KEGG   PATHWAY: panu05160
Entry
panu05160                   Pathway                                
Name
Hepatitis C - Papio anubis (olive baboon)
Description
Hepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the cytoplasm of the host cell and forms membrane-associated replication complexes along with non-structural proteins. Viral RNA can trigger the RIG-I pathway and interferon production during this process. Translated HCV protein products regulate immune response to inhibit the action of interferon. HCV core and NS5A proteins appear to be the most important molecules with regulatory functions that modulate transcription, cellular proliferation, and apoptosis.
Class
Human Diseases; Infectious disease: viral
Pathway map
panu05160  Hepatitis C
panu05160

Organism
Papio anubis (olive baboon) [GN:panu]
Gene
101016912  LDLR; low-density lipoprotein receptor [KO:K12473]
101019088  SCARB1; scavenger receptor class B member 1 isoform X2 [KO:K13885]
101001823  CD81; CD81 antigen [KO:K06508]
100137459  CLDN12; claudin-12 [KO:K06087]
101022503  CLDN19; claudin-19 isoform X2 [KO:K06087]
101023816  CLDN11; claudin-11 [KO:K06087]
101013882  CLDN18; claudin-18 isoform X1 [KO:K06087]
101015375  CLDN2; claudin-2 [KO:K06087]
101026397  CLDN1; claudin-1 [KO:K06087]
101026754  CLDN16; claudin-16 [KO:K06087]
101020651  CLDN8; claudin-8 [KO:K06087]
101020994  CLDN17; claudin-17 [KO:K06087]
101020655  CLDN15; claudin-15 [KO:K06087]
101014245  CLDN3; claudin-3 [KO:K06087]
101014597  CLDN4; claudin-4 [KO:K06087]
101014356  CLDN14; claudin-14 [KO:K06087]
101021217  CLDN7; claudin-7 [KO:K06087]
101021750  LOW QUALITY PROTEIN: claudin-7-like [KO:K06087]
116272592  claudin-20 [KO:K06087]
101005235  CLDN10; claudin-10 isoform X1 [KO:K06087]
101001622  CLDN20; claudin-20 [KO:K06087]
101016784  CLDN24; putative claudin-24 [KO:K06087]
108580413  claudin-22 [KO:K06087]
101025178  CLDN23; claudin-23 [KO:K06087]
101019772  CLDN5; claudin-5 [KO:K06087]
101014276  CLDN9; claudin-9 [KO:K06087]
101013941  CLDN34; claudin-34 [KO:K06087]
100997521  CLDN25; putative claudin-25 [KO:K06087]
101014992  CLDN6; claudin-6 [KO:K06087]
101012708  OCLN; occludin isoform X1 [KO:K06088]
101010639  OAS2; 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
101010277  OAS1; LOW QUALITY PROTEIN: 2'-5'-oligoadenylate synthase 1 [KO:K14216] [EC:2.7.7.84]
101015624  OAS3; 2'-5'-oligoadenylate synthase 3 [KO:K14216] [EC:2.7.7.84]
101012661  RNASEL; 2-5A-dependent ribonuclease isoform X1 [KO:K01165]
100997060  DDX58; probable ATP-dependent RNA helicase DDX58 isoform X2 [KO:K12646] [EC:5.6.2.6]
101008300  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
101015482  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
100999858  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
101001355  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X2 [KO:K07211] [EC:2.7.11.10]
101013579  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
101005316  IRF7; interferon regulatory factor 7 isoform X5 [KO:K09447]
101023828  LOW QUALITY PROTEIN: interferon alpha-21 [KO:K05414]
101016516  interferon alpha-1/13 [KO:K05414]
116270026  interferon alpha-1/13 [KO:K05414]
101019008  LOW QUALITY PROTEIN: interferon alpha-1/13 [KO:K05414]
101018652  LOW QUALITY PROTEIN: interferon alpha-1/13 [KO:K05414]
101017918  interferon alpha-8 [KO:K05414]
101018287  interferon alpha-2 [KO:K05414]
101019380  interferon alpha-6 [KO:K05414]
101021706  interferon alpha-14 [KO:K05414]
101023118  interferon alpha-4 [KO:K05414]
101024523  IFNB1; interferon beta [KO:K05415]
100126724  IFNG; interferon gamma precursor [KO:K04687]
101003041  TLR3; toll-like receptor 3 [KO:K05401]
101015106  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
101002649  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
101011511  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X2 [KO:K02861] [EC:2.7.11.1]
100998877  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
101016447  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X5 [KO:K07209] [EC:2.7.11.10]
101023751  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
101026781  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X6 [KO:K02580]
101017078  RELA; transcription factor p65 isoform X1 [KO:K04735]
101009748  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
101014663  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 isoform X1 [KO:K16194] [EC:2.7.11.1]
101011480  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
101007255  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
101014886  EIF2AK4; eIF-2-alpha kinase GCN2 isoform X1 [KO:K16196] [EC:2.7.11.1]
101023647  IFIT1B; interferon-induced protein with tetratricopeptide repeats 1B [KO:K14217]
101025406  IFIT1; interferon-induced protein with tetratricopeptide repeats 1 [KO:K14217]
101015491  EIF3E; eukaryotic translation initiation factor 3 subunit E isoform X1 [KO:K03250]
101025391  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
100998929  STAT3; signal transducer and activator of transcription 3 isoform X9 [KO:K04692]
101007066  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
100137245  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
100137545  IFNAR2; interferon alpha/beta receptor 2 precursor [KO:K05131]
101002872  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
101020681  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
101005886  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
101011342  STAT2; LOW QUALITY PROTEIN: signal transducer and activator of transcription 2 [KO:K11221]
101020807  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
101020760  MX1; interferon-induced GTP-binding protein Mx1 [KO:K14754]
101021095  MX2; interferon-induced GTP-binding protein Mx2 isoform X1 [KO:K14754]
101014221  RSAD2; radical S-adenosyl methionine domain-containing protein 2 [KO:K15045]
101003925  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X4 [KO:K03456]
101000613  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
101020551  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
101017040  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
116272968  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
101020796  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X6 [KO:K04354]
101011219  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
101021745  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
101011206  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
101018585  PIAS1; E3 SUMO-protein ligase PIAS1 isoform X1 [KO:K04706] [EC:2.3.2.-]
101026665  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
101003588  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
101002675  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
101022024  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
101003749  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
101002992  HRAS; GTPase HRas isoform X2 [KO:K02833]
101017528  KRAS; GTPase KRas isoform X2 [KO:K07827]
101026253  NRAS; GTPase NRas isoform X2 [KO:K07828]
101022780  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
101009029  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
101019640  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
101022263  YWHAQ; 14-3-3 protein theta isoform X4 [KO:K16197]
101021050  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
101022352  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
101012101  14-3-3 protein zeta/delta [KO:K16197]
101010193  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
101005569  YWHAG; 14-3-3 protein gamma [KO:K16198]
100126764  YWHAH; 14-3-3 protein eta [KO:K16198]
101008394  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
101004074  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
101012041  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101006756  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
100510873  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X4 [KO:K02649]
101009981  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101002971  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101004976  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101008699  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101002278  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
100997634  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101000402  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100381179  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100998800  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
101014712  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
101012551  BAD; bcl2-associated agonist of cell death [KO:K02158]
100999911  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
101006608  TP53; cellular tumor antigen p53 [KO:K04451]
101025892  CDK2; cyclin-dependent kinase 2 isoform X2 [KO:K02206] [EC:2.7.11.22]
101011004  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
101013902  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
101017005  RB1; retinoblastoma-associated protein [KO:K06618]
101000533  E2F1; transcription factor E2F1 [KO:K17454]
101015623  E2F2; transcription factor E2F2 isoform X1 [KO:K09389]
101025116  E2F3; transcription factor E2F3 isoform X3 [KO:K06620]
101013835  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
101006641  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2 [KO:K03171]
101017914  TRAF2; LOW QUALITY PROTEIN: TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
101000210  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
101017433  FADD; FAS-associated death domain protein [KO:K02373]
101009470  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
101023728  CASP3; caspase-3 isoform X2 [KO:K02187] [EC:3.4.22.56]
101006231  CFLAR; CASP8 and FADD-like apoptosis regulator isoform X1 [KO:K04724]
101008656  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
101000115  BAK1; bcl-2 homologous antagonist/killer isoform X2 [KO:K14021]
101025906  cytochrome c-like [KO:K08738]
101020480  cytochrome c-like [KO:K08738]
101021327  cytochrome c-like [KO:K08738]
101014039  cytochrome c-like [KO:K08738]
101008579  cytochrome c [KO:K08738]
100997529  cytochrome c [KO:K08738]
101021349  cytochrome c-like [KO:K08738]
100997503  cytochrome c-like [KO:K08738]
101019410  cytochrome c-like [KO:K08738]
103878393  cytochrome c-like [KO:K08738]
108582823  cytochrome c-like [KO:K08738]
101014473  cytochrome c-like [KO:K08738]
101023208  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
101009907  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
101013416  PSME3; proteasome activator complex subunit 3 isoform X2 [KO:K06698]
103877419  proteasome activator complex subunit 3-like [KO:K06698]
101012079  RXRA; retinoic acid receptor RXR-alpha isoform X3 [KO:K08524]
101011461  PPARA; peroxisome proliferator-activated receptor alpha isoform X2 [KO:K07294]
100997292  NR1H3; oxysterols receptor LXR-alpha isoform X2 [KO:K08536]
101019923  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
101000645  MYC; myc proto-oncogene protein [KO:K04377]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20935  2-5A
Reference
PMID:24520529
  Authors
Hassan M, Selimovic D, El-Khattouti A, Ghozlan H, Haikel Y, Abdelkader O
  Title
Hepatitis C virus-host interactions: Etiopathogenesis and therapeutic strategies.
  Journal
World J Exp Med 2:7-25 (2012)
DOI:10.5493/wjem.v2.i2.7
Reference
PMID:23641066
  Authors
Yamauchi Y, Helenius A
  Title
Virus entry at a glance.
  Journal
J Cell Sci 126:1289-95 (2013)
DOI:10.1242/jcs.119685
Reference
PMID:24509809
  Authors
Feneant L, Levy S, Cocquerel L
  Title
CD81 and hepatitis C virus (HCV) infection.
  Journal
Viruses 6:535-72 (2014)
DOI:10.3390/v6020535
Reference
PMID:18081727
  Authors
Dubuisson J, Helle F, Cocquerel L
  Title
Early steps of the hepatitis C virus life cycle.
  Journal
Cell Microbiol 10:821-7 (2008)
DOI:10.1111/j.1462-5822.2007.01107.x
Reference
PMID:23675659
  Authors
Liang TJ, Ghany MG
  Title
Current and future therapies for hepatitis C virus infection.
  Journal
N Engl J Med 368:1907-17 (2013)
DOI:10.1056/NEJMra1213651
Reference
PMID:23836234
  Authors
Scheel TK, Rice CM
  Title
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies.
  Journal
Nat Med 19:837-49 (2013)
DOI:10.1038/nm.3248
Reference
PMID:26586968
  Authors
Holmes JA, Thompson AJ
  Title
Interferon-free combination therapies for the treatment of hepatitis C: current insights.
  Journal
Hepat Med 7:51-70 (2015)
DOI:10.2147/HMER.S55864
Reference
PMID:15039538
  Authors
Taguchi T, Nagano-Fujii M, Akutsu M, Kadoya H, Ohgimoto S, Ishido S, Hotta H
  Title
Hepatitis C virus NS5A protein interacts with 2',5'-oligoadenylate synthetase and inhibits antiviral activity of IFN in an IFN sensitivity-determining region-independent manner.
  Journal
J Gen Virol 85:959-69 (2004)
DOI:10.1099/vir.0.19513-0
Reference
PMID:19708811
  Authors
Horner SM, Gale M Jr
  Title
Intracellular innate immune cascades and interferon defenses that control hepatitis C virus.
  Journal
J Interferon Cytokine Res 29:489-98 (2009)
DOI:10.1089/jir.2009.0063
Reference
PMID:20457596
  Authors
Lemon SM
  Title
Induction and evasion of innate antiviral responses by hepatitis C virus.
  Journal
J Biol Chem 285:22741-7 (2010)
DOI:10.1074/jbc.R109.099556
Reference
PMID:23836238
  Authors
Horner SM, Gale M Jr
  Title
Regulation of hepatic innate immunity by hepatitis C virus.
  Journal
Nat Med 19:879-88 (2013)
DOI:10.1038/nm.3253
Reference
PMID:28862649
  Authors
Ortega-Prieto AM, Dorner M
  Title
Immune Evasion Strategies during Chronic Hepatitis B and C Virus Infection.
  Journal
Vaccines (Basel) 5:E24 (2017)
DOI:10.3390/vaccines5030024
Reference
PMID:25852264
  Authors
Yang DR, Zhu HZ
  Title
Hepatitis C virus and antiviral innate immunity: who wins at tug-of-war?
  Journal
World J Gastroenterol 21:3786-800 (2015)
DOI:10.3748/wjg.v21.i13.3786
Reference
PMID:16107833
  Authors
Gale M Jr, Foy EM
  Title
Evasion of intracellular host defence by hepatitis C virus.
  Journal
Nature 436:939-45 (2005)
DOI:10.1038/nature04078
Reference
PMID:17467654
  Authors
Bode JG, Brenndorfer ED, Haussinger D
  Title
Subversion of innate host antiviral strategies by the hepatitis C virus.
  Journal
Arch Biochem Biophys 462:254-65 (2007)
DOI:10.1016/j.abb.2007.03.033
Reference
PMID:12686421
  Authors
Panteva M, Korkaya H, Jameel S
  Title
Hepatitis viruses and the MAPK pathway: is this a survival strategy?
  Journal
Virus Res 92:131-40 (2003)
DOI:10.1016/S0168-1702(02)00356-8
Reference
PMID:16239065
  Authors
Pang R, Tse E, Poon RT
  Title
Molecular pathways in hepatocellular carcinoma.
  Journal
Cancer Lett 240:157-69 (2006)
DOI:10.1016/j.canlet.2005.08.031
Reference
PMID:15302943
  Authors
Macdonald A, Harris M
  Title
Hepatitis C virus NS5A: tales of a promiscuous protein.
  Journal
J Gen Virol 85:2485-502 (2004)
DOI:10.1099/vir.0.80204-0
Reference
PMID:21250384
  Authors
He Y, Staschke KA, Tan SL
  Title
HCV NS5A: A Multifunctional Regulator of Cellular Pathways and Virus Replication
  Journal
Hepatitis C Viruses: Genomes and Molecular Biology (2006)
Reference
PMID:12101418
  Authors
Lan KH, Sheu ML, Hwang SJ, Yen SH, Chen SY, Wu JC, Wang YJ, Kato N, Omata M, Chang FY, Lee SD
  Title
HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis.
  Journal
Oncogene 21:4801-11 (2002)
DOI:10.1038/sj.onc.1205589
Reference
PMID:11886269
  Authors
Majumder M, Ghosh AK, Steele R, Zhou XY, Phillips NJ, Ray R, Ray RB
  Title
Hepatitis C virus NS5A protein impairs TNF-mediated hepatic apoptosis, but not by an anti-FAS antibody, in transgenic mice.
  Journal
Virology 294:94-105 (2002)
DOI:10.1006/viro.2001.1309
Reference
PMID:15381253
  Authors
Hassan M, Ghozlan H, Abdel-Kader O
  Title
Activation of RB/E2F signaling pathway is required for the modulation of hepatitis C virus core protein-induced cell growth in liver and non-liver cells.
  Journal
Cell Signal 16:1375-85 (2004)
DOI:10.1016/j.cellsig.2004.04.005
Reference
PMID:11514734
  Authors
Kwun HJ, Jung EY, Ahn JY, Lee MN, Jang KL
  Title
p53-dependent transcriptional repression of p21(waf1) by hepatitis C virus NS3.
  Journal
J Gen Virol 82:2235-41 (2001)
DOI:10.1099/0022-1317-82-9-2235
Reference
PMID:12056797
  Authors
Yamanaka T, Uchida M, Doi T
  Title
Innate form of HCV core protein plays an important role in the localization and the function of HCV core protein.
  Journal
Biochem Biophys Res Commun 294:521-7 (2002)
DOI:10.1016/S0006-291X(02)00507-7
Reference
PMID:22611309
  Authors
Lim EJ, Chin R, Angus PW, Torresi J
  Title
Enhanced apoptosis in post-liver transplant hepatitis C: effects of virus and immunosuppressants.
  Journal
World J Gastroenterol 18:2172-9 (2012)
DOI:10.3748/wjg.v18.i18.2172
Reference
PMID:17828818
  Authors
Fischer R, Baumert T, Blum HE
  Title
Hepatitis C virus infection and apoptosis.
  Journal
World J Gastroenterol 13:4865-72 (2007)
DOI:10.3748/wjg.v13.i36.4865
Reference
PMID:16611896
  Authors
Saito K, Meyer K, Warner R, Basu A, Ray RB, Ray R
  Title
Hepatitis C virus core protein inhibits tumor necrosis factor alpha-mediated apoptosis by a protective effect involving cellular FLICE inhibitory protein.
  Journal
J Virol 80:4372-9 (2006)
DOI:10.1128/JVI.80.9.4372-4379.2006
Reference
PMID:19148799
  Authors
Koike K
  Title
Steatosis, liver injury, and hepatocarcinogenesis in hepatitis C viral infection.
  Journal
J Gastroenterol 44 Suppl 19:82-8 (2009)
DOI:10.1007/s00535-008-2276-4
Reference
PMID:17764115
  Authors
Tanaka N, Moriya K, Kiyosawa K, Koike K, Aoyama T
  Title
Hepatitis C virus core protein induces spontaneous and persistent activation of peroxisome proliferator-activated receptor alpha in transgenic mice: implications for HCV-associated hepatocarcinogenesis.
  Journal
Int J Cancer 122:124-31 (2008)
DOI:10.1002/ijc.23056
Reference
PMID:18251977
  Authors
Tan A, Yeh SH, Liu CJ, Cheung C, Chen PJ
  Title
Viral hepatocarcinogenesis: from infection to cancer.
  Journal
Liver Int 28:175-88 (2008)
DOI:10.1111/j.1478-3231.2007.01652.x
Related
pathway
panu03320  PPAR signaling pathway
panu04010  MAPK signaling pathway
panu04144  Endocytosis
panu04210  Apoptosis
panu04514  Cell adhesion molecules
panu04620  Toll-like receptor signaling pathway
panu04622  RIG-I-like receptor signaling pathway
panu04630  JAK-STAT signaling pathway
panu04668  TNF signaling pathway
KO pathway
ko05160   
LinkDB

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