like isoform X1 [KO:K09228]
115870354  ZNF112; zinc finger protein 112 [KO:K09228]
101637981  zinc finger protein 227 isoform X1 [KO:K09228]
101658699  zinc finger protein 235 isoform X1 [KO:K09228]
101638932  zinc finger protein 229 isoform X1 [KO:K09228]
101638613  zinc finger protein 229 [KO:K09228]
123521963  zinc finger protein 432-like [KO:K09228]
105978213  zinc finger protein 350-like [KO:K09228]
101650059  zinc finger protein 605-like isoform X1 [KO:K09228]
105979348  zinc finger protein 84-like isoform X1 [KO:K09228]
105978209  ZNF615; LOW QUALITY PROTEIN: zinc finger protein 615 [KO:K09228]
123521964  zinc finger protein 160-like isoform X1 [KO:K09228]
115870304  zinc finger protein 2 homolog isoform X1 [KO:K09228]
123521965  zinc finger protein 345-like [KO:K09228]
115870342  zinc finger protein 160-like [KO:K09228]
101662521  zinc finger protein 613 isoform X1 [KO:K09228]
101664091  zinc finger protein 883 [KO:K09228]
105979349  zinc finger protein 432-like [KO:K09228]
101650681  zinc finger protein 614 isoform X1 [KO:K09228]
123521966  zinc finger protein 350-like [KO:K09228]
115870348  zinc finger protein OZF-like [KO:K09228]
115870344  zinc finger protein 613-like [KO:K09228]
105979771  ZNF331; zinc finger protein 331 [KO:K09228]
101650371  zinc finger protein 577 [KO:K09228]
101651294  zinc finger protein 501-like isoform X1 [KO:K09228]
101650818  ZNF792; zinc finger protein 792 [KO:K09228]
123522002  zinc finger protein 567 isoform X1 [KO:K09228]
115870364  zinc finger protein 571-like [KO:K09228]
115867885  zinc finger protein 571-like [KO:K09228]
101661781  ZFP82; zinc finger protein 82 homolog isoform X1 [KO:K09228]
101663048  ZNF181; zinc finger protein 181 isoform X1 [KO:K09228]
123522003  ZNF565; zinc finger protein 565 isoform X1 [KO:K09228]
115870330  zinc finger protein 383 isoform X1 [KO:K09228]
101649210  ZNF189; zinc finger protein 189 isoform X1 [KO:K09228]
101652226  ZNF641; zinc finger protein 641 isoform X1 [KO:K09228]
101641668  ZNF182; zinc finger protein 182 isoform X2 [KO:K09228]
101643873  zinc finger protein 501-like isoform X2 [KO:K09228]
105979779  zinc finger protein 28 homolog isoform X1 [KO:K09228]
101664297  zinc finger protein 239-like [KO:K09228]
101661470  zinc finger protein 566 isoform X2 [KO:K09228]
101648835  ZNF214; zinc finger protein 214 isoform X1 [KO:K09228]
101646869  zinc finger protein 436-like [KO:K09228]
101658003  ZNF275; zinc finger protein 275 isoform X1 [KO:K09228]
101646687  zinc finger protein 205-like [KO:K09228]
101646194  ZNF81; zinc finger protein 81 [KO:K09228]
101638174  LOW QUALITY PROTEIN: gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
101656048  zinc finger protein 501-like [KO:K09228]
101662644  ZNF184; zinc finger protein 184 [KO:K09228]
115870124  zinc finger protein 84-like [KO:K09228]
101662090  zinc finger protein 14 homolog [KO:K09228]
115870321  ZNF8; zinc finger protein 8 isoform X3 [KO:K09228]
101662401  zinc finger protein 543-like [KO:K09228]
115870329  zinc finger protein 420 [KO:K09228]
101640704  zinc finger protein 343-like isoform X2 [KO:K09228]
101663539  LOW QUALITY PROTEIN: zinc finger protein 234 [KO:K09228]
101640551  zinc finger protein 30 homolog isoform X1 [KO:K09228]
115870576  ZNF25; zinc finger protein 25 [KO:K09228]
101639490  zinc finger protein 883-like isoform X3 [KO:K09228]
101651686  ZNF605; LOW QUALITY PROTEIN: zinc finger protein 605 [KO:K09228]
101649333  ZNF354A; zinc finger protein 354A isoform X2 [KO:K09228]
101658724  ZNF454; zinc finger protein 454 [KO:K09228]
105979528  ZNF250; zinc finger protein 250 isoform X1 [KO:K09228]
101663460  zinc finger protein 709 [KO:K09228]
101653512  zinc finger protein 883-like isoform X2 [KO:K09228]
101663032  ZNF133; zinc finger protein 133 isoform X2 [KO:K09228]
101646415  ZNF777; zinc finger protein 777 isoform X2 [KO:K09228]
101651343  zinc finger protein 239-like [KO:K09228]
101641305  ZNF3; zinc finger protein 3 isoform X1 [KO:K09228]
101664645  zinc finger protein 2 isoform X1 [KO:K09228]
123520943  gastrula zinc finger protein XlCGF7.1-like [KO:K09228]
101644454  ZNF436; zinc finger protein 436 isoform X1 [KO:K09228]
123521000  zinc finger protein 429-like [KO:K09228]
123521001  zinc finger protein 432-like [KO:K09228]
101647674  zinc finger protein 875 [KO:K09228]
101651407  zinc finger protein 850 [KO:K09228]
101640590  ZNF768; zinc finger protein 768 [KO:K09228]
105978899  zinc finger protein 764 [KO:K09228]
123521093  zinc finger protein 343-like [KO:K09228]
123521137  zinc finger protein OZF-like [KO:K09228]
123521138  zinc finger protein 501-like [KO:K09228]
101661607  zinc finger protein 883-like [KO:K09228]
123521140  zinc finger protein OZF-like [KO:K09228]
101662541  LOW QUALITY PROTEIN: zinc finger protein 883 [KO:K09228]
123521141  zinc finger protein 501-like [KO:K09228]
123521143  zinc finger protein 699-like [KO:K09228]
101661912  zinc finger protein 699-like [KO:K09228]
123521147  zinc finger protein 420-like [KO:K09228]
123521171  zinc finger protein 615-like [KO:K09228]
101662986  ZNF689; zinc finger protein 689 [KO:K09228]
101658113  ZNF667; zinc finger protein 667 [KO:K09228]
101638742  zinc finger protein 568 isoform X1 [KO:K09228]
115873493  ZNF316; zinc finger protein 316 [KO:K09228]
123521188  RBAK; RB-associated KRAB zinc finger protein [KO:K09228]
101657935  ZNF12; zinc finger protein 12 isoform X1 [KO:K09228]
101643299  ZNF853; zinc finger protein 853 [KO:K09228]
101642436  zinc finger protein 585A-like [KO:K09228]
101641502  LOW QUALITY PROTEIN: zinc finger protein 84-like [KO:K09228]
123521205  ZNF713; zinc finger protein 713 [KO:K09228]
101639418  zinc finger protein 205 [KO:K09228]
101658896  zinc finger protein 200 [KO:K09228]
101664179  zinc finger protein OZF-like [KO:K09228]
123521303  ZNF7; zinc finger protein 7 isoform X1 [KO:K09228]
101659473  ZNF707; zinc finger protein 707 [KO:K09228]
101638412  ZNF34; zinc finger protein 34 [KO:K09228]
123521378  zinc finger protein 420-like isoform X1 [KO:K09228]
101661244  ZNF398; zinc finger protein 398 [KO:K09228]
101659677  ZNF746; zinc finger protein 746 [KO:K09228]
101660616  ZNF212; zinc finger protein 212 isoform X1 [KO:K09228]
123521562  zinc finger protein 615-like [KO:K09228]
123521563  zinc finger protein 615-like [KO:K09228]
101644328  IFNG; interferon gamma [KO:K04687]
101642657  IFNGR1; interferon gamma receptor 1 [KO:K05132]
101640830  IFNGR2; interferon gamma receptor 2 [KO:K05133]
101659376  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
101644605  DAXX; death domain-associated protein 6 [KO:K02308]
101649587  nuclear autoantigen Sp-100 [KO:K15413]
101659033  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
101639668  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
101651090  antigen peptide transporter 2-like [KO:K05654] [EC:7.4.2.14]
101651392  LOW QUALITY PROTEIN: antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
101653895  tapasin isoform X1 [KO:K08058]
101644593  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
101661269  calreticulin-like [KO:K08057]
101651535  CALR; calreticulin [KO:K08057]
105979518  LOW QUALITY PROTEIN: patr class I histocompatibility antigen, B-2 alpha chain-like [KO:K06751]
101659346  class I histocompatibility antigen, Gogo-C*0203 alpha chain isoform X1 [KO:K06751]
101648901  HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
101651706  HLA class I histocompatibility antigen, B alpha chain-like isoform X2 [KO:K06751]
101651748  patr class I histocompatibility antigen, A-2 alpha chain-like isoform X2 [KO:K06751]
101656976  HLA class I histocompatibility antigen, alpha chain G-like isoform X1 [KO:K06751]
101653058  B2M; beta-2-microglobulin [KO:K08055]
101651698  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
101655577  HLA class II histocompatibility antigen, DR beta 5 chain-like [KO:K06752]
101655267  mamu class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
123522014  HLA class II histocompatibility antigen, DO beta chain-like [KO:K06752]
101638712  mamu class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
101639035  mamu class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
101652007  HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752]
101652643  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
101651302  CD74; HLA class II histocompatibility antigen gamma chain [KO:K06505]
101641853  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101654217  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101640675  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
101655654  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101659995  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101657368  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101643102  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101649881  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101655315  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101654757  TSC1; hamartin isoform X2 [KO:K07206]
101663717  TSC2; tuberin isoform X1 [KO:K07207]
101648247  RHEB; GTP-binding protein Rheb [KO:K07208]
101664135  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
101645648  eukaryotic translation initiation factor 4E-binding protein 1-like [KO:K07205]
101651127  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
101655576  SRPK1; SRSF protein kinase 1 isoform X1 [KO:K15409] [EC:2.7.11.1]
101652301  SRSF1; serine/arginine-rich splicing factor 1 [KO:K12890]
101648722  serine/arginine-rich splicing factor 2-like [KO:K12891]
101658177  SRSF3; serine/arginine-rich splicing factor 3 [KO:K12892]
115873771  serine/arginine-rich splicing factor 3-like [KO:K12892]
123521257  serine/arginine-rich splicing factor 3-like [KO:K12892]
101647736  SRSF4; serine/arginine-rich splicing factor 4 isoform X1 [KO:K12893]
101645685  SRSF6; serine/arginine-rich splicing factor 6 [KO:K12893]
101655088  SRSF5; serine/arginine-rich splicing factor 5 isoform X1 [KO:K12893]
101647873  SRSF7; serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896]
101659330  SRSF9; serine/arginine-rich splicing factor 9 [KO:K21123]
123521716  nuclear RNA export factor 1-like [KO:K14284]
101647612  nuclear RNA export factor 2 [KO:K14284]
101648549  nuclear RNA export factor 2-like [KO:K14284]
101650421  nuclear RNA export factor 2-like isoform X1 [KO:K14284]
123521723  nuclear RNA export factor 3-like [KO:K14284]
123521724  nuclear RNA export factor 3-like [KO:K14284]
123521725  nuclear RNA export factor 1-like isoform X1 [KO:K14284]
123521751  nuclear RNA export factor 3-like [KO:K14284]
101664005  nuclear RNA export factor 3-like [KO:K14284]
101652766  NXF1; nuclear RNA export factor 1 [KO:K14284]
101657422  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
101643813  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X3 [KO:K03171]
101638051  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
101659226  BID; BH3-interacting domain death agonist [KO:K04726]
101646711  BAX; apoptosis regulator BAX [KO:K02159]
101656097  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
101658729  BAD; bcl2-associated agonist of cell death [KO:K02158]
101659722  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
101644838  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
101659262  bcl-2-like protein 1 [KO:K04570]
101661288  cytochrome c, testis-specific [KO:K08738]
101650600  cytochrome c-like [KO:K08738]
101656765  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
101659735  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
101643856  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
C20935  2-5A
Reference
PMID:12787566
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Granger SW, Rickert S
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LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
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Cytokine Growth Factor Rev 14:289-96 (2003)
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Reference
PMID:19495760
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Steinberg MW, Shui JW, Ware CF, Kronenberg M
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Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
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Semin Immunopathol 31:207-21 (2009)
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Reference
PMID:20221426
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Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
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PLoS One 5:e9560 (2010)
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Reference
PMID:23150579
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Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
  Title
alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
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Proc Natl Acad Sci U S A 109:19792-7 (2012)
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Reference
PMID:25375272
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Gianni T, Campadelli-Fiume G
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The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
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PLoS Pathog 10:e1004477 (2014)
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Reference
PMID:15056211
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Spear PG
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Herpes simplex virus: receptors and ligands for cell entry.
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Cell Microbiol 6:401-10 (2004)
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Reference
PMID:12855695
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Boutell C, Everett RD
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The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
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J Biol Chem 278:36596-602 (2003)
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Reference
PMID:24262390
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Ma Y, He B
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Recognition of herpes simplex viruses: toll-like receptors and beyond.
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J Mol Biol 426:1133-47 (2014)
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Reference
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Evasion of host antiviral innate immunity by HSV-1, an update.
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Virol J 13:38 (2016)
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Reference
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Melchjorsen J, Matikainen S, Paludan SR
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Activation and evasion of innate antiviral immunity by herpes simplex virus.
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Viruses 1:737-59 (2009)
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Reference
PMID:15276609
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Morrison LA
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The Toll of herpes simplex virus infection.
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Trends Microbiol 12:353-6 (2004)
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Reference
PMID:29298887
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Zheng C
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Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
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J Virol 92:e00099-17 (2018)
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Reference
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Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
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Design and application of oncolytic HSV vectors for glioblastoma therapy.
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Expert Rev Neurother 9:505-17 (2009)
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Reference
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The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
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J Virol 87:859-71 (2013)
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Reference
PMID:17229694
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Sanchez R, Mohr I
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Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
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J Virol 81:3455-64 (2007)
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Reference
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The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
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Trends Biochem Sci 28:294-304 (2003)
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Reference
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Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
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Vaccines (Basel) 4:E23 (2016)
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Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
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Reference
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J Virol 87:10244-54 (2013)
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Reference
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Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
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Viruses 1:1240-64 (2009)
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Reference
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Viral evasion of T cell immunity: ancient mechanisms offering new applications.
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Curr Opin Immunol 23:96-103 (2011)
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Reference
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Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.
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J Immunol 171:3075-83 (2003)
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Reference
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The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
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Virology 479-480:568-77 (2015)
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Reference
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Vink EI, Smiley JR, Mohr I
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Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
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J Virol 91:e00295-17 (2017)
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Reference
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The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
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Front Biosci 13:5241-56 (2008)
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Reference
PMID:15078920
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Viral regulation of mRNA export.
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J Virol 78:4389-96 (2004)
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Reference
PMID:27154074
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The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
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Virol J 13:77 (2016)
DOI:10.1186/s12985-016-0528-0
Related
pathway
etf03040  Spliceosome
etf03050  Proteasome
etf04115  p53 signaling pathway
etf04151  PI3K-Akt signaling pathway
etf04210  Apoptosis
etf04610  Complement and coagulation cascades
etf04612  Antigen processing and presentation
etf04620  Toll-like receptor signaling pathway
etf04622  RIG-I-like receptor signaling pathway
etf04630  JAK-STAT signaling pathway
KO pathway
ko05168   
LinkDB

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