KEGG   PATHWAY: llv04820
Entry
llv04820                    Pathway                                
Name
Cytoskeleton in muscle cells - Lutra lutra (Eurasian river otter)
Class
Cellular Processes; Cell motility
Pathway map
llv04820  Cytoskeleton in muscle cells
llv04820

Organism
Lutra lutra (Eurasian river otter) [GN:llv]
Gene
125087421  collagen alpha-1(I) chain [KO:K06236]
125081239  collagen alpha-2(I) chain [KO:K06236]
125095183  collagen alpha-1(III) chain isoform X1 [KO:K19720]
125083218  collagen alpha-1(V) chain isoform X1 [KO:K19721]
125083611  collagen alpha-1(XXVII) chain-like isoform X1 [KO:K19721]
125085068  collagen alpha-3(V) chain isoform X1 [KO:K19721]
125102135  collagen alpha-2(XI) chain isoform X1 [KO:K19721]
125094893  collagen alpha-2(V) chain [KO:K19721]
125098784  collagen alpha-1(XI) chain isoform X1 [KO:K19721]
125098807  collagen alpha-1(XXIV) chain [KO:K19721]
125108388  collagen alpha-3(IX) chain [KO:K08131]
125102455  collagen alpha-1(IX) chain isoform X1 [KO:K08131]
125099164  collagen alpha-2(IX) chain isoform X1 [KO:K08131]
125107056  decorin [KO:K04660]
125100307  versican core protein-like isoform X1 [KO:K06793]
125091055  elastin-like [KO:K14211]
125093138  collagen alpha-2(VI) chain isoform X1 [KO:K06238]
125093156  collagen alpha-1(VI) chain [KO:K06238]
125095261  collagen alpha-3(VI) chain isoform X1 [KO:K06238]
125104592  collagen alpha-5(VI) chain-like isoform X1 [KO:K06238]
125104609  collagen alpha-6(VI) chain [KO:K06238]
125104624  collagen alpha-4(VI) chain-like isoform X1 [KO:K06238]
125104839  thrombospondin-1 [KO:K16857]
125099919  thrombospondin-4 isoform X1 [KO:K04659]
125085843  thrombospondin-3 isoform X1 [KO:K04659]
125102904  thrombospondin-2 [KO:K04659]
125081937  cartilage oligomeric matrix protein [KO:K04659]
125104033  fibrillin-1 [KO:K06825]
125100470  fibrillin-2 [KO:K23342]
125085878  fibrillin-3-like isoform X1 [KO:K23342]
125091570  collagen alpha-6(IV) chain-like isoform X1 [KO:K06237]
125091771  collagen alpha-5(IV) chain isoform X1 [KO:K06237]
125094828  collagen alpha-2(IV) chain [KO:K06237]
125094830  collagen alpha-1(IV) chain [KO:K06237]
125095149  collagen alpha-4(IV) chain-like isoform X1 [KO:K06237]
125095151  collagen alpha-3(IV) chain-like isoform X1 [KO:K06237]
125108138  fibulin-2-like isoform X1 [KO:K17307]
125107493  fibulin-1 isoform X1 [KO:K17307]
125096806  basement membrane-specific heparan sulfate proteoglycan core protein isoform X1 [KO:K06255]
125084578  nidogen-1 [KO:K06826]
125103935  nidogen-2-like isoform X1 [KO:K06826]
125095065  fibronectin isoform X1 [KO:K05717]
125109159  syndecan-1-like [KO:K06257]
125097576  syndecan-2 [KO:K16336]
125082175  LOW QUALITY PROTEIN: syndecan-2-like [KO:K16336]
125098119  syndecan-3 [KO:K16337]
125108602  syndecan-4-like isoform X1 [KO:K16338]
125097169  agrin-like isoform X1 [KO:K06254]
125091994  biglycan [KO:K08118]
125082414  desmocollin-2-like isoform X1 [KO:K07601]
125082152  desmoglein-2-like [KO:K07597]
125106687  plakophilin-2 [KO:K12642]
125087544  junction plakoglobin [KO:K10056]
125082256  LOW QUALITY PROTEIN: junction plakoglobin-like [KO:K10056]
125102303  desmoplakin isoform X1 [KO:K10381]
125095918  LOW QUALITY PROTEIN: vimentin-like [KO:K07606]
125106656  vimentin [KO:K07606]
125095395  desmin [KO:K07610]
125101767  LOW QUALITY PROTEIN: laminin subunit alpha-2-like [KO:K05637]
125082438  laminin subunit alpha-1-like isoform X1 [KO:K05637]
125099644  LOW QUALITY PROTEIN: integrin alpha-1-like [KO:K06480]
125100104  integrin alpha-2 [KO:K06481]
125088045  integrin alpha-IIb-like [KO:K06476]
125087601  integrin alpha-3 [KO:K06482]
125095810  integrin alpha-4 [KO:K06483]
125106595  integrin alpha-5 [KO:K06484]
125095729  integrin alpha-6 isoform X1 [KO:K06485]
125106761  integrin alpha-7 isoform X1 [KO:K06583]
125107407  integrin alpha-8 [KO:K06584]
125106522  integrin alpha-9 [KO:K06585]
125097111  integrin alpha-10 isoform X1 [KO:K06586]
125105223  integrin alpha-11 [KO:K06587]
125094948  LOW QUALITY PROTEIN: integrin alpha-V-like [KO:K06487]
125095857  integrin alpha-V [KO:K06487]
125106516  integrin beta-1 isoform X1 [KO:K05719]
125087241  integrin beta-3 [KO:K06493]
125087146  integrin beta-4 isoform X1 [KO:K06525]
125103094  integrin beta-5 isoform X1 [KO:K06588]
125095459  integrin beta-6 isoform X1 [KO:K06589]
125107565  integrin beta-7 isoform X1 [KO:K06590]
125081023  integrin beta-8 isoform X1 [KO:K06591]
125083943  talin-1 isoform X1 [KO:K06271]
125104171  talin-2 isoform X1 [KO:K06271]
125085203  vinculin isoform X1 [KO:K05700]
125084478  alpha-actinin-2 [KO:K21073]
125079171  alpha-actinin-3 [KO:K21073]
125092924  actin, cytoplasmic 2-like [KO:K05692]
125093566  actin, cytoplasmic 2-like [KO:K05692]
125102727  actin, cytoplasmic 2-like [KO:K05692]
125087003  actin, cytoplasmic 2 [KO:K05692]
125090635  actin, cytoplasmic 1 [KO:K05692]
125109470  actin, gamma-enteric smooth muscle [KO:K12315]
125080128  dystroglycan 1 [KO:K06265]
125087849  LOW QUALITY PROTEIN: alpha-sarcoglycan-like [KO:K12565]
125081241  epsilon-sarcoglycan isoform X1 [KO:K27061]
125093715  beta-sarcoglycan isoform X1 [KO:K12566]
125099948  delta-sarcoglycan [KO:K12563]
125096185  gamma-sarcoglycan isoform X1 [KO:K12564]
125091872  zeta-sarcoglycan [KO:K27062]
125106666  sarcospan isoform X1 [KO:K22194]
125091783  LOW QUALITY PROTEIN: dystrophin-like [KO:K10366]
125109442  alpha-1-syntrophin isoform X1 [KO:K24063]
125089128  beta-2-syntrophin isoform X1 [KO:K24064]
125097509  beta-1-syntrophin [KO:K24064]
125081703  dystrobrevin alpha isoform X1 [KO:K26998]
125080716  filamin-C isoform X1 [KO:K27393]
125085919  sodium/potassium-transporting ATPase subunit alpha-2 isoform X1 [KO:K01539] [EC:7.2.2.13]
125086256  sodium/potassium-transporting ATPase subunit alpha-4 isoform X1 [KO:K01539] [EC:7.2.2.13]
125097511  sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
125089713  sodium/potassium-transporting ATPase subunit alpha-3 [KO:K01539] [EC:7.2.2.13]
125092004  protein ATP1B4 isoform X1 [KO:K01540]
125085446  sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
125087038  sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540]
125098204  sodium/potassium-transporting ATPase subunit beta-3-like [KO:K01540]
125085285  ankyrin-3-like isoform X1 [KO:K09259]
125084102  spectrin alpha chain, non-erythrocytic 1 isoform X1 [KO:K06114]
125109026  spectrin beta chain, non-erythrocytic 1 isoform X1 [KO:K06115]
125104285  spectrin beta chain, non-erythrocytic 5-like [KO:K06115]
125088932  spectrin beta chain, non-erythrocytic 4 isoform X1 [KO:K06115]
125078449  spectrin beta chain, non-erythrocytic 2 isoform X1 [KO:K23932]
125085763  cysteine and glycine-rich protein 1 [KO:K09377]
125079479  cysteine and glycine-rich protein 3 [KO:K09377]
125107253  cysteine and glycine-rich protein 2 [KO:K09377]
125110068  myosin-7B isoform X1 [KO:K24220]
125086739  myosin-2 [KO:K24220]
125086740  LOW QUALITY PROTEIN: myosin-3-like [KO:K24220]
125086741  myosin-1 [KO:K24220]
125086742  myosin-13 [KO:K24220]
125086744  myosin-4 [KO:K24220]
125086745  LOW QUALITY PROTEIN: myosin-8-like [KO:K24220]
125103828  myosin-7 isoform X1 [KO:K17751]
125103829  myosin-6 [KO:K17751]
125091184  myosin-11 isoform X1 [KO:K10352]
125087466  myosin-10 isoform X1 [KO:K10352]
125106648  LOW QUALITY PROTEIN: myosin-9-like [KO:K10352]
125089999  myosin-14 isoform X1 [KO:K10352]
125095061  myosin light chain 1/3, skeletal muscle isoform isoform X1 [KO:K05738]
125081109  myosin light chain 3 [KO:K12749]
125087137  myosin light chain 4 isoform X1 [KO:K12750]
125082476  myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
125094143  myosin light chain 5 [KO:K12753]
125081246  myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
125108508  myosin regulatory light polypeptide 9 [KO:K12755]
125091061  myosin regulatory light chain 2, skeletal muscle isoform type 2 [KO:K12758]
125106765  myosin-binding protein C, slow-type isoform X1 [KO:K12557]
125089347  myosin-binding protein C, fast-type [KO:K12558]
125078752  myosin-binding protein C, cardiac-type [KO:K12568]
125085964  myosin-binding protein H [KO:K24494]
125096834  myosin-binding protein H-like [KO:K24494]
125084321  actin, alpha skeletal muscle [KO:K10354]
125105260  actin, alpha cardiac muscle 1 [KO:K12314]
125079067  troponin C, slow skeletal and cardiac muscles [KO:K05865]
125086136  troponin I, slow skeletal muscle isoform X1 [KO:K10371]
125089167  troponin T, slow skeletal muscle isoform X1 [KO:K10372]
125108837  troponin C, skeletal muscle [KO:K12042]
125079619  troponin I, fast skeletal muscle [KO:K12043]
125078161  troponin T, fast skeletal muscle isoform X1 [KO:K12046]
125089169  troponin I, cardiac muscle [KO:K12044]
125086115  troponin T, cardiac muscle isoform X1 [KO:K12045]
125082891  tropomyosin beta chain isoform X1 [KO:K10374]
125085655  tropomyosin alpha-3 chain isoform X1 [KO:K09290]
125103632  tropomyosin alpha-3 chain isoform X1 [KO:K09290]
125104436  tropomyosin alpha-3 chain-like [KO:K09290]
125083050  tropomyosin alpha-4 chain isoform X1 [KO:K10375]
125095799  LOW QUALITY PROTEIN: titin-like [KO:K12567] [EC:2.7.11.1]
125099984  myotilin isoform X1 [KO:K19875]
125093315  synaptopodin-2-like [KO:K24066]
125095381  nebulin-like [KO:K18267]
125106233  nebulette isoform X1 [KO:K25865]
125084664  myozenin-1 [KO:K26050]
125093327  myozenin-2 isoform X1 [KO:K26050]
125100397  myozenin-3-like isoform X1 [KO:K26050]
125091410  PDZ and LIM domain protein 3 isoform X1 [KO:K23353]
125084740  PDZ and LIM domain protein 1 isoform X1 [KO:K23353]
125100893  PDZ and LIM domain protein 4 isoform X1 [KO:K23353]
125092860  PDZ and LIM domain protein 2-like isoform X1 [KO:K23353]
125095825  F-actin-capping protein subunit alpha-1-like [KO:K10364]
125080740  F-actin-capping protein subunit alpha-2 [KO:K10364]
125098176  F-actin-capping protein subunit alpha-1 [KO:K10364]
125107449  F-actin-capping protein subunit alpha-3 [KO:K10364]
125099131  F-actin-capping protein subunit beta isoform X1 [KO:K10365]
125106262  xin actin-binding repeat-containing protein 1-like isoform X1 [KO:K27381]
125095551  xin actin-binding repeat-containing protein 2-like isoform X1 [KO:K27381]
125084668  nebulin-related-anchoring protein isoform X1 [KO:K24421]
125084782  myopalladin isoform X1 [KO:K22028]
125100217  PDZ and LIM domain protein 7 isoform X1 [KO:K19867]
125084438  LIM domain-binding protein 3 isoform X1 [KO:K19867]
125093189  PDZ and LIM domain protein 5 isoform X1 [KO:K19867]
125083553  tropomodulin-1 isoform X1 [KO:K10370]
125104023  tropomodulin-2 [KO:K10370]
125104565  tropomodulin-3 [KO:K10370]
125104884  tropomodulin-2 isoform X1 [KO:K10370]
125097674  tropomodulin-4 isoform X1 [KO:K10370]
125080777  zyxin [KO:K06273]
125091816  four and a half LIM domains protein 1 isoform X1 [KO:K14365]
125108242  LOW QUALITY PROTEIN: four and a half LIM domains protein 2-like [KO:K14380]
125098621  four and a half LIM domains protein 3 isoform X1 [KO:K24414]
125085429  leiomodin-1 [KO:K22030]
125109947  leiomodin-3-like [KO:K22030]
125080929  leiomodin-2 [KO:K22030]
125084704  ankyrin repeat domain-containing protein 1 [KO:K21433]
125084923  ankyrin repeat domain-containing protein 2-like [KO:K21434]
125109450  ankyrin repeat domain-containing protein 23-like isoform X1 [KO:K21438]
125086837  formin-like protein 1 isoform X1 [KO:K23957]
125095388  formin-like protein 2 isoform X1 [KO:K23957]
125106365  formin-like protein 3 isoform X1 [KO:K23957]
125103686  inverted formin-2-like isoform X1 [KO:K23958]
125102127  disheveled-associated activator of morphogenesis 2 isoform X1 [KO:K04512]
125104357  disheveled-associated activator of morphogenesis 1 [KO:K04512]
125100253  protein diaphanous homolog 1 isoform X1 [KO:K05740]
125094672  protein diaphanous homolog 3 isoform X1 [KO:K05745]
125086036  formin-2-like [KO:K02184]
125081682  myomesin-1 isoform X1 [KO:K24495]
125098132  myomesin-3 isoform X1 [KO:K24495]
125090675  LOW QUALITY PROTEIN: myomesin-2-like [KO:K24495]
125087161  beta-enolase [KO:K01689] [EC:4.2.1.11]
125096898  alpha-enolase isoform X1 [KO:K01689] [EC:4.2.1.11]
125106088  gamma-enolase [KO:K01689] [EC:4.2.1.11]
125093300  ankyrin-2-like isoform X1 [KO:K09255]
125089057  creatine kinase M-type [KO:K27382] [EC:2.7.3.2]
125108670  tripartite motif-containing protein 54 [KO:K10653]
125098188  tripartite motif-containing protein 55 isoform X1 [KO:K10654]
125098684  E3 ubiquitin-protein ligase TRIM63 isoform X1 [KO:K10655] [EC:2.3.2.27]
125079575  AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
125097763  AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
125097984  AMP deaminase 1 isoform X1 [KO:K01490] [EC:3.5.4.6]
125099867  obscurin-like isoform X1 [KO:K17531] [EC:2.7.11.1]
125105494  calpain-3 isoform X1 [KO:K08573] [EC:3.4.22.54]
125098021  plectin isoform X1 [KO:K10388]
125104124  nesprin-3-like [KO:K21761]
125102600  LOW QUALITY PROTEIN: nesprin-1-like [KO:K19326]
125105363  nesprin-2-like isoform X1 [KO:K19346]
125090686  SUN domain-containing protein 1-like isoform X1 [KO:K19347]
125107371  SUN domain-containing protein 2-like isoform X1 [KO:K19347]
125108202  transmembrane protein 43 isoform X1 [KO:K27488]
125091323  emerin [KO:K12569]
125085971  delta(14)-sterol reductase LBR-like [KO:K19532] [EC:1.3.1.70]
125086167  prelamin-A/C [KO:K12641]
125100263  lamin-B1 [KO:K07611]
125087180  lamin-B2 [KO:K07611]
Reference
PMID:12142273
  Authors
Clark KA, McElhinny AS, Beckerle MC, Gregorio CC
  Title
Striated muscle cytoarchitecture: an intricate web of form and function.
  Journal
Annu Rev Cell Dev Biol 18:637-706 (2002)
DOI:10.1146/annurev.cellbio.18.012502.105840
Reference
PMID:31407867
  Authors
Mukund K, Subramaniam S
  Title
Skeletal muscle: A review of molecular structure and function, in health and disease.
  Journal
Wiley Interdiscip Rev Syst Biol Med 12:e1462 (2020)
DOI:10.1002/wsbm.1462
Reference
PMID:24481844
  Authors
Stroud MJ, Banerjee I, Veevers J, Chen J
  Title
Linker of nucleoskeleton and cytoskeleton complex proteins in cardiac structure, function, and disease.
  Journal
Circ Res 114:538-48 (2014)
DOI:10.1161/CIRCRESAHA.114.301236
Reference
PMID:28640448
  Authors
Henderson CA, Gomez CG, Novak SM, Mi-Mi L, Gregorio CC
  Title
Overview of the Muscle Cytoskeleton.
  Journal
Compr Physiol 7:891-944 (2017)
DOI:10.1002/cphy.c160033
Reference
PMID:32265741
  Authors
Csapo R, Gumpenberger M, Wessner B
  Title
Skeletal Muscle Extracellular Matrix - What Do We Know About Its Composition, Regulation, and Physiological Roles? A Narrative Review.
  Journal
Front Physiol 11:253 (2020)
DOI:10.3389/fphys.2020.00253
Reference
PMID:27114860
  Authors
Pinch M, Guth R, Samanta MP, Chaidez A, Unguez GA
  Title
The myogenic electric organ of Sternopygus macrurus: a non-contractile tissue with a skeletal muscle transcriptome.
  Journal
PeerJ 4:e1828 (2016)
DOI:10.7717/peerj.1828
Reference
PMID:23860255
  Authors
Sequeira V, Nijenkamp LL, Regan JA, van der Velden J
  Title
The physiological role of cardiac cytoskeleton and its alterations in heart failure.
  Journal
Biochim Biophys Acta 1838:700-22 (2014)
DOI:10.1016/j.bbamem.2013.07.011
Reference
PMID:36960155
  Authors
Zhang B, Powers JD, McCulloch AD, Chi NC
  Title
Nuclear mechanosignaling in striated muscle diseases.
  Journal
Front Physiol 14:1126111 (2023)
DOI:10.3389/fphys.2023.1126111
Reference
PMID:21464301
  Authors
Al-Amoudi A, Castano-Diez D, Devos DP, Russell RB, Johnson GT, Frangakis AS
  Title
The three-dimensional molecular structure of the desmosomal plaque.
  Journal
Proc Natl Acad Sci U S A 108:6480-5 (2011)
DOI:10.1073/pnas.1019469108
Reference
PMID:33067392
  Authors
Sikora M, Ermel UH, Seybold A, Kunz M, Calloni G, Reitz J, Vabulas RM, Hummer G, Frangakis AS
  Title
Desmosome architecture derived from molecular dynamics simulations and cryo-electron tomography.
  Journal
Proc Natl Acad Sci U S A 117:27132-27140 (2020)
DOI:10.1073/pnas.2004563117
Reference
PMID:26910421
  Authors
Xu XP, Kim E, Swift M, Smith JW, Volkmann N, Hanein D
  Title
Three-Dimensional Structures of Full-Length, Membrane-Embedded Human alpha(IIb)beta(3) Integrin Complexes.
  Journal
Biophys J 110:798-809 (2016)
DOI:10.1016/j.bpj.2016.01.016
Reference
PMID:22945352
  Authors
Wang W, Shi Z, Jiao S, Chen C, Wang H, Liu G, Wang Q, Zhao Y, Greene MI, Zhou Z
  Title
Structural insights into SUN-KASH complexes across the nuclear envelope.
  Journal
Cell Res 22:1440-52 (2012)
DOI:10.1038/cr.2012.126
Reference
PMID:23597672
  Authors
Sosa BA, Kutay U, Schwartz TU
  Title
Structural insights into LINC complexes.
  Journal
Curr Opin Struct Biol 23:285-91 (2013)
DOI:10.1016/j.sbi.2013.03.005
Reference
PMID:33058875
  Authors
Cruz VE, Esra Demircioglu F, Schwartz TU
  Title
Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes.
  Journal
J Mol Biol 432:6028-6041 (2020)
DOI:10.1016/j.jmb.2020.09.019
Reference
PMID:36523505
  Authors
Schuler SC, Liu Y, Dumontier S, Grandbois M, Le Moal E, Cornelison D, Bentzinger CF
  Title
Extracellular matrix: Brick and mortar in the skeletal muscle stem cell niche.
  Journal
Front Cell Dev Biol 10:1056523 (2022)
DOI:10.3389/fcell.2022.1056523
Reference
PMID:30425656
  Authors
Brull A, Morales Rodriguez B, Bonne G, Muchir A, Bertrand AT
  Title
The Pathogenesis and Therapies of Striated Muscle Laminopathies.
  Journal
Front Physiol 9:1533 (2018)
DOI:10.3389/fphys.2018.01533
Reference
PMID:36552829
  Authors
Storey EC, Fuller HR
  Title
Genotype-Phenotype Correlations in Human Diseases Caused by Mutations of LINC Complex-Associated Genes: A Systematic Review and Meta-Summary.
  Journal
Cells 11:cells11244065 (2022)
DOI:10.3390/cells11244065
Related
pathway
llv04512  ECM-receptor interaction
llv04814  Motor proteins
KO pathway
ko04820   
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