KEGG   PATHWAY: pbg05202
Entry
pbg05202                    Pathway                                
Name
Transcriptional misregulation in cancer - Prionailurus bengalensis (leopard cat)
Description
In tumor cells, genes encoding transcription factors (TFs) are often amplified, deleted, rearranged via chromosomal translocation and inversion, or subjected to point mutations that result in a gain- or loss-of- function. In hematopoietic cancers and solid tumors, the translocations and inversions increase or deregulate transcription of the oncogene. Recurrent chromosome translocations generate novel fusion oncoproteins, which are common in myeloid cancers and soft-tissue sarcomas. The fusion proteins have aberrant transcriptional function compared to their wild-type counterparts. These fusion transcription factors alter expression of target genes, and thereby result in a variety of altered cellular properties that contribute to the tumourigenic process.
Class
Human Diseases; Cancer: overview
Pathway map
pbg05202  Transcriptional misregulation in cancer
pbg05202

Organism
Prionailurus bengalensis (leopard cat) [GN:pbg]
Gene
122491197  RUNX1; runt-related transcription factor 1 isoform X1 [KO:K08367]
122493494  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
122485326  MPO; myeloperoxidase [KO:K10789] [EC:1.11.2.2]
122472728  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
122472647  IL3; interleukin-3 [KO:K04736]
122495592  RUNX1T1; protein CBFA2T1 isoform X1 [KO:K10053]
122480238  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
122489890  HDAC2; histone deacetylase 2 isoform X1 [KO:K06067] [EC:3.5.1.98]
122468404  SIN3A; paired amphipathic helix protein Sin3a [KO:K11644]
122485002  NCOR1; nuclear receptor corepressor 1 isoform X1 [KO:K04650]
122494136  CEBPA; CCAAT/enhancer-binding protein alpha [KO:K09055]
122481974  PER2; period circadian protein homolog 2 isoform X1 [KO:K02633]
122484442  SPI1; transcription factor PU.1 isoform X1 [KO:K09438]
122488155  CD14; monocyte differentiation antigen CD14 [KO:K04391]
122471411  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
122481082  FCGR1A; LOW QUALITY PROTEIN: high affinity immunoglobulin gamma Fc receptor I [KO:K06498]
122485580  junction plakoglobin [KO:K10056]
122468444  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
122485502  RARA; retinoic acid receptor alpha isoform X1 [KO:K08527]
122481431  CCNA1; cyclin-A1 isoform X1 [KO:K06627]
122476514  CCNA2; cyclin-A2 [KO:K06627]
122467930  CEBPE; CCAAT/enhancer-binding protein epsilon [KO:K10051]
122467511  BCL2A1; bcl-2-related protein A1 isoform X1 [KO:K02162]
122482982  ZBTB16; zinc finger and BTB domain-containing protein 16 [KO:K10055]
122495809  MYC; myc proto-oncogene protein [KO:K04377]
122472452  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
122488608  TCF3; transcription factor E2-alpha isoform X1 [KO:K09063]
122476368  PBX1; pre-B-cell leukemia transcription factor 1 isoform X1 [KO:K09355]
122488147  WNT16; protein Wnt-16 [KO:K01558]
122490353  ETV7; transcription factor ETV7 isoform X1 [KO:K03211]
122472235  ETV6; transcription factor ETV6 isoform X1 [KO:K03211]
122486349  neutrophil elastase-like [KO:K01327] [EC:3.4.21.37]
122468966  mast cell protease 1A-like isoform X1 [KO:K01353] [EC:3.4.21.79]
122468967  granzyme B(G,H)-like [KO:K01353] [EC:3.4.21.79]
122483027  KMT2A; histone-lysine N-methyltransferase 2A isoform X1 [KO:K09186] [EC:2.1.1.354]
122478685  AFF1; AF4/FMR2 family member 1 isoform X1 [KO:K15184]
122474795  CDK9; cyclin-dependent kinase 9 [KO:K02211] [EC:2.7.11.22 2.7.11.23]
122479356  CCNT2; cyclin-T2 isoform X1 [KO:K15188]
122472334  CCNT1; cyclin-T1 [KO:K15188]
122486777  MLLT1; protein ENL isoform X1 [KO:K15187]
122474914  MLLT3; protein AF-9 isoform X1 [KO:K15187]
122486637  DOT1L; histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1 [KO:K11427] [EC:2.1.1.360]
122483684  LMO2; rhombotin-2 [KO:K15612]
122474884  PBX3; pre-B-cell leukemia transcription factor 3 isoform X1 [KO:K15610]
122489581  RUNX2; runt-related transcription factor 2 isoform X1 [KO:K09278]
122475908  SMAD1; mothers against decapentaplegic homolog 1 [KO:K04676]
122478953  KLF3; Krueppel-like factor 3 [KO:K15605]
122490917  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
122488036  HOXA9; homeobox protein Hox-A9 [KO:K21950]
122488035  HOXA10; homeobox protein Hox-A10 [KO:K17443]
122492800  JMJD1C; LOW QUALITY PROTEIN: probable JmjC domain-containing histone demethylation protein 2C [KO:K11449] [EC:1.14.11.-]
122472945  HMGA2; high mobility group protein HMGI-C isoform X1 [KO:K09283]
122477307  KDM6A; lysine-specific demethylase 6A isoform X1 [KO:K11447] [EC:1.14.11.68]
122489582  SUPT3H; transcription initiation protein SPT3 homolog [KO:K11313]
122479016  PROM1; prominin-1 isoform X1 [KO:K06532]
122480968  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
122478744  BMP2K; BMP-2-inducible protein kinase isoform X1 [KO:K08854] [EC:2.7.11.1]
122468290  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
122473385  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
122487860  CDK14; cyclin-dependent kinase 14 isoform X1 [KO:K08821] [EC:2.7.11.22]
122496921  MEIS1; homeobox protein Meis1 isoform X1 [KO:K15613]
122488038  HOXA11; homeobox protein Hox-A11 [KO:K21951]
122469178  SIX1; homeobox protein SIX1 [KO:K15614]
122469179  SIX4; homeobox protein SIX4 [KO:K15615]
122495479  EYA1; LOW QUALITY PROTEIN: eyes absent homolog 1 [KO:K15616] [EC:3.1.3.48]
122482154  CDKN2C; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
122474480  HPGD; 15-hydroxyprostaglandin dehydrogenase [NAD(+)] [KO:K00069] [EC:1.1.1.141]
122477589  GRIA3; glutamate receptor 3 isoform X1 [KO:K05199]
122469227  FUT8; alpha-(1,6)-fucosyltransferase [KO:K00717] [EC:2.4.1.68]
122492419  TLX3; T-cell leukemia homeobox protein 3 [KO:K15607]
122493156  TLX1; T-cell leukemia homeobox protein 1 [KO:K09340]
122469517  BCL11B; B-cell lymphoma/leukemia 11B isoform X1 [KO:K22046]
122493172  LDB1; LIM domain-binding protein 1 isoform X1 [KO:K15617]
122486953  LYL1; protein lyl-1 [KO:K15604]
122493031  HHEX; hematopoietically-expressed homeobox protein HHEX [KO:K08024]
122489529  PTCRA; pre T-cell antigen receptor alpha [KO:K06056]
122496880  REL; proto-oncogene c-Rel [KO:K09254]
122472689  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
122482885  baculoviral IAP repeat-containing protein 3-like [KO:K16060]
122482886  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
122475453  TRAF1; TNF receptor-associated factor 1 [KO:K03172]
122496407  BCL2L1; bcl-2-like protein 1 [KO:K04570]
122491502  CD86; T-lymphocyte activation antigen CD86 isoform X1 [KO:K05413]
122467321  CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
122491620  BCL6; B-cell lymphoma 6 protein isoform X1 [KO:K15618]
122469619  immunoglobulin delta heavy chain-like [KO:K06856]
122494493  MAF; transcription factor Maf isoform X1 [KO:K09035]
122473466  ITGB7; integrin beta-7 [KO:K06590]
122479128  NSD2; histone-lysine N-methyltransferase NSD2 isoform X1 [KO:K11424] [EC:2.1.1.357]
122489122  histone H3.1 [KO:K11253]
122490252  uncharacterized protein LOC122490252 [KO:K11253]
122489123  histone H3.1 [KO:K11253]
122490321  histone H3-5-like [KO:K11253]
122490255  histone H3.1-like [KO:K11253]
122490287  histone H3.1 [KO:K11253]
122490286  histone H3.1 [KO:K11253]
122490322  histone H3.1-like [KO:K11253]
122471152  LOW QUALITY PROTEIN: histone H3.1 [KO:K11253]
122485915  histone H3.3A [KO:K11253]
122469300  histone H3.3A-like [KO:K11253]
122476524  histone H3.3A [KO:K11253]
122490213  uncharacterized protein LOC122490213 [KO:K11253]
122490254  uncharacterized protein LOC122490254 [KO:K11253]
122474631  PAX5; paired box protein Pax-5 [KO:K09383]
122497160  PAX8; paired box protein Pax-8 isoform X1 [KO:K09293]
122487517  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
122475004  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
122489388  RXRB; retinoic acid receptor RXR-beta isoform X1 [KO:K08525]
122476622  RXRG; retinoic acid receptor RXR-gamma isoform X1 [KO:K08526]
122476443  PRCC; proline-rich protein PRCC [KO:K13105]
122477965  TFE3; transcription factor E3 isoform X1 [KO:K09105]
122489448  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
122491150  TMPRSS2; transmembrane protease serine 2 [KO:K09633] [EC:3.4.21.122]
122491167  ERG; transcriptional regulator ERG isoform X1 [KO:K09435]
122493469  PLAU; urokinase-type plasminogen activator isoform X1 [KO:K01348] [EC:3.4.21.73]
122473009  PLAT; tissue-type plasminogen activator [KO:K01343] [EC:3.4.21.68]
122482892  stromelysin-1-like [KO:K01394] [EC:3.4.24.17]
122467326  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
122472194  ZEB1; zinc finger E-box-binding homeobox 1 isoform X1 [KO:K09299]
122496691  IL1R2; interleukin-1 receptor type 2 isoform X1 [KO:K04387]
122468030  SPINT1; kunitz-type protease inhibitor 1 [KO:K15619]
122487943  ETV1; ETS translocation variant 1 isoform X1 [KO:K09431]
122485653  ETV4; ETS translocation variant 4 isoform X1 [KO:K15592]
122491640  ETV5; ETS translocation variant 5 [KO:K15593]
122476506  SLC45A3; solute carrier family 45 member 3 [KO:K15379]
122476504  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
122485783  DDX5; probable ATP-dependent RNA helicase DDX5 isoform X1 [KO:K12823] [EC:5.6.2.7]
122497445  MYCN; N-myc proto-oncogene protein [KO:K09109]
122469223  MAX; LOW QUALITY PROTEIN: protein max [KO:K04453]
122474007  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
122495851  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
122484900  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
122473714  BMI1; polycomb complex protein BMI-1 [KO:K11459]
122473480  SP1; transcription factor Sp1 [KO:K04684]
122479975  ZBTB17; zinc finger and BTB domain-containing protein 17 isoform X1 [KO:K10500]
122475682  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
122485394  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
122483977  MEN1; menin isoform X1 [KO:K14970]
122470420  EWSR1; RNA-binding protein EWS isoform X1 [KO:K13209]
122483140  FLI1; Friend leukemia integration 1 transcription factor isoform X1 [KO:K09436]
122472604  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
122497493  ID2; DNA-binding protein inhibitor ID-2 [KO:K17693]
122492079  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
122487652  IGFBP3; insulin-like growth factor-binding protein 3 [KO:K10138]
122479729  FEV; protein FEV [KO:K09437]
122473389  ATF1; cyclic AMP-dependent transcription factor ATF-1 isoform X1 [KO:K09053]
122467518  ARNT2; aryl hydrocarbon receptor nuclear translocator 2 isoform X1 [KO:K15589]
122482919  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
122487430  MITF; microphthalmia-associated transcription factor isoform X1 [KO:K09455]
122483665  WT1; Wilms tumor protein isoform X1 [KO:K09234]
122471191  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
122472705  IL2RB; LOW QUALITY PROTEIN: interleukin-2 receptor subunit beta [KO:K05069]
122471869  BAIAP3; BAI1-associated protein 3 isoform X1 [KO:K15621]
122477727  TSPAN7; tetraspanin-7 isoform X1 [KO:K06571]
122491799  MLF1; myeloid leukemia factor 1 isoform X1 [KO:K15622]
122474303  NR4A3; nuclear receptor subfamily 4 group A member 3 [KO:K08559]
122485243  TAF15; TATA-binding protein-associated factor 2N isoform X1 [KO:K14651]
122471415  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
122473818  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
122467278  CEBPB; CCAAT/enhancer-binding protein beta [KO:K10048]
122487989  IL6; interleukin-6 [KO:K05405]
122491390  NFKBIZ; NF-kappa-B inhibitor zeta [KO:K14242]
122478010  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
122484468  RELA; transcription factor p65 [KO:K04735]
122478799  C-X-C motif chemokine 15-like [KO:K10030]
122478804  CXCL8; interleukin-8 [KO:K10030]
122480005  PAX7; paired box protein Pax-7 isoform X1 [KO:K09381]
122481827  PAX3; paired box protein Pax-3 isoform X1 [KO:K09381]
122481792  FOXO1; forkhead box protein O1 [KO:K07201]
122481013  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
122467194  SS18L1; calcium-responsive transactivator isoform X1 [KO:K15623]
122470656  SS18; protein SSXT isoform X1 [KO:K15623]
122476953  protein SSX1-like [KO:K15624]
122471502  NUPR1; nuclear protein 1 [KO:K15626]
122485968  ASPSCR1; tether containing UBX domain for GLUT4 isoform X1 [KO:K15627]
122488133  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
122480620  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
122486654  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
122474523  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
122494846  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
122489414  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
122484438  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
122489887  POLK; DNA polymerase kappa isoform X1 [KO:K03511] [EC:2.7.7.7]
Reference
PMID:11607818
  Authors
Alcalay M, Orleth A, Sebastiani C, Meani N, Chiaradonna F, Casciari C, Sciurpi MT, Gelmetti V, Riganelli D, Minucci S, Fagioli M, Pelicci PG
  Title
Common themes in the pathogenesis of acute myeloid leukemia.
  Journal
Oncogene 20:5680-94 (2001)
DOI:10.1038/sj.onc.1204642
Reference
PMID:12032780
  Authors
Scandura JM, Boccuni P, Cammenga J, Nimer SD
  Title
Transcription factor fusions in acute leukemia: variations on a theme.
  Journal
Oncogene 21:3422-44 (2002)
DOI:10.1038/sj.onc.1205315
Reference
PMID:12529654
  Authors
Roumier C, Fenaux P, Lafage M, Imbert M, Eclache V, Preudhomme C
  Title
New mechanisms of AML1 gene alteration in hematological malignancies.
  Journal
Leukemia 17:9-16 (2003)
DOI:10.1038/sj.leu.2402766
Reference
PMID:10717473
  Authors
Lutterbach B, Hiebert SW
  Title
Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation.
  Journal
Gene 245:223-35 (2000)
DOI:10.1016/S0378-1119(00)00014-7
Reference
PMID:19075268
  Authors
Koschmieder S, Halmos B, Levantini E, Tenen DG
  Title
Dysregulation of the C/EBPalpha differentiation pathway in human cancer.
  Journal
J Clin Oncol 27:619-28 (2009)
DOI:10.1200/JCO.2008.17.9812
Reference
PMID:11340171
  Authors
Johansen LM, Iwama A, Lodie TA, Sasaki K, Felsher DW, Golub TR, Tenen DG
  Title
c-Myc is a critical target for c/EBPalpha in granulopoiesis.
  Journal
Mol Cell Biol 21:3789-806 (2001)
DOI:10.1128/MCB.21.11.3789-3806.2001
Reference
PMID:15985538
  Authors
Gery S, Gombart AF, Yi WS, Koeffler C, Hofmann WK, Koeffler HP
  Title
Transcription profiling of C/EBP targets identifies Per2 as a gene implicated in myeloid leukemia.
  Journal
Blood 106:2827-36 (2005)
DOI:10.1182/blood-2005-01-0358
Reference
PMID:12393465
  Authors
Vangala RK, Heiss-Neumann MS, Rangatia JS, Singh SM, Schoch C, Tenen DG, Hiddemann W, Behre G
  Title
The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia.
  Journal
Blood 101:270-7 (2003)
DOI:10.1182/blood-2002-04-1288
Reference
PMID:12130514
  Authors
Mueller BU, Pabst T, Osato M, Asou N, Johansen LM, Minden MD, Behre G, Hiddemann W, Ito Y, Tenen DG
  Title
Heterozygous PU.1 mutations are associated with acute myeloid leukemia.
  Journal
Blood 100:998-1007 (2002)
DOI:10.1182/blood.V100.3.998
Reference
PMID:15160934
  Authors
Jing Y
  Title
The PML-RARalpha fusion protein and targeted therapy for acute promyelocytic leukemia.
  Journal
Leuk Lymphoma 45:639-48 (2004)
DOI:10.1080/10428190310001609933
Reference
PMID:15024077
  Authors
Muller-Tidow C, Steffen B, Cauvet T, Tickenbrock L, Ji P, Diederichs S, Sargin B, Kohler G, Stelljes M, Puccetti E, Ruthardt M, deVos S, Hiebert SW, Koeffler HP, Berdel WE, Serve H
  Title
Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells.
  Journal
Mol Cell Biol 24:2890-904 (2004)
DOI:10.1128/MCB.24.7.2890-2904.2004
Reference
PMID:19855079
  Authors
Rice KL, Hormaeche I, Doulatov S, Flatow JM, Grimwade D, Mills KI, Leiva M, Ablain J, Ambardekar C, McConnell MJ, Dick JE, Licht JD
  Title
Comprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYC.
  Journal
Blood 114:5499-511 (2009)
DOI:10.1182/blood-2009-03-206524
Reference
PMID:10500199
  Authors
McWhirter JR, Neuteboom ST, Wancewicz EV, Monia BP, Downing JR, Murre C
  Title
Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia.
  Journal
Proc Natl Acad Sci U S A 96:11464-9 (1999)
DOI:10.1073/pnas.96.20.11464
Reference
PMID:15156184
  Authors
Zelent A, Greaves M, Enver T
  Title
Role of the TEL-AML1 fusion gene in the molecular pathogenesis of childhood acute lymphoblastic leukaemia.
  Journal
Oncogene 23:4275-83 (2004)
DOI:10.1038/sj.onc.1207672
Reference
PMID:14630078
  Authors
Sawinska M, Ladon D
  Title
Mechanism, detection and clinical significance of the reciprocal translocation t(12;21)(p12;q22) in the children suffering from acute lymphoblastic leukaemia.
  Journal
Leuk Res 28:35-42 (2004)
DOI:10.1016/S0145-2126(03)00160-7
Reference
PMID:19141473
  Authors
Guenther MG, Lawton LN, Rozovskaia T, Frampton GM, Levine SS, Volkert TL, Croce CM, Nakamura T, Canaani E, Young RA
  Title
Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia.
  Journal
Genes Dev 22:3403-8 (2008)
DOI:10.1101/gad.1741408
Reference
PMID:16169901
  Authors
Xia ZB, Popovic R, Chen J, Theisler C, Stuart T, Santillan DA, Erfurth F, Diaz MO, Zeleznik-Le NJ
  Title
The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression.
  Journal
Proc Natl Acad Sci U S A 102:14028-33 (2005)
DOI:10.1073/pnas.0506464102
Reference
PMID:21518926
  Authors
Wang QF, Wu G, Mi S, He F, Wu J, Dong J, Luo RT, Mattison R, Kaberlein JJ, Prabhakar S, Ji H, Thirman MJ
  Title
MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome.
  Journal
Blood 117:6895-905 (2011)
DOI:10.1182/blood-2010-12-324699
Reference
PMID:14701735
  Authors
Zeisig BB, Milne T, Garcia-Cuellar MP, Schreiner S, Martin ME, Fuchs U, Borkhardt A, Chanda SK, Walker J, Soden R, Hess JL, Slany RK
  Title
Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization.
  Journal
Mol Cell Biol 24:617-28 (2004)
DOI:10.1128/MCB.24.2.617-628.2004
Reference
PMID:19133982
  Authors
Riz I, Hawley TS, Johnston H, Hawley RG
  Title
Role of TLX1 in T-cell acute lymphoblastic leukaemia pathogenesis.
  Journal
Br J Haematol 145:140-3 (2009)
DOI:10.1111/j.1365-2141.2008.07556.x
Reference
PMID:12511414
  Authors
Barth TF, Martin-Subero JI, Joos S, Menz CK, Hasel C, Mechtersheimer G, Parwaresch RM, Lichter P, Siebert R, Mooller P
  Title
Gains of 2p involving the REL locus correlate with nuclear c-Rel protein accumulation in neoplastic cells of classical Hodgkin lymphoma.
  Journal
Blood 101:3681-6 (2003)
DOI:10.1182/blood-2002-08-2577
Reference
PMID:11313274
  Authors
Hinz M, Loser P, Mathas S, Krappmann D, Dorken B, Scheidereit C
  Title
Constitutive NF-kappaB maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Sternberg cells.
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Blood 97:2798-807 (2001)
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The biology of hairy cells.
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Best Pract Res Clin Haematol 16:1-13 (2003)
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Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma.
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Cancer Cell 5:191-9 (2004)
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The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells.
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Blood 117:211-20 (2011)
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The t(9;14)(p13;q32) translocation in B-cell non-Hodgkin's lymphoma.
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Leuk Lymphoma 36:435-45 (2000)
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Curr Opin Genet Dev 19:82-91 (2009)
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Translocations in epithelial cancers.
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Biochim Biophys Acta 1796:201-15 (2009)
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The paired box-8/peroxisome proliferator-activated receptor-gamma oncogene in thyroid tumorigenesis.
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Endocrinology 148:932-5 (2007)
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Exp Cell Res 315:2399-409 (2009)
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Nat Rev Cancer 8:497-511 (2008)
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An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression.
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Cancer Cell 17:443-54 (2010)
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TMPRSS2/ERG promotes epithelial to mesenchymal transition through the ZEB1/ZEB2 axis in a prostate cancer model.
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PLoS One 6:e21650 (2011)
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ETV1 is a novel androgen receptor-regulated gene that mediates prostate cancer cell invasion.
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Mol Endocrinol 21:1835-46 (2007)
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Characterization of TMPRSS2:ETV5 and SLC45A3:ETV5 gene fusions in prostate cancer.
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Cancer Res 68:73-80 (2008)
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The MYCN oncogene and differentiation in neuroblastoma.
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Semin Cancer Biol 21:256-66 (2011)
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PMID:20153925
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MYCN oncoprotein targets and their therapeutic potential.
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PMID:15644444
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The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma.
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Proc Natl Acad Sci U S A 102:731-6 (2005)
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Bmi1 is a MYCN target gene that regulates tumorigenesis through repression of KIF1Bbeta and TSLC1 in neuroblastoma.
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p53 is a direct transcriptional target of MYCN in neuroblastoma.
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N-MYC regulates focal adhesion kinase expression in human neuroblastoma.
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J Biol Chem 282:12503-16 (2007)
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Cancer Res 71:404-12 (2011)
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Mechanisms of disease: multiple endocrine neoplasia type 1-relation to chromatin modifications and transcription regulation.
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Nat Clin Pract Endocrinol Metab 2:562-70 (2006)
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Curr Mol Med 8:805-15 (2008)
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Unusual clinical and pathological presentation of a neuroendocrine tumor in a patient with multiple endocrine neoplasia type 1.
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Upregulation of Id2, an oncogenic helix-loop-helix protein, is mediated by the chimeric EWS/ets protein in Ewing sarcoma.
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Oncogene 22:1-9 (2003)
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Ewing Sarcoma, an enigmatic malignancy of likely progenitor cell origin, driven by transcription factor oncogenic fusions.
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Cancer Res 69:7140-50 (2009)
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Oncogene 22:41-9 (2003)
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Semin Cancer Biol 15:197-205 (2005)
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J Pathol 217:83-93 (2009)
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Fusion of the EWS-related gene TAF2N to TEC in extraskeletal myxoid chondrosarcoma.
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Myxoid liposarcoma FUS-DDIT3 fusion oncogene induces C/EBP beta-mediated interleukin 6 expression.
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Int J Cancer 115:556-60 (2005)
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Oncogene 28:270-8 (2009)
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Kinome profiling of myxoid liposarcoma reveals NF-kappaB-pathway kinase activity and casein kinase II inhibition as a potential treatment option.
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PAX3-FOXO1 fusion gene in rhabdomyosarcoma.
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Cancer Lett 270:10-8 (2008)
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Identification of target genes regulated by PAX3 and PAX3-FKHR in embryogenesis and alveolar rhabdomyosarcoma.
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Genomics 79:278-84 (2002)
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Ishida M, Miyamoto M, Naitoh S, Tatsuda D, Hasegawa T, Nemoto T, Yokozeki H, Nishioka K, Matsukage A, Ohki M, Ohta T
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The SYT-SSX fusion protein down-regulates the cell proliferation regulator COM1 in t(x;18) synovial sarcoma.
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Mol Cell Biol 27:1348-55 (2007)
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PMID:19472090
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Jun HJ, Lee J, Lim do H, Park JO, Ahn G, Seo SW, Sung KS, Lim do H, Yoo KH, Choi YL
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Expression of MET in alveolar soft part sarcoma.
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Med Oncol 27:459-65 (2010)
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Mutations in the p53 Tumor Suppressor Gene: Important Milestones at the Various Steps of Tumorigenesis.
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Genes Cancer 2:466-74 (2011)
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Recent advances in p53 research and cancer treatment.
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J Biomed Biotechnol 2011:978312 (2011)
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Related
pathway
pbg04115  p53 signaling pathway
pbg05211  Renal cell carcinoma
pbg05215  Prostate cancer
pbg05216  Thyroid cancer
pbg05221  Acute myeloid leukemia
KO pathway
ko05202   
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