KEGG   PATHWAY: etf05168
Entry
etf05168                    Pathway                                
Name
Herpes simplex virus 1 infection - Echinops telfairi (small Madagascar hedgehog)
Description
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class
Human Diseases; Infectious disease: viral
Pathway map
etf05168  Herpes simplex virus 1 infection
etf05168

Disease
H00365  Herpes simplex virus infection
Organism
Echinops telfairi (small Madagascar hedgehog) [GN:etf]
Gene
101638051  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
101638709  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
101638712  [KO:K06752]
101639035  [KO:K06752]
101639333  IL1B; interleukin-1 beta [KO:K04519]
101639489  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
101639566  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
101639668  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
101640115  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
101640204  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
101640636  EIF2B2; translation initiation factor eIF-2B subunit beta [KO:K03754]
101640652  ITGA5; integrin alpha-5 [KO:K06484]
101640675  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
101640829  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
101640830  IFNGR2; interferon gamma receptor 2 [KO:K05133]
101641002  [KO:K14624]
101641434  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
101641618  IL12A; interleukin-12 subunit alpha [KO:K05406]
101641853  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101642220  HCFC2; host cell factor 2 [KO:K27390]
101642439  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
101642657  IFNGR1; interferon gamma receptor 1 [KO:K05132]
101642693  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
101642915  [KO:K15412]
101643102  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101643108  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X2 [KO:K04733] [EC:2.7.11.1]
101643318  [KO:K14216] [EC:2.7.7.84]
101643417  TLR2; toll-like receptor 2 isoform X1 [KO:K10159]
101643556  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
101643629  OAS2; 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
101643813  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X3 [KO:K03171]
101643856  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
101644240  IL6; interleukin-6 [KO:K05405]
101644328  IFNG; interferon gamma [KO:K04687]
101644448  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
101644593  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
101644605  DAXX; death domain-associated protein 6 [KO:K02308]
101644613  CGAS; cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
101644838  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
101645531  CCL5; C-C motif chemokine 5 [KO:K12499]
101645648  [KO:K07205]
101645685  SRSF6; serine/arginine-rich splicing factor 6 [KO:K12893]
101645846  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 [KO:K16194] [EC:2.7.11.1]
101646711  BAX; apoptosis regulator BAX [KO:K02159]
101647154  EIF2B5; translation initiation factor eIF-2B subunit epsilon [KO:K03240]
101647452  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
101647612  [KO:K14284]
101647709  IRF7; interferon regulatory factor 7 [KO:K09447]
101647736  SRSF4; serine/arginine-rich splicing factor 4 isoform X1 [KO:K12893]
101647784  [KO:K04451]
101647812  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
101647873  SRSF7; serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896]
101647976  TLR3; toll-like receptor 3 [KO:K05401]
101648095  POU2F3; POU domain, class 2, transcription factor 3 [KO:K09364]
101648136  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
101648247  RHEB; GTP-binding protein Rheb [KO:K07208]
101648549  [KO:K14284]
101648722  [KO:K12891]
101648901  [KO:K06751]
101649079  IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
101649228  STING1; stimulator of interferon genes protein [KO:K12654]
101649346  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
101649582  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
101649587  [KO:K15413]
101649684  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
101649686  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
101649743  EIF2B4; translation initiation factor eIF-2B subunit delta isoform X1 [KO:K03680]
101649881  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101650421  [KO:K14284]
101650484  IL12B; interleukin-12 subunit beta [KO:K05425]
101650550  IFNB1; interferon beta [KO:K05415]
101650561  EIF2B1; translation initiation factor eIF-2B subunit alpha isoform X2 [KO:K03239]
101650600  [KO:K08738]
101650838  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
101650862  [KO:K05414]
101651090  [KO:K05654] [EC:7.4.2.14]
101651114  CARD9; caspase recruitment domain-containing protein 9 isoform X1 [KO:K12794]
101651127  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
101651201  C5; complement C5 [KO:K03994]
101651302  CD74; HLA class II histocompatibility antigen gamma chain [KO:K06505]
101651392  [KO:K05654] [EC:7.4.2.14]
101651495  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
101651535  CALR; calreticulin [KO:K08057]
101651698  [KO:K06752]
101651706  [KO:K06751]
101651748  [KO:K06751]
101652007  [KO:K06752]
101652271  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
101652301  SRSF1; serine/arginine-rich splicing factor 1 [KO:K12890]
101652544  POU2F2; POU domain, class 2, transcription factor 2 [KO:K09364]
101652643  [KO:K06752]
101652766  NXF1; nuclear RNA export factor 1 [KO:K14284]
101652914  HCFC1; host cell factor 1 isoform X5 [KO:K14966]
101653058  B2M; beta-2-microglobulin [KO:K08055]
101653170  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
101653184  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
101653361  ITGB3; integrin beta-3 [KO:K06493]
101653895  [KO:K08058]
101654217  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101654325  LTA; lymphotoxin-alpha [KO:K05468]
101654642  TNF; tumor necrosis factor [KO:K03156]
101654757  TSC1; hamartin isoform X2 [KO:K07206]
101654763  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
101655088  SRSF5; serine/arginine-rich splicing factor 5 isoform X1 [KO:K12893]
101655200  TRAF5; TNF receptor-associated factor 5 [KO:K09849]
101655267  [KO:K06752]
101655315  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101655576  SRPK1; SRSF protein kinase 1 isoform X1 [KO:K15409] [EC:2.7.11.1]
101655577  [KO:K06752]
101655654  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101655890  [KO:K16060]
101656097  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
101656238  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
101656530  TP53; cellular tumor antigen p53 [KO:K04451]
101656573  [KO:K06269] [EC:3.1.3.16]
101656725  NECTIN1; nectin-1 [KO:K06081]
101656765  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
101656976  [KO:K06751]
101657008  POU2F1; POU domain, class 2, transcription factor 1 isoform X1 [KO:K09364]
101657011  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
101657368  [KO:K02649]
101657422  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
101657758  EIF2AK4; eIF-2-alpha kinase GCN2 [KO:K16196] [EC:2.7.11.1]
101658177  SRSF3; serine/arginine-rich splicing factor 3 [KO:K12892]
101658729  BAD; bcl2-associated agonist of cell death [KO:K02158]
101658809  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
101659021  NECTIN2; nectin-2 isoform X1 [KO:K06531]
101659033  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
101659133  [KO:K16060]
101659226  BID; BH3-interacting domain death agonist [KO:K04726]
101659262  [KO:K04570]
101659330  SRSF9; serine/arginine-rich splicing factor 9 [KO:K21123]
101659346  [KO:K06751]
101659376  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
101659722  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
101659735  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
101659995  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101661246  C3; complement C3 [KO:K03990]
101661269  [KO:K08057]
101661288  [KO:K08738]
101661569  TNFSF14; tumor necrosis factor ligand superfamily member 14 isoform X1 [KO:K05477]
101661602  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
101661897  EIF2B3; translation initiation factor eIF-2B subunit gamma isoform X3 [KO:K03241]
101662141  [KO:K14624]
101662447  RNASEL; 2-5A-dependent ribonuclease [KO:K01165]
101662652  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101662706  ZC3HAV1; zinc finger CCCH-type antiviral protein 1 [KO:K28004]
101663462  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
101663486  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
101663717  TSC2; tuberin isoform X1 [KO:K07207]
101663779  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
101663870  RELA; transcription factor p65 [KO:K04735]
101663948  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
101663983  IRF9; LOW QUALITY PROTEIN: interferon regulatory factor 9 [KO:K04693]
101664005  [KO:K14284]
101664135  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
101664197  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
105979518  [KO:K06751]
115869468  [KO:K16060]
115872044  TLR9; toll-like receptor 9 [KO:K10161]
115873309  [KO:K05842]
115873771  [KO:K12892]
123521257  [KO:K12892]
123521716  [KO:K14284]
123521723  [KO:K14284]
123521724  [KO:K14284]
123521725  [KO:K14284]
123521751  [KO:K14284]
123522014  [KO:K06752]
123522712  [KO:K05405]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
C20935  2-5A
Reference
PMID:12787566
  Authors
Granger SW, Rickert S
  Title
LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
  Journal
Cytokine Growth Factor Rev 14:289-96 (2003)
DOI:10.1016/S1359-6101(03)00031-5
Reference
PMID:19495760
  Authors
Steinberg MW, Shui JW, Ware CF, Kronenberg M
  Title
Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
  Journal
Semin Immunopathol 31:207-21 (2009)
DOI:10.1007/s00281-009-0157-4
Reference
PMID:20221426
  Authors
MacLeod IJ, Minson T
  Title
Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
  Journal
PLoS One 5:e9560 (2010)
DOI:10.1371/journal.pone.0009560
Reference
PMID:23150579
  Authors
Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
  Title
alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
  Journal
Proc Natl Acad Sci U S A 109:19792-7 (2012)
DOI:10.1073/pnas.1212597109
Reference
PMID:25375272
  Authors
Gianni T, Campadelli-Fiume G
  Title
The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
  Journal
PLoS Pathog 10:e1004477 (2014)
DOI:10.1371/journal.ppat.1004477
Reference
PMID:15056211
  Authors
Spear PG
  Title
Herpes simplex virus: receptors and ligands for cell entry.
  Journal
Cell Microbiol 6:401-10 (2004)
DOI:10.1111/j.1462-5822.2004.00389.x
Reference
PMID:12855695
  Authors
Boutell C, Everett RD
  Title
The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
  Journal
J Biol Chem 278:36596-602 (2003)
DOI:10.1074/jbc.M300776200
Reference
PMID:24262390
  Authors
Ma Y, He B
  Title
Recognition of herpes simplex viruses: toll-like receptors and beyond.
  Journal
J Mol Biol 426:1133-47 (2014)
DOI:10.1016/j.jmb.2013.11.012
Reference
PMID:26952111
  Authors
Su C, Zhan G, Zheng C
  Title
Evasion of host antiviral innate immunity by HSV-1, an update.
  Journal
Virol J 13:38 (2016)
DOI:10.1186/s12985-016-0495-5
Reference
PMID:21994567
  Authors
Melchjorsen J, Matikainen S, Paludan SR
  Title
Activation and evasion of innate antiviral immunity by herpes simplex virus.
  Journal
Viruses 1:737-59 (2009)
DOI:10.3390/v1030737
Reference
PMID:15276609
  Authors
Morrison LA
  Title
The Toll of herpes simplex virus infection.
  Journal
Trends Microbiol 12:353-6 (2004)
DOI:10.1016/j.tim.2004.06.001
Reference
PMID:29298887
  Authors
Zheng C
  Title
Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
  Journal
J Virol 92:e00099-17 (2018)
DOI:10.1128/JVI.00099-17
Reference
PMID:19344302
  Authors
Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
  Title
Design and application of oncolytic HSV vectors for glioblastoma therapy.
  Journal
Expert Rev Neurother 9:505-17 (2009)
DOI:10.1586/ern.09.9
Reference
PMID:23115300
  Authors
Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A
  Title
The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
  Journal
J Virol 87:859-71 (2013)
DOI:10.1128/JVI.01158-12
Reference
PMID:17229694
  Authors
Sanchez R, Mohr I
  Title
Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
  Journal
J Virol 81:3455-64 (2007)
DOI:10.1128/JVI.02520-06
Reference
PMID:12826401
  Authors
Wysocka J, Herr W
  Title
The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
  Journal
Trends Biochem Sci 28:294-304 (2003)
DOI:10.1016/S0968-0004(03)00088-4
Reference
PMID:27367734
  Authors
Fleming SB
  Title
Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
  Journal
Vaccines (Basel) 4:E23 (2016)
DOI:10.3390/vaccines4030023
Reference
PMID:15163721
  Authors
Yokota S, Yokosawa N, Okabayashi T, Suzutani T, Miura S, Jimbow K, Fujii N
  Title
Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
  Journal
J Virol 78:6282-6 (2004)
DOI:10.1128/JVI.78.12.6282-6286.2004
Reference
PMID:23864622
  Authors
Gu H, Zheng Y, Roizman B
  Title
Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.
  Journal
J Virol 87:10244-54 (2013)
DOI:10.1128/JVI.01487-13
Reference
PMID:21994592
  Authors
Tavalai N, Stamminger T
  Title
Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
  Journal
Viruses 1:1240-64 (2009)
DOI:10.3390/v1031240
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:12960333
  Authors
Neumann J, Eis-Hubinger AM, Koch N
  Title
Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.
  Journal
J Immunol 171:3075-83 (2003)
DOI:10.4049/jimmunol.171.6.3075
Reference
PMID:25798530
  Authors
Liu X, Cohen JI
  Title
The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
  Journal
Virology 479-480:568-77 (2015)
DOI:10.1016/j.virol.2015.02.040
Reference
PMID:28468873
  Authors
Vink EI, Smiley JR, Mohr I
  Title
Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
  Journal
J Virol 91:e00295-17 (2017)
DOI:10.1128/JVI.00295-17
Reference
PMID:18508584
  Authors
Sandri-Goldin RM
  Title
The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
  Journal
Front Biosci 13:5241-56 (2008)
DOI:10.2741/3078
Reference
PMID:15078920
  Authors
Sandri-Goldin RM
  Title
Viral regulation of mRNA export.
  Journal
J Virol 78:4389-96 (2004)
DOI:10.1128/JVI.78.9.4389-4396.2004
Reference
PMID:27154074
  Authors
Yu X, He S
  Title
The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
  Journal
Virol J 13:77 (2016)
DOI:10.1186/s12985-016-0528-0
Related
pathway
etf03040  Spliceosome
etf03050  Proteasome
etf04115  p53 signaling pathway
etf04151  PI3K-Akt signaling pathway
etf04210  Apoptosis
etf04610  Complement and coagulation cascades
etf04612  Antigen processing and presentation
etf04620  Toll-like receptor signaling pathway
etf04622  RIG-I-like receptor signaling pathway
etf04630  JAK-STAT signaling pathway
KO pathway
ko05168   

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