KEGG   PATHWAY: mcc05208
Entry
mcc05208                    Pathway                                
Name
Chemical carcinogenesis - reactive oxygen species - Macaca mulatta (rhesus monkey)
Description
It is well established that cancer is a multi-step process which involves initiation, promotion and progression. Chemical carcinogens can alter any of these processes to induce their carcinogenic effects. In the majority of instances, chemical carcinogens, directly or after xenobiotic metabolism, induce DNA damage and act in a 'genotoxic' manner. There is, however, a group of carcinogens that induce cancer via nongenotoxic mechanisms. The biochemical modes of action for nongenotoxic carcinogens are diverse, one example of which is induction of oxidative stress. Trace metals and organic xenobiotics are typical classes of environmental pollutants with prooxidant effects. Trace metals generate reactive oxygen species (ROS) depending on their ability to lose electrons and catalyze Haber Weiss and Fenton reactions. ROS are also generated due to induction of various cytochrome P450 isoenzymes during detoxification of chemical carcinogens. Increased ROS generation often has been linked to DNA damage that can lead to mutations and may, therefore, play an important role in the initiation and progression of multistage carcinogenesis. Besides causing DNA damage, ROS further induce multiple intracellular signaling pathways, notably NF-kappa B, JNK/SAPK/p38, as well as Erk/MAPK. These signaling routes can lead to transcriptional induction of target genes that could promote proliferation or confer apoptosis resistance to exposed cells.
Class
Human Diseases; Cancer: overview
Pathway map
mcc05208  Chemical carcinogenesis - reactive oxygen species
mcc05208

Organism
Macaca mulatta (rhesus monkey) [GN:mcc]
Gene
714122  AS3MT; arsenite methyltransferase [KO:K07755] [EC:2.1.1.137]
709498  GSTA3; glutathione S-transferase A3 [KO:K00799] [EC:2.5.1.18]
697983  MGST2; microsomal glutathione S-transferase 2 precursor [KO:K00799] [EC:2.5.1.18]
700185  GSTT2; glutathione S-transferase theta 2 [KO:K00799] [EC:2.5.1.18]
700314  GSTT1; glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
695275  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
700303  GSTM3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
709666  GSTA4; glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
701652  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
715291  GSTO2; glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
709037  GSTA2; glutathione S-transferase alpha 2 [KO:K00799] [EC:2.5.1.18]
709232  GSTA1; glutathione S-transferase alpha 1 [KO:K00799] [EC:2.5.1.18]
709417  glutathione S-transferase A5 [KO:K00799] [EC:2.5.1.18]
699923  GSTM4; glutathione S-transferase Mu 4 [KO:K00799] [EC:2.5.1.18]
699679  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
100426406  GSTM5; glutathione S-transferase Mu 5 [KO:K00799] [EC:2.5.1.18]
716078  GSTO1; glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
700053  GSTM2; glutathione S-transferase mu 2 [KO:K00799] [EC:2.5.1.18]
700178  GSTM1; glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
706634  glutathione S-transferase theta-2B isoform X1 [KO:K00799] [EC:2.5.1.18]
700446  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
711533  glutathione S-transferase A1-like [KO:K00799] [EC:2.5.1.18]
2846627  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
2846626  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
2846622  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
2846630  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
2846621  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
2846631  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
2846632  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
711412  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
706067  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
722400  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
694635  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
697736  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
705004  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
106994854  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 isoform X1 [KO:K03947]
641333  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
714483  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
114671531  LOW QUALITY PROTEIN: cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
114669899  cytochrome c oxidase subunit NDUFA4 [KO:K03948]
695066  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949]
694520  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949]
100430178  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
709640  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
711212  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 isoform X1 [KO:K03951]
698706  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
721906  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial isoform X1 [KO:K03953]
697681  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X2 [KO:K03954]
700718  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
697843  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
711970  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
716666  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
697745  NDUFB1; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
693431  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial isoform X1 [KO:K03958]
700944  NDUFB3; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
694795  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959]
114675522  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959]
713428  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
708821  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
704867  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
717849  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
710521  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
711387  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
693482  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
705984  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
107000976  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial-like [KO:K11351]
706912  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1 [KO:K03934] [EC:7.1.1.2]
719935  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
721639  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial-like [KO:K03935] [EC:7.1.1.2]
713040  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
704137  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X2 [KO:K03937]
693506  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
718553  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
114669847  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
709426  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
721259  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
710845  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
697242  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
100426173  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
708018  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
723069  LOW QUALITY PROTEIN: succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial-like [KO:K00234] [EC:1.3.5.1]
699810  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
702309  succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
719978  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
704336  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like isoform X1 [KO:K00236]
701966  succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
711326  SDHD; succinate dehydrogenase complex, subunit D, integral membrane protein [KO:K00237]
106992278  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
705178  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
700087  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
2846625  CYTB; cytochrome b [KO:K00412]
700518  CYC1; cytochrome c1, heme protein, mitochondrial [KO:K00413]
677864  UQCRC1; cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
697967  UQCRC2; cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
707968  UQCRH; cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
701223  cytochrome b-c1 complex subunit 7 isoform X1 [KO:K00417]
708950  UQCRQ; ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa [KO:K00418]
720636  cytochrome b-c1 complex subunit 9 [KO:K00419]
708396  UQCR; ubiquinol-cytochrome c reductase, 6.4kDa subunit [KO:K00420]
2846633  COX3; cytochrome c oxidase subunit III [KO:K02262]
2846624  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
2846628  COX2; cytochrome c oxidase subunit II [KO:K02261]
693811  COX4I1; cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
713095  COX4I2; cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
692061  COX5A; cytochrome c oxidase subunit 5A, mitochondrial precursor [KO:K02264]
697409  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 5A, mitochondrial-like [KO:K02264]
701661  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
707227  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
710274  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
713995  COX6A2; cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
696956  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
100425382  COX6B2; cytochrome c oxidase subunit 6B2 [KO:K02267]
692062  COX6B1; cytochrome c oxidase subunit 6B1 [KO:K02267]
703685  cytochrome c oxidase subunit 6C [KO:K02268]
100428417  COX6C; cytochrome c oxidase subunit 6C [KO:K02268]
100424587  cytochrome c oxidase subunit 6C-like [KO:K02268]
106994954  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 6C-like [KO:K02268]
692060  COX7AH; cytochrome c oxidase subunit 7AH [KO:K02270]
712764  COX7A2L; cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
106992283  cytochrome c oxidase subunit 7A-related protein, mitochondrial isoform X3 [KO:K02270]
717879  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
114674848  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
706099  COX7B; cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
100428437  COX7B2; cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
100429280  COX7C; cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
100423866  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
114671073  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
114673956  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
114678228  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
114679364  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
114679428  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
114677410  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
114678786  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
106998836  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
114680400  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
718007  COX8A; cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
106996000  uncharacterized protein LOC106996000 isoform X1 [KO:K02273]
106993150  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 8B, mitochondrial-like [KO:K02273]
701389  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
713284  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
713768  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
705944  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
574260  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
2846629  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
704072  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
711417  ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
706691  ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
697950  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
703751  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial isoform X1 [KO:K02128]
707476  ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
696144  ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
700815  ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
694260  LOW QUALITY PROTEIN: ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
702893  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
700338  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
699117  ATP synthase subunit d, mitochondrial [KO:K02138]
698480  ATP5O; ATP synthase subunit O, mitochondrial [KO:K02137]
708411  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
2846623  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
574097  SOD2; superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
710045  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
704257  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
705116  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
695102  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
710042  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
719811  ADP/ATP translocase 3 [KO:K05863]
693502  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
574137  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
574096  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
693966  LOW QUALITY PROTEIN: superoxide dismutase [Cu-Zn]-like [KO:K04565] [EC:1.15.1.1]
717406  CAT; catalase [KO:K03781] [EC:1.11.1.6]
703052  SLC26A1; sulfate anion transporter 1 isoform X1 [KO:K14700]
709998  SLC26A2; sulfate transporter [KO:K14701]
106996923  SLC26A6; solute carrier family 26 member 6 isoform X1 [KO:K14704]
696461  SLC26A9; solute carrier family 26 member 9 [KO:K14706]
678688  CYP2E1; cytochrome P450 2E1 precursor [KO:K07415] [EC:1.14.14.-]
114669719  cytochrome P450 2E1-like [KO:K07415] [EC:1.14.14.-]
114669866  cytochrome P450 2E1-like [KO:K07415] [EC:1.14.14.-]
678696  CYP2F1; cytochrome P450, family 2, subfamily F, polypeptide 6 precursor [KO:K07416] [EC:1.14.14.1]
100424795  cytochrome P450 2F1-like [KO:K07416] [EC:1.14.14.1]
678694  CYP1A1; cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
710385  CYP1B1; cytochrome P450 1B1 [KO:K07410] [EC:1.14.14.1]
700180  EPHX1; epoxide hydrolase 1 precursor [KO:K01253] [EC:3.3.2.9]
712926  EPHX2; bifunctional epoxide hydrolase 2 isoform X1 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
718176  EPHX3; epoxide hydrolase 3 [KO:K22368] [EC:3.3.2.10]
705422  EPHX4; epoxide hydrolase 4 isoform X1 [KO:K22369] [EC:3.3.-.-]
693380  AKR1A1; alcohol dehydrogenase [NADP(+)] [KO:K00002] [EC:1.1.1.2]
711198  AKR1C1; aldo-keto reductase family 1 member C1 [KO:K00212] [EC:1.1.1.149 1.1.1.357 1.3.1.20]
711360  AKR1C2; aldo-keto reductase family 1 member C2 [KO:K00212] [EC:1.1.1.149 1.1.1.357 1.3.1.20]
711440  aldo-keto reductase family 1 member C3 homolog [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
100430336  LOW QUALITY PROTEIN: putative aldo-keto reductase family 1 member C8 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
722485  aldo-keto reductase family 1 member C15 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
722496  aldo-keto reductase family 1 member C15 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
722490  AKR1C4; aldo-keto reductase family 1 member C4 isoform X1 [KO:K00037] [EC:1.1.1.50 1.1.1.357 1.1.1.225]
722483  aldo-keto reductase family 1 member C4 [KO:K00037] [EC:1.1.1.50 1.1.1.357 1.1.1.225]
705635  NQO1; NAD(P)H dehydrogenase [quinone] 1 [KO:K00355] [EC:1.6.5.2]
699655  carbonyl reductase [NADPH] 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
714254  AHR; aryl hydrocarbon receptor [KO:K09093]
100423621  aryl hydrocarbon receptor-like isoform X1 [KO:K09093]
709848  LPO; lactoperoxidase [KO:K12550] [EC:1.11.1.7]
705931  NOX4; NADPH oxidase 4 isoform X5 [KO:K21423] [EC:1.6.3.-]
696748  cytochrome b-245 light chain isoform X2 [KO:K08009]
701376  NOX1; NADPH oxidase 1 [KO:K08008]
694207  NCF1; neutrophil cytosol factor 1 [KO:K08011]
715052  NCF2; neutrophil cytosol factor 2 isoform X1 [KO:K08010]
698619  EGF; pro-epidermal growth factor isoform X2 [KO:K04357]
613027  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
708316  HGF; hepatocyte growth factor isoform X3 [KO:K05460]
704562  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
702041  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
713777  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
705601  SOS2; son of sevenless homolog 2 [KO:K03099]
698830  HRAS; GTPase HRas [KO:K02833]
707977  KRAS; GTPase KRas [KO:K07827]
709089  NRAS; GTPase NRas [KO:K07828]
707169  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
693554  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
694725  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
710415  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
721821  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
708938  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
698569  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
711382  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
718155  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
710077  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
699736  MAPK10; mitogen-activated protein kinase 10 isoform 1 [KO:K04440] [EC:2.7.11.24]
711115  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
715782  MAPK9; mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
715745  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
715794  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
718976  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
719085  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
716452  JUN; transcription factor AP-1 [KO:K04448]
702077  FOS; proto-oncogene c-Fos [KO:K04379]
707310  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
719367  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
698996  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
716098  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
709959  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
710552  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
717755  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
697523  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X2 [KO:K06276] [EC:2.7.11.1]
714717  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
697747  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
700591  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
700731  FOXO3; forkhead box protein O3 [KO:K09408]
717740  BAD; bcl2-associated agonist of cell death [KO:K02158]
702016  PTPN1; tyrosine-protein phosphatase non-receptor type 1 [KO:K05696] [EC:3.1.3.48]
705121  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
709511  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X3 [KO:K04467] [EC:2.7.11.10]
704683  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
701237  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
695335  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
715919  RELA; transcription factor p65 isoform X1 [KO:K04735]
710324  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
694656  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
710347  PTPRJ; receptor-type tyrosine-protein phosphatase eta [KO:K05698] [EC:3.1.3.48]
721397  ACP1; low molecular weight phosphotyrosine protein phosphatase isoform X1 [KO:K14394] [EC:3.1.3.2 3.1.3.48]
712044  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
701057  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
722449  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
717037  ABL2; tyrosine-protein kinase ABL2 isoform X1 [KO:K08887] [EC:2.7.10.2]
709647  PRKD3; serine/threonine-protein kinase D3 [KO:K06070] [EC:2.7.11.13]
716937  PRKD1; serine/threonine-protein kinase D1 isoform X1 [KO:K06070] [EC:2.7.11.13]
716736  PRKD2; serine/threonine-protein kinase D2 isoform X1 [KO:K06070] [EC:2.7.11.13]
700634  PTK2; focal adhesion kinase 1 isoform X8 [KO:K05725] [EC:2.7.10.2]
721573  PLD2; phospholipase D2 isoform X2 [KO:K01115] [EC:3.1.4.4]
694963  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
716258  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
704678  HIF1A; hypoxia-inducible factor 1-alpha isoform X4 [KO:K08268]
715971  ARNT; aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
574209  VEGFA; vascular endothelial growth factor A isoform 1 precursor [KO:K05448]
720514  KEAP1; kelch-like ECH-associated protein 1 [KO:K10456]
707606  NFE2L2; nuclear factor erythroid 2-related factor 2 [KO:K05638]
719266  HMOX1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
Compound
C00001  H2O
C00003  NAD+
C00005  NADPH
C00006  NADP+
C00007  Oxygen
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00023  Iron
C00027  Hydrogen peroxide
C00051  Glutathione
C00070  Copper
C00084  Acetaldehyde
C00127  Glutathione disulfide
C00146  Phenol
C00291  Nickel
C00469  Ethanol
C00472  p-Benzoquinone
C00530  Hydroquinone
C00704  Superoxide
C00951  Estradiol-17beta
C01407  Benzene
C01413  Cadmium
C01782  Benzene oxide
C02389  p-Benzosemiquinone
C02575  Pentachlorophenol
C02814  Benzene-1,2,4-triol
C03434  Tetrachlorohydroquinone
C03622  N-Hydroxy-4-aminobiphenyl
C04623  DDT
C05301  2-Hydroxyestradiol
C05309  Semiquinone
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06268  Chromium
C06269  Arsenic
C06696  Lead
C07294  Methylarsonate
C07295  Methanearsonous acid
C07308  Cacodylate
C07535  Benzo[a]pyrene
C07557  2,3,7,8-Tetrachlorodibenzodioxin
C10998  4-Aminobiphenyl
C14209  4-Hydroxy-17beta-estradiol
C14850  Benzo[a]pyrene-7,8-oxide
C14852  Benzo[a]pyrene-7,8-dihydrodiol
C16038  2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
C16844  Hydroxyl radical
C18205  2,2',4,4'-Tetrabromodiphenyl ether
C18933  Chloranil
C19171  Cobalt
C20300  Dimethylarsinous acid
C20316  4-Nitrosobiphenyl
C20319  Hydronitroxide radical
C22355  Benzo[a]pyrene-7,8-diol
C22356  Benzo[a]pyrene-7,8-dione
C22357  17beta-Estradiol-2,3-quinone
C22381  Reactive oxygen species
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Related
pathway
mcc00190  Oxidative phosphorylation
mcc00980  Metabolism of xenobiotics by cytochrome P450
mcc04010  MAPK signaling pathway
mcc04064  NF-kappa B signaling pathway
mcc04066  HIF-1 signaling pathway
mcc04151  PI3K-Akt signaling pathway
mcc04370  VEGF signaling pathway
mcc05207  Chemical carcinogenesis - receptor activation
mcc05211  Renal cell carcinoma
mcc05215  Prostate cancer
mcc05219  Bladder cancer
mcc05221  Acute myeloid leukemia
mcc05222  Small cell lung cancer
mcc05223  Non-small cell lung cancer
mcc05224  Breast cancer
mcc05225  Hepatocellular carcinoma
KO pathway
ko05208   
LinkDB

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