KEGG   PATHWAY: hmh04936
Entry
hmh04936                    Pathway                                
Name
Alcoholic liver disease - Hylobates moloch (silvery gibbon)
Description
Alcoholic liver disease (ALD) refers to the damages to the liver and its functions due to alcohol overconsumption. It ranges from simple steatosis to steatohepatitis, cirrhosis, and even hepatocellular carcinoma. Alcohol consumption promotes liver inflammation by increasing the translocation of gut-derived endotoxins to the portal circulation and activating Kupffer cells to produce TNF-alpha through the LPS/Toll like receptor (TLR) 4 pathways. TNF-alpha induces hepatocellular damage. When alcohol intake is chronic and heavy, steatosis is caused via generation of acetaldehyde, reactive oxygen species (ROS) and ER stress. ROS inhibits key hepatic transcriptional regulators such as AMP-activated kinase (AMPK) and peroxisome proliferator-activated receptor alpha (PPAR-alpha), which are responsible for fatty acid oxidation and export via ACC and CPT-1. The blockade of AMPK also leads to overexpression of SREBP-1, resulting in an increase of de novo lipogenesis. Moreover, excessive intracellular ROS production induced by ethanol and its metabolite have a critical role in ethanol-induced apoptosis, which may be the critical process in the exacerbation of ALD. It is inferred that the apoptotic signal derived from ROS that was produced by NOX, is mainly transduced through the JNK and p38 MAPK pathways.
Class
Human Diseases; Endocrine and metabolic disease
Pathway map
hmh04936  Alcoholic liver disease
hmh04936

Organism
Hylobates moloch (silvery gibbon) [GN:hmh]
Gene
116813049  C1QA; complement C1q subcomponent subunit A [KO:K03986]
116813046  C1QB; complement C1q subcomponent subunit B [KO:K03987]
116813047  C1QC; complement C1q subcomponent subunit C isoform X1 [KO:K03988]
116460294  C2; complement C2 [KO:K01332] [EC:3.4.21.43]
116460300  complement C4-B isoform X1 [KO:K03989]
116478338  C3; complement C3 [KO:K03990]
116472636  C3AR1; C3a anaphylatoxin chemotactic receptor [KO:K04009]
116475606  C5; complement C5 isoform X2 [KO:K03994]
116478286  C5AR1; C5a anaphylatoxin chemotactic receptor 1 [KO:K04010]
116461488  LBP; lipopolysaccharide-binding protein [KO:K05399]
116471599  CD14; monocyte differentiation antigen CD14 [KO:K04391]
116812651  LY96; lymphocyte antigen 96 [KO:K05400]
116475593  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
116477149  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein isoform X1 [KO:K05403]
116473667  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
116481090  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
116812171  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
116476347  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
116458812  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X2 [KO:K04403]
116463159  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
116463202  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
116469793  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
116485121  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
116461632  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
116464818  IKBKG; NF-kappa-B essential modulator isoform X2 [KO:K07210]
116484638  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
116469011  RELA; transcription factor p65 isoform X1 [KO:K04735]
116483343  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
116460115  TNF; tumor necrosis factor isoform X2 [KO:K03156]
116483283  IL1B; interleukin-1 beta [KO:K04519]
116813186  IL6; interleukin-6 isoform X1 [KO:K05405]
116463392  interleukin-12 subunit alpha [KO:K05406]
116463424  interleukin-12 subunit alpha [KO:K05406]
116471783  IL12B; interleukin-12 subunit beta [KO:K05425]
116467002  CXCL8; interleukin-8 [KO:K10030]
116457855  LOW QUALITY PROTEIN: TIR domain-containing adapter molecule 1-like [KO:K05842]
116483533  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
116485188  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
116457541  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
116480802  TBK1; serine/threonine-protein kinase TBK1 isoform X2 [KO:K05410] [EC:2.7.11.10]
116478197  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
116458330  interferon alpha-5 [KO:K05414]
116458331  interferon alpha-6 [KO:K05414]
116458332  interferon alpha-2 [KO:K05414]
116458527  interferon alpha-14 [KO:K05414]
116458611  interferon alpha-1/13 [KO:K05414]
116458660  interferon alpha-8 [KO:K05414]
116458843  IFNB1; interferon beta [KO:K05415]
116459965  IL17A; interleukin-17A [KO:K05489]
116458598  IL17RA; interleukin-17 receptor A [KO:K05164]
116466714  IL17RC; interleukin-17 receptor C isoform X1 [KO:K05166]
116466971  C-X-C motif chemokine 2 isoform X1 [KO:K05505]
116475080  C-X-C motif chemokine 3 [KO:K05505]
116475085  CXCL1; growth-regulated alpha protein [KO:K05505]
116472296  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
116457822  FAS; tumor necrosis factor receptor superfamily member 6 isoform X2 [KO:K04390]
116469121  FADD; FAS-associated death domain protein [KO:K02373]
116471376  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
116810454  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
116466067  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
116459720  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
116811588  TAB3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X2 [KO:K12793]
116483411  SREBF1; sterol regulatory element-binding protein 1 isoform X2 [KO:K07197]
116810414  LOW QUALITY PROTEIN: fatty acid synthase-like [KO:K00665] [EC:2.3.1.85]
116483000  FASN; fatty acid synthase [KO:K00665] [EC:2.3.1.85]
116474552  ACACA; acetyl-CoA carboxylase 1 isoform X1 [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
116485077  SCD; stearoyl-CoA desaturase [KO:K00507] [EC:1.14.19.1]
116466109  SCD5; stearoyl-CoA desaturase 5 [KO:K00507] [EC:1.14.19.1]
116468705  LPIN2; phosphatidate phosphatase LPIN2 [KO:K15728] [EC:3.1.3.4]
116461178  LPIN3; phosphatidate phosphatase LPIN3 isoform X1 [KO:K15728] [EC:3.1.3.4]
116480248  LPIN1; phosphatidate phosphatase LPIN1 isoform X3 [KO:K15728] [EC:3.1.3.4]
116458587  SIRT1; NAD-dependent protein deacetylase sirtuin-1 isoform X1 [KO:K11411] [EC:2.3.1.286]
116479933  TRA2B; transformer-2 protein homolog beta isoform X1 [KO:K12897]
116813066  TRA2A; transformer-2 protein homolog alpha [KO:K12897]
116457860  ADIPOR1; adiponectin receptor protein 1 isoform X1 [KO:K07297]
116472520  ADIPOR2; adiponectin receptor protein 2 isoform X2 [KO:K07297]
116477793  CAMKK2; calcium/calmodulin-dependent protein kinase kinase 2 isoform X1 [KO:K07359] [EC:2.7.11.17]
116458112  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
116456560  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
116468021  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 isoform X1 [KO:K07199]
116477841  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
116810283  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
116461671  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
116814555  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
116467191  FOXO1; forkhead box protein O1 [KO:K07201]
116470667  FOXO3; forkhead box protein O3 isoform X1 [KO:K09408]
116456631  PPARGC1A; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202]
116458344  PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294]
116469106  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform isoform X1 [KO:K08765] [EC:2.3.1.21]
116459317  ACADVL; very long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1 [KO:K09479] [EC:1.3.8.9]
116469881  ACADM; medium-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1 [KO:K00249] [EC:1.3.8.7]
116456701  ACOX3; peroxisomal acyl-coenzyme A oxidase 3 isoform X1 [KO:K00232] [EC:1.3.3.6]
116483725  ACOX1; peroxisomal acyl-coenzyme A oxidase 1 [KO:K00232] [EC:1.3.3.6]
116483396  FABP1; fatty acid-binding protein, liver [KO:K08750]
116484931  alcohol dehydrogenase 1C [KO:K13951] [EC:1.1.1.1]
116484973  ADH1B; all-trans-retinol dehydrogenase [NAD(+)] ADH1B [KO:K13951] [EC:1.1.1.1]
116485043  alcohol dehydrogenase 1A [KO:K13951] [EC:1.1.1.1]
116474877  ADH7; all-trans-retinol dehydrogenase [NAD(+)] ADH7 isoform X1 [KO:K13951] [EC:1.1.1.1]
116456129  ADH4; all-trans-retinol dehydrogenase [NAD(+)] ADH4 isoform X1 [KO:K13980] [EC:1.1.1.1]
116456279  ADH5; alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
116456091  ADH6; alcohol dehydrogenase 6 [KO:K13952] [EC:1.1.1.1]
116477912  ALDH2; aldehyde dehydrogenase, mitochondrial [KO:K00128] [EC:1.2.1.3]
116483121  ALDH3A2; aldehyde dehydrogenase family 3 member A2 isoform X1 [KO:K00128] [EC:1.2.1.3]
116475108  ALDH1B1; aldehyde dehydrogenase X, mitochondrial [KO:K00128] [EC:1.2.1.3]
116470879  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
116473299  ALDH9A1; 4-trimethylaminobutyraldehyde dehydrogenase [KO:K00149] [EC:1.2.1.47 1.2.1.3]
116481584  cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
116477970  ACACB; acetyl-CoA carboxylase 2 [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
116470765  MLYCD; malonyl-CoA decarboxylase, mitochondrial [KO:K01578] [EC:4.1.1.9]
116458992  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K19523] [EC:2.3.1.21]
116478189  CPT1C; carnitine O-palmitoyltransferase 1, brain isoform [KO:K19524] [EC:2.3.1.21]
116476796  NOX4; NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
116457903  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
116485139  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
116480683  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
116466895  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
116473623  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
116471505  TCF7; LOW QUALITY PROTEIN: transcription factor 7 [KO:K02620]
116483590  TCF7L1; transcription factor 7-like 1 isoform X2 [KO:K04490]
116483446  TCF7L2; transcription factor 7-like 2 isoform X12 [KO:K04491]
116479176  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
116469117  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
116472781  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
116459332  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X2 [KO:K04430] [EC:2.7.12.2]
116478375  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
116460769  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
116471970  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
116463128  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
116483006  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
116483711  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
116458518  MAPK12; mitogen-activated protein kinase 12 isoform X2 [KO:K04441] [EC:2.7.11.24]
116458519  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
116459642  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
116459649  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
116474979  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
Compound
C00003  NAD+
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00033  Acetate
C00040  Acyl-CoA
C00076  Calcium cation
C00083  Malonyl-CoA
C00084  Acetaldehyde
C00469  Ethanol
C22381  Reactive oxygen species
Reference
PMID:25782093
  Authors
Louvet A, Mathurin P
  Title
Alcoholic liver disease: mechanisms of injury and targeted treatment.
  Journal
Nat Rev Gastroenterol Hepatol 12:231-42 (2015)
DOI:10.1038/nrgastro.2015.35
Reference
PMID:21920463
  Authors
Gao B, Bataller R
  Title
Alcoholic liver disease: pathogenesis and new therapeutic targets.
  Journal
Gastroenterology 141:1572-85 (2011)
DOI:10.1053/j.gastro.2011.09.002
Reference
PMID:28134813
  Authors
Magdaleno F, Blajszczak CC, Nieto N
  Title
Key Events Participating in the Pathogenesis of Alcoholic Liver Disease.
  Journal
Biomolecules 7:E9 (2017)
DOI:10.3390/biom7010009
Reference
PMID:19553649
  Authors
Lucey MR, Mathurin P, Morgan TR
  Title
Alcoholic hepatitis.
  Journal
N Engl J Med 360:2758-69 (2009)
DOI:10.1056/NEJMra0805786
Reference
PMID:26919968
  Authors
Nagy LE, Ding WX, Cresci G, Saikia P, Shah VH
  Title
Linking Pathogenic Mechanisms of Alcoholic Liver Disease With Clinical Phenotypes.
  Journal
Gastroenterology 150:1756-68 (2016)
DOI:10.1053/j.gastro.2016.02.035
Reference
PMID:25009376
  Authors
Fujii H, Kawada N
  Title
Fibrogenesis in alcoholic liver disease.
  Journal
World J Gastroenterol 20:8048-54 (2014)
DOI:10.3748/wjg.v20.i25.8048
Reference
PMID:26755857
  Authors
Kim MS, Ong M, Qu X
  Title
Optimal management for alcoholic liver disease: Conventional medications, natural therapy or combination?
  Journal
World J Gastroenterol 22:8-23 (2016)
DOI:10.3748/wjg.v22.i1.8
Reference
PMID:15194557
  Authors
You M, Crabb DW
  Title
Recent advances in alcoholic liver disease II. Minireview: molecular mechanisms of alcoholic fatty liver.
  Journal
Am J Physiol Gastrointest Liver Physiol 287:G1-6 (2004)
DOI:10.1152/ajpgi.00056.2004
Reference
PMID:26695748
  Authors
Nagy LE
  Title
The Role of Innate Immunity in Alcoholic Liver Disease.
  Journal
Alcohol Res 37:237-50 (2015)
Reference
PMID:21252049
  Authors
Gao B, Seki E, Brenner DA, Friedman S, Cohen JI, Nagy L, Szabo G, Zakhari S
  Title
Innate immunity in alcoholic liver disease.
  Journal
Am J Physiol Gastrointest Liver Physiol 300:G516-25 (2011)
DOI:10.1152/ajpgi.00537.2010
Reference
PMID:22524187
  Authors
Wang HJ, Gao B, Zakhari S, Nagy LE
  Title
Inflammation in alcoholic liver disease.
  Journal
Annu Rev Nutr 32:343-68 (2012)
DOI:10.1146/annurev-nutr-072610-145138
Reference
PMID:29597356
  Authors
McCullough RL, McMullen MR, Sheehan MM, Poulsen KL, Roychowdhury S, Chiang DJ, Pritchard MT, Caballeria J, Nagy LE
  Title
Complement Factor D protects mice from ethanol-induced inflammation and liver injury.
  Journal
Am J Physiol Gastrointest Liver Physiol 315:G66-G79 (2018)
DOI:10.1152/ajpgi.00334.2017
Reference
PMID:24385684
  Authors
Kawaratani H, Tsujimoto T, Douhara A, Takaya H, Moriya K, Namisaki T, Noguchi R, Yoshiji H, Fujimoto M, Fukui H
  Title
The effect of inflammatory cytokines in alcoholic liver disease.
  Journal
Mediators Inflamm 2013:495156 (2013)
DOI:10.1155/2013/495156
Reference
PMID:20238398
  Authors
Szabo G, Bala S
  Title
Alcoholic liver disease and the gut-liver axis.
  Journal
World J Gastroenterol 16:1321-9 (2010)
DOI:10.3748/wjg.v16.i11.1321
Reference
PMID:28627645
  Authors
Kawaratani H, Moriya K, Namisaki T, Uejima M, Kitade M, Takeda K, Okura Y, Kaji K, Takaya H, Nishimura N, Sato S, Sawada Y, Seki K, Kubo T, Mitoro A, Yamao J, Yoshiji H
  Title
Therapeutic strategies for alcoholic liver disease: Focusing on inflammation and fibrosis (Review).
  Journal
Int J Mol Med 40:263-270 (2017)
DOI:10.3892/ijmm.2017.3015
Reference
PMID:23855294
  Authors
Roh YS, Seki E
  Title
Toll-like receptors in alcoholic liver disease, non-alcoholic steatohepatitis and carcinogenesis.
  Journal
J Gastroenterol Hepatol 28 Suppl 1:38-42 (2013)
DOI:10.1111/jgh.12019
Reference
PMID:18709650
  Authors
Rogers CQ, Ajmo JM, You M
  Title
Adiponectin and alcoholic fatty liver disease.
  Journal
IUBMB Life 60:790-7 (2008)
DOI:10.1002/iub.124
Reference
PMID:26278388
  Authors
You M, Jogasuria A, Lee K, Wu J, Zhang Y, Lee YK, Sadana P
  Title
Signal Transduction Mechanisms of Alcoholic Fatty Liver Disease: Emer ging Role of Lipin-1.
  Journal
Curr Mol Pharmacol 10:226-236 (2017)
DOI:10.2174/1874467208666150817112109
Reference
PMID:26005675
  Authors
You M, Jogasuria A, Taylor C, Wu J
  Title
Sirtuin 1 signaling and alcoholic fatty liver disease.
  Journal
Hepatobiliary Surg Nutr 4:88-100 (2015)
DOI:10.3978/j.issn.2304-3881.2014.12.06
Reference
PMID:33162823
  Authors
Ren R, Wang Z, Wu M, Wang H
  Title
Emerging Roles of SIRT1 in Alcoholic Liver Disease.
  Journal
Int J Biol Sci 16:3174-3183 (2020)
DOI:10.7150/ijbs.49535
Reference
PMID:19032584
  Authors
Purohit V, Gao B, Song BJ
  Title
Molecular mechanisms of alcoholic fatty liver.
  Journal
Alcohol Clin Exp Res 33:191-205 (2009)
DOI:10.1111/j.1530-0277.2008.00827.x
Reference
PMID:34071962
  Authors
Hyun J, Han J, Lee C, Yoon M, Jung Y
  Title
Pathophysiological Aspects of Alcohol Metabolism in the Liver.
  Journal
Int J Mol Sci 22:5717 (2021)
DOI:10.3390/ijms22115717
Reference
PMID:24297186
  Authors
Combs TP, Marliss EB
  Title
Adiponectin signaling in the liver.
  Journal
Rev Endocr Metab Disord 15:137-47 (2014)
DOI:10.1007/s11154-013-9280-6
Reference
PMID:25548474
  Authors
Ceni E, Mello T, Galli A
  Title
Pathogenesis of alcoholic liver disease: role of oxidative metabolism.
  Journal
World J Gastroenterol 20:17756-72 (2014)
DOI:10.3748/wjg.v20.i47.17756
Reference
PMID:31159489
  Authors
Kong LZ, Chandimali N, Han YH, Lee DH, Kim JS, Kim SU, Kim TD, Jeong DK, Sun HN, Lee DS, Kwon T
  Title
Pathogenesis, Early Diagnosis, and Therapeutic Management of Alcoholic Liver Disease.
  Journal
Int J Mol Sci 20:E2712 (2019)
DOI:10.3390/ijms20112712
Reference
PMID:31214376
  Authors
Ohashi K, Pimienta M, Seki E
  Title
Alcoholic liver disease: A current molecular and clinical perspective.
  Journal
Liver Res 2:161-172 (2018)
DOI:10.1016/j.livres.2018.11.002
Reference
PMID:30658725
  Authors
You M, Arteel GE
  Title
Effect of ethanol on lipid metabolism.
  Journal
J Hepatol 70:237-248 (2019)
DOI:10.1016/j.jhep.2018.10.037
Reference
PMID:25595739
  Authors
Bi L, Jiang Z, Zhou J
  Title
The role of lipin-1 in the pathogenesis of alcoholic fatty liver.
  Journal
Alcohol Alcohol 50:146-51 (2015)
DOI:10.1093/alcalc/agu102
Reference
PMID:31263795
  Authors
Ali H, Assiri MA, Shearn CT, Fritz KS
  Title
Lipid peroxidation derived reactive aldehydes in alcoholic liver disease.
  Journal
Curr Opin Toxicol 13:110-117 (2019)
DOI:10.1016/j.cotox.2018.10.003
Reference
PMID:24262277
  Authors
Yin H, Hu M, Liang X, Ajmo JM, Li X, Bataller R, Odena G, Stevens SM Jr, You M
  Title
Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver.
  Journal
Gastroenterology 146:801-11 (2014)
DOI:10.1053/j.gastro.2013.11.008
Reference
PMID:22110053
  Authors
Stickel F, Hampe J
  Title
Genetic determinants of alcoholic liver disease.
  Journal
Gut 61:150-9 (2012)
DOI:10.1136/gutjnl-2011-301239
Reference
PMID:29336467
  Authors
Yang CF, Zhong YJ, Ma Z, Li L, Shi L, Chen L, Li C, Wu D, Chen Q, Li YW
  Title
NOX4/ROS mediate ethanolinduced apoptosis via MAPK signal pathway in L02 cells.
  Journal
Int J Mol Med 41:2306-2316 (2018)
DOI:10.3892/ijmm.2018.3390
Related
pathway
hmh00061  Fatty acid biosynthesis
hmh00071  Fatty acid degradation
hmh01040  Biosynthesis of unsaturated fatty acids
hmh03040  Spliceosome
hmh04010  MAPK signaling pathway
hmh04064  NF-kappa B signaling pathway
hmh04152  AMPK signaling pathway
hmh04210  Apoptosis
hmh04310  Wnt signaling pathway
hmh04610  Complement and coagulation cascades
hmh04620  Toll-like receptor signaling pathway
hmh04657  IL-17 signaling pathway
hmh04668  TNF signaling pathway
hmh04920  Adipocytokine signaling pathway
hmh05034  Alcoholism
hmh05225  Hepatocellular carcinoma
KO pathway
ko04936   
LinkDB

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