KEGG   PATHWAY: mmma04936
Entry
mmma04936                   Pathway                                
Name
Alcoholic liver disease - Marmota marmota marmota (Alpine marmot)
Description
Alcoholic liver disease (ALD) refers to the damages to the liver and its functions due to alcohol overconsumption. It ranges from simple steatosis to steatohepatitis, cirrhosis, and even hepatocellular carcinoma. Alcohol consumption promotes liver inflammation by increasing the translocation of gut-derived endotoxins to the portal circulation and activating Kupffer cells to produce TNF-alpha through the LPS/Toll like receptor (TLR) 4 pathways. TNF-alpha induces hepatocellular damage. When alcohol intake is chronic and heavy, steatosis is caused via generation of acetaldehyde, reactive oxygen species (ROS) and ER stress. ROS inhibits key hepatic transcriptional regulators such as AMP-activated kinase (AMPK) and peroxisome proliferator-activated receptor alpha (PPAR-alpha), which are responsible for fatty acid oxidation and export via ACC and CPT-1. The blockade of AMPK also leads to overexpression of SREBP-1, resulting in an increase of de novo lipogenesis. Moreover, excessive intracellular ROS production induced by ethanol and its metabolite have a critical role in ethanol-induced apoptosis, which may be the critical process in the exacerbation of ALD. It is inferred that the apoptotic signal derived from ROS that was produced by NOX, is mainly transduced through the JNK and p38 MAPK pathways.
Class
Human Diseases; Endocrine and metabolic disease
Pathway map
mmma04936  Alcoholic liver disease
mmma04936

Organism
Marmota marmota marmota (Alpine marmot) [GN:mmma]
Gene
107142146  C1qa; complement C1q subcomponent subunit A isoform X1 [KO:K03986]
107142148  C1qb; complement C1q subcomponent subunit B [KO:K03987]
107142147  C1qc; complement C1q subcomponent subunit C [KO:K03988]
107143589  C2; complement C2 [KO:K01332] [EC:3.4.21.43]
107143751  complement C4-A [KO:K03989]
107159936  C3ar1; C3a anaphylatoxin chemotactic receptor [KO:K04009]
107152133  complement C5-like isoform X1 [KO:K03994]
107152134  complement C5-like [KO:K03994]
107151318  C5ar1; C5a anaphylatoxin chemotactic receptor 1 isoform X2 [KO:K04010]
107138143  lipopolysaccharide-binding protein-like [KO:K05399]
107138161  lipopolysaccharide-binding protein [KO:K05399]
107141725  Cd14; monocyte differentiation antigen CD14 [KO:K04391]
107142453  Ly96; lymphocyte antigen 96 isoform X1 [KO:K05400]
107152144  Tlr4; toll-like receptor 4 isoform X1 [KO:K10160]
107153503  toll/interleukin-1 receptor domain-containing adapter protein isoform X1 [KO:K05403]
107145496  Myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
107148556  Irak4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
107160297  Irak1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
107135761  Traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
107155868  Tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
107156048  Tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
107153854  Map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
107149793  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
107159633  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
107160284  Ikbkg; NF-kappa-B essential modulator isoform X3 [KO:K07210]
107143750  Nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
107156942  Rela; transcription factor p65 [KO:K04735]
107141352  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
107143715  Tnf; tumor necrosis factor [KO:K03156]
107154164  Il1b; interleukin-1 beta [KO:K04519]
107146026  Il6; interleukin-6 [KO:K05405]
107143551  Il12a; interleukin-12 subunit alpha [KO:K05406]
107148164  Il12b; interleukin-12 subunit beta [KO:K05425]
107158812  Cxcl8; interleukin-8 [KO:K10030]
125611315  C-X-C motif chemokine 15-like [KO:K10030]
107150805  Traf3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
107140610  Ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
107140093  Tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
107151239  Irf3; interferon regulatory factor 3 isoform X1 [KO:K05411]
107134700  interferon alpha-5-like [KO:K05414]
107147930  interferon alpha-5-like [KO:K05414]
107135123  interferon alpha-13-like [KO:K05414]
107156481  interferon alpha-5-like [KO:K05414]
107156482  interferon alpha-5-like [KO:K05414]
107156485  interferon alpha-5-like [KO:K05414]
107156486  interferon alpha-5-like [KO:K05414]
107156487  interferon alpha-5-like [KO:K05414]
107156488  interferon alpha-5-like [KO:K05414]
107156465  interferon beta-like [KO:K05415]
107156489  Ifnb1; interferon beta [KO:K05415]
107144093  Il17a; interleukin-17A [KO:K05489]
107154895  Il17ra; interleukin-17 receptor A [KO:K05164]
107150130  Il17rc; interleukin-17 receptor C [KO:K05166]
107158780  uncharacterized protein LOC107158780 isoform X1 [KO:K05505]
107158783  growth-regulated protein homolog gamma isoform X1 [KO:K05505]
107147374  Faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
107153328  Fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
107157044  Fadd; FAS-associated death domain protein [KO:K02373]
107154973  Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
107151005  Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
107138607  Casp8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
107142678  Casp3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
107158031  caspase-3-like [KO:K02187] [EC:3.4.22.56]
107149201  Ripk1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
107144286  Tab3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1 [KO:K12793]
107157159  Srebf1; sterol regulatory element-binding protein 1 isoform X1 [KO:K07197]
107157670  Fasn; fatty acid synthase isoform X2 [KO:K00665] [EC:2.3.1.85]
107150363  Acaca; acetyl-CoA carboxylase 1 isoform X1 [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
107149798  acyl-CoA desaturase 1-like [KO:K00507] [EC:1.14.19.1]
107149799  stearoyl-CoA desaturase isoform X1 [KO:K00507] [EC:1.14.19.1]
107149800  acyl-CoA desaturase 1 [KO:K00507] [EC:1.14.19.1]
107149801  acyl-CoA desaturase 1-like [KO:K00507] [EC:1.14.19.1]
107153622  Scd5; stearoyl-CoA desaturase 5 [KO:K00507] [EC:1.14.19.1]
107149944  stearoyl-CoA desaturase-like [KO:K00507] [EC:1.14.19.1]
107137492  Lpin1; phosphatidate phosphatase LPIN1 isoform X2 [KO:K15728] [EC:3.1.3.4]
107139612  Lpin2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
107138969  Lpin3; phosphatidate phosphatase LPIN3 [KO:K15728] [EC:3.1.3.4]
107154762  Sirt1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
107146109  Tra2a; transformer-2 protein homolog alpha isoform X1 [KO:K12897]
107154345  Tra2b; transformer-2 protein homolog beta isoform X1 [KO:K12897]
107154358  Adipoq; adiponectin [KO:K07296]
107140684  Adipor1; adiponectin receptor protein 1 isoform X1 [KO:K07297]
107136673  LOW QUALITY PROTEIN: adiponectin receptor protein 1-like [KO:K07297]
107155011  Adipor2; LOW QUALITY PROTEIN: adiponectin receptor protein 2 [KO:K07297]
107149424  adiponectin receptor protein 1-like [KO:K07297]
107156420  Camkk2; calcium/calmodulin-dependent protein kinase kinase 2 isoform X1 [KO:K07359] [EC:2.7.11.17]
107146329  Prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
107141439  Prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
107158637  Prkab2; 5'-AMP-activated protein kinase subunit beta-2 isoform X2 [KO:K07199]
107158690  Prkab1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
107138705  Prkag3; 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
107148597  Prkag1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
107148919  Prkag2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
107151439  LOW QUALITY PROTEIN: 5'-AMP-activated protein kinase subunit gamma-1-like [KO:K07200]
107136379  forkhead box protein O1 [KO:K07201]
107140789  Foxo1; forkhead box protein O1 [KO:K07201]
107154329  Foxo3; forkhead box protein O3 [KO:K09408]
107139157  Ppargc1a; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X3 [KO:K07202]
107155798  Ppara; peroxisome proliferator-activated receptor alpha isoform X1 [KO:K07294]
107157031  Cpt1a; carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
107157970  Acadvl; very long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X2 [KO:K09479] [EC:1.3.8.9]
107146423  Acadm; medium-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1 [KO:K00249] [EC:1.3.8.7]
107139104  Acox3; peroxisomal acyl-coenzyme A oxidase 3 isoform X2 [KO:K00232] [EC:1.3.3.6]
107157863  Acox1; peroxisomal acyl-coenzyme A oxidase 1 [KO:K00232] [EC:1.3.3.6]
107159740  Fabp1; fatty acid-binding protein, liver [KO:K08750]
107141336  alcohol dehydrogenase E chain [KO:K13951] [EC:1.1.1.1]
107141337  Adh7; all-trans-retinol dehydrogenase [NAD(+)] ADH7 [KO:K13951] [EC:1.1.1.1]
107141335  Adh4; all-trans-retinol dehydrogenase [NAD(+)] ADH4 [KO:K13980] [EC:1.1.1.1]
107141333  Adh5; alcohol dehydrogenase class-3 isoform X1 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
107151252  Aldh16a1; aldehyde dehydrogenase family 16 member A1 isoform X1 [KO:K00128] [EC:1.2.1.3]
107147775  Aldh1b1; aldehyde dehydrogenase X, mitochondrial [KO:K00128] [EC:1.2.1.3]
107156443  Aldh2; aldehyde dehydrogenase, mitochondrial isoform X2 [KO:K00128] [EC:1.2.1.3]
107157132  Aldh3a2; aldehyde dehydrogenase family 3 member A2 isoform X1 [KO:K00128] [EC:1.2.1.3]
107143029  Aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
107147436  Aldh9a1; 4-trimethylaminobutyraldehyde dehydrogenase [KO:K00149] [EC:1.2.1.47 1.2.1.3]
107152888  cytochrome P450 2E1 isoform X1 [KO:K07415] [EC:1.14.14.-]
107154522  Acacb; acetyl-CoA carboxylase 2 [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
107151040  Mlycd; malonyl-CoA decarboxylase, mitochondrial [KO:K01578] [EC:4.1.1.9]
107160253  Cpt1b; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K19523] [EC:2.3.1.21]
107151236  Cpt1c; LOW QUALITY PROTEIN: carnitine O-palmitoyltransferase 1, brain isoform [KO:K19524] [EC:2.3.1.21]
107135438  Nox4; NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
107151082  Akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
107140468  Akt3; RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
107151462  Akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
107136282  Gsk3b; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
107145471  Ctnnb1; catenin beta-1 [KO:K02105]
107148128  Tcf7; transcription factor 7 isoform X6 [KO:K02620]
107159692  Tcf7l1; transcription factor 7-like 1 isoform X1 [KO:K04490]
107149900  Tcf7l2; transcription factor 7-like 2 isoform X2 [KO:K04491]
107141378  Lef1; lymphoid enhancer-binding factor 1 isoform X7 [KO:K04492]
107156886  Ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
107155636  Map3k5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
107158053  Map2k4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
107157355  Map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
107159793  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
107153372  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
107153644  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
107144171  LOW QUALITY PROTEIN: mitogen-activated protein kinase 8-like [KO:K04440] [EC:2.7.11.24]
107157178  dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
107157181  Map2k6; dual specificity mitogen-activated protein kinase kinase 6 isoform X2 [KO:K04433] [EC:2.7.12.2]
107143838  Mapk14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
107143841  Mapk13; mitogen-activated protein kinase 13 isoform X3 [KO:K04441] [EC:2.7.11.24]
107134469  mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
107134485  mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
107160230  mitogen-activated protein kinase 12-like isoform X1 [KO:K04441] [EC:2.7.11.24]
107150497  Map3k14; mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
Compound
C00003  NAD+
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00033  Acetate
C00040  Acyl-CoA
C00076  Calcium cation
C00083  Malonyl-CoA
C00084  Acetaldehyde
C00469  Ethanol
C22381  Reactive oxygen species
Reference
PMID:25782093
  Authors
Louvet A, Mathurin P
  Title
Alcoholic liver disease: mechanisms of injury and targeted treatment.
  Journal
Nat Rev Gastroenterol Hepatol 12:231-42 (2015)
DOI:10.1038/nrgastro.2015.35
Reference
PMID:21920463
  Authors
Gao B, Bataller R
  Title
Alcoholic liver disease: pathogenesis and new therapeutic targets.
  Journal
Gastroenterology 141:1572-85 (2011)
DOI:10.1053/j.gastro.2011.09.002
Reference
PMID:28134813
  Authors
Magdaleno F, Blajszczak CC, Nieto N
  Title
Key Events Participating in the Pathogenesis of Alcoholic Liver Disease.
  Journal
Biomolecules 7:E9 (2017)
DOI:10.3390/biom7010009
Reference
PMID:19553649
  Authors
Lucey MR, Mathurin P, Morgan TR
  Title
Alcoholic hepatitis.
  Journal
N Engl J Med 360:2758-69 (2009)
DOI:10.1056/NEJMra0805786
Reference
PMID:26919968
  Authors
Nagy LE, Ding WX, Cresci G, Saikia P, Shah VH
  Title
Linking Pathogenic Mechanisms of Alcoholic Liver Disease With Clinical Phenotypes.
  Journal
Gastroenterology 150:1756-68 (2016)
DOI:10.1053/j.gastro.2016.02.035
Reference
PMID:25009376
  Authors
Fujii H, Kawada N
  Title
Fibrogenesis in alcoholic liver disease.
  Journal
World J Gastroenterol 20:8048-54 (2014)
DOI:10.3748/wjg.v20.i25.8048
Reference
PMID:26755857
  Authors
Kim MS, Ong M, Qu X
  Title
Optimal management for alcoholic liver disease: Conventional medications, natural therapy or combination?
  Journal
World J Gastroenterol 22:8-23 (2016)
DOI:10.3748/wjg.v22.i1.8
Reference
PMID:15194557
  Authors
You M, Crabb DW
  Title
Recent advances in alcoholic liver disease II. Minireview: molecular mechanisms of alcoholic fatty liver.
  Journal
Am J Physiol Gastrointest Liver Physiol 287:G1-6 (2004)
DOI:10.1152/ajpgi.00056.2004
Reference
PMID:26695748
  Authors
Nagy LE
  Title
The Role of Innate Immunity in Alcoholic Liver Disease.
  Journal
Alcohol Res 37:237-50 (2015)
Reference
PMID:21252049
  Authors
Gao B, Seki E, Brenner DA, Friedman S, Cohen JI, Nagy L, Szabo G, Zakhari S
  Title
Innate immunity in alcoholic liver disease.
  Journal
Am J Physiol Gastrointest Liver Physiol 300:G516-25 (2011)
DOI:10.1152/ajpgi.00537.2010
Reference
PMID:22524187
  Authors
Wang HJ, Gao B, Zakhari S, Nagy LE
  Title
Inflammation in alcoholic liver disease.
  Journal
Annu Rev Nutr 32:343-68 (2012)
DOI:10.1146/annurev-nutr-072610-145138
Reference
PMID:29597356
  Authors
McCullough RL, McMullen MR, Sheehan MM, Poulsen KL, Roychowdhury S, Chiang DJ, Pritchard MT, Caballeria J, Nagy LE
  Title
Complement Factor D protects mice from ethanol-induced inflammation and liver injury.
  Journal
Am J Physiol Gastrointest Liver Physiol 315:G66-G79 (2018)
DOI:10.1152/ajpgi.00334.2017
Reference
PMID:24385684
  Authors
Kawaratani H, Tsujimoto T, Douhara A, Takaya H, Moriya K, Namisaki T, Noguchi R, Yoshiji H, Fujimoto M, Fukui H
  Title
The effect of inflammatory cytokines in alcoholic liver disease.
  Journal
Mediators Inflamm 2013:495156 (2013)
DOI:10.1155/2013/495156
Reference
PMID:20238398
  Authors
Szabo G, Bala S
  Title
Alcoholic liver disease and the gut-liver axis.
  Journal
World J Gastroenterol 16:1321-9 (2010)
DOI:10.3748/wjg.v16.i11.1321
Reference
PMID:28627645
  Authors
Kawaratani H, Moriya K, Namisaki T, Uejima M, Kitade M, Takeda K, Okura Y, Kaji K, Takaya H, Nishimura N, Sato S, Sawada Y, Seki K, Kubo T, Mitoro A, Yamao J, Yoshiji H
  Title
Therapeutic strategies for alcoholic liver disease: Focusing on inflammation and fibrosis (Review).
  Journal
Int J Mol Med 40:263-270 (2017)
DOI:10.3892/ijmm.2017.3015
Reference
PMID:23855294
  Authors
Roh YS, Seki E
  Title
Toll-like receptors in alcoholic liver disease, non-alcoholic steatohepatitis and carcinogenesis.
  Journal
J Gastroenterol Hepatol 28 Suppl 1:38-42 (2013)
DOI:10.1111/jgh.12019
Reference
PMID:18709650
  Authors
Rogers CQ, Ajmo JM, You M
  Title
Adiponectin and alcoholic fatty liver disease.
  Journal
IUBMB Life 60:790-7 (2008)
DOI:10.1002/iub.124
Reference
PMID:26278388
  Authors
You M, Jogasuria A, Lee K, Wu J, Zhang Y, Lee YK, Sadana P
  Title
Signal Transduction Mechanisms of Alcoholic Fatty Liver Disease: Emer ging Role of Lipin-1.
  Journal
Curr Mol Pharmacol 10:226-236 (2017)
DOI:10.2174/1874467208666150817112109
Reference
PMID:26005675
  Authors
You M, Jogasuria A, Taylor C, Wu J
  Title
Sirtuin 1 signaling and alcoholic fatty liver disease.
  Journal
Hepatobiliary Surg Nutr 4:88-100 (2015)
DOI:10.3978/j.issn.2304-3881.2014.12.06
Reference
PMID:33162823
  Authors
Ren R, Wang Z, Wu M, Wang H
  Title
Emerging Roles of SIRT1 in Alcoholic Liver Disease.
  Journal
Int J Biol Sci 16:3174-3183 (2020)
DOI:10.7150/ijbs.49535
Reference
PMID:19032584
  Authors
Purohit V, Gao B, Song BJ
  Title
Molecular mechanisms of alcoholic fatty liver.
  Journal
Alcohol Clin Exp Res 33:191-205 (2009)
DOI:10.1111/j.1530-0277.2008.00827.x
Reference
PMID:34071962
  Authors
Hyun J, Han J, Lee C, Yoon M, Jung Y
  Title
Pathophysiological Aspects of Alcohol Metabolism in the Liver.
  Journal
Int J Mol Sci 22:5717 (2021)
DOI:10.3390/ijms22115717
Reference
PMID:24297186
  Authors
Combs TP, Marliss EB
  Title
Adiponectin signaling in the liver.
  Journal
Rev Endocr Metab Disord 15:137-47 (2014)
DOI:10.1007/s11154-013-9280-6
Reference
PMID:25548474
  Authors
Ceni E, Mello T, Galli A
  Title
Pathogenesis of alcoholic liver disease: role of oxidative metabolism.
  Journal
World J Gastroenterol 20:17756-72 (2014)
DOI:10.3748/wjg.v20.i47.17756
Reference
PMID:31159489
  Authors
Kong LZ, Chandimali N, Han YH, Lee DH, Kim JS, Kim SU, Kim TD, Jeong DK, Sun HN, Lee DS, Kwon T
  Title
Pathogenesis, Early Diagnosis, and Therapeutic Management of Alcoholic Liver Disease.
  Journal
Int J Mol Sci 20:E2712 (2019)
DOI:10.3390/ijms20112712
Reference
PMID:31214376
  Authors
Ohashi K, Pimienta M, Seki E
  Title
Alcoholic liver disease: A current molecular and clinical perspective.
  Journal
Liver Res 2:161-172 (2018)
DOI:10.1016/j.livres.2018.11.002
Reference
PMID:30658725
  Authors
You M, Arteel GE
  Title
Effect of ethanol on lipid metabolism.
  Journal
J Hepatol 70:237-248 (2019)
DOI:10.1016/j.jhep.2018.10.037
Reference
PMID:25595739
  Authors
Bi L, Jiang Z, Zhou J
  Title
The role of lipin-1 in the pathogenesis of alcoholic fatty liver.
  Journal
Alcohol Alcohol 50:146-51 (2015)
DOI:10.1093/alcalc/agu102
Reference
PMID:31263795
  Authors
Ali H, Assiri MA, Shearn CT, Fritz KS
  Title
Lipid peroxidation derived reactive aldehydes in alcoholic liver disease.
  Journal
Curr Opin Toxicol 13:110-117 (2019)
DOI:10.1016/j.cotox.2018.10.003
Reference
PMID:24262277
  Authors
Yin H, Hu M, Liang X, Ajmo JM, Li X, Bataller R, Odena G, Stevens SM Jr, You M
  Title
Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver.
  Journal
Gastroenterology 146:801-11 (2014)
DOI:10.1053/j.gastro.2013.11.008
Reference
PMID:22110053
  Authors
Stickel F, Hampe J
  Title
Genetic determinants of alcoholic liver disease.
  Journal
Gut 61:150-9 (2012)
DOI:10.1136/gutjnl-2011-301239
Reference
PMID:29336467
  Authors
Yang CF, Zhong YJ, Ma Z, Li L, Shi L, Chen L, Li C, Wu D, Chen Q, Li YW
  Title
NOX4/ROS mediate ethanolinduced apoptosis via MAPK signal pathway in L02 cells.
  Journal
Int J Mol Med 41:2306-2316 (2018)
DOI:10.3892/ijmm.2018.3390
Related
pathway
mmma00061  Fatty acid biosynthesis
mmma00071  Fatty acid degradation
mmma01040  Biosynthesis of unsaturated fatty acids
mmma03040  Spliceosome
mmma04010  MAPK signaling pathway
mmma04064  NF-kappa B signaling pathway
mmma04152  AMPK signaling pathway
mmma04210  Apoptosis
mmma04310  Wnt signaling pathway
mmma04610  Complement and coagulation cascades
mmma04620  Toll-like receptor signaling pathway
mmma04657  IL-17 signaling pathway
mmma04668  TNF signaling pathway
mmma04920  Adipocytokine signaling pathway
mmma05034  Alcoholism
mmma05225  Hepatocellular carcinoma
KO pathway
ko04936   
LinkDB

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