KEGG   PATHWAY: mmf05205
Entry
mmf05205                    Pathway                                
Name
Proteoglycans in cancer - Molossus molossus (Pallas's mastiff bat)
Description
Many proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis and metastasis, affecting tumor progress. The four main types of proteoglycans include hyaluronan (HA), which does not occur as a PG but in free form, heparan sulfate proteoglycans (HSPGs), chondroitin sulfate proteoglycans (CSPGs), dematan sulfate proteoglycans (DSPG) and keratan sulfate proteoglycans (KSPGs) [BR:00535]. Among these proteoglycans such as HA, acting with CD44, promotes tumor cell growth and migration, whereas other proteoglycans such as syndecans (-1~-4), glypican (-1, -3) and perlecan may interact with growth factors, cytokines, morphogens and enzymes through HS chains [BR:00536], also leading to tumor growth and invasion. In contrast, some of the small leucine-rich proteolgycans, such as decorin and lumican, can function as tumor repressors, and modulate the signaling pathways by the interaction of their core proteins and multiple receptors.
Class
Human Diseases; Cancer: overview
Pathway map
mmf05205  Proteoglycans in cancer
mmf05205

Organism
Molossus molossus (Pallas's mastiff bat) [GN:mmf]
Gene
118627527  CD44; CD44 antigen isoform X1 [KO:K06256]
118618720  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
118617269  HCLS1; hematopoietic lineage cell-specific protein [KO:K06106]
118643166  CTTN; src substrate cortactin [KO:K06106]
118633888  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
118633806  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
118629384  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
118643718  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
118637802  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
118643162  HRAS; GTPase HRas isoform X1 [KO:K02833]
118624619  KRAS; GTPase KRas isoform X1 [KO:K07827]
118637822  NRAS; GTPase NRas [KO:K07828]
118628014  RRAS2; ras-related protein R-Ras2 [KO:K07830]
118633604  MRAS; ras-related protein M-Ras [KO:K07831]
118619570  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
118633343  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
118635666  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
118628434  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
118615385  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
118640210  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
118642307  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
118616519  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
118640887  IQGAP1; ras GTPase-activating-like protein IQGAP1 isoform X1 [KO:K16848]
118626070  CDC42; cell division control protein 42 homolog [KO:K04393]
118638912  LOW QUALITY PROTEIN: cell division control protein 42 homolog [KO:K04393]
118636653  ELK1; LOW QUALITY PROTEIN: ETS domain-containing protein Elk-1 [KO:K04375]
118621009  ESR1; estrogen receptor isoform X1 [KO:K08550]
118628257  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
118635031  ACTG1; actin, cytoplasmic 2 [KO:K05692]
118616016  ACTB; actin, cytoplasmic 1 [KO:K05692]
118636593  FLNA; filamin-A isoform X1 [KO:K04437]
118627562  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
118617355  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
118638816  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
118632939  RHOA; transforming protein RhoA [KO:K04513]
118618764  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
118630612  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
118623001  ANK1; ankyrin-1 isoform X1 [KO:K10380]
118616294  ANK2; ankyrin-2 isoform X1 [KO:K09255]
118632402  ANK3; ankyrin-3 isoform X1 [KO:K09259]
118615769  GAB1; GRB2-associated-binding protein 1 isoform X1 [KO:K09593]
118632927  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118626944  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118617106  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118626685  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
118642883  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
118616460  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
118640620  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118619617  LOW QUALITY PROTEIN: RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
118630299  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118638405  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118626285  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
118627965  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
118630486  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
118639818  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
118623369  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
118640525  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
118639397  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
118628975  ARHGEF12; rho guanine nucleotide exchange factor 12 [KO:K07532]
118632322  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
118632878  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
118623451  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
118621173  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
118619531  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
118643618  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
118615118  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
118632270  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
118642122  homeobox protein NANOG-like [KO:K10164]
118623320  NANOG; homeobox protein NANOG [KO:K10164]
118633967  DDX5; probable ATP-dependent RNA helicase DDX5 [KO:K12823] [EC:5.6.2.7]
118641774  DROSHA; ribonuclease 3 isoform X1 [KO:K03685] [EC:3.1.26.3]
118634787  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
118625844  TWIST2; twist-related protein 2 [KO:K09069]
118620113  TWIST1; twist-related protein 1 [KO:K09069]
118625647  HOXD10; homeobox protein Hox-D10 [KO:K09295]
118623889  DCN; decorin [KO:K04660]
118624040  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
118640813  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
118627075  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
118642806  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
118634239  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
118627654  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
118623888  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
118632909  40S ribosomal protein S6-like [KO:K02991]
118634553  40S ribosomal protein S6-like [KO:K02991]
118641681  40S ribosomal protein S6-like [KO:K02991]
118642003  40S ribosomal protein S6-like [KO:K02991]
118629558  RPS6; 40S ribosomal protein S6 [KO:K02991]
118620077  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
118620482  CAV1; caveolin-1 isoform X1 [KO:K06278]
118619898  CAV2; caveolin-2 [KO:K12958]
118633298  CAV3; caveolin-3 [KO:K12959]
118624089  CD63; CD63 antigen [KO:K06497]
118621843  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
118622705  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
118638486  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
118616119  TLR2; toll-like receptor 2 [KO:K10159]
118629497  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
118632349  PDCD4; programmed cell death protein 4 isoform X1 [KO:K16865]
118621647  TNF; tumor necrosis factor [KO:K03156]
118615760  IL12B; interleukin-12 subunit beta [KO:K05425]
118624257  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
118625188  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
118631560  MYC; myc proto-oncogene protein [KO:K04377]
118632900  CTNNB1; catenin beta-1 [KO:K02105]
118627941  HIF1A; hypoxia-inducible factor 1-alpha [KO:K08268]
118642350  TFAP4; transcription factor AP-4 [KO:K09108]
118621078  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
118639624  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
118619859  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
118628368  CBL; E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
118624042  TIMP3; metalloproteinase inhibitor 3 [KO:K16866]
118632173  THBS1; thrombospondin-1 [KO:K16857]
118639416  MMP2; 72 kDa type IV collagenase [KO:K01398] [EC:3.4.24.24]
118618723  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
118624171  LUM; lumican [KO:K08122]
118637768  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
118632575  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
118623649  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
118634552  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
118640680  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
118618734  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
118640491  HPSE; heparanase [KO:K07964] [EC:3.2.1.166]
118632232  HPSE2; inactive heparanase-2 isoform X1 [KO:K07965] [EC:3.2.1.-]
118631230  SDC1; syndecan-1 [KO:K06257]
118632750  PLAU; urokinase-type plasminogen activator isoform X1 [KO:K01348] [EC:3.4.21.73]
118639507  PLAUR; urokinase plasminogen activator surface receptor isoform X1 [KO:K03985]
118633930  COL1A1; collagen alpha-1(I) chain [KO:K06236]
118620424  COL1A2; collagen alpha-2(I) chain [KO:K06236]
118641528  ITGA2; integrin alpha-2 [KO:K06481]
118629439  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
118634858  VTN; vitronectin [KO:K06251]
118625208  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
118634259  ITGB3; integrin beta-3 [KO:K06493]
118625141  FN1; fibronectin isoform X1 [KO:K05717]
118617706  ITGB5; integrin beta-5 [KO:K06588]
118620202  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
118624573  WNT1; proto-oncogene Wnt-1 [KO:K03209]
118625867  FZD7; frizzled-7 [KO:K02432]
118619950  FZD1; frizzled-1 [KO:K02432]
118634409  FZD2; frizzled-2 [KO:K02235]
118615606  FZD3; frizzled-3 [KO:K02329]
118628199  FZD4; frizzled-4 [KO:K02354]
118625653  FZD5; frizzled-5 [KO:K02375]
118635933  FZD8; frizzled-8 [KO:K02375]
118631778  FZD6; frizzled-6 [KO:K02376]
118640089  FZD10; frizzled-10 [KO:K02842]
118641870  FZD9; frizzled-9 [KO:K02842]
118623674  ITGA5; integrin alpha-5 [KO:K06484]
118631553  SDC2; syndecan-2 [KO:K16336]
118620909  EZR; ezrin [KO:K08007]
118627915  RDX; radixin isoform X1 [KO:K05762]
118636343  MSN; moesin [KO:K05763]
118619335  SDC4; syndecan-4 [KO:K16338]
118616042  FGF2; fibroblast growth factor 2 [KO:K18497]
118622697  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
118624066  FRS2; fibroblast growth factor receptor substrate 2 [KO:K12461]
118639877  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
118630966  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
118616724  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
118618299  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
118639621  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
118633872  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
118641370  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
118638191  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
118641901  NUDT16L1; tudor-interacting repair regulator protein isoform X1 [KO:K16867]
118639815  PXN; paxillin isoform X1 [KO:K05760]
118631501  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
118615761  HBEGF; proheparin-binding EGF-like growth factor [KO:K08523]
118625815  GPC1; glypican-1 [KO:K08107]
118628029  IGF2; insulin-like growth factor II [KO:K13769]
118636273  GPC3; glypican-3 [KO:K08109]
118620145  WNT2; protein Wnt-2 [KO:K00182]
118636917  WNT2B; protein Wnt-2b [KO:K00182]
118634682  WNT3; proto-oncogene Wnt-3 [KO:K00312]
118616112  WNT3A; protein Wnt-3a [KO:K00312]
118626972  WNT4; protein Wnt-4 [KO:K00408]
118633580  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
118624082  WNT5B; protein Wnt-5b [KO:K00444]
118625699  WNT6; protein Wnt-6 [KO:K00445]
118617714  WNT7A; protein Wnt-7a [KO:K00572]
118641133  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
118643565  WNT8A; protein Wnt-8a [KO:K00714]
118632516  WNT8B; protein Wnt-8b [KO:K00714]
118634738  WNT9B; protein Wnt-9b [KO:K01064]
118616322  WNT9A; protein Wnt-9a [KO:K01064]
118624238  WNT10B; protein Wnt-10b [KO:K01357]
118625452  WNT10A; protein Wnt-10a [KO:K01357]
118627787  WNT11; protein Wnt-11 [KO:K01384]
118620176  WNT16; protein Wnt-16 [KO:K01558]
118620273  SHH; sonic hedgehog protein isoform X1 [KO:K11988]
118625692  IHH; indian hedgehog protein [KO:K11989]
118629803  PTCH1; protein patched homolog 1 [KO:K06225]
118620268  SMO; smoothened homolog isoform X1 [KO:K06226]
118626818  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein [KO:K06255]
118629279  CTSL; LOW QUALITY PROTEIN: cathepsin L1 [KO:K01365] [EC:3.4.22.15]
118629594  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
118629621  CTSV; cathepsin L2 [KO:K01365] [EC:3.4.22.15]
118626166  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
118615793  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
118641186  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
118641187  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
118621004  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
118621005  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
118628817  HSPB2; heat shock protein beta-2 [KO:K09543]
118623590  PTPN6; tyrosine-protein phosphatase non-receptor type 6 isoform X1 [KO:K05697] [EC:3.1.3.48]
Compound
C00426  Dermatan sulfate
C00573  Keratan sulfate
C00607  Chondroitin sulfate
C00925  Heparan sulfate
G10505  Hyaluronic acid
G13063  Binding domain for FGF2 in heparin/heparan sulfate
G13064  Binding domain for HGF in heparin/heparan sulfate
Reference
PMID:18450475
  Authors
Bourguignon LY
  Title
Hyaluronan-mediated CD44 activation of RhoGTPase signaling and cytoskeleton function promotes tumor progression.
  Journal
Semin Cancer Biol 18:251-9 (2008)
DOI:10.1016/j.semcancer.2008.03.007
Reference
PMID:12729888
  Authors
Briggs MW, Sacks DB
  Title
IQGAP1 as signal integrator: Ca2+, calmodulin, Cdc42 and the cytoskeleton.
  Journal
FEBS Lett 542:7-11 (2003)
DOI:10.1016/S0014-5793(03)00333-8
Reference
PMID:12748184
  Authors
Bourguignon LY, Singleton PA, Zhu H, Diedrich F
  Title
Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and phosphatidylinositol 3-kinase signaling leading to cytokine (macrophage-colony stimulating factor) production and breast tumor progression.
  Journal
J Biol Chem 278:29420-34 (2003)
DOI:10.1074/jbc.M301885200
Reference
PMID:15655247
  Authors
Bourguignon LY, Gilad E, Rothman K, Peyrollier K
  Title
Hyaluronan-CD44 interaction with IQGAP1 promotes Cdc42 and ERK signaling, leading to actin binding, Elk-1/estrogen receptor transcriptional activation, and ovarian cancer progression.
  Journal
J Biol Chem 280:11961-72 (2005)
DOI:10.1074/jbc.M411985200
Reference
PMID:11717317
  Authors
Turley EA, Noble PW, Bourguignon LY
  Title
Signaling properties of hyaluronan receptors.
  Journal
J Biol Chem 277:4589-92 (2002)
DOI:10.1074/jbc.R100038200
Reference
PMID:9346940
  Authors
Bourguignon LY, Zhu H, Chu A, Iida N, Zhang L, Hung MC
  Title
Interaction between the adhesion receptor, CD44, and the oncogene product, p185HER2, promotes human ovarian tumor cell activation.
  Journal
J Biol Chem 272:27913-8 (1997)
DOI:10.1074/jbc.272.44.27913
Reference
PMID:22735579
  Authors
Neill T, Schaefer L, Iozzo RV
  Title
Decorin: a guardian from the matrix.
  Journal
Am J Pathol 181:380-7 (2012)
DOI:10.1016/j.ajpath.2012.04.029
Reference
PMID:22194599
  Authors
Neill T, Painter H, Buraschi S, Owens RT, Lisanti MP, Schaefer L, Iozzo RV
  Title
Decorin antagonizes the angiogenic network: concurrent inhibition of Met, hypoxia inducible factor 1alpha, vascular endothelial growth factor A, and induction of thrombospondin-1 and TIMP3.
  Journal
J Biol Chem 287:5492-506 (2012)
DOI:10.1074/jbc.M111.283499
Reference
PMID:19433454
  Authors
Goldoni S, Humphries A, Nystrom A, Sattar S, Owens RT, McQuillan DJ, Ireton K, Iozzo RV
  Title
Decorin is a novel antagonistic ligand of the Met receptor.
  Journal
J Cell Biol 185:743-54 (2009)
DOI:10.1083/jcb.200901129
Reference
PMID:15994311
  Authors
Zhu JX, Goldoni S, Bix G, Owens RT, McQuillan DJ, Reed CC, Iozzo RV
  Title
Decorin evokes protracted internalization and degradation of the epidermal growth factor receptor via caveolar endocytosis.
  Journal
J Biol Chem 280:32468-79 (2005)
DOI:10.1074/jbc.M503833200
Reference
PMID:20974860
  Authors
Buraschi S, Pal N, Tyler-Rubinstein N, Owens RT, Neill T, Iozzo RV
  Title
Decorin antagonizes Met receptor activity and down-regulates {beta}-catenin and Myc levels.
  Journal
J Biol Chem 285:42075-85 (2010)
DOI:10.1074/jbc.M110.172841
Reference
PMID:18798267
  Authors
Goldoni S, Iozzo RV
  Title
Tumor microenvironment: Modulation by decorin and related molecules harboring leucine-rich tandem motifs.
  Journal
Int J Cancer 123:2473-9 (2008)
DOI:10.1002/ijc.23930
Reference
PMID:23058688
  Authors
Sofeu Feugaing DD, Gotte M, Viola M
  Title
More than matrix: the multifaceted role of decorin in cancer.
  Journal
Eur J Cell Biol 92:1-11 (2013)
DOI:10.1016/j.ejcb.2012.08.004
Reference
PMID:22087031
  Authors
Merline R, Moreth K, Beckmann J, Nastase MV, Zeng-Brouwers J, Tralhao JG, Lemarchand P, Pfeilschifter J, Schaefer RM, Iozzo RV, Schaefer L
  Title
Signaling by the matrix proteoglycan decorin controls inflammation and cancer through PDCD4 and MicroRNA-21.
  Journal
Sci Signal 4:ra75 (2011)
DOI:10.1126/scisignal.2001868
Reference
PMID:22033227
  Authors
Teng YH, Aquino RS, Park PW
  Title
Molecular functions of syndecan-1 in disease.
  Journal
Matrix Biol 31:3-16 (2012)
DOI:10.1016/j.matbio.2011.10.001
Reference
PMID:11830493
  Authors
Derksen PW, Keehnen RM, Evers LM, van Oers MH, Spaargaren M, Pals ST
  Title
Cell surface proteoglycan syndecan-1 mediates hepatocyte growth factor binding and promotes Met signaling in multiple myeloma.
  Journal
Blood 99:1405-10 (2002)
DOI:10.1182/blood.V99.4.1405
Reference
PMID:19733083
  Authors
Fux L, Ilan N, Sanderson RD, Vlodavsky I
  Title
Heparanase: busy at the cell surface.
  Journal
Trends Biochem Sci 34:511-9 (2009)
DOI:10.1016/j.tibs.2009.06.005
Reference
PMID:18812315
  Authors
Purushothaman A, Chen L, Yang Y, Sanderson RD
  Title
Heparanase stimulation of protease expression implicates it as a master regulator of the aggressive tumor phenotype in myeloma.
  Journal
J Biol Chem 283:32628-36 (2008)
DOI:10.1074/jbc.M806266200
Reference
PMID:19255147
  Authors
Beauvais DM, Ell BJ, McWhorter AR, Rapraeger AC
  Title
Syndecan-1 regulates alphavbeta3 and alphavbeta5 integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor.
  Journal
J Exp Med 206:691-705 (2009)
DOI:10.1084/jem.20081278
Reference
PMID:20655987
  Authors
Mahtouk K, Tjin EP, Spaargaren M, Pals ST
  Title
The HGF/MET pathway as target for the treatment of multiple myeloma and B-cell lymphomas.
  Journal
Biochim Biophys Acta 1806:208-19 (2010)
DOI:10.1016/j.bbcan.2010.07.006
Reference
PMID:11931647
  Authors
Munesue S, Kusano Y, Oguri K, Itano N, Yoshitomi Y, Nakanishi H, Yamashina I, Okayama M
  Title
The role of syndecan-2 in regulation of actin-cytoskeletal organization of Lewis lung carcinoma-derived metastatic clones.
  Journal
Biochem J 363:201-9 (2002)
DOI:10.1042/bj3630201
Reference
PMID:10687947
  Authors
Nugent MA, Iozzo RV
  Title
Fibroblast growth factor-2.
  Journal
Int J Biochem Cell Biol 32:115-20 (2000)
DOI:10.1016/S1357-2725(99)00123-5
Reference
PMID:10633082
  Authors
Baciu PC, Saoncella S, Lee SH, Denhez F, Leuthardt D, Goetinck PF
  Title
Syndesmos, a protein that interacts with the cytoplasmic domain of syndecan-4, mediates cell spreading and actin cytoskeletal organization.
  Journal
J Cell Sci 113 Pt 2:315-24 (2000)
Reference
PMID:12509413
  Authors
Thodeti CK, Albrechtsen R, Grauslund M, Asmar M, Larsson C, Takada Y, Mercurio AM, Couchman JR, Wewer UM
  Title
ADAM12/syndecan-4 signaling promotes beta 1 integrin-dependent cell spreading through protein kinase Calpha and RhoA.
  Journal
J Biol Chem 278:9576-84 (2003)
DOI:10.1074/jbc.M208937200
Reference
PMID:14711376
  Authors
Beauvais DM, Rapraeger AC
  Title
Syndecans in tumor cell adhesion and signaling.
  Journal
Reprod Biol Endocrinol 2:3 (2004)
DOI:10.1186/1477-7827-2-3
Reference
PMID:17971838
  Authors
Morgan MR, Humphries MJ, Bass MD
  Title
Synergistic control of cell adhesion by integrins and syndecans.
  Journal
Nat Rev Mol Cell Biol 8:957-69 (2007)
DOI:10.1038/nrm2289
Reference
PMID:18505598
  Authors
Filmus J, Capurro M, Rast J
  Title
Glypicans.
  Journal
Genome Biol 9:224 (2008)
DOI:10.1186/gb-2008-9-5-224
Reference
PMID:23305321
  Authors
Filmus J, Capurro M
  Title
Glypican-3: a marker and a therapeutic target in hepatocellular carcinoma.
  Journal
FEBS J 280:2471-6 (2013)
DOI:10.1111/febs.12126
Reference
PMID:22563565
  Authors
Gao W, Ho M
  Title
The role of glypican-3 in regulating Wnt in hepatocellular carcinomas.
  Journal
Cancer Rep 1:14-19 (2011)
Reference
PMID:24412155
  Authors
Filmus J, Capurro M
  Title
The role of glypicans in Hedgehog signaling.
  Journal
Matrix Biol 35:248-52 (2014)
DOI:10.1016/j.matbio.2013.12.007
Reference
PMID:18413366
  Authors
Cheng W, Tseng CJ, Lin TT, Cheng I, Pan HW, Hsu HC, Lee YM
  Title
Glypican-3-mediated oncogenesis involves the Insulin-like growth factor-signaling pathway.
  Journal
Carcinogenesis 29:1319-26 (2008)
DOI:10.1093/carcin/bgn091
Reference
PMID:21155971
  Authors
Iozzo RV, Sanderson RD
  Title
Proteoglycans in cancer biology, tumour microenvironment and angiogenesis.
  Journal
J Cell Mol Med 15:1013-31 (2011)
DOI:10.1111/j.1582-4934.2010.01236.x
Reference
PMID:18949819
  Authors
Nikitovic D, Katonis P, Tsatsakis A, Karamanos NK, Tzanakakis GN
  Title
Lumican, a small leucine-rich proteoglycan.
  Journal
IUBMB Life 60:818-23 (2008)
DOI:10.1002/iub.131
Related
pathway
mmf04010  MAPK signaling pathway
mmf04020  Calcium signaling pathway
mmf04066  HIF-1 signaling pathway
mmf04150  mTOR signaling pathway
mmf04151  PI3K-Akt signaling pathway
mmf04210  Apoptosis
mmf04310  Wnt signaling pathway
mmf04340  Hedgehog signaling pathway
mmf04350  TGF-beta signaling pathway
mmf04370  VEGF signaling pathway
mmf04510  Focal adhesion
mmf04520  Adherens junction
mmf04810  Regulation of actin cytoskeleton
KO pathway
ko05205   
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