Entry
Name
Salmonella infection - Sphaerodactylus townsendi (Townsend's least gecko)
Description
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, Salmonella enterica, which has numerous serovars.
Following intestinal colonization Salmonella inject effector proteins into the host cells using a type III secretion system (T3SS), T3SS1. Then a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membrane ruffles and rapid internalization of the bacteria.The T3SS2 is responsible for translocating effector proteins that direct Salmonella-containing vacuole (SCV) maturation. The majority of the bacteria are known to survive and replicate in SCV.
Class
Human Diseases; Infectious disease: bacterial
BRITE hierarchy
Pathway map
Ortholog table
Organism
Sphaerodactylus townsendi (Townsend's least gecko) [GN:
stow ]
Gene
125441635 VPS11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179 ]
125440379 VPS16; LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 16 homolog [KO:K20180 ]
125427165 VPS18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181 ]
125442786 VPS33A; vacuolar protein sorting-associated protein 33A [KO:K20182 ]
125441109 VPS41; vacuolar protein sorting-associated protein 41 homolog [KO:K20184 ]
125426380 DYNC1H1; LOW QUALITY PROTEIN: cytoplasmic dynein 1 heavy chain 1 [KO:K10413 ]
125431110 DYNC2H1; LOW QUALITY PROTEIN: cytoplasmic dynein 2 heavy chain 1 [KO:K10414 ]
125440853 DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415 ]
125426177 DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415 ]
125440806 DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416 ]
125443508 DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416 ]
125425400 DYNC2LI1; cytoplasmic dynein 2 light intermediate chain 1 [KO:K10417 ]
125440950 FYCO1; FYVE and coiled-coil domain-containing protein 1 [KO:K21954 ]
125425780 RUFY4; RUN and FYVE domain-containing protein 4 isoform X1 [KO:K21954 ]
125429154 ARL8B; ADP-ribosylation factor-like protein 8B isoform X1 [KO:K07955 ]
125445696 PLEKHM2; pleckstrin homology domain-containing family M member 2 isoform X1 [KO:K15348 ]
125431063 GCC2; GRIP and coiled-coil domain-containing protein 2 isoform X1 [KO:K20282 ]
125441894 AHNAK; LOW QUALITY PROTEIN: neuroblast differentiation-associated protein AHNAK [KO:K23934 ]
125440683 ELMO1; engulfment and cell motility protein 1 isoform X1 [KO:K12366 ]
125433546 ELMO2; engulfment and cell motility protein 2 isoform X1 [KO:K18985 ]
125441896 MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754 ]
125438809 myosin regulatory light chain 2, smooth muscle minor isoform isoform X1 [KO:K12757 ]
125444872 MYL11; myosin regulatory light chain 2, skeletal muscle isoform isoform X1 [KO:K12758 ]
125443666 FHOD1; FH1/FH2 domain-containing protein 1 isoform X1 [KO:K23938 ]
125445651 CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393 ]
125442525 wiskott-Aldrich syndrome protein family member 3-like isoform X1 [KO:K06083 ]
125431114 WASF3; wiskott-Aldrich syndrome protein family member 3 isoform X1 [KO:K06083 ]
125441908 ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754 ]
125445925 PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
125437957 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
125438330 PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
125444496 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
125434578 PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289 ] [EC:2.7.1.153 ]
125425984 PIK3C2A; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha [KO:K00923 ] [EC:2.7.1.154 ]
125432703 PIK3C2B; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta [KO:K00923 ] [EC:2.7.1.154 ]
125434676 WASL; neural Wiskott-Aldrich syndrome protein isoform X1 [KO:K23612 ]
125441715 toll/interleukin-1 receptor domain-containing adapter protein [KO:K05403 ]
125425446 MYD88; LOW QUALITY PROTEIN: myeloid differentiation primary response protein MyD88 [KO:K04729 ]
125435645 TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403 ]
125428599 TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404 ]
125431633 TAB3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1 [KO:K12793 ]
125441266 NOD1; nucleotide-binding oligomerization domain-containing protein 1 [KO:K08727 ]
125428363 MAP2K4; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430 ] [EC:2.7.12.2 ]
125437205 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
125443906 TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171 ]
125438099 TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721 ]
125441986 tumor necrosis factor receptor superfamily member 10B-like [KO:K04722 ]
125444315 PYCARD; apoptosis-associated speck-like protein containing a CARD [KO:K12799 ]
Compound
C01194 1-Phosphatidyl-D-myo-inositol
C04549 1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
C11554 1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
Authors
Bernal-Bayard J, Ramos-Morales F
Title
Molecular Mechanisms Used by Salmonella to Evade the Immune System.
Journal
Reference
Authors
Hume PJ, Singh V, Davidson AC, Koronakis V
Title
Swiss Army Pathogen: The Salmonella Entry Toolkit.
Journal
Reference
Authors
Wemyss MA, Pearson JS
Title
Host Cell Death Responses to Non-typhoidal Salmonella Infection.
Journal
Reference
Authors
Bierschenk D, Boucher D, Schroder K
Title
Salmonella-induced inflammasome activation in humans.
Journal
Reference
Authors
Pinaud L, Sansonetti PJ, Phalipon A
Title
Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
Journal
Reference
Authors
LaRock DL, Chaudhary A, Miller SI
Title
Salmonellae interactions with host processes.
Journal
Reference
Authors
Ramsden AE, Holden DW, Mota LJ
Title
Membrane dynamics and spatial distribution of Salmonella-containing vacuoles.
Journal
Reference
Authors
van der Heijden J, Finlay BB
Title
Type III effector-mediated processes in Salmonella infection.
Journal
Reference
Authors
Galan JE
Title
Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi.
Journal
Reference
Authors
McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
Title
Salmonella takes control: effector-driven manipulation of the host.
Journal
Reference
Authors
Miao EA, Brittnacher M, Haraga A, Jeng RL, Welch MD, Miller SI
Title
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.
Journal
Reference
Authors
Patel JC, Galan JE
Title
Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
Journal
Reference
Authors
Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH
Title
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
Journal
Reference
Authors
Fu Y, Galan JE
Title
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.
Journal
Related pathway
stow04621 NOD-like receptor signaling pathway
KO pathway
LinkDB
All DBs