KEGG   PATHWAY: hoc04810
Entry
hoc04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Hemiscyllium ocellatum (epaulette shark)
Class
Cellular Processes; Cell motility
Pathway map
hoc04810  Regulation of actin cytoskeleton
hoc04810

Other DBs
GO: 0030036
Organism
Hemiscyllium ocellatum (epaulette shark) [GN:hoc]
Gene
132824720  lpar1; lysophosphatidic acid receptor 1 [KO:K04289]
132830247  lysophosphatidic acid receptor 3-like [KO:K04291]
132835958  lpar2a; lysophosphatidic acid receptor 2a [KO:K04291]
132835178  lysophosphatidic acid receptor 6-like [KO:K04275]
132835280  lysophosphatidic acid receptor 6-like [KO:K04275]
132820457  lpar4; lysophosphatidic acid receptor 4 [KO:K04275]
132834992  stromal cell-derived factor 1-like [KO:K10031]
132834996  stromal cell-derived factor 1-like [KO:K10031]
132817406  C-X-C chemokine receptor type 4-like [KO:K04189]
132824537  f2; prothrombin [KO:K01313] [EC:3.4.21.5]
132827166  proteinase-activated receptor 1-like [KO:K03914]
132822485  proteinase-activated receptor 1-like [KO:K03914]
132824540  insulin-like [KO:K04526]
132816749  egf; pro-epidermal growth factor isoform X1 [KO:K04357]
132823253  fibroblast growth factor 1-like [KO:K18496]
132833422  fgf2; fibroblast growth factor 2 [KO:K18497]
132834394  fgf7; fibroblast growth factor 7 [KO:K04358]
132836918  fibroblast growth factor 17-like [KO:K04358]
132823150  fibroblast growth factor 18-like [KO:K04358]
132818787  fibroblast growth factor 10-like [KO:K04358]
132819179  fibroblast growth factor 9-like [KO:K04358]
132823844  fgf24; fibroblast growth factor 24 [KO:K04358]
132824283  fgf4; fibroblast growth factor 4 [KO:K04358]
132824284  fgf3; fibroblast growth factor 3 [KO:K04358]
132820135  fgf16; fibroblast growth factor 16 [KO:K04358]
132828171  fibroblast growth factor 6-like [KO:K04358]
132816785  fibroblast growth factor 9 isoform X1 [KO:K04358]
132821227  fgf9; fibroblast growth factor 4A [KO:K04358]
132826338  fgf8b; fibroblast growth factor 8b isoform X1 [KO:K04358]
132828868  fgf22; fibroblast growth factor 22 [KO:K04358]
132817413  fgf5; fibroblast growth factor 5 [KO:K04358]
132814826  fibroblast growth factor 19-like [KO:K22603]
132824325  fgf19; fibroblast growth factor 19 [KO:K22603]
132826606  fibroblast growth factor 19-like [KO:K22428]
132825167  platelet-derived growth factor subunit A-like isoform X1 [KO:K04359]
132831333  platelet-derived growth factor subunit B-like isoform X1 [KO:K17386]
132833271  pdgfc; platelet-derived growth factor C [KO:K05450]
132816450  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
132815743  egfra; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
132836850  fibroblast growth factor receptor 1-like isoform X1 [KO:K04362] [EC:2.7.10.1]
132830486  si:ch211-167j9.5; tyrosine kinase receptor Cad96Ca [KO:K05093] [EC:2.7.10.1]
132826283  fibroblast growth factor receptor 2-like isoform X1 [KO:K05093] [EC:2.7.10.1]
132828619  fibroblast growth factor receptor 3-like isoform X1 [KO:K05094] [EC:2.7.10.1]
132823310  fibroblast growth factor receptor 4-like [KO:K05095] [EC:2.7.10.1]
132815312  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
132823488  pdgfrb; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
132817267  fibronectin-like isoform X1 [KO:K05717]
132810559  itga1; integrin alpha-1 [KO:K06480]
132810713  itga2.2; integrin alpha-2 [KO:K06481]
132831019  itga3b; integrin alpha-3b [KO:K06482]
132817503  itga4; integrin alpha-4 [KO:K06483]
132805742  integrin alpha-5-like [KO:K06484]
132817116  integrin alpha-6-like [KO:K06485]
132805812  integrin alpha-7-like isoform X1 [KO:K06583]
132830713  integrin alpha-8-like [KO:K06584]
132815769  itga8; integrin alpha-8 [KO:K06584]
132812346  itga9; integrin alpha-9 [KO:K06585]
132805507  itga10; integrin alpha-10 [KO:K06586]
132834389  itga11a; integrin alpha-11a isoform X1 [KO:K06587]
132817146  itgav; integrin alpha-V [KO:K06487]
132808897  integrin alpha-D-like [KO:K06461]
132830416  integrin alpha-E-like [KO:K06524]
132815812  integrin beta-1-like [KO:K05719]
132816136  integrin beta-1-like isoform X1 [KO:K05719]
132817242  itgb2; integrin beta-2 [KO:K06464]
132830920  integrin beta-3-like [KO:K06493]
132827702  itgb4; integrin beta-4 isoform X1 [KO:K06525]
132817070  itgb5; integrin beta-5 [KO:K06588]
132817082  itgb6; integrin beta-6 isoform X1 [KO:K06589]
132815934  itgb8; integrin beta-8 [KO:K06591]
132818010  B2 bradykinin receptor-like [KO:K03916]
132818435  B2 bradykinin receptor-like isoform X1 [KO:K03916]
132832439  muscarinic acetylcholine receptor M2-like [KO:K04130]
132832456  muscarinic acetylcholine receptor M2-like [KO:K04130]
132832579  muscarinic acetylcholine receptor M2-like [KO:K04130]
132832582  muscarinic acetylcholine receptor M2-like [KO:K04130]
132832584  muscarinic acetylcholine receptor M2-like [KO:K04130]
132832585  muscarinic acetylcholine receptor M2-like [KO:K04130]
132832587  muscarinic acetylcholine receptor M2-like [KO:K04130]
132832591  muscarinic acetylcholine receptor M2-like [KO:K04130]
132832592  muscarinic acetylcholine receptor M2-like [KO:K04130]
132832593  muscarinic acetylcholine receptor M2-like [KO:K04130]
132832594  muscarinic acetylcholine receptor M2-like [KO:K04130]
132832595  muscarinic acetylcholine receptor M2-like [KO:K04130]
132832597  muscarinic acetylcholine receptor M2-like [KO:K04130]
132832599  muscarinic acetylcholine receptor M2-like [KO:K04130]
132832602  muscarinic acetylcholine receptor M2-like [KO:K04130]
132832605  muscarinic acetylcholine receptor M2-like [KO:K04130]
132832606  muscarinic acetylcholine receptor M2-like [KO:K04130]
132832607  muscarinic acetylcholine receptor M2-like [KO:K04130]
132836323  muscarinic acetylcholine receptor M1-like [KO:K04130]
132824712  chrm2a; muscarinic acetylcholine receptor M2a [KO:K04130]
132819372  muscarinic acetylcholine receptor M3-like [KO:K04131]
132824152  chrm4a; muscarinic acetylcholine receptor M4 [KO:K04132]
132818178  chrm5b; muscarinic acetylcholine receptor M5b [KO:K04133]
132825699  c5; complement C5 [KO:K03994]
132829809  complement component C7-like [KO:K03996]
132818746  c8a; complement component C8 alpha chain [KO:K03997]
132826423  c9; complement component C9 [KO:K04000]
132831524  guanine nucleotide-binding protein subunit alpha-12-like [KO:K04346]
132825238  gna12a; guanine nucleotide-binding protein subunit alpha-12a [KO:K04346]
132828016  gna13a; guanine nucleotide-binding protein subunit alpha-13a [KO:K04639]
132819067  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
132822332  fgd; faciogenital dysplasia isoform X1 [KO:K05722]
132815081  focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
132823971  bcar1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
132830512  crk; adapter molecule crk [KO:K04438]
132827236  crkl; crk-like protein [KO:K04438]
132826251  dock1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
132822974  proto-oncogene tyrosine-protein kinase Src-like [KO:K05704] [EC:2.7.10.2]
132818310  sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
132819837  son of sevenless homolog 1 isoform X1 [KO:K03099]
132824459  GTPase HRas [KO:K02833]
132831454  GTPase HRas-like [KO:K07827]
132826791  GTPase HRas isoform X1 [KO:K07827]
132828445  nras; GTPase NRas [KO:K07828]
132831165  ras-related protein R-Ras2-like [KO:K07830]
132824439  rras2; ras-related protein R-Ras2 [KO:K07830]
132817024  ras-related protein M-Ras isoform X1 [KO:K07831]
132820347  arhgef6; rho guanine nucleotide exchange factor 6 isoform X1 [KO:K05729]
132833826  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
132835344  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
132821912  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
132822331  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
132819107  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
132836055  proto-oncogene vav-like [KO:K05730]
132818574  guanine nucleotide exchange factor VAV3-like [KO:K05730]
132825975  vav2; guanine nucleotide exchange factor VAV2 [KO:K05730]
132821023  tiam1a; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
132814149  RAF proto-oncogene serine/threonine-protein kinase-like [KO:K08845] [EC:2.7.11.1]
132825020  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
132822314  raf1b; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
132814232  mos; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
132834257  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
132829027  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
132827194  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
132836721  RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
132818315  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
132819668  akt3a; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
132820191  regulator of cell cycle RGCC-like [KO:K26108]
132820650  rgcc; regulator of cell cycle RGCC isoform X1 [KO:K26108]
132829722  rho guanine nucleotide exchange factor 12-like isoform X1 [KO:K07532]
132836577  arhgap35a; rho GTPase-activating protein 35 [KO:K05732]
132822248  transforming protein RhoA [KO:K04513]
132829929  rho-related GTP-binding protein RhoB-like [KO:K04513]
132831498  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
132831499  ras-related C3 botulinum toxin substrate 1-like isoform X1 [KO:K04392]
132825385  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
132828036  rac3a; ras-related C3 botulinum toxin substrate 3a [KO:K07861]
132833674  cdc42; cell division control protein 42 homolog [KO:K04393]
132816550  pak1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
132821958  serine/threonine-protein kinase PAK 2-like [KO:K04410] [EC:2.7.11.1]
132820398  serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
132836593  pak4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
132819525  serine/threonine-protein kinase PAK 5-like isoform X1 [KO:K05736] [EC:2.7.11.1]
132818074  serine/threonine-protein kinase PAK 4-like [KO:K05735] [EC:2.7.11.1]
132816363  rho guanine nucleotide exchange factor 7-like [KO:K13710]
132830558  git1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
132814782  rock1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
132834548  rock2a; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
132832260  mylk4b; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
132830892  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
132823711  mylk3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
132817098  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
132827119  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit A [KO:K06269] [EC:3.1.3.16]
132831101  ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
132824378  zmp:0000001167; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
132824834  ppp1r12a; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
132828413  protein phosphatase 1 regulatory subunit 12B-like isoform X1 [KO:K12329]
132831243  protein phosphatase 1 regulatory subunit 12C-like [KO:K17457]
132827118  myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
132833455  myosin light chain 5-like [KO:K12753]
132837052  myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
132822971  myosin regulatory light polypeptide 9 [KO:K12755]
132830564  myosin regulatory light chain 2, ventricular/cardiac muscle isoform-like [KO:K12756]
132814948  myl12.1; myosin, light chain 12, genome duplicate 1 [KO:K12757]
132831254  myosin-9-like isoform X1 [KO:K10352]
132827645  myosin-10 isoform X1 [KO:K10352]
132825314  myosin-11-like isoform X1 [KO:K10352]
132823514  protein diaphanous homolog 1-like [KO:K05741]
132820465  diaph2; protein diaphanous homolog 2 isoform X1 [KO:K05741]
132830143  slc9a1a; sodium/hydrogen exchanger 1 [KO:K05742]
132824894  phosphatidylinositol 4-phosphate 5-kinase type-1 beta-like isoform X1 [KO:K00889] [EC:2.7.1.68]
132829234  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma-like isoform X1 [KO:K00889] [EC:2.7.1.68]
132831016  phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X1 [KO:K00920] [EC:2.7.1.149]
132808959  phosphatidylinositol 5-phosphate 4-kinase type-2 gamma-like isoform X1 [KO:K00920] [EC:2.7.1.149]
132816118  pip4k2aa; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [KO:K00920] [EC:2.7.1.149]
132817202  pikfyve; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
132830305  limk1a; LIM domain kinase 1a isoform X1 [KO:K05743] [EC:2.7.11.1]
132816349  protein diaphanous homolog 3-like [KO:K05745]
132827966  brain-specific angiogenesis inhibitor 1-associated protein 2-like isoform X1 [KO:K05627]
132830348  enah; protein enabled homolog [KO:K05746]
132824983  actin nucleation-promoting factor WASL-like [KO:K23612]
132829889  wasf2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
132823280  cyfip2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
132816532  cyfip1; cytoplasmic FMR1-interacting protein 1 homolog [KO:K05749]
132805843  nck-associated protein 1-like [KO:K05750]
132817142  nckap1; nck-associated protein 1 [KO:K05750]
132817227  abl interactor 2 isoform X1 [KO:K05751]
132822070  brk1; probable protein BRICK1 [KO:K05752]
132836827  wasf1; actin-binding protein WASF1 isoform X1 [KO:K05753]
132819906  actin-related protein 2 isoform X1 [KO:K17260]
132816149  actin-related protein 3B-like isoform X1 [KO:K18584]
132817059  actin-related protein 3 [KO:K18584]
132825497  arpc1b; actin-related protein 2/3 complex subunit 1B [KO:K05757]
132825499  actin-related protein 2/3 complex subunit 1A-B [KO:K05757]
132817368  arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
132827121  arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
132822282  actin-related protein 2/3 complex subunit 4 [KO:K05755]
132819040  actin-related protein 2/3 complex subunit 5-like [KO:K05754]
132825849  arpc5lb; actin related protein 2/3 complex, subunit 5-like, b [KO:K05754]
132815054  actin, cytoplasmic type 5-like isoform X1 [KO:K05692]
132815056  actin, cytoplasmic type 5-like isoform X1 [KO:K05692]
132815057  actin-3-like [KO:K05692]
132815131  actin, non-muscle 6.2-like [KO:K05692]
132815132  actin, non-muscle 6.2 [KO:K05692]
132815133  actin, non-muscle 6.2-like [KO:K05692]
132825506  actb2; actin, cytoplasmic 2 [KO:K05692]
132828025  actin, cytoplasmic type 5 [KO:K05692]
132829913  profilin-3-like [KO:K05759]
132835257  profilin-1-like [KO:K05759]
132836900  profilin-2-like [KO:K05759]
132831467  profilin-3-like [KO:K05759]
132806468  pfn4; profilin-4 [KO:K05759]
132821429  profilin-2-like [KO:K05759]
132834481  paxillin-like [KO:K05760]
132827187  paxillin-like isoform X1 [KO:K05760]
132819807  ezrb; ezrin b [KO:K08007]
132820413  msna; moesin a [KO:K05762]
132816457  radixin isoform X1 [KO:K05762]
132823408  thymosin beta-11-like [KO:K05764]
132817876  cfl2; cofilin-2 [KO:K05765]
132836095  cofilin-2-like [KO:K05765]
132819832  cofilin-2-like [KO:K05765]
132830329  ssh2a; protein phosphatase Slingshot homolog 2 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
132827448  protein phosphatase Slingshot homolog 1-like [KO:K05766] [EC:3.1.3.16 3.1.3.48]
132834896  vinculin isoform X1 [KO:K05700]
132834848  iqgap1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
132805502  iqgap3; ras GTPase-activating-like protein IQGAP3 [KO:K05767]
132822498  iqgap2; ras GTPase-activating-like protein IQGAP2 isoform X1 [KO:K05767]
132819169  scinderin-like [KO:K05768]
132815684  scin; adseverin [KO:K05768]
132825876  gsna; gelsolin a isoform X1 [KO:K05768]
132836592  alpha-actinin-1-like [KO:K05699]
132818127  actn1; alpha-actinin-1 isoform X1 [KO:K05699]
132823472  apc; adenomatous polyposis coli protein isoform X1 [KO:K02085]
132829207  apc2; adenomatous polyposis coli protein 2 [KO:K02085]
132816471  uncharacterized protein LOC132816471 isoform X1 [KO:K05769]
132821356  rho guanine nucleotide exchange factor 4-like [KO:K05769]
132821357  rho guanine nucleotide exchange factor 4-like [KO:K05769]
132821934  uncharacterized protein LOC132821934 isoform X1 [KO:K05769]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
hoc04010  MAPK signaling pathway
hoc04510  Focal adhesion
hoc04520  Adherens junction
KO pathway
ko04810   
LinkDB

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