KEGG   PATHWAY: sclv03040
Entry
sclv03040                   Pathway                                
Name
Spliceosome - Styela clava (leathery sea squirt)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
sclv03040  Spliceosome
sclv03040

Other DBs
GO: 0005681
Organism
Styela clava (leathery sea squirt) [GN:sclv]
Gene
120340239  U1 spliceosomal RNA [KO:K14276]
120340240  U2 spliceosomal RNA [KO:K14277]
120327330  U4 spliceosomal RNA [KO:K14278]
120327331  U4 spliceosomal RNA [KO:K14278]
120327355  U4 spliceosomal RNA [KO:K14278]
120327367  U4 spliceosomal RNA [KO:K14278]
120327334  U4 spliceosomal RNA [KO:K14278]
120327336  U4 spliceosomal RNA [KO:K14278]
120327320  U4 spliceosomal RNA [KO:K14278]
120325553  U5 spliceosomal RNA [KO:K14279]
120338709  U5 spliceosomal RNA [KO:K14279]
120328687  probable ATP-dependent RNA helicase DDX46 [KO:K12811] [EC:5.6.2.7]
120344944  spliceosome RNA helicase DDX39B isoform X1 [KO:K12812] [EC:5.6.2.7]
120329296  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16-like [KO:K12813] [EC:5.6.2.6]
120328314  pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16-like [KO:K12815] [EC:5.6.2.6]
120342716  pre-mRNA-processing factor 17-like [KO:K12816]
120328071  pre-mRNA-splicing factor 18-like [KO:K12817]
120343017  ATP-dependent RNA helicase DHX8-like [KO:K12818] [EC:5.6.2.6]
120334910  pre-mRNA-splicing factor SLU7-like [KO:K12819]
120340650  putative pre-mRNA-splicing factor ATP-dependent RNA helicase PRP1 [KO:K12820] [EC:5.6.2.6]
120347087  small nuclear ribonucleoprotein-associated protein B'-like [KO:K11086]
120344320  small nuclear ribonucleoprotein Sm D1-like [KO:K11087]
120326190  small nuclear ribonucleoprotein Sm D2-like [KO:K11096]
120344483  small nuclear ribonucleoprotein Sm D3-like [KO:K11088]
120331009  small nuclear ribonucleoprotein Sm D3-like [KO:K11088]
120344478  small nuclear ribonucleoprotein F [KO:K11098]
120344550  small nuclear ribonucleoprotein F-like [KO:K11098]
120331443  small nuclear ribonucleoprotein F-like [KO:K11098]
120328439  U1 small nuclear ribonucleoprotein 70 kDa-like [KO:K11093]
120342623  U1 small nuclear ribonucleoprotein C-like [KO:K11095]
120331172  pre-mRNA-processing factor 40 homolog B-like [KO:K12821]
120330806  RNA-binding protein 25-like [KO:K12822]
120332512  DEAD-box ATP-dependent RNA helicase 20-like [KO:K12823] [EC:5.6.2.7]
120345481  glycine-rich cell wall structural protein 1.8-like isoform X1 [KO:K13098]
120344706  U2 small nuclear ribonucleoprotein A'-like [KO:K11092]
120336823  U1 small nuclear ribonucleoprotein A-like [KO:K11094]
120338343  splicing factor 3A subunit 1-like [KO:K12825]
120334778  splicing factor 3A subunit 2-like [KO:K12826]
120334875  splicing factor 3A subunit 2-like [KO:K12826]
120328166  splicing factor 3A subunit 3-like [KO:K12827]
120336517  splicing factor 3B subunit 1-like [KO:K12828]
120335388  splicing factor 3B subunit 2-like [KO:K12829]
120336537  splicing factor 3B subunit 2-like [KO:K12829]
120332409  splicing factor 3B subunit 3-like [KO:K12830]
120331012  LOW QUALITY PROTEIN: splicing factor 3B subunit 4-like [KO:K12831]
120332284  splicing factor 3B subunit 5-like [KO:K12832]
120340787  splicing factor 3B subunit 6-like [KO:K12833]
120325967  ATP-dependent RNA helicase DDX42-like isoform X1 [KO:K12835] [EC:5.6.2.7]
120326261  splicing factor U2AF 35 kDa subunit-like [KO:K12836]
120330126  splicing factor U2AF 50 kDa subunit-like isoform X1 [KO:K12837]
120346121  poly(U)-binding-splicing factor PUF60-like [KO:K12838]
120338703  poly(U)-binding-splicing factor PUF60-like [KO:K12838]
120332188  survival of motor neuron-related-splicing factor 30-like [KO:K12839]
120342262  splicing factor 45-like [KO:K12840]
120343115  calcium homeostasis endoplasmic reticulum protein-like [KO:K12841]
120339193  LOW QUALITY PROTEIN: U2 snRNP-associated SURP motif-containing protein-like [KO:K12842]
120327558  retinitis pigmentosa 9 protein homolog [KO:K19604]
120330132  U6 snRNA-associated Sm-like protein LSm3 [KO:K12622]
120332382  U6 snRNA-associated Sm-like protein LSm4 [KO:K12623]
120332719  U6 snRNA-associated Sm-like protein LSm4 [KO:K12623]
120329408  U6 snRNA-associated Sm-like protein LSm5 [KO:K12624]
120340894  U6 snRNA-associated Sm-like protein LSm8 [KO:K12627]
120333168  U4/U6 small nuclear ribonucleoprotein Prp3-like [KO:K12843]
120344396  U4/U6 small nuclear ribonucleoprotein Prp4-like [KO:K12662]
120330670  peptidyl-prolyl cis-trans isomerase H-like [KO:K09567] [EC:5.2.1.8]
120339810  peptidyl-prolyl cis-trans isomerase H-like [KO:K09567] [EC:5.2.1.8]
120341486  U4/U6 small nuclear ribonucleoprotein Prp31-like [KO:K12844]
120325762  NHP2-like protein 1 [KO:K12845]
120345527  U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein-like [KO:K12846]
120345460  U4/U6.U5 tri-snRNP-associated protein 2-like [KO:K12847]
120331441  U4/U6.U5 tri-snRNP-associated protein 1-like [KO:K11984]
120347727  pre-mRNA-splicing factor 38A-like [KO:K12849]
120344365  pre-mRNA-splicing factor 38B-like [KO:K12850]
120334167  pre-mRNA-splicing factor 38B-like [KO:K12850]
120332120  116 kDa U5 small nuclear ribonucleoprotein component-like [KO:K12852]
120340440  U5 small nuclear ribonucleoprotein 200 kDa helicase-like [KO:K12854] [EC:5.6.2.6]
120328146  pre-mRNA-processing factor 6-like [KO:K12855]
120337743  pre-mRNA-processing-splicing factor 8 [KO:K12856]
120348171  LOW QUALITY PROTEIN: U5 small nuclear ribonucleoprotein 40 kDa protein-like [KO:K12857]
120339607  probable ATP-dependent RNA helicase DDX23 [KO:K12858] [EC:5.6.2.7]
120336351  thioredoxin-like protein 4A [KO:K12859]
120343042  pre-mRNA-processing factor 19-like [KO:K10599] [EC:2.3.2.27]
120342473  cell division cycle 5-like protein [KO:K12860]
120340187  pre-mRNA-splicing factor SPF27-like [KO:K12861]
120341299  pleiotropic regulator 1-like [KO:K12862]
120327593  protein CWC15 homolog [KO:K12863]
120336886  beta-catenin-like protein 1 [KO:K12864]
120343240  heat shock 70 kDa protein II-like [KO:K03283]
120343250  heat shock cognate 71 kDa protein-like [KO:K03283]
120343254  heat shock 70 kDa protein homolog [KO:K03283]
120343255  major heat shock 70 kDa protein Bbb-like [KO:K03283]
120343262  heat shock cognate 71 kDa protein-like [KO:K03283]
120343266  heat shock 70 kDa protein II-like [KO:K03283]
120343430  heat shock 70 kDa protein 1-like isoform X1 [KO:K03283]
120343432  heat shock 70 kDa protein-like [KO:K03283]
120343433  heat shock 70 kDa protein II-like [KO:K03283]
120343458  heat shock cognate 71 kDa protein-like isoform X1 [KO:K03283]
120343471  heat shock 70 kDa protein 1-like isoform X1 [KO:K03283]
120343534  heat shock 70 kDa protein cognate 4-like [KO:K03283]
120343535  heat shock cognate 71 kDa protein-like [KO:K03283]
120343536  heat shock 70 kDa protein II-like [KO:K03283]
120343547  heat shock 70 kDa protein 1-like [KO:K03283]
120328696  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
120333404  heat shock 70 kDa protein-like [KO:K03283]
120333406  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
120333407  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
120341957  heat shock 70 kDa protein II-like [KO:K03283]
120341958  heat shock 70 kDa protein II-like [KO:K03283]
120341968  heat shock 70 kDa protein II-like [KO:K03283]
120341969  heat shock cognate 71 kDa protein-like [KO:K03283]
120341970  heat shock 70 kDa protein II-like [KO:K03283]
120341971  heat shock cognate 71 kDa protein-like [KO:K03283]
120341972  heat shock 70 kDa protein II-like [KO:K03283]
120342073  heat shock 70 kDa protein II-like [KO:K03283]
120342225  heat shock 70 kDa protein II-like [KO:K03283]
120342233  heat shock 70 kDa protein II-like isoform X1 [KO:K03283]
120342234  heat shock 70 kDa protein-like [KO:K03283]
120342333  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
120342390  heat shock cognate 71 kDa protein-like [KO:K03283]
120342403  heat shock cognate 71 kDa protein [KO:K03283]
120342404  heat shock 70 kDa protein 1B-like [KO:K03283]
120342414  heat shock 70 kDa protein cognate 4-like [KO:K03283]
120334019  heat shock 70 kDa protein 1-like [KO:K03283]
120334030  heat shock 70 kDa protein II-like [KO:K03283]
120342918  heat shock 70 kDa protein II-like [KO:K03283]
120342969  heat shock 70 kDa protein II-like [KO:K03283]
120343013  heat shock 70 kDa protein 1A-like [KO:K03283]
120343030  heat shock 70 kDa protein-like [KO:K03283]
120343032  heat shock 70 kDa protein-like [KO:K03283]
120343056  uncharacterized protein LOC120343056 [KO:K03283]
120343059  putative heat shock 70 kDa protein 7 [KO:K03283]
120343064  heat shock 70 kDa protein-like [KO:K03283]
120343068  heat shock 70 kDa protein II-like [KO:K03283]
120343069  heat shock cognate 71 kDa protein-like [KO:K03283]
120343089  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
120343091  chromosome partition protein Smc-like [KO:K03283]
120343098  heat shock 70 kDa protein II-like [KO:K03283]
120343099  heat shock 70 kDa protein 4L-like [KO:K03283]
120343104  heat shock 70 kDa protein 1-like [KO:K03283]
120343109  uncharacterized protein LOC120343109 [KO:K03283]
120343132  heat shock 70 kDa protein II-like [KO:K03283]
120347747  polyglutamine-binding protein 1-like [KO:K12865]
120328357  WW domain-binding protein 11-like [KO:K12866]
120348308  SNW domain-containing protein 1-like [KO:K06063]
120328520  LOW QUALITY PROTEIN: pre-mRNA-splicing factor SYF1-like [KO:K12867]
120330811  pre-mRNA-splicing factor SYF1-like [KO:K12867]
120331760  pre-mRNA-splicing factor syf2-like [KO:K12868]
120331699  LOW QUALITY PROTEIN: crooked neck-like protein 1 [KO:K12869]
120331396  pre-mRNA-splicing factor ISY1 homolog [KO:K12870]
120338802  peptidyl-prolyl cis-trans isomerase-like 1 [KO:K12733] [EC:5.2.1.8]
120345877  peptidyl-prolyl cis-trans isomerase-like [KO:K09564] [EC:5.2.1.8]
120346578  peptidyl-prolyl cis-trans isomerase-like [KO:K09564] [EC:5.2.1.8]
120342173  peptidyl-prolyl cis-trans isomerase-like [KO:K09564] [EC:5.2.1.8]
120345461  coiled-coil domain-containing protein 12-like [KO:K12871]
120347411  pre-mRNA-splicing factor RBM22-like [KO:K12872]
120337912  protein BUD31 homolog [KO:K12873]
120328956  RNA helicase aquarius-like [KO:K12874]
120335474  apoptotic chromatin condensation inducer in the nucleus-like isoform X1 [KO:K12875]
120347700  eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
120336858  RNA-binding protein 8A-like [KO:K12876]
120338457  protein mago nashi homolog [KO:K12877]
120342842  THO complex subunit 1-like isoform X1 [KO:K12878]
120340659  THO complex subunit 2-like [KO:K12879]
120342826  THO complex subunit 3-like [KO:K12880]
120325985  THO complex subunit 4-like [KO:K12881]
120329545  nuclear cap-binding protein subunit 1-like [KO:K12882]
120342928  nuclear cap-binding protein subunit 2-like [KO:K12883]
120342717  heterogeneous nuclear ribonucleoproteins A1 homolog isoform X1 [KO:K12741]
120342922  heterogeneous nuclear ribonucleoprotein A3 homolog 1-like isoform X1 [KO:K12741]
120333764  serine/arginine repetitive matrix protein 1-like [KO:K12885]
120347300  heterogeneous nuclear ribonucleoprotein K-like [KO:K12886]
120342592  heterogeneous nuclear ribonucleoprotein K-like isoform X1 [KO:K12886]
120346147  serine/arginine-rich splicing factor 1B-like [KO:K12890]
120337280  serine/arginine-rich splicing factor 2-like isoform X1 [KO:K12891]
120346829  serine/arginine-rich splicing factor 5-like [KO:K12893]
120330893  serine/arginine-rich splicing factor 3-like [KO:K12896]
120333840  serine/arginine-rich splicing factor 3-like [KO:K12896]
120343028  serine/arginine-rich splicing factor 7-like [KO:K12896]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   
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