Entry Name JAK-STAT signaling pathway - Papio anubis (olive baboon)
Description The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Papio anubis (olive baboon) [GN:
panu ]
Gene 101004576 IL2RA; interleukin-2 receptor subunit alpha isoform X3 [KO:K05068 ]
101014683 IL2RB; interleukin-2 receptor subunit beta isoform X4 [KO:K05069 ]
101022672 IL4R; interleukin-4 receptor subunit alpha isoform X4 [KO:K05071 ]
100126743 CSF2; granulocyte-macrophage colony-stimulating factor precursor [KO:K05427 ]
101000289 LOW QUALITY PROTEIN: interleukin-3 receptor subunit alpha-like [KO:K04737 ]
101009794 CSF2RB; cytokine receptor common subunit beta isoform X1 [KO:K04738 ]
101015191 CLCF1; cardiotrophin-like cytokine factor 1 isoform X2 [KO:K05421 ]
100998383 IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060 ]
101011618 IL11RA; interleukin-11 receptor subunit alpha isoform X1 [KO:K05056 ]
101026802 IL13RA1; interleukin-13 receptor subunit alpha-1 isoform X1 [KO:K05076 ]
101000722 IL31RA; interleukin-31 receptor subunit alpha isoform X1 [KO:K22630 ]
101008737 OSMR; oncostatin-M-specific receptor subunit beta isoform X2 [KO:K05057 ]
101007168 CNTFR; ciliary neurotrophic factor receptor subunit alpha isoform X2 [KO:K05059 ]
101014353 IL10RA; interleukin-10 receptor subunit alpha isoform X2 [KO:K05134 ]
100137244 IL10RB; interleukin-10 receptor subunit beta precursor [KO:K05135 ]
101001402 IL20RA; interleukin-20 receptor subunit alpha isoform X2 [KO:K05136 ]
101016009 IL20RB; interleukin-20 receptor subunit beta isoform X1 [KO:K05137 ]
101021910 IL22RA1; interleukin-22 receptor subunit alpha-1 isoform X2 [KO:K05138 ]
101001055 IL22RA2; interleukin-22 receptor subunit alpha-2 isoform X1 [KO:K05139 ]
101015690 IL12RB1; interleukin-12 receptor subunit beta-1 isoform X8 [KO:K05063 ]
101015443 CSF3; granulocyte colony-stimulating factor isoform X1 [KO:K05423 ]
101012178 CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061 ]
101026665 EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357 ]
100998521 PDGFA; platelet-derived growth factor subunit A isoform X2 [KO:K04359 ]
101005886 STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220 ]
101011342 STAT2; LOW QUALITY PROTEIN: signal transducer and activator of transcription 2 [KO:K11221 ]
100998929 STAT3; signal transducer and activator of transcription 3 isoform X9 [KO:K04692 ]
101007479 STAT4; signal transducer and activator of transcription 4 isoform X1 [KO:K11222 ]
100998364 signal transducer and activator of transcription 5A isoform X1 [KO:K11223 ]
101000002 STAT5B; signal transducer and activator of transcription 5B isoform X1 [KO:K11224 ]
101023204 STAT6; signal transducer and activator of transcription 6 isoform X1 [KO:K11225 ]
101001596 CISH; cytokine-inducible SH2-containing protein isoform X2 [KO:K04701 ]
101018141 MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539 ]
101023435 STAM2; signal transducing adapter molecule 2 isoform X1 [KO:K04705 ]
101010387 STAM; signal transducing adapter molecule 1 isoform X1 [KO:K04705 ]
101018585 PIAS1; E3 SUMO-protein ligase PIAS1 isoform X1 [KO:K04706 ] [EC:2.3.2.-]
101000815 PIAS2; E3 SUMO-protein ligase PIAS2 isoform X5 [KO:K16063 ] [EC:2.3.2.-]
101002944 FHL1; four and a half LIM domains protein 1 isoform X3 [KO:K14365 ]
101004976 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
101008699 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
101002278 PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
100510873 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X4 [KO:K02649 ]
101009981 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
101002971 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
Reference Authors Harrison DA
Title The Jak/STAT pathway.
Journal Reference Authors Kiu H, Nicholson SE
Title Biology and significance of the JAK/STAT signalling pathways.
Journal Reference Authors Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A, Sanmamed MF, Le Bon A, Melero I
Title Direct effects of type I interferons on cells of the immune system.
Journal Reference Authors Fish EN, Platanias LC
Title Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes.
Journal Reference Authors Ivanenkov YA, Balakin KV, Lavrovsky Y
Title Small molecule inhibitors of NF-kB and JAK/STAT signal transduction pathways as promising anti-inflammatory therapeutics.
Journal Reference Authors O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A
Title The JAK-STAT pathway: impact on human disease and therapeutic intervention.
Journal Reference Authors Zoranovic T, Grmai L, Bach EA
Title Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway.
Journal Reference Authors Ungureanu D, Silvennoinen O
Title SLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling.
Journal Reference Authors Richard AJ, Stephens JM
Title The role of JAK-STAT signaling in adipose tissue function.
Journal Reference Authors Sun Y, Lehmbecker A, Kalkuhl A, Deschl U, Sun W, Rohn K, Tzvetanova ID, Nave KA, Baumgartner W, Ulrich R
Title STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis.
Journal Reference Authors Hirano T, Ishihara K, Hibi M
Title Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors.
Journal Reference Authors Rane SG, Reddy EP
Title Janus kinases: components of multiple signaling pathways.
Journal Reference Authors Heim MH
Title The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus.
Journal Reference Authors Morris R, Kershaw NJ, Babon JJ
Title The molecular details of cytokine signaling via the JAK/STAT pathway.
Journal Reference Authors Tzeng HT, Chyuan IT, Lai JH
Title Targeting the JAK-STAT pathway in autoimmune diseases and cancers: A focus on molecular mechanisms and therapeutic potential.
Journal Reference Authors Salas A, Hernandez-Rocha C, Duijvestein M, Faubion W, McGovern D, Vermeire S, Vetrano S, Vande Casteele N
Title JAK-STAT pathway targeting for the treatment of inflammatory bowel disease.
Journal Related panu04060 Cytokine-cytokine receptor interaction
KO pathway LinkDB All DBs
