KEGG   PATHWAY: pov04148
Entry
pov04148                    Pathway                                
Name
Efferocytosis - Paralichthys olivaceus (Japanese flounder)
Class
Cellular Processes; Transport and catabolism
Pathway map
pov04148  Efferocytosis
pov04148

Organism
Paralichthys olivaceus (Japanese flounder) [GN:pov]
Gene
109639599  caspase-3-like [KO:K02187] [EC:3.4.22.56]
109631395  caspase-3-like [KO:K02187] [EC:3.4.22.56]
109644782  casp7; caspase-7 [KO:K04397] [EC:3.4.22.60]
109648155  caspase-3-like [KO:K04397] [EC:3.4.22.60]
109630250  caspase-1-like isoform X1 [KO:K01370] [EC:3.4.22.36]
109647920  pannexin-1-like [KO:K03443]
109627524  panx1; pannexin-1 isoform X1 [KO:K03443]
109645215  pannexin-1-like [KO:K03443]
109630398  p2ry2; P2Y purinoceptor 2 [KO:K04269]
109630003  p2ry6; P2Y purinoceptor 6 [KO:K04272]
109630151  P2Y purinoceptor 12-like [KO:K04298]
109644606  sphingosine kinase 2-like [KO:K04718] [EC:2.7.1.91]
109639502  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
109627230  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
109633239  sphingosine kinase 2-like [KO:K04718] [EC:2.7.1.91]
109646393  s1pr1; sphingosine 1-phosphate receptor 1 [KO:K04288]
109639269  pla2g6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
109627531  abca1; ATP-binding cassette sub-family A member 1 isoform X1 [KO:K05641]
109636653  ATP-binding cassette sub-family A member 1-like [KO:K05641]
109634879  ATP-binding cassette sub-family A member 1-like isoform X1 [KO:K05641]
109647926  probable G-protein coupled receptor 132 [KO:K08426]
109647739  probable G-protein coupled receptor 132 [KO:K08426]
109647613  disintegrin and metalloproteinase domain-containing protein 17-like [KO:K06059] [EC:3.4.24.86]
109647706  disintegrin and metalloproteinase domain-containing protein 17-like [KO:K06059] [EC:3.4.24.86]
109628009  disintegrin and metalloproteinase domain-containing protein 17-like [KO:K06059] [EC:3.4.24.86]
109624447  disintegrin and metalloproteinase domain-containing protein 10-like [KO:K06704] [EC:3.4.24.81]
109625416  disintegrin and metalloproteinase domain-containing protein 10-like [KO:K06704] [EC:3.4.24.81]
109636872  adam10; disintegrin and metalloproteinase domain-containing protein 10 [KO:K06704] [EC:3.4.24.81]
109645580  nuclear factor of activated T-cells, cytoplasmic 2-like [KO:K17332]
109635435  nuclear factor of activated T-cells, cytoplasmic 2-like [KO:K17332]
109631959  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
109625161  nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
109645229  nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
109642132  nuclear factor of activated T-cells, cytoplasmic 4-like [KO:K17334]
109628061  hif1a; hypoxia-inducible factor 1-alpha [KO:K08268]
109640140  hypoxia-inducible factor 1-alpha-like [KO:K08268]
109633245  aryl hydrocarbon receptor nuclear translocator-like isoform X1 [KO:K09097]
109639698  epo; LOW QUALITY PROTEIN: erythropoietin [KO:K05437]
109644517  erythropoietin receptor-like [KO:K05079]
109626499  tyrosine-protein kinase JAK2-like [KO:K04447] [EC:2.7.10.2]
109637124  tyrosine-protein kinase JAK2-like [KO:K04447] [EC:2.7.10.2]
109639504  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
109640677  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
109640616  CCAAT/enhancer-binding protein beta-like [KO:K10048]
109635570  pparg; peroxisome proliferator-activated receptor gamma [KO:K08530]
109639832  bromodomain-containing protein 3-like [KO:K08524]
109645008  retinoic acid receptor RXR-alpha-A [KO:K08524]
109633203  retinoic acid receptor RXR-beta-A-like isoform X1 [KO:K08524]
109637208  EGF-like repeat and discoidin I-like domain-containing protein 3 [KO:K17253]
109624494  lactadherin-like isoform X1 [KO:K17253]
109625107  gas6; growth arrest-specific protein 6 [KO:K05464]
109635472  tyrosine-protein kinase Mer-like [KO:K05117] [EC:2.7.10.1]
109644727  cd36; platelet glycoprotein 4 [KO:K06259]
109627896  thrombospondin-1-like [KO:K16857]
109636170  thrombospondin-1-like [KO:K16857]
109624327  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
109625750  dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
109636696  ptgs2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
109640537  prostaglandin E2 receptor EP2 subtype-like [KO:K04259]
109632432  prostaglandin E2 receptor EP2 subtype-like [KO:K04259]
109636581  prostaglandin E2 receptor EP4 subtype-like [KO:K04261]
109641558  prostaglandin E2 receptor EP4 subtype-like [KO:K04261]
109626118  prostaglandin E2 receptor EP4 subtype-like [KO:K04261]
109637012  prostaglandin E2 receptor EP4 subtype-like [KO:K04261]
109636466  DNA (cytosine-5)-methyltransferase 3A-like isoform X1 [KO:K17398] [EC:2.1.1.37]
109642379  DNA (cytosine-5)-methyltransferase 3A-like isoform X1 [KO:K17398] [EC:2.1.1.37]
109640884  creb1; cyclic AMP-responsive element-binding protein 1 [KO:K05870]
109644135  cyclic AMP-responsive element-binding protein 1-like [KO:K05870]
109630415  transforming growth factor beta-1-like [KO:K13375]
109633747  sarcoplasmic/endoplasmic reticulum calcium ATPase 2-like isoform X1 [KO:K05853] [EC:7.2.2.10]
109628562  atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
109627366  sarcoplasmic/endoplasmic reticulum calcium ATPase 2-like [KO:K05853] [EC:7.2.2.10]
109639510  sarcoplasmic/endoplasmic reticulum calcium ATPase 1-like isoform X1 [KO:K05853] [EC:7.2.2.10]
109626276  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
109647126  sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
109633197  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
109641257  calcium/calmodulin-dependent protein kinase type II subunit beta-like [KO:K04515] [EC:2.7.11.17]
109643417  calcium/calmodulin-dependent protein kinase type II subunit alpha-like [KO:K04515] [EC:2.7.11.17]
109643698  calcium/calmodulin-dependent protein kinase type II subunit gamma-like [KO:K04515] [EC:2.7.11.17]
109637646  calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
109626490  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
109637852  calcium/calmodulin-dependent protein kinase type II subunit delta-like isoform X1 [KO:K04515] [EC:2.7.11.17]
109630822  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
109632714  mitogen-activated protein kinase 14-like [KO:K04441] [EC:2.7.11.24]
109632715  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
109629252  mitogen-activated protein kinase 14A [KO:K04441] [EC:2.7.11.24]
109630593  mitogen-activated protein kinase 14B-like [KO:K04441] [EC:2.7.11.24]
109630994  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
109638988  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
109629213  MAP kinase-activated protein kinase 2-like [KO:K04443] [EC:2.7.11.1]
109631496  alox5; arachidonate 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
109647439  dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109635615  dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109642696  dusp8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109626466  dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109627745  dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109636948  dusp2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109635299  dual specificity protein phosphatase 7-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109632925  ano6; anoctamin-6 [KO:K19500]
109624142  ano3; anoctamin-3 [KO:K19498]
109637566  ano4; anoctamin-4 isoform X1 [KO:K19499]
109624143  ano5; anoctamin-5 isoform X1 [KO:K19480]
109624830  anoctamin-5-like [KO:K19480]
109642355  ano7; anoctamin-7 [KO:K19501]
109630661  anoctamin-7-like [KO:K19501]
109624144  anoctamin-9-like [KO:K19503]
109625821  bsg; basigin isoform X1 [KO:K06535]
109640415  XK-related protein 8-like [KO:K26813]
109640412  LOW QUALITY PROTEIN: XK-related protein 8-like [KO:K26813]
109629626  xkr9; XK-related protein 9 [KO:K26814]
109642728  XK-related protein 7-like [KO:K26811]
109643017  XK-related protein 7-like [KO:K26811]
109637937  xkr4; XK-related protein 4 [KO:K26811]
109632605  xkr6; XK-related protein 6 [KO:K26811]
109629544  phospholipid-transporting ATPase IB-like [KO:K14802] [EC:7.6.2.1]
109641773  phospholipid-transporting ATPase IB-like [KO:K14802] [EC:7.6.2.1]
109626717  atp8a1; phospholipid-transporting ATPase IA isoform X1 [KO:K14802] [EC:7.6.2.1]
109634466  atp11c; phospholipid-transporting ATPase IG [KO:K26934] [EC:7.6.2.1]
109637918  probable phospholipid-transporting ATPase IH [KO:K26934] [EC:7.6.2.1]
109640097  probable phospholipid-transporting ATPase IH isoform X1 [KO:K26934] [EC:7.6.2.1]
109640239  atp11b; probable phospholipid-transporting ATPase IF [KO:K26934] [EC:7.6.2.1]
109647005  cell cycle control protein 50A-like [KO:K26935]
109628127  cell cycle control protein 50A-like [KO:K26935]
109624729  pros1; vitamin K-dependent protein S [KO:K03908]
109640660  itgav; integrin alpha-V [KO:K06487]
109634031  integrin beta-3-like [KO:K06493]
109627018  itgb3; integrin beta-3 isoform X1 [KO:K06493]
109640916  diacylglycerol kinase gamma-like [KO:K06588]
109630280  axl; tyrosine-protein kinase receptor UFO [KO:K05115] [EC:2.7.10.1]
109643085  tyrosine-protein kinase receptor TYRO3-like [KO:K05116] [EC:2.7.10.1]
109639115  brain-specific angiogenesis inhibitor 1-like [KO:K04596]
109635575  stab1; stabilin-1 isoform X1 [KO:K19020]
109641649  stabilin-2-like [KO:K19013]
109632156  LOW QUALITY PROTEIN: focal adhesion kinase 1-like [KO:K05725] [EC:2.7.10.2]
109638831  ptk2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
109642993  breast cancer anti-estrogen resistance protein 1-like [KO:K05726]
109634381  adapter molecule crk-like [KO:K04438]
109626378  crkl; crk-like protein [KO:K04438]
109635835  adapter molecule crk-like [KO:K04438]
109631816  engulfment and cell motility protein 1 isoform X1 [KO:K12366]
109626977  dock1; dedicator of cytokinesis protein 1 [KO:K13708]
109638710  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
109626935  rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
109626756  disintegrin and metalloproteinase domain-containing protein 9-like [KO:K06834] [EC:3.4.24.-]
109645752  calreticulin-like [KO:K08057]
109625829  calreticulin-like [KO:K08057]
109625866  calreticulin-like [KO:K08057]
109635432  complement C1q subcomponent subunit B-like [KO:K03987]
109635433  complement C1q subcomponent subunit C-like [KO:K03988]
109635117  lrp1; prolow-density lipoprotein receptor-related protein 1 isoform X1 [KO:K04550]
109628960  low-density lipoprotein receptor-related protein 1-like [KO:K04550]
109623997  megf11; multiple epidermal growth factor-like domains protein 11 [KO:K24068]
109626127  megf10; multiple epidermal growth factor-like domains protein 10 [KO:K24068]
109645484  scavenger receptor class F member 1-like [KO:K24318]
109637410  gulp1; PTB domain-containing engulfment adapter protein 1 isoform X1 [KO:K23285]
109630897  PTB domain-containing engulfment adapter protein 1-like [KO:K23285]
109637338  ras-related protein Rab-17-like [KO:K07909]
109631800  ras-related protein Rab-5A-like [KO:K07887]
109642220  ras-related protein Rab-5A [KO:K07887]
109645470  ras-related protein Rab-5C-like [KO:K07888]
109640507  ras-related protein Rab-5C-like [KO:K07888]
109627133  ras-related protein Rab-5C-like [KO:K07889]
109634069  rab5c; ras-related protein Rab-5C [KO:K07889]
109625109  tgfbrap1; transforming growth factor-beta receptor-associated protein 1 [KO:K20177]
109647971  transforming growth factor-beta receptor-associated protein 1-like [KO:K20177]
109636261  transforming growth factor-beta receptor-associated protein 1-like [KO:K20177]
109639861  vps8; vacuolar protein sorting-associated protein 8 homolog [KO:K20178]
109628754  vps11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
109642801  vps16; vacuolar protein sorting-associated protein 16 homolog isoform X1 [KO:K20180]
109632548  vps18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
109633578  vps33a; vacuolar protein sorting-associated protein 33A [KO:K20182]
109626265  ras-related protein Rab-14 [KO:K07881]
109646152  ras-related protein Rab-14-like [KO:K07881]
109636447  vps39; vam6/Vps39-like protein isoform X1 [KO:K20183]
109629812  vps41; vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
109629150  ras-related protein rab7-like [KO:K07897]
109629191  ras-related protein rab7 [KO:K07897]
109629311  ras-related protein rab7-like [KO:K07897]
109634389  pqlc2l; putative uncharacterized protein PQLC2L [KO:K23678]
109630761  pqlc2; lysosomal amino acid transporter 1 homolog isoform X1 [KO:K23678]
109644398  arginase, hepatic-like [KO:K01476] [EC:3.5.3.1]
109642479  arg2; arginase-2, mitochondrial [KO:K01476] [EC:3.5.3.1]
109627976  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
109628143  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
109633719  cholesterol 25-hydroxylase-like protein [KO:K10223] [EC:1.14.99.38]
109624069  cholesterol 25-hydroxylase-like protein 1, member 1 [KO:K10223] [EC:1.14.99.38]
109624296  cholesterol 25-hydroxylase-like protein 1, member 2 [KO:K10223] [EC:1.14.99.38]
109626203  cholesterol 25-hydroxylase-like protein 2 [KO:K10223] [EC:1.14.99.38]
109646054  cholesterol 25-hydroxylase-like protein [KO:K10223] [EC:1.14.99.38]
109637258  nr1h3; oxysterols receptor LXR-alpha isoform X1 [KO:K08536]
109644453  carnitine O-palmitoyltransferase 1, liver isoform-like [KO:K08765] [EC:2.3.1.21]
109626920  carnitine O-palmitoyltransferase 1, liver isoform-like isoform X1 [KO:K08765] [EC:2.3.1.21]
109648033  cpt1b; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K08765] [EC:2.3.1.21]
109638956  carnitine O-palmitoyltransferase 1, liver isoform-like isoform X1 [KO:K08765] [EC:2.3.1.21]
109624998  cytochrome b-c1 complex subunit Rieske, mitochondrial-like [KO:K00411] [EC:7.1.1.8]
109641918  cytochrome b-c1 complex subunit Rieske, mitochondrial-like [KO:K00411] [EC:7.1.1.8]
109634091  sirt1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
109625243  pre-B-cell leukemia transcription factor 1-like isoform X1 [KO:K09355]
109640132  pre-B-cell leukemia transcription factor 1 isoform X1 [KO:K09355]
109629080  il10; interleukin-10 [KO:K05443]
109644899  lysosomal acid lipase/cholesteryl ester hydrolase-like [KO:K01052] [EC:3.1.1.13]
109640726  group XV phospholipase A2-like [KO:K06129] [EC:3.1.1.5]
109630810  ppard; peroxisome proliferator-activated receptor delta [KO:K04504]
109635536  solute carrier family 2, facilitated glucose transporter member 1-like [KO:K07299]
109642352  solute carrier family 2, facilitated glucose transporter member 1-like isoform X1 [KO:K07299]
109636461  solute carrier family 2, facilitated glucose transporter member 1-like [KO:K07299]
109641620  monocarboxylate transporter 1-like [KO:K08179]
109635421  monocarboxylate transporter 1-like isoform X1 [KO:K08179]
109642399  serine/threonine-protein kinase Sgk1-like isoform X1 [KO:K13302] [EC:2.7.11.1]
109632568  sgk1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
109633033  serine/threonine-protein kinase Sgk1-like [KO:K13302] [EC:2.7.11.1]
109639491  platelet endothelial cell adhesion molecule-like [KO:K06471]
109627237  platelet endothelial cell adhesion molecule-like isoform X1 [KO:K06471]
109633079  myelin-associated glycoprotein-like [KO:K06749]
109633267  ptpn6; tyrosine-protein phosphatase non-receptor type 6 isoform X1 [KO:K05697] [EC:3.1.3.48]
109626354  ptpn11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
109630583  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
pov00010  Glycolysis / Gluconeogenesis
pov04140  Autophagy - animal
pov04145  Phagosome
KO pathway
ko04148   
LinkDB

DBGET integrated database retrieval system