KEGG   PATHWAY: nle05207
Entry
nle05207                    Pathway                                
Name
Chemical carcinogenesis - receptor activation - Nomascus leucogenys (northern white-cheeked gibbon)
Description
Carcinogenesis is a multistage process that consists of initiation, promotion, and progression stages. Chemicals or environmental factors may act at any of these stages to induce and/or enhance the carcinogenic process. Based on their mode-of-action, carcinogens can be classified as genotoxic or non-genotoxic. Genotoxic agent begins their action at the deoxyribonucleic acid (DNA) level, causing DNA damage through several mechanisms. Non-genotoxic carcinogens are chemicals that cause the development of tumors through multiple non-genotoxic events and epigenetic alterations without direct interaction with DNA. One non-genotoxic mechanism involves receptor activation. Biological mechanisms involving receptor activation fall into two broad categories: (i) those that involve cell surface receptors and some intracellular receptors that activate signal transduction pathways, resulting in biological responses, including gene transcription, and (ii) those that involve intracellular receptors that translocate into the nucleus and act as transcription factors regulating gene expression. Both classes of receptors can be involved in mechanisms of carcinogenesis.
Class
Human Diseases; Cancer: overview
Pathway map
nle05207  Chemical carcinogenesis - receptor activation
nle05207

Organism
Nomascus leucogenys (northern white-cheeked gibbon) [GN:nle]
Gene
100588609  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 isoform X1 [KO:K04809]
100598721  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
100599882  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
100602214  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
100582599  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100588629  RB1; retinoblastoma-associated protein [KO:K06618]
100601097  E2F1; transcription factor E2F1 [KO:K17454]
100598415  BIRC5; baculoviral IAP repeat-containing protein 5 isoform X1 [KO:K08731]
100597865  XIAP; E3 ubiquitin-protein ligase XIAP isoform X4 [KO:K04725] [EC:2.3.2.27]
100582562  CDC6; cell division control protein 6 homolog [KO:K02213]
100588003  CDC25A; M-phase inducer phosphatase 1 isoform X1 [KO:K06645] [EC:3.1.3.48]
100588880  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
100598877  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
100605137  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
100605736  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
100588141  CHRNA4; neuronal acetylcholine receptor subunit alpha-4 isoform X1 [KO:K04806]
100604733  CHRNB2; neuronal acetylcholine receptor subunit beta-2 isoform X1 [KO:K04813]
100581530  CHRNA3; neuronal acetylcholine receptor subunit alpha-3 [KO:K04805]
100595897  CHRNB4; neuronal acetylcholine receptor subunit beta-4 isoform X1 [KO:K04815]
100580437  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
100600997  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
100590475  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
100589614  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
100584807  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
100602682  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
100588218  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100580872  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100584384  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100605788  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100591270  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100599301  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100604331  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100587864  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100587109  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100594291  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
100581655  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100588439  RELA; transcription factor p65 [KO:K04735]
100595274  HRAS; GTPase HRas isoform X1 [KO:K02833]
100593773  KRAS; GTPase KRas isoform X1 [KO:K07827]
100592103  NRAS; GTPase NRas [KO:K07828]
100579506  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100591827  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100600574  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100584480  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100585899  FOS; proto-oncogene c-Fos [KO:K04379]
100586501  JUN; transcription factor AP-1 [KO:K04448]
100589322  MYC; myc proto-oncogene protein [KO:K04377]
100599011  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
100591651  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
100590939  PRKCB; protein kinase C beta type isoform X2 [KO:K19662] [EC:2.7.11.13]
100601464  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
100601396  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
100593123  FGF2; fibroblast growth factor 2 isoform X1 [KO:K18497]
100606030  ADRB1; beta-1 adrenergic receptor [KO:K04141]
100589389  ADRB2; beta-2 adrenergic receptor [KO:K04142]
100596541  ADRB3; beta-3 adrenergic receptor [KO:K04143]
101176289  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoform X7 [KO:K04632]
115830355  neuroendocrine secretory protein 55 [KO:K04632]
100595636  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
100600367  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
100586735  ADCY3; adenylate cyclase type 3 isoform X2 [KO:K08043] [EC:4.6.1.1]
100603282  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
100580455  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
100589304  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
100587036  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
100592592  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
100599484  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
100583577  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X8 [KO:K04345] [EC:2.7.11.11]
100579779  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
100607741  PRKACG; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
100586647  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X2 [KO:K05870]
100582751  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
100588160  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
100603387  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
100595943  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
100594080  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
100597876  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
100592170  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
100600059  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
100598020  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
100588993  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
100583621  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
100604896  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X2 [KO:K04630]
101178725  BAD; bcl2-associated agonist of cell death [KO:K02158]
100585681  CHRNA9; neuronal acetylcholine receptor subunit alpha-9 [KO:K04810]
100590499  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
100606015  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
100594380  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X2 [KO:K04373] [EC:2.7.11.1]
100606014  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X2 [KO:K04373] [EC:2.7.11.1]
100580202  ESR1; estrogen receptor isoform X2 [KO:K08550]
100595169  ESR2; estrogen receptor beta isoform X1 [KO:K08551]
100590313  VDR; vitamin D3 receptor isoform X1 [KO:K08539]
100580170  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
100597255  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100588468  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100590165  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100600495  SOS2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
105740136  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
100606492  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
100593862  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
100580527  PAQR7; membrane progestin receptor alpha [KO:K25039]
100587080  PAQR8; membrane progestin receptor beta [KO:K25040]
100591535  PAQR5; membrane progestin receptor gamma [KO:K25041]
100605580  PGR; progesterone receptor isoform X1 [KO:K08556]
100599838  TNFSF11; tumor necrosis factor ligand superfamily member 11 isoform X1 [KO:K05473]
100602815  signal transducer and activator of transcription 5A isoform X1 [KO:K11223]
100602489  signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
100603934  BCL6; B-cell lymphoma 6 protein isoform X1 [KO:K15618]
100607414  KLF5; Krueppel-like factor 5 [KO:K09206]
100582613  Krueppel-like factor 5 isoform X1 [KO:K09206]
100582129  KLF4; Krueppel-like factor 4 isoform X1 [KO:K17846]
100587307  WNT1; proto-oncogene Wnt-1 [KO:K03209]
100584613  NOTCH2; neurogenic locus notch homolog protein 2 isoform X1 [KO:K20994]
100590989  JAG1; protein jagged-1 [KO:K06052]
100598603  AR; androgen receptor isoform X1 [KO:K08557]
100588963  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
100588427  FGF18; fibroblast growth factor 18 [KO:K04358]
100598611  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
100587475  FGF4; fibroblast growth factor 4 [KO:K04358]
100587808  FGF3; fibroblast growth factor 3 [KO:K04358]
100603249  FGF20; fibroblast growth factor 20 [KO:K04358]
100601992  FGF9; fibroblast growth factor 9 [KO:K04358]
100580620  FGF7; fibroblast growth factor 7 [KO:K04358]
100605698  fibroblast growth factor 6 [KO:K04358]
100590822  FGF10; fibroblast growth factor 10 [KO:K04358]
100591900  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
100585623  FGF16; fibroblast growth factor 16 [KO:K04358]
100583276  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
100598059  FGF22; fibroblast growth factor 22 isoform X2 [KO:K04358]
100592674  DLL3; delta-like protein 3 isoform X2 [KO:K06051]
100606767  DLL1; delta-like protein 1 [KO:K06051]
100587621  DLL4; delta-like protein 4 [KO:K06051]
100607267  PTGES3; prostaglandin E synthase 3 isoform X2 [KO:K15730] [EC:5.3.99.3]
100588011  prostaglandin E synthase 3-like isoform X1 [KO:K15730] [EC:5.3.99.3]
100607865  AIP; AH receptor-interacting protein isoform X2 [KO:K17767]
100593497  AIPL1; aryl-hydrocarbon-interacting protein-like 1 isoform X1 [KO:K17767]
100587761  AHR; aryl hydrocarbon receptor [KO:K09093]
100602573  heat shock protein HSP 90-alpha [KO:K04079]
100600046  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
100603153  LOW QUALITY PROTEIN: endoplasmin-like [KO:K09487]
100599149  HSP90B1; endoplasmin [KO:K09487]
100603828  KPNA1; importin subunit alpha-5 isoform X1 [KO:K23940]
100594767  KPNA2; importin subunit alpha-1 [KO:K15043]
100589465  KPNA7; importin subunit alpha-8 [KO:K15043]
100602409  LOW QUALITY PROTEIN: importin subunit alpha-8-like [KO:K15043]
100579775  KPNA4; importin subunit alpha-3 [KO:K23583]
100595857  KPNA3; importin subunit alpha-4 [KO:K23583]
100583554  KPNA6; importin subunit alpha-7 [KO:K15042]
100600089  KPNA5; importin subunit alpha-6 isoform X1 [KO:K15042]
100600123  KPNB1; importin subunit beta-1 [KO:K14293]
115834321  LOW QUALITY PROTEIN: importin subunit beta-1-like [KO:K14293]
100579793  ARNT; aryl hydrocarbon receptor nuclear translocator isoform X3 [KO:K09097]
100585507  cytochrome P450 1A1 isoform X1 [KO:K07408] [EC:1.14.14.1]
100583040  cytochrome P450 1B1 [KO:K07410] [EC:1.14.14.1]
100592261  EPHX1; epoxide hydrolase 1 [KO:K01253] [EC:3.3.2.9]
100585861  EPHX2; bifunctional epoxide hydrolase 2 isoform X1 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
100592370  EPHX3; epoxide hydrolase 3 [KO:K22368] [EC:3.3.2.10]
100587235  EPHX4; epoxide hydrolase 4 isoform X1 [KO:K22369] [EC:3.3.-.-]
100604706  GSTO1; glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
100606364  GSTO2; glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
100583420  GSTA4; glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
100584415  glutathione S-transferase A1 isoform X1 [KO:K00799] [EC:2.5.1.18]
100583757  glutathione S-transferase A3 isoform X1 [KO:K00799] [EC:2.5.1.18]
100584083  glutathione S-transferase A5 [KO:K00799] [EC:2.5.1.18]
100606903  glutathione S-transferase omega-1-like isoform X2 [KO:K00799] [EC:2.5.1.18]
100589494  glutathione S-transferase theta-2B [KO:K00799] [EC:2.5.1.18]
100590747  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
100597491  MGST2; microsomal glutathione S-transferase 2 isoform X2 [KO:K00799] [EC:2.5.1.18]
100603656  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
100582253  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
100588847  GSTM3; glutathione S-transferase mu 3 [KO:K00799] [EC:2.5.1.18]
100586279  GSTM4; glutathione S-transferase Mu 4 isoform X1 [KO:K00799] [EC:2.5.1.18]
100587851  GSTM1; glutathione S-transferase Mu 1 isoform X2 [KO:K00799] [EC:2.5.1.18]
100587060  GSTM2; glutathione S-transferase Mu 2 [KO:K00799] [EC:2.5.1.18]
100593636  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
115830401  GSTM5; LOW QUALITY PROTEIN: glutathione S-transferase Mu 5 [KO:K00799] [EC:2.5.1.18]
115835864  LOW QUALITY PROTEIN: glutathione S-transferase theta-3-like [KO:K00799] [EC:2.5.1.18]
100583601  glutathione S-transferase theta-4-like [KO:K00799] [EC:2.5.1.18]
100595736  UDP-glucuronosyltransferase 2B10 isoform X2 [KO:K00699] [EC:2.4.1.17]
100596642  UDP-glucuronosyltransferase 2B7 isoform X1 [KO:K00699] [EC:2.4.1.17]
100597206  UDP-glucuronosyltransferase 2B11 isoform X1 [KO:K00699] [EC:2.4.1.17]
100598804  UDP-glucuronosyltransferase 2B4 isoform X1 [KO:K00699] [EC:2.4.1.17]
100599929  UDP-glucuronosyltransferase 2A1 isoform X1 [KO:K00699] [EC:2.4.1.17]
100592283  UDP-glucuronosyltransferase 1-1 isoform X4 [KO:K00699] [EC:2.4.1.17]
100599361  UDP-glucuronosyltransferase 2B19 isoform X1 [KO:K00699] [EC:2.4.1.17]
100596311  UDP-glucuronosyltransferase 2A3 [KO:K00699] [EC:2.4.1.17]
105738256  UDP-glucuronosyltransferase 2B4-like [KO:K00699] [EC:2.4.1.17]
100591991  UDP-glucuronosyltransferase 2B15 isoform X1 [KO:K00699] [EC:2.4.1.17]
100595401  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 2B17 [KO:K00699] [EC:2.4.1.17]
100600348  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 1-7 [KO:K00699] [EC:2.4.1.17]
101179527  cytochrome P450 2B6 isoform X1 [KO:K17709] [EC:1.14.14.-]
100604173  NR1I3; LOW QUALITY PROTEIN: nuclear receptor subfamily 1 group I member 3 [KO:K08541]
100585339  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
100580742  RXRB; retinoic acid receptor RXR-beta isoform X2 [KO:K08525]
100592610  RXRG; retinoic acid receptor RXR-gamma [KO:K08526]
100593175  cytochrome P450 3A4 isoform X3 [KO:K17689] [EC:1.14.13.32 1.14.14.55 1.14.14.56 1.14.14.57 1.14.14.73 1.14.14.-]
100586622  cytochrome P450 1A2 [KO:K07409] [EC:1.14.14.1]
100602258  PPARA; peroxisome proliferator-activated receptor alpha isoform X1 [KO:K07294]
Compound
C00076  Calcium cation
C00410  Progesterone
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00745  Nicotine
C00780  Serotonin
C00788  L-Adrenaline
C00951  Estradiol-17beta
C03690  Bis(2-ethylhexyl)phthalate
C04623  DDT
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06697  Arsenite
C06790  Trichloroethene
C06916  Clofibrate
C07020  Gemfibrozil
C07434  Phenobarbital
C07535  Benzo[a]pyrene
C07557  2,3,7,8-Tetrachlorodibenzodioxin
C08150  Medroxyprogesterone acetate
C11042  Hexachlorobenzene
C11150  Trichloroacetate
C11371  Nafenopin
C11906  Sodium arsenite
C13624  Bisphenol A
C14240  Di(2-ethylhexyl) adipate
C14573  3,3',4,4',5-Pentachlorobiphenyl
C15995  Bombesin
C16452  N'-Nitrosonornicotine
C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
Reference
PMID:15660110
  Authors
Luch A.
  Title
Nature and nurture - lessons from chemical carcinogenesis.
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Nat Rev Cancer 5:113-25 (2005)
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Reference
PMID:19631282
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Hernandez LG, van Steeg H, Luijten M, van Benthem J
  Title
Mechanisms of non-genotoxic carcinogens and importance of a weight of evidence approach.
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Mutat Res 682:94-109 (2009)
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Reference
PMID:21444681
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Wu CH, Lee CH, Ho YS
  Title
Nicotinic acetylcholine receptor-based blockade: applications of molecular targets for cancer therapy.
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Clin Cancer Res 17:3533-41 (2011)
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Reference
PMID:19194381
  Authors
Schuller HM
  Title
Is cancer triggered by altered signalling of nicotinic acetylcholine receptors?
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Nat Rev Cancer 9:195-205 (2009)
DOI:10.1038/nrc2590
Reference
PMID:21541211
  Authors
Singh S, Pillai S, Chellappan S
  Title
Nicotinic acetylcholine receptor signaling in tumor growth and metastasis.
  Journal
J Oncol 2011:456743 (2011)
DOI:10.1155/2011/456743
Reference
PMID:31956359
  Authors
Cheng WL, Chen KY, Lee KY, Feng PH, Wu SM
  Title
Nicotinic-nAChR signaling mediates drug resistance in lung cancer.
  Journal
J Cancer 11:1125-1140 (2020)
DOI:10.7150/jca.36359
Reference
PMID:24827506
  Authors
Grando SA
  Title
Connections of nicotine to cancer.
  Journal
Nat Rev Cancer 14:419-29 (2014)
DOI:10.1038/nrc3725
Reference
PMID:24398389
  Authors
Schaal C, Chellappan SP
  Title
Nicotine-mediated cell proliferation and tumor progression in smoking-related cancers.
  Journal
Mol Cancer Res 12:14-23 (2014)
DOI:10.1158/1541-7786.MCR-13-0541
Reference
PMID:21640716
  Authors
Improgo MR, Tapper AR, Gardner PD
  Title
Nicotinic acetylcholine receptor-mediated mechanisms in lung cancer.
  Journal
Biochem Pharmacol 82:1015-21 (2011)
DOI:10.1016/j.bcp.2011.05.020
Reference
PMID:18262664
  Authors
Egleton RD, Brown KC, Dasgupta P
  Title
Nicotinic acetylcholine receptors in cancer: multiple roles in proliferation and inhibition of apoptosis.
  Journal
Trends Pharmacol Sci 29:151-8 (2008)
DOI:10.1016/j.tips.2007.12.006
Reference
PMID:24830349
  Authors
Xue J, Yang S, Seng S
  Title
Mechanisms of Cancer Induction by Tobacco-Specific NNK and NNN.
  Journal
Cancers (Basel) 6:1138-56 (2014)
DOI:10.3390/cancers6021138
Reference
PMID:21801603
  Authors
Wen J, Fu JH, Zhang W, Guo M
  Title
Lung carcinoma signaling pathways activated by smoking.
  Journal
Chin J Cancer 30:551-8 (2011)
DOI:10.5732/cjc.011.10059
Reference
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Related
pathway
nle00980  Metabolism of xenobiotics by cytochrome P450
nle03320  PPAR signaling pathway
nle04010  MAPK signaling pathway
nle04024  cAMP signaling pathway
nle04150  mTOR signaling pathway
nle04151  PI3K-Akt signaling pathway
nle04370  VEGF signaling pathway
nle04915  Estrogen signaling pathway
nle05204  Chemical carcinogenesis - DNA adducts
nle05206  MicroRNAs in cancer
nle05208  Chemical carcinogenesis - reactive oxygen species
KO pathway
ko05207   
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