KEGG   PATHWAY: gvr05167
Entry
gvr05167                    Pathway                                
Name
Kaposi sarcoma-associated herpesvirus infection - Galeopterus variegatus (Sunda flying lemur)
Description
Kaposi sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-8), is the most recently identified human tumor virus, and is associated with the pathogenesis of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and Multicentric Castleman's disease (MCD). Like all other herpesviruses, KSHV displays two modes of life cycle, latency and lytic replication, which are characterized by the patterns of viral gene expression. Genes expressed in latency (LANA, v-cyclin, v-FLIP, Kaposins A, B and C and viral miRNAs) are mainly thought to facilitate the establishment of life long latency in its host and survival against the host innate, and adaptive immune surveillance mechanisms. Among the viral proteins shown to be expressed during lytic replication are potent signaling molecules such as vGPCR, vIL6, vIRFs, vCCLs, K1 and K15, which have been implicated experimentally in the angiogenic and inflammatory phenotype observed in KS lesions. Several of these latent viral and lytic proteins are known to transform host cells, linking KSHV with the development of severe human malignancies.
Class
Human Diseases; Infectious disease: viral
Pathway map
gvr05167  Kaposi sarcoma-associated herpesvirus infection
gvr05167

Organism
Galeopterus variegatus (Sunda flying lemur) [GN:gvr]
Gene
103599528  C3; complement C3 [KO:K03990]
103581831  TLR3; toll-like receptor 3 [KO:K05401]
103603246  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
103609553  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
103590768  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
103590122  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
103609517  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
103598039  interferon alpha-4-like [KO:K05414]
103598040  interferon alpha-10-like [KO:K05414]
103598043  interferon alpha-10-like [KO:K05414]
103598044  interferon alpha-3-like [KO:K05414]
103592597  IRF3; interferon regulatory factor 3 [KO:K05411]
103595030  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
103591893  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
103609847  interferon beta-like [KO:K05415]
103609850  interferon beta-like [KO:K05415]
103584029  interferon beta-like [KO:K05415]
103585996  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
103585997  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
103591505  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
103594750  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
103588074  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
103594016  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
103590163  IRF9; interferon regulatory factor 9 [KO:K04693]
103605127  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
103607428  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
103607442  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
103587477  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
103587478  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
103600441  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
103583282  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
103598176  ZFP36; tristetraprolin [KO:K15308]
103585928  IL6; interleukin-6 [KO:K05405]
103590058  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
103598168  CCR3; C-C chemokine receptor type 3 [KO:K04178]
103598166  CCR5; C-C chemokine receptor type 5 [KO:K04180]
103606504  CCR1; C-C chemokine receptor type 1 [KO:K04176]
103599474  CCR4; C-C chemokine receptor type 4 [KO:K04179]
103596008  CCR8; C-C chemokine receptor type 8 [KO:K04183]
103607184  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
103605154  FADD; FAS-associated death domain protein [KO:K02373]
103597790  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
103594881  BID; BH3-interacting domain death agonist [KO:K04726]
103587762  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
103599851  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
103610678  cytochrome c, somatic [KO:K08738]
103590229  cytochrome c, somatic-like [KO:K08738]
103590595  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
103589530  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
103605365  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
103602860  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
103610047  TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
103610988  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
103588798  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
103589266  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103604367  IKBKG; NF-kappa-B essential modulator [KO:K07210]
103591436  NFKBIA; LOW QUALITY PROTEIN: NF-kappa-B inhibitor alpha [KO:K04734]
103597025  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
103595334  RELA; transcription factor p65 [KO:K04735]
103591400  TP53; cellular tumor antigen p53 [KO:K04451]
103607313  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
103609174  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
103590136  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
103593663  RB1; retinoblastoma-associated protein [KO:K06618]
103586861  E2F1; transcription factor E2F1 [KO:K17454]
103590624  E2F2; transcription factor E2F2 [KO:K09389]
103590253  E2F3; transcription factor E2F3 [KO:K06620]
103609219  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, A-11 alpha chain-like [KO:K06751]
103610244  LOW QUALITY PROTEIN: saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
103602353  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
103610772  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
103606064  patr class I histocompatibility antigen, A-2 alpha chain [KO:K06751]
103586434  LOW QUALITY PROTEIN: saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
103592560  HLA class I histocompatibility antigen, alpha chain E-like [KO:K06751]
103591435  IFNGR1; interferon gamma receptor 1 [KO:K05132]
103594756  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
103583502  CD86; T-lymphocyte activation antigen CD86 isoform X1 [KO:K05413]
103606065  MHC class I polypeptide-related sequence B-like [KO:K07985]
103594808  CLEC2B; C-type lectin domain family 2 member B [KO:K10071]
103606030  UBA52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
103595441  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
103588961  UBB; polyubiquitin-B [KO:K04551]
103591776  UBC; polyubiquitin-C [KO:K08770]
103594994  beclin-2-like [KO:K08334]
103582423  LOW QUALITY PROTEIN: beclin-1-like [KO:K08334]
103589852  BECN1; beclin-1 isoform X1 [KO:K08334]
103593656  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
103603652  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
103591341  ATG3; ubiquitin-like-conjugating enzyme ATG3 [KO:K08343]
103587192  LOW QUALITY PROTEIN: ubiquitin-like-conjugating enzyme ATG3 [KO:K08343]
103581725  LOW QUALITY PROTEIN: microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
103589305  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
103598197  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
103599715  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
103596930  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
103586407  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
103586779  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
103601724  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
103591088  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
103592984  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X1 [KO:K04544]
103589599  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
103588774  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
103589588  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 isoform X1 [KO:K04548]
103610513  HRAS; GTPase HRas isoform X1 [KO:K02833]
103599501  KRAS; GTPase KRas [KO:K07827]
103589329  NRAS; GTPase NRas [KO:K07828]
103590618  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
103596129  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103600170  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
103592192  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103600324  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103585213  HIF1A; hypoxia-inducible factor 1-alpha [KO:K08268]
103592390  JUN; transcription factor AP-1 [KO:K04448]
103605891  FOS; proto-oncogene c-Fos [KO:K04379]
103586741  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
103584426  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
103584437  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
103586572  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
103586784  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103587883  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
103585463  PIK3R3; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
103593683  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
103608454  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
103596384  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103590279  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103598325  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103605698  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
103601062  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
103594179  PREX1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein isoform X1 [KO:K12365]
103594082  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
103582610  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
103603521  mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
103585627  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
103606635  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
103606476  cell surface glycoprotein CD200 receptor 1-like [KO:K21668]
103606477  LOW QUALITY PROTEIN: cell surface glycoprotein CD200 receptor 1-like [KO:K21668]
103585244  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
103592660  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
103594006  HCK; tyrosine-protein kinase HCK [KO:K08893] [EC:2.7.10.2]
103597005  tyrosine-protein kinase Lyn-like [KO:K05854] [EC:2.7.10.2]
103600274  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
103596394  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
103591521  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
103606318  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
103598637  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
103597698  inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
103601309  calmodulin-like protein 3 [KO:K02183]
103601310  CALML5; calmodulin-like protein 5 [KO:K02183]
103588449  CALM1; calmodulin [KO:K02183]
103601992  calmodulin-like [KO:K02183]
103591330  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
103592983  CALM3; LOW QUALITY PROTEIN: calmodulin [KO:K02183]
103599723  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
103591114  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
103598106  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
103598210  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
103604521  PPP3R2; calcineurin subunit B type 2 isoform X1 [KO:K06268]
103585050  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
103598251  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
103586032  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
103590142  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
103591379  CXCL8; interleukin-8 [KO:K10030]
103592767  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
103590267  growth-regulated protein homolog gamma-like [KO:K05505]
103591375  growth-regulated protein homolog gamma-like [KO:K05505]
103600597  growth-regulated protein homolog gamma-like isoform X1 [KO:K05505]
103600599  growth-regulated protein homolog gamma-like [KO:K05505]
103600600  growth-regulated protein homolog beta-like [KO:K05505]
103586962  RCAN1; calcipressin-1 [KO:K17901]
103585760  VEGFA; LOW QUALITY PROTEIN: vascular endothelial growth factor A [KO:K05448]
103600468  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
103589952  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
103588371  IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
103594579  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
103595356  signal transducer and activator of transcription 3-like [KO:K04692]
103595392  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
103600945  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
103592399  TCF7; transcription factor 7 isoform X1 [KO:K02620]
103585949  TCF7L1; transcription factor 7-like 1 isoform X1 [KO:K04490]
103589124  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
103593743  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
103586701  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
103607082  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
103587820  MYC; myc proto-oncogene protein [KO:K04377]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00350  Phosphatidylethanolamine
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:22403573
  Authors
Lee HR, Brulois K, Wong L, Jung JU
  Title
Modulation of Immune System by Kaposi's Sarcoma-Associated Herpesvirus: Lessons from Viral Evasion Strategies.
  Journal
Front Microbiol 3:44 (2012)
DOI:10.3389/fmicb.2012.00044
Reference
PMID:18948197
  Authors
Liang C, Lee JS, Jung JU
  Title
Immune evasion in Kaposi's sarcoma-associated herpes virus associated oncogenesis.
  Journal
Semin Cancer Biol 18:423-36 (2008)
DOI:10.1016/j.semcancer.2008.09.003
Reference
PMID:21040832
  Authors
Cai Q, Verma SC, Lu J, Robertson ES
  Title
Molecular biology of Kaposi's sarcoma-associated herpesvirus and related oncogenesis.
  Journal
Adv Virus Res 78:87-142 (2010)
DOI:10.1016/B978-0-12-385032-4.00003-3
Reference
PMID:16760382
  Authors
Rezaee SA, Cunningham C, Davison AJ, Blackbourn DJ
  Title
Kaposi's sarcoma-associated herpesvirus immune modulation: an overview.
  Journal
J Gen Virol 87:1781-804 (2006)
DOI:10.1099/vir.0.81919-0
Reference
PMID:19230674
  Authors
Areste C, Blackbourn DJ
  Title
Modulation of the immune system by Kaposi's sarcoma-associated herpesvirus.
  Journal
Trends Microbiol 17:119-29 (2009)
DOI:10.1016/j.tim.2008.12.001
Reference
PMID:16905191
  Authors
Mark L, Spiller OB, Villoutreix BO, Blom AM
  Title
Kaposi's sarcoma-associated herpes virus complement control protein: KCP--complement inhibition and more.
  Journal
Mol Immunol 44:11-22 (2007)
DOI:10.1016/j.molimm.2006.06.018
Reference
PMID:11500830
  Authors
Weber KS, Grone HJ, Rocken M, Klier C, Gu S, Wank R, Proudfoot AE, Nelson PJ, Weber C
  Title
Selective recruitment of Th2-type cells and evasion from a cytotoxic immune response mediated by viral macrophage inhibitory protein-II.
  Journal
Eur J Immunol 31:2458-66 (2001)
DOI:10.1002/1521-4141(200108)31:8<2458::AID-IMMU2458>3.0.CO;2-L
Reference
PMID:10666184
  Authors
Stine JT, Wood C, Hill M, Epp A, Raport CJ, Schweickart VL, Endo Y, Sasaki T, Simmons G, Boshoff C, Clapham P, Chang Y, Moore P, Gray PW, Chantry D
  Title
KSHV-encoded CC chemokine vMIP-III is a CCR4 agonist, stimulates angiogenesis, and selectively chemoattracts TH2 cells.
  Journal
Blood 95:1151-7 (2000)
Reference
PMID:26431609
  Authors
Schulz TF, Cesarman E
  Title
Kaposi Sarcoma-associated Herpesvirus: mechanisms of oncogenesis.
  Journal
Curr Opin Virol 14:116-28 (2015)
DOI:10.1016/j.coviro.2015.08.016
Reference
PMID:10377196
  Authors
Endres MJ, Garlisi CG, Xiao H, Shan L, Hedrick JA
  Title
The Kaposi's sarcoma-related herpesvirus (KSHV)-encoded chemokine vMIP-I is a specific agonist for the CC chemokine receptor (CCR)8.
  Journal
J Exp Med 189:1993-8 (1999)
DOI:10.1084/jem.189.12.1993
Reference
PMID:18434408
  Authors
Choi YB, Nicholas J
  Title
Autocrine and paracrine promotion of cell survival and virus replication by human herpesvirus 8 chemokines.
  Journal
J Virol 82:6501-13 (2008)
DOI:10.1128/JVI.02396-07
Reference
PMID:15692053
  Authors
McCormick C, Ganem D
  Title
The kaposin B protein of KSHV activates the p38/MK2 pathway and stabilizes cytokine mRNAs.
  Journal
Science 307:739-41 (2005)
DOI:10.1126/science.1105779
Reference
PMID:15967719
  Authors
Wang HW, Boshoff C
  Title
Linking Kaposi virus to cancer-associated cytokines.
  Journal
Trends Mol Med 11:309-12 (2005)
DOI:10.1016/j.molmed.2005.06.002
Reference
PMID:16828973
  Authors
Jarviluoma A, Ojala PM
  Title
Cell signaling pathways engaged by KSHV.
  Journal
Biochim Biophys Acta 1766:140-58 (2006)
DOI:10.1016/j.bbcan.2006.05.001
Reference
PMID:12032073
  Authors
Wang HW, Sharp TV, Koumi A, Koentges G, Boshoff C
  Title
Characterization of an anti-apoptotic glycoprotein encoded by Kaposi's sarcoma-associated herpesvirus which resembles a spliced variant of human survivin.
  Journal
EMBO J 21:2602-15 (2002)
DOI:10.1093/emboj/21.11.2602
Reference
PMID:10510092
  Authors
Djerbi M, Screpanti V, Catrina AI, Bogen B, Biberfeld P, Grandien A
  Title
The inhibitor of death receptor signaling, FLICE-inhibitory protein defines a new class of tumor progression factors.
  Journal
J Exp Med 190:1025-32 (1999)
DOI:10.1084/jem.190.7.1025
Reference
PMID:10523854
  Authors
Chaudhary PM, Jasmin A, Eby MT, Hood L
  Title
Modulation of the NF-kappa B pathway by virally encoded death effector domains-containing proteins.
  Journal
Oncogene 18:5738-46 (1999)
DOI:10.1038/sj.onc.1202976
Reference
PMID:12890756
  Authors
Field N, Low W, Daniels M, Howell S, Daviet L, Boshoff C, Collins M
  Title
KSHV vFLIP binds to IKK-gamma to activate IKK.
  Journal
J Cell Sci 116:3721-8 (2003)
DOI:10.1242/jcs.00691
Reference
PMID:20865011
  Authors
Mesri EA, Cesarman E, Boshoff C
  Title
Kaposi's sarcoma and its associated herpesvirus.
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Nat Rev Cancer 10:707-19 (2010)
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PMID:10799607
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Ishido S, Wang C, Lee BS, Cohen GB, Jung JU
  Title
Downregulation of major histocompatibility complex class I molecules by Kaposi's sarcoma-associated herpesvirus K3 and K5 proteins.
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J Virol 74:5300-9 (2000)
DOI:10.1128/JVI.74.11.5300-5309.2000
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PMID:17166914
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Li Q, Means R, Lang S, Jung JU
  Title
Downregulation of gamma interferon receptor 1 by Kaposi's sarcoma-associated herpesvirus K3 and K5.
  Journal
J Virol 81:2117-27 (2007)
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PMID:18230726
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Thomas M, Boname JM, Field S, Nejentsev S, Salio M, Cerundolo V, Wills M, Lehner PJ
  Title
Down-regulation of NKG2D and NKp80 ligands by Kaposi's sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicity.
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Proc Natl Acad Sci U S A 105:1656-61 (2008)
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PMID:11413168
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Coscoy L, Ganem D
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A viral protein that selectively downregulates ICAM-1 and B7-2 and modulates T cell costimulation.
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J Clin Invest 107:1599-606 (2001)
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Cells 1:617-30 (2012)
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Schulz TF, Moore PS
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Kaposi's sarcoma-associated herpesvirus: a new human tumor virus, but how?
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Trends Microbiol 7:196-200 (1999)
DOI:10.1016/S0966-842X(99)01495-X
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PMID:9594662
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  Title
Antiviral activity of tumor-suppressor pathways: clues from molecular piracy by KSHV.
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Trends Genet 14:144-50 (1998)
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  Authors
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  Title
Molecular biology and pathogenesis of Kaposi sarcoma-associated herpesvirus.
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FEMS Microbiol Lett 222:155-63 (2003)
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PMID:11960692
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The molecular pathology of Kaposi's sarcoma-associated herpesvirus.
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Biochim Biophys Acta 1602:1-22 (2002)
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PMID:15220441
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Foster-Cuevas M, Wright GJ, Puklavec MJ, Brown MH, Barclay AN
  Title
Human herpesvirus 8 K14 protein mimics CD200 in down-regulating macrophage activation through CD200 receptor.
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J Virol 78:7667-76 (2004)
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PMID:10987301
  Authors
Sodhi A, Montaner S, Patel V, Zohar M, Bais C, Mesri EA, Gutkind JS
  Title
The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1alpha.
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Cancer Res 60:4873-80 (2000)
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Abere B, Schulz TF
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KSHV non-structural membrane proteins involved in the activation of intracellular signaling pathways and the pathogenesis of Kaposi's sarcoma.
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Curr Opin Virol 20:11-19 (2016)
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PMID:15573137
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Sodhi A, Montaner S, Gutkind JS
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Viral hijacking of G-protein-coupled-receptor signalling networks.
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Nat Rev Mol Cell Biol 5:998-1012 (2004)
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Montaner S
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Akt/TSC/mTOR activation by the KSHV G protein-coupled receptor: emerging insights into the molecular oncogenesis and treatment of Kaposi's sarcoma.
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Cell Cycle 6:438-43 (2007)
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PMID:23028325
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Kaposi's sarcoma herpesvirus K15 protein contributes to virus-induced angiogenesis by recruiting PLCgamma1 and activating NFAT1-dependent RCAN1 expression.
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PLoS Pathog 8:e1002927 (2012)
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PMID:10318948
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Lagunoff M, Majeti R, Weiss A, Ganem D
  Title
Deregulated signal transduction by the K1 gene product of Kaposi's sarcoma-associated herpesvirus.
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Proc Natl Acad Sci U S A 96:5704-9 (1999)
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PMID:26192396
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Biology and oncogenicity of the Kaposi sarcoma herpesvirus K1 protein.
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Rev Med Virol 25:273-85 (2015)
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PMID:25187543
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Havemeier A, Gramolelli S, Pietrek M, Jochmann R, Sturzl M, Schulz TF
  Title
Activation of NF-kappaB by the Kaposi's sarcoma-associated herpesvirus K15 protein involves recruitment of the NF-kappaB-inducing kinase, IkappaB kinases, and phosphorylation of p65.
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J Virol 88:13161-72 (2014)
DOI:10.1128/JVI.01766-14
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PMID:17050609
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Brinkmann MM, Pietrek M, Dittrich-Breiholz O, Kracht M, Schulz TF
  Title
Modulation of host gene expression by the K15 protein of Kaposi's sarcoma-associated herpesvirus.
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J Virol 81:42-58 (2007)
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PMID:16585191
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Wang L, Dittmer DP, Tomlinson CC, Fakhari FD, Damania B
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Immortalization of primary endothelial cells by the K1 protein of Kaposi's sarcoma-associated herpesvirus.
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Cancer Res 66:3658-66 (2006)
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PMID:22521915
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Morris VA, Punjabi AS, Wells RC, Wittkopp CJ, Vart R, Lagunoff M
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The KSHV viral IL-6 homolog is sufficient to induce blood to lymphatic endothelial cell differentiation.
  Journal
Virology 428:112-20 (2012)
DOI:10.1016/j.virol.2012.03.013
Reference
PMID:25594835
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Purushothaman P, Uppal T, Verma SC
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Molecular biology of KSHV lytic reactivation.
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Viruses 7:116-53 (2015)
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PMID:14991150
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Fujimuro M, Hayward SD
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Manipulation of glycogen-synthase kinase-3 activity in KSHV-associated cancers.
  Journal
J Mol Med (Berl) 82:223-31 (2004)
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PMID:26870016
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Purushothaman P, Dabral P, Gupta N, Sarkar R, Verma SC
  Title
KSHV Genome Replication and Maintenance.
  Journal
Front Microbiol 7:54 (2016)
DOI:10.3389/fmicb.2016.00054
Related
pathway
gvr04010  MAPK signaling pathway
gvr04064  NF-kappa B signaling pathway
gvr04110  Cell cycle
gvr04115  p53 signaling pathway
gvr04140  Autophagy - animal
gvr04144  Endocytosis
gvr04151  PI3K-Akt signaling pathway
gvr04210  Apoptosis
gvr04310  Wnt signaling pathway
gvr04610  Complement and coagulation cascades
gvr04620  Toll-like receptor signaling pathway
gvr04630  JAK-STAT signaling pathway
gvr04650  Natural killer cell mediated cytotoxicity
gvr04668  TNF signaling pathway
KO pathway
ko05167   
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