KEGG   PATHWAY: stow04510
Entry
stow04510                   Pathway                                
Name
Focal adhesion - Sphaerodactylus townsendi (Townsend's least gecko)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
stow04510  Focal adhesion
stow04510

Other DBs
GO: 0005925
Organism
Sphaerodactylus townsendi (Townsend's least gecko) [GN:stow]
Gene
125440960  COL1A2; collagen alpha-2(I) chain [KO:K06236]
125444006  COL1A1; collagen alpha-1(I) chain [KO:K06236]
125428289  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
125435038  COL4A2; LOW QUALITY PROTEIN: collagen alpha-2(IV) chain [KO:K06237]
125435045  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
125442929  COL4A6; LOW QUALITY PROTEIN: collagen alpha-6(IV) chain [KO:K06237]
125438334  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
125438371  collagen alpha-3(IV) chain-like [KO:K06237]
125434906  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
125434912  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
125440610  collagen alpha-6(VI) chain-like [KO:K06238]
125440828  collagen alpha-6(VI) chain-like [KO:K06238]
125435412  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
125432595  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
125433412  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
125429621  LAMA2; laminin subunit alpha-2 [KO:K05637]
125439359  LAMA1; laminin subunit alpha-1 [KO:K05637]
125433409  LAMA5; LOW QUALITY PROTEIN: laminin subunit alpha-5 [KO:K06240]
125439433  LAMA3; laminin subunit alpha-3 [KO:K06240]
125430550  LAMA4; laminin subunit alpha-4 [KO:K06241]
125434542  LAMB1; laminin subunit beta-1 [KO:K05636]
125429270  laminin subunit beta-1-like isoform X1 [KO:K06243]
125427756  LAMB2; laminin subunit beta-2 [KO:K06243]
125433092  LAMB3; laminin subunit beta-3 [KO:K06244]
125435712  LAMB4; laminin subunit beta-4 isoform X1 [KO:K06245]
125425025  LAMC1; laminin subunit gamma-1 [KO:K05635]
125425026  LAMC2; laminin subunit gamma-2 [KO:K06246]
125441580  LAMC3; laminin subunit gamma-3 [KO:K06247]
125429320  CHAD; chondroadherin [KO:K06248]
125434479  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
125426101  THBS1; thrombospondin-1 [KO:K16857]
125436612  THBS4; thrombospondin-4 [KO:K04659]
125425364  THBS3; LOW QUALITY PROTEIN: thrombospondin-3 [KO:K04659]
125432826  cartilage oligomeric matrix protein [KO:K04659]
125427520  THBS2; thrombospondin-2 [KO:K04659]
125425836  FN1; fibronectin [KO:K05717]
125440303  SPP1; osteopontin [KO:K06250]
125445444  VTN; vitronectin [KO:K06251]
125428522  TNXB; tenascin-X [KO:K06252]
125441717  TNC; tenascin isoform X1 [KO:K06252]
125433321  TNN; tenascin-N [KO:K06252]
125433465  TNR; tenascin-R isoform X1 [KO:K06252]
125443325  VWF; von Willebrand factor [KO:K03900]
125440419  bone sialoprotein 2 [KO:K06253]
125436559  ITGA1; integrin alpha-1 [KO:K06480]
125436042  ITGA2; integrin alpha-2 [KO:K06481]
125443986  ITGA2B; integrin alpha-IIb [KO:K06476]
125444920  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
125426006  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
125425972  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
125428032  ITGA7; integrin alpha-7 [KO:K06583]
125441062  ITGA8; integrin alpha-8 [KO:K06584]
125441198  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
125424422  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
125424675  ITGA11; integrin alpha-11 [KO:K06587]
125426725  ITGAV; integrin alpha-V [KO:K06487]
125440489  ITGB1; integrin beta-1 [KO:K05719]
125445133  ITGB3; LOW QUALITY PROTEIN: integrin beta-3 [KO:K06493]
125429564  ITGB4; integrin beta-4 [KO:K06525]
125425945  ITGB5; integrin beta-5 [KO:K06588]
125427213  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
125429605  ITGB7; integrin beta-7 [KO:K06590]
125440812  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
125431549  EMP2; epithelial membrane protein 2 [KO:K26256]
125431785  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
125435734  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
125440228  PDGFC; platelet-derived growth factor C [KO:K05450]
125431530  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
125439707  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
125435887  IGF1; insulin-like growth factor I [KO:K05459]
125441576  VEGFB; vascular endothelial growth factor B [KO:K05448]
125425795  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
125425808  PGF; placenta growth factor [KO:K16859]
125440139  VEGFC; vascular endothelial growth factor C [KO:K05449]
125430889  VEGFD; vascular endothelial growth factor D [KO:K05449]
125435141  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
125440368  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
125429083  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
125424423  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
125440164  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
125440695  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
125442741  vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
125431642  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
125429724  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
125434856  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
125444708  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
125435680  EMP1; epithelial membrane protein 1 [KO:K26255]
125432635  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
125434711  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
125426466  ARHGAP5; rho GTPase-activating protein 5 [KO:K13709]
125429059  RHOA; transforming protein RhoA [KO:K04513]
125429442  transforming protein RhoA-like [KO:K04513]
125443796  DIAPH1; protein diaphanous homolog 1 [KO:K05740]
125438730  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
125433814  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
125436573  MYL5; myosin light chain 5 [KO:K12753]
125441896  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
125433639  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
125445758  MYL10; myosin regulatory light chain 10 isoform X1 [KO:K12756]
125438809  myosin regulatory light chain 2, smooth muscle minor isoform isoform X1 [KO:K12757]
125444872  MYL11; myosin regulatory light chain 2, skeletal muscle isoform isoform X1 [KO:K12758]
125441803  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
125442686  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
125425980  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
125434445  PPP1R12A; LOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 12A [KO:K06270]
125432776  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
125444583  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
125443835  MYLK3; LOW QUALITY PROTEIN: myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
125427209  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
125438688  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
125433536  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
125440768  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
125436783  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
125438210  LOW QUALITY PROTEIN: phosphatidylinositol 4-phosphate 5-kinase type-1 gamma-like [KO:K00889] [EC:2.7.1.68]
125429156  ACTG1; actin, cytoplasmic 2 [KO:K05692]
125424584  actin, clone 302-like [KO:K05692]
125431726  ACTB; actin, cytoplasmic 1 [KO:K05692]
125437841  actin, clone 302-like [KO:K05692]
125437843  actin, clone 302-like [KO:K05692]
125432758  actin-like [KO:K05692]
125424689  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
125436868  calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
125426045  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
125446157  TLN2; LOW QUALITY PROTEIN: talin-2 [KO:K06271]
125436515  TLN1; talin-1 [KO:K06271]
125428004  LOW QUALITY PROTEIN: filamin-A-like [KO:K04437]
125428244  FLNB; filamin-B isoform X1 [KO:K27392]
125444312  TGFB1I1; transforming growth factor beta-1-induced transcript 1 protein [KO:K05760]
125431774  ILK; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
125437115  ZYX; zyxin isoform X1 [KO:K06273]
125434237  vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
125436229  VCL; vinculin isoform X1 [KO:K05700]
125426012  PARVA; alpha-parvin [KO:K06275]
125431736  PDPK1; LOW QUALITY PROTEIN: 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
125426629  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
125426854  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
125436058  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
125441293  CTNNB1; catenin beta-1 [KO:K02105]
125433134  catenin beta-1-like isoform X1 [KO:K02105]
125427662  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
125432066  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
125444571  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
125445925  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
125437957  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
125438330  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
125444496  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
125436164  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
125432754  phosphatidylinositol 3-kinase regulatory subunit beta-like [KO:K02649]
125433242  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
125437559  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
125441577  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
125432956  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
125427954  VAV1; proto-oncogene vav [KO:K05730]
125430903  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
125435678  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
125430253  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
125437706  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
125442923  PAK3; LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
125434229  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
125435070  PAK5; serine/threonine-protein kinase PAK 5 isoform X1 [KO:K05736] [EC:2.7.11.1]
125427346  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
125445651  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
125443644  BCAR1; breast cancer anti-estrogen resistance protein 1 [KO:K05726]
125445863  CRK; adapter molecule crk isoform X1 [KO:K04438]
125442799  CRKL; crk-like protein isoform X1 [KO:K04438]
125444678  crk-like protein [KO:K04438]
125437648  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
125441665  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
125433058  RAP1A; ras-related protein Rap-1A [KO:K04353]
125434778  RAP1B; ras-related protein Rap-1b [KO:K07836]
125440222  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
125437878  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
125427657  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
125433193  JUN; transcription factor Jun [KO:K04448]
125434335  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
125434888  CAV1; caveolin-1 isoform X1 [KO:K06278]
125428090  caveolin-2-like [KO:K12958]
125435641  CAV2; caveolin-2 [KO:K12958]
125429415  caveolin-3-like [KO:K12959]
125430582  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
125440647  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
125433261  SHC2; SHC-transforming protein 2 [KO:K17447]
125436789  SHC3; SHC-transforming protein 3 isoform X1 [KO:K17448]
125429172  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
125424526  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
125427095  SOS2; son of sevenless homolog 2 [KO:K03099]
125426937  HRAS; GTPase HRas [KO:K02833]
125429531  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
125444669  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
125427982  ELK1; LOW QUALITY PROTEIN: ETS domain-containing protein Elk-1 [KO:K04375]
125426154  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
125443877  CCND2; G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
125433053  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
125430428  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
125442974  E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
125441612  BAD; bcl2-associated agonist of cell death [KO:K02158]
125439074  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
stow04010  MAPK signaling pathway
stow04060  Cytokine-cytokine receptor interaction
stow04070  Phosphatidylinositol signaling system
stow04110  Cell cycle
stow04310  Wnt signaling pathway
stow04512  ECM-receptor interaction
stow04810  Regulation of actin cytoskeleton
KO pathway
ko04510   
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