KEGG   PATHWAY: rbb04020
Entry
rbb04020                    Pathway                                
Name
Calcium signaling pathway - Rhinopithecus bieti (black snub-nosed monkey)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
rbb04020  Calcium signaling pathway
rbb04020

Other DBs
GO: 0019722
Organism
Rhinopithecus bieti (black snub-nosed monkey) [GN:rbb]
Gene
108542784  SLC8A1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
108520278  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
108540286  SLC8A2; LOW QUALITY PROTEIN: sodium/calcium exchanger 2 [KO:K05849]
108515001  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
108512290  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
108527219  ATP2B1; LOW QUALITY PROTEIN: plasma membrane calcium-transporting ATPase 1 [KO:K05850] [EC:7.2.2.10]
108535088  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
108536133  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
108534413  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
108518797  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
108540662  ADORA2A; adenosine receptor A2a [KO:K04266]
108522165  ADORA2B; adenosine receptor A2b [KO:K04267]
108542470  ADRB1; LOW QUALITY PROTEIN: beta-1 adrenergic receptor [KO:K04141]
108532068  ADRB2; beta-2 adrenergic receptor [KO:K04142]
108513564  ADRB3; LOW QUALITY PROTEIN: beta-3 adrenergic receptor [KO:K04143]
108523468  LOW QUALITY PROTEIN: D(1A) dopamine receptor-like [KO:K04144]
108523462  D(1A) dopamine receptor [KO:K04144]
108529476  DRD5; D(1B) dopamine receptor [KO:K05840]
108523474  HRH2; histamine H2 receptor isoform X1 [KO:K04150]
108532069  HTR4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
108544981  5-hydroxytryptamine receptor 5B-like [KO:K04161]
108521018  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
108515276  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
108544933  HTR7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
108541624  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
108541626  neuroendocrine secretory protein 55 [KO:K04632]
108527485  GNAL; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(olf) subunit alpha [KO:K04633]
108534793  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
108536960  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
108543021  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
108540946  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
108522948  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
108514094  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
108538326  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
108514761  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
108540003  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
108527683  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
108530264  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
108544714  PLN; cardiac phospholamban [KO:K05852]
108517393  SLN; sarcolipin [KO:K22642]
108540727  MRLN; myoregulin [KO:K22643]
108520950  CUNH4orf3; uncharacterized protein C4orf3 homolog [KO:K26467]
108537356  SMIM6; small integral membrane protein 6 [KO:K26468]
108523688  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
108520719  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
108534362  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
108535849  HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein [KO:K23450]
108543766  STIM1; stromal interaction molecule 1 isoform X1 [KO:K16059]
108515244  STIM2; LOW QUALITY PROTEIN: stromal interaction molecule 2 [KO:K18196]
108529632  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
108518904  ORAI2; protein orai-2 isoform X1 [KO:K16057]
108530460  ORAI3; protein orai-3 [KO:K16058]
108522695  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
108515198  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
108521361  voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
108545075  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
108544091  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
108542921  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
108512687  voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
108516476  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
108519362  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
108520455  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
108531792  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
108542864  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
108541249  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
108530279  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
108537403  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
108523108  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
108537157  GRIN3A; glutamate receptor ionotropic, NMDA 3A isoform X1 [KO:K05213]
108537879  GRIN3B; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 3B [KO:K05214]
108520720  P2RX1; P2X purinoceptor 1 isoform X1 [KO:K05215]
108544495  P2RX2; P2X purinoceptor 2 [KO:K05216]
108514836  P2RX3; P2X purinoceptor 3 [KO:K05217]
108529639  P2RX4; P2X purinoceptor 4 isoform X1 [KO:K05218]
108523100  P2RX5; P2X purinoceptor 5 isoform X1 [KO:K05219]
108536090  P2RX6; P2X purinoceptor 6 isoform X1 [KO:K05221]
108529640  P2RX7; P2X purinoceptor 7 [KO:K05220]
108538989  RYR1; ryanodine receptor 1 [KO:K04961]
108522194  RYR2; LOW QUALITY PROTEIN: ryanodine receptor 2 [KO:K04962]
108518794  RYR3; ryanodine receptor 3 [KO:K04963]
108535645  TRDN; LOW QUALITY PROTEIN: triadin [KO:K23449]
108524040  CASQ1; calsequestrin-1 [KO:K23468]
108528128  CASQ2; calsequestrin-2 [KO:K23445]
108543145  ASPH; aspartyl/asparaginyl beta-hydroxylase [KO:K00476] [EC:1.14.11.16]
108523977  CYSLTR1; LOW QUALITY PROTEIN: cysteinyl leukotriene receptor 1 [KO:K04322]
108530706  CYSLTR2; LOW QUALITY PROTEIN: cysteinyl leukotriene receptor 2 [KO:K04323]
108525697  LOW QUALITY PROTEIN: cysteinyl leukotriene receptor 2-like [KO:K04323]
108532444  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
108537638  ADRA1A; alpha-1A adrenergic receptor isoform X1 [KO:K04135]
108537942  ADRA1B; alpha-1B adrenergic receptor isoform X1 [KO:K04136]
108533428  ADRA1D; LOW QUALITY PROTEIN: alpha-1D adrenergic receptor [KO:K04137]
108518305  AGTR1; type-1 angiotensin II receptor [KO:K04166]
108514049  EDNRA; endothelin-1 receptor isoform X1 [KO:K04197]
108529118  EDNRB; endothelin B receptor [KO:K04198]
108513076  F2R; proteinase-activated receptor 1 isoform X1 [KO:K03914]
108539155  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
108519323  HRH1; histamine H1 receptor [KO:K04149]
108521967  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
108517033  5-hydroxytryptamine receptor 2C [KO:K04157]
108517034  LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 2C-like [KO:K04157]
108538319  HTR2B; 5-hydroxytryptamine receptor 2B isoform X1 [KO:K04157]
108527512  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
108535260  NTSR1; neurotensin receptor type 1 [KO:K04211]
108530949  OXTR; oxytocin receptor [KO:K04229]
108537929  AVPR1A; vasopressin V1a receptor [KO:K04226]
108535121  AVPR1B; vasopressin V1b receptor [KO:K04227]
108540943  LTB4R2; leukotriene B4 receptor 2 [KO:K04297]
108518184  PTAFR; platelet-activating factor receptor [KO:K04279]
108514763  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
108534626  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
108534641  PTGFR; LOW QUALITY PROTEIN: prostaglandin F2-alpha receptor [KO:K04262]
108519130  BDKRB1; B1 bradykinin receptor [KO:K03915]
108519129  BDKRB2; LOW QUALITY PROTEIN: B2 bradykinin receptor [KO:K03916]
108531692  TACR1; substance-P receptor [KO:K04222]
108530363  TACR2; substance-K receptor isoform X1 [KO:K04223]
108532829  TACR3; neuromedin-K receptor [KO:K04224]
108512663  TBXA2R; thromboxane A2 receptor [KO:K04264]
108541827  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
108515174  CCKAR; cholecystokinin receptor type A [KO:K04194]
108543233  CCKBR; gastrin/cholecystokinin type B receptor isoform X1 [KO:K04195]
108539652  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
108542641  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
108512657  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
108542660  GNA14; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
108512682  GNA15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
108541026  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
108524582  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
108542315  PDGFA; LOW QUALITY PROTEIN: platelet-derived growth factor subunit A [KO:K04359]
108520474  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
108534757  PDGFD; platelet-derived growth factor D [KO:K05450]
108529019  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
108530219  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
108515579  FGF2; fibroblast growth factor 2 [KO:K18497]
108535339  FGF10; fibroblast growth factor 10 [KO:K04358]
108515073  FGF8; fibroblast growth factor 8 [KO:K04358]
108517319  FGF7; fibroblast growth factor 7 [KO:K04358]
108537873  FGF22; LOW QUALITY PROTEIN: fibroblast growth factor 22 [KO:K04358]
108544577  FGF16; fibroblast growth factor 16 [KO:K04358]
108536494  FGF6; fibroblast growth factor 6 [KO:K04358]
108538230  FGF4; fibroblast growth factor 4 [KO:K04358]
108538240  FGF3; fibroblast growth factor 3 [KO:K04358]
108538283  FGF9; fibroblast growth factor 9 [KO:K04358]
108513599  FGF18; fibroblast growth factor 18 [KO:K04358]
108521318  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
108526452  FGF20; fibroblast growth factor 20 [KO:K04358]
108532456  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
108538219  FGF19; fibroblast growth factor 19 [KO:K22603]
108536498  FGF23; fibroblast growth factor 23 [KO:K22428]
108533452  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
108542677  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
108539697  VEGFD; vascular endothelial growth factor D [KO:K05449]
108534048  VEGFC; vascular endothelial growth factor C [KO:K05449]
108528126  NGF; beta-nerve growth factor isoform X1 [KO:K02582]
108536940  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
108526982  MST1; hepatocyte growth factor-like protein isoform X1 [KO:K23441]
108515989  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
108522039  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
108527784  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
108515999  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
108517585  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
108533750  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
108532047  PDGFRB; LOW QUALITY PROTEIN: platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
108512401  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
108529768  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
108532286  FGFR3; LOW QUALITY PROTEIN: fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
108544759  FGFR4; LOW QUALITY PROTEIN: fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
108512923  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
108514173  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
108531591  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
108515538  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
108520515  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
108535790  NTRK3; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
108528695  MET; LOW QUALITY PROTEIN: hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
108526969  MST1R; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
108513309  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
108522153  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
108511997  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
108512001  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 isoform X1 [KO:K06856]
108520828  uncharacterized protein LOC108520828 [KO:K06856]
108519975  uncharacterized protein LOC108519975 [KO:K06856]
108519976  LOW QUALITY PROTEIN: uncharacterized protein LOC108519976 [KO:K06856]
108519983  uncharacterized protein LOC108519983 [KO:K06856]
108519992  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
108524775  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
108532211  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 [KO:K05857] [EC:3.1.4.11]
108518456  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [KO:K05857] [EC:3.1.4.11]
108512236  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
108526885  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
108542252  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
108527553  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
108527564  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
108519825  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
108539491  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
108521233  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
108539721  PLCZ1; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
108528737  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
108523739  ITPR2; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
108516255  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
108531741  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
108512191  TPCN1; two pore calcium channel protein 1 isoform X1 [KO:K16896]
108538678  TPCN2; two pore calcium channel protein 2 isoform X1 [KO:K14077]
108534588  MCOLN1; LOW QUALITY PROTEIN: mucolipin-1 [KO:K04992]
108514811  MCOLN2; mucolipin-2 isoform X1 [KO:K04993]
108514774  MCOLN3; mucolipin-3 isoform X1 [KO:K04994]
108537441  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
108523630  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
108516879  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
108529563  VDAC1; voltage-dependent anion-selective channel protein 1 isoform X1 [KO:K05862]
108529513  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
108540717  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
108515615  ADP/ATP translocase 1 [KO:K05863]
108529787  ADP/ATP translocase 3-like [KO:K05863]
108520942  SLC25A6; ADP/ATP translocase 3 isoform X1 [KO:K05863]
108535888  LOW QUALITY PROTEIN: calcium-binding mitochondrial carrier SAL1-like [KO:K05863]
108538574  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
108518758  ADP/ATP translocase 2-like [KO:K05863]
108512004  ADP/ATP translocase 2 [KO:K05863]
108524230  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
108522336  TNNC1; troponin C, slow skeletal and cardiac muscles isoform X1 [KO:K05865]
108533340  TNNC2; troponin C, skeletal muscle [KO:K12042]
108536001  CALML6; calmodulin-like protein 6 isoform X1 [KO:K02183]
108512653  CALM2; calmodulin [KO:K02183]
108514692  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
108529886  CALML3; calmodulin-like protein 3 [KO:K02183]
108529898  CALML5; calmodulin-like protein 5 [KO:K02183]
108531068  CALM3; calmodulin isoform X1 [KO:K02183]
108533995  calmodulin [KO:K02183]
108535906  CALM1; calmodulin [KO:K02183]
108526509  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
108530886  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
108522034  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
108514260  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
108524142  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
108534775  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
108517416  MYLK; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
108539550  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
108538536  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D isoform X1 [KO:K08794] [EC:2.7.11.17]
108532044  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
108544005  LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type II subunit beta-like [KO:K04515] [EC:2.7.11.17]
108529387  calcium/calmodulin-dependent protein kinase type II subunit beta-like isoform X1 [KO:K04515] [EC:2.7.11.17]
108516884  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
108512486  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
108540302  CAMK4; LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
108542795  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
108516875  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
108540785  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
108537161  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
108533510  TFEB; transcription factor EB isoform X1 [KO:K15590]
108525049  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
108539466  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
108515354  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
108540953  NFATC4; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
108539288  NOS1; LOW QUALITY PROTEIN: nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
108539959  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
108532525  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
108514647  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
108532373  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
108526644  PDE1A; LOW QUALITY PROTEIN: calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
108537591  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
108539002  ITPKC; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
108544326  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
108535934  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
108517746  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
108538857  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
108529452  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
rbb04010  MAPK signaling pathway
rbb04070  Phosphatidylinositol signaling system
rbb04210  Apoptosis
rbb04720  Long-term potentiation
rbb04730  Long-term depression
KO pathway
ko04020   
LinkDB

DBGET integrated database retrieval system