KEGG   PATHWAY: sasa03015
Entry
sasa03015                   Pathway                                
Name
mRNA surveillance pathway - Salmo salar (Atlantic salmon)
Description
The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.
Class
Genetic Information Processing; Translation
Pathway map
sasa03015  mRNA surveillance pathway
sasa03015

Other DBs
GO: 0071028
Organism
Salmo salar (Atlantic salmon) [GN:sasa]
Gene
106611634  nuclear cap-binding protein subunit 1-like [KO:K12882]
100306803  nbp1a; Nuclear cap-binding protein subunit 1-A [KO:K12882]
100196301  ncbp2; nuclear cap binding protein subunit 2 [KO:K12883]
106604442  upf3b; UPF3 regulator of nonsense transcripts homolog B (yeast) [KO:K14328]
106611515  regulator of nonsense transcripts 3B-like [KO:K14328]
106581644  regulator of nonsense transcripts 3A-like [KO:K14328]
106586023  regulator of nonsense transcripts 3A-like [KO:K14328]
106581844  RBM8A; RNA-binding protein 8A [KO:K12876]
100196667  rbm8a; RNA binding motif protein 8A [KO:K12876]
106560432  MGN; protein mago nashi homolog [KO:K12877]
106584057  MGN; protein mago nashi homolog [KO:K12877]
106600823  protein CASC3-like [KO:K14323]
106607498  protein CASC3-like [KO:K14323]
106564785  eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
100195929  if4a3; Eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
106575588  SAP18; histone deacetylase complex subunit SAP18-like [KO:K14324]
101448003  sap18; Histone deacetylase complex subunit SAP18 [KO:K14324]
106601115  pinin-like [KO:K13114]
100380709  pinin [KO:K13114]
106600278  apoptotic chromatin condensation inducer in the nucleus-like [KO:K12875]
106608850  apoptotic chromatin condensation inducer in the nucleus-like [KO:K12875]
106569440  acin1; apoptotic chromatin condensation inducer 1 [KO:K12875]
106577794  apoptotic chromatin condensation inducer in the nucleus-like [KO:K12875]
106601855  RNA-binding protein with serine-rich domain 1-like [KO:K14325]
106606404  RNA-binding protein with serine-rich domain 1-like [KO:K14325]
106606410  RNA-binding protein with serine-rich domain 1-like [KO:K14325]
106579022  RNA-binding protein with serine-rich domain 1-like [KO:K14325]
106588091  THOC4; THO complex subunit 4-like [KO:K12881]
106601422  THO complex subunit 4-like [KO:K12881]
106601423  THO complex subunit 4-like [KO:K12881]
106606965  THO complex subunit 4-like [KO:K12881]
106606979  THOC4; THO complex subunit 4-like [KO:K12881]
106564930  THOC4; THO complex subunit 4-A-like [KO:K12881]
106566108  ATP-dependent RNA helicase DDX19A-like [KO:K18655] [EC:5.6.2.7]
106567140  ATP-dependent RNA helicase DDX19B [KO:K18655] [EC:5.6.2.7]
106572556  ATP-dependent RNA helicase DDX19A-like [KO:K18655] [EC:5.6.2.7]
106582679  ATP-dependent RNA helicase DDX19A-like [KO:K18655] [EC:5.6.2.7]
100380333  gle1; GLE1, RNA export mediator [KO:K18723]
106604390  nuclear RNA export factor 1-like [KO:K14284]
106603139  nuclear RNA export factor 1-like [KO:K14284]
100380454  nxf1; nuclear RNA export factor 1 [KO:K14284]
106604300  NXT2; NTF2-related export protein 2-like [KO:K14285]
106612158  NXT2; NTF2-related export protein 2-like [KO:K14285]
100194897  uap56; Spliceosome RNA helicase BAT1 [KO:K12812] [EC:5.6.2.7]
106567193  pym1b; partner of Y14 and mago B [KO:K14294]
106572489  pym1a; partner of Y14 and mago A [KO:K14294]
106579139  SRRM1; serine/arginine repetitive matrix protein 1-like [KO:K13171]
106610815  SRRM1; serine/arginine repetitive matrix protein 1-like [KO:K13171]
100380472  rngtt; RNA guanylyltransferase and 5'-phosphatase [KO:K13917] [EC:2.7.7.50 3.6.1.74]
100195852  rnmt; RNA guanine-7 methyltransferase [KO:K00565] [EC:2.1.1.56]
106600706  fus; FUS RNA binding protein [KO:K13098]
106580678  RNA-binding protein FUS-like [KO:K13098]
106612447  RNA-binding protein FUS-like [KO:K13098]
106565996  TADBP; TAR DNA-binding protein 43-like [KO:K23600]
106566965  TADBP; TAR DNA-binding protein 43-like [KO:K23600]
106572054  tardbp; TAR DNA binding protein [KO:K23600]
106582768  TADBP; TAR DNA-binding protein 43-like [KO:K23600]
106579615  polyadenylate-binding protein 2-like [KO:K14396]
106562065  embryonic polyadenylate-binding protein 2-B-like [KO:K14396]
106587263  embryonic polyadenylate-binding protein 2-B-like [KO:K14396]
100380487  pabp2; Polyadenylate-binding protein 2 [KO:K14396]
106573732  nudt21; nudix hydrolase 21 [KO:K14397]
106562230  CPSF5; cleavage and polyadenylation specificity factor subunit 5-like [KO:K14397]
106587420  CPSF5; cleavage and polyadenylation specificity factor subunit 5-like [KO:K14397]
106609799  cpsf6; cleavage and polyadenylation specific factor 6 [KO:K14398]
106562322  cleavage and polyadenylation specificity factor subunit 7-like [KO:K14398]
106593552  cleavage and polyadenylation specificity factor subunit 6-like [KO:K14398]
100380414  cpsf7; Cleavage and polyadenylation specificity factor subunit 7 [KO:K14398]
106613820  papolg; poly(A) polymerase gamma [KO:K14376] [EC:2.7.7.19]
106608231  poly(A) polymerase beta-like [KO:K14376] [EC:2.7.7.19]
106571105  poly(A) polymerase type 3-like [KO:K14376] [EC:2.7.7.19]
106577330  poly(A) polymerase gamma-like [KO:K14376] [EC:2.7.7.19]
106604661  polyribonucleotide 5'-hydroxyl-kinase Clp1-like [KO:K14399] [EC:2.7.1.78]
106611664  polyribonucleotide 5'-hydroxyl-kinase Clp1 [KO:K14399] [EC:2.7.1.78]
106570221  cleavage and polyadenylation specificity factor subunit 1-like [KO:K14401]
106588592  cleavage and polyadenylation specificity factor subunit 1-like [KO:K14401]
106608196  CPSF2; cleavage and polyadenylation specificity factor subunit 2 [KO:K14402]
100195522  cpsf2; cleavage and polyadenylation specific factor 2 [KO:K14402]
100194853  cpsf3; cleavage and polyadenylation specific factor 3 [KO:K14403] [EC:3.1.27.-]
106593953  cpsf4; cleavage and polyadenylation specific factor 4 [KO:K14404]
106563615  pre-mRNA 3'-end-processing factor FIP1-like [KO:K14405]
106560219  pre-mRNA 3'-end-processing factor FIP1-like [KO:K14405]
106584116  fip1l1; factor interacting with PAPOLA and CPSF1 [KO:K14405]
106594676  pre-mRNA 3'-end-processing factor FIP1-like [KO:K14405]
106594963  E3 ubiquitin-protein ligase RBBP6-like [KO:K15541]
106568653  wdr33; WD repeat domain 33 [KO:K15542]
106565976  WD repeat-containing protein 82 [KO:K14962]
106565138  WDR82; WD repeat-containing protein 82-like [KO:K14962]
106582801  WDR82; WD repeat-containing protein 82-like [KO:K14962]
106601579  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
100380634  pp1b; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
106606888  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
106577544  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
106579953  ppp1cc; protein phosphatase 1 catalytic subunit gamma [KO:K06269] [EC:3.1.3.16]
106571634  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
100196659  ppp1cb; protein phosphatase 1, catalytic subunit, beta isoform [KO:K06269] [EC:3.1.3.16]
100194534  ppp1cc; protein phosphatase 1, catalytic subunit, gamma isoform [KO:K06269] [EC:3.1.3.16]
100196690  pp1g; Serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
100194568  ssu72l; Ssu72 RNA polymerase II CTD phosphatase-like [KO:K15544] [EC:3.1.3.16]
100217353  ssu72; SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae) [KO:K15544] [EC:3.1.3.16]
106566270  cstf1; cleavage stimulation factor subunit 1 [KO:K14406]
106583831  uncharacterized LOC106583831 [KO:K14406]
106583836  uncharacterized LOC106583836 [KO:K14406]
106604758  cstf2; cleavage stimulation factor subunit 2 [KO:K14407]
106611711  cleavage stimulation factor subunit 2-like [KO:K14407]
106562763  cleavage stimulation factor subunit 3-like [KO:K14408]
100380363  cstf3; cleavage stimulation factor subunit 3 [KO:K14408]
106587796  cleavage stimulation factor subunit 3-like [KO:K14408]
106563407  sympk; symplekin [KO:K06100]
106603292  RNA-binding protein Musashi homolog 2-like [KO:K14411]
106613649  DAZ-associated protein 1-like [KO:K14411]
106613081  RNA-binding protein Musashi homolog 2-like [KO:K14411]
106565386  RNA-binding protein Musashi homolog 1-like [KO:K14411]
106581265  RNA-binding protein Musashi homolog 2-like [KO:K14411]
106573877  DAZP1; DAZ-associated protein 1-like [KO:K14411]
106579940  msi1; musashi RNA binding protein 1 [KO:K14411]
100195286  msi2h; RNA-binding protein Musashi homolog 2 [KO:K14411]
106583321  RNA-binding protein Musashi homolog 1-like [KO:K14411]
106585492  RNA-binding protein Musashi homolog 1 [KO:K14411]
106578531  polyadenylate-binding protein 4-like [KO:K13126]
106610810  polyadenylate-binding protein 4-like [KO:K13126]
106566651  embryonic polyadenylate-binding protein-like [KO:K13126]
106570793  polyadenylate-binding protein 1-like [KO:K13126]
106593394  polyadenylate-binding protein 1 [KO:K13126]
106573364  polyadenylate-binding protein 1-A-like [KO:K13126]
106603260  eukaryotic peptide chain release factor subunit 1 [KO:K03265]
100194717  eukaryotic peptide chain release factor subunit 1 [KO:K03265]
106611818  eukaryotic peptide chain release factor subunit 1-like [KO:K03265]
106568098  eukaryotic peptide chain release factor subunit 1-like [KO:K03265]
106609499  eukaryotic peptide chain release factor GTP-binding subunit ERF3A-like [KO:K03267]
106601640  eukaryotic peptide chain release factor GTP-binding subunit ERF3A [KO:K03267]
106589547  gspt1; G1 to S phase transition 1 [KO:K03267]
100195130  erf3b; Eukaryotic peptide chain release factor GTP-binding subunit ERF3B [KO:K03267]
106568944  regulator of nonsense transcripts 1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
106573910  regulator of nonsense transcripts 1-like [KO:K14326] [EC:5.6.2.5 5.6.2.3]
106599024  regulator of nonsense transcripts 1-like [KO:K14326] [EC:5.6.2.5 5.6.2.3]
106613627  regulator of nonsense transcripts 1-like [KO:K14326] [EC:5.6.2.5 5.6.2.3]
106609128  regulator of nonsense transcripts 2-like [KO:K14327]
106576024  regulator of nonsense transcripts 2-like [KO:K14327]
106601970  smg1; SMG1, nonsense mediated mRNA decay associated PI3K related kinase [KO:K08873] [EC:2.7.11.1]
106599431  smg7; SMG7, nonsense mediated mRNA decay factor [KO:K14409]
106569064  protein SMG7-like [KO:K14409]
106581883  protein SMG5-like [KO:K11125]
106605282  protein SMG5-like [KO:K11125]
106603994  telomerase-binding protein EST1A-like [KO:K11124] [EC:3.1.-.-]
106563799  telomerase-binding protein EST1A-like [KO:K11124] [EC:3.1.-.-]
106603992  smg6; SMG6, nonsense mediated mRNA decay factor [KO:K11124] [EC:3.1.-.-]
106571349  PP2AB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
106603816  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like [KO:K04382] [EC:3.1.3.16]
106562890  PP2AB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
106567527  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like [KO:K04382] [EC:3.1.3.16]
106612245  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like [KO:K04382] [EC:3.1.3.16]
100380324  pp2aa; Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
106587035  PP2AB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform-like [KO:K04382] [EC:3.1.3.16]
106612458  2AAB; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
106607298  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform-like [KO:K04354]
106565222  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform-like [KO:K04354]
106604263  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform-like [KO:K04354]
106603879  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
106604865  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform [KO:K04354]
106611902  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform-like [KO:K04354]
106612152  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform-like [KO:K04354]
106567445  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
106577354  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform-like [KO:K04354]
106579878  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform-like [KO:K04354]
106563219  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform-like [KO:K04354]
106577025  ppp2r2d; protein phosphatase 2 regulatory subunit Bdelta [KO:K04354]
106585558  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
106590778  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform-like [KO:K04354]
106592990  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform-like [KO:K04354]
106600826  ppp2r3c; protein phosphatase 2 regulatory subunit B''gamma [KO:K11583]
106611177  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
106581654  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta-like [KO:K11583]
106574471  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha-like [KO:K11583]
106575383  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha-like [KO:K11583]
106611338  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform-like [KO:K11584]
106599033  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
106605890  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
106609029  ppp2r5b; protein phosphatase 2 regulatory subunit B'beta [KO:K11584]
106608134  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform-like [KO:K11584]
106607584  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform-like [KO:K11584]
106610635  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform [KO:K11584]
106571593  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform-like [KO:K11584]
106571204  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform-like [KO:K11584]
106578082  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform-like [KO:K11584]
106576729  ppp2r5d; protein phosphatase 2 regulatory subunit B'delta [KO:K11584]
100195340  2a5e; Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
100195249  hbs1l; HBS1-like (S. cerevisiae) [KO:K14416]
100195974  pelo; pelota homolog (Drosophila) [KO:K06965]
Reference
PMID:15040442
  Authors
Maquat LE
  Title
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.
  Journal
Nat Rev Mol Cell Biol 5:89-99 (2004)
DOI:10.1038/nrm1310
Reference
PMID:16723977
  Authors
Amrani N, Sachs MS, Jacobson A
  Title
Early nonsense: mRNA decay solves a translational problem.
  Journal
Nat Rev Mol Cell Biol 7:415-25 (2006)
DOI:10.1038/nrm1942
Reference
PMID:17183357
  Authors
Eulalio A, Behm-Ansmant I, Izaurralde E
  Title
P bodies: at the crossroads of post-transcriptional pathways.
  Journal
Nat Rev Mol Cell Biol 8:9-22 (2007)
DOI:10.1038/nrm2080
Reference
PMID:18158581
  Authors
Mandel CR, Bai Y, Tong L
  Title
Protein factors in pre-mRNA 3'-end processing.
  Journal
Cell Mol Life Sci 65:1099-122 (2008)
DOI:10.1007/s00018-007-7474-3
Reference
PMID:16715045
  Authors
Clement SL, Lykke-Andersen J
  Title
No mercy for messages that mess with the ribosome.
  Journal
Nat Struct Mol Biol 13:299-301 (2006)
DOI:10.1038/nsmb0406-299
Related
pathway
sasa03013  Nucleocytoplasmic transport
sasa03018  RNA degradation
sasa03040  Spliceosome
KO pathway
ko03015   
LinkDB

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