KEGG   PATHWAY: vvp04015
Entry
vvp04015                    Pathway                                
Name
Rap1 signaling pathway - Vulpes vulpes (red fox)
Description
Rap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an active GTP-bound conformation. A variety of extracellular signals control this cycle through the regulation of several unique guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). Rap1 plays a dominant role in the control of cell-cell and cell-matrix interactions by regulating the function of integrins and other adhesion molecules in various cell types. Rap1 also regulates MAP kinase (MAPK) activity in a manner highly dependent on the context of cell types.
Class
Environmental Information Processing; Signal transduction
Pathway map
vvp04015  Rap1 signaling pathway
vvp04015

Other DBs
GO: 0007264
Organism
Vulpes vulpes (red fox) [GN:vvp]
Gene
112907935  RAP1A; ras-related protein Rap-1A [KO:K04353]
112922290  RAP1B; ras-related protein Rap-1b [KO:K07836]
112935006  MRAS; ras-related protein M-Ras [KO:K07831]
112915725  RAPGEF5; rap guanine nucleotide exchange factor 5 [KO:K08019]
112929906  DOCK4; dedicator of cytokinesis protein 4 [KO:K17697]
112911422  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
112923309  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
112917264  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
112927180  calmodulin-alpha-like [KO:K02183]
112926172  CALML6; calmodulin-like protein 6 isoform X1 [KO:K02183]
112915227  CALM2; calmodulin-2 [KO:K02183]
112930936  CALML4; calmodulin-like protein 4 [KO:K02183]
112931188  CALM3; calmodulin-3 [KO:K02183]
112907343  CALM1; calmodulin-1 [KO:K02183]
112907557  CALML5; calmodulin-like protein 5 [KO:K02183]
112933710  CALML3; calmodulin-like protein 3 [KO:K02183]
112919743  F2R; proteinase-activated receptor 1 [KO:K03914]
112913182  F2RL3; proteinase-activated receptor 4 [KO:K04236]
112932768  P2RY1; P2Y purinoceptor 1 [KO:K04270]
112923052  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
112912747  LPAR2; lysophosphatidic acid receptor 2 isoform X1 [KO:K04291]
112924485  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
112909196  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
112917350  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
112907458  ADORA2A; adenosine receptor A2a [KO:K04266]
112924933  ADORA2B; adenosine receptor A2b [KO:K04267]
112932168  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
112932169  neuroendocrine secretory protein 55 [KO:K04632]
112911455  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
112934273  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
112908545  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
112926558  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
112913504  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
112921089  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
112929565  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
112915982  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
112923266  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
112921075  RAPGEF3; rap guanine nucleotide exchange factor 3 isoform X1 [KO:K08014]
112916400  RAPGEF4; rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351]
112922087  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
112924037  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
112930053  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
112930054  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
112919942  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
112933007  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
112924301  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
112934223  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
112934748  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
112933647  FGF2; fibroblast growth factor 2 [KO:K18497]
112926828  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
112928529  FGF18; fibroblast growth factor 18 [KO:K04358]
112919573  FGF5; fibroblast growth factor 5 [KO:K04358]
112913369  FGF8; fibroblast growth factor 8 [KO:K04358]
112909183  FGF16; fibroblast growth factor 16 [KO:K04358]
112924012  FGF3; fibroblast growth factor 3 [KO:K04358]
112924013  FGF4; fibroblast growth factor 4 [KO:K04358]
112917377  FGF6; fibroblast growth factor 6 [KO:K04358]
112918609  FGF9; fibroblast growth factor 9 [KO:K04358]
112920051  FGF7; fibroblast growth factor 7 [KO:K04358]
112908925  FGF20; fibroblast growth factor 20 [KO:K04358]
112933766  FGF10; fibroblast growth factor 10 [KO:K04358]
112924014  FGF19; fibroblast growth factor 19 [KO:K22603]
112931222  FGF21; fibroblast growth factor 21 [KO:K22429]
112917521  FGF23; fibroblast growth factor 23 [KO:K22428]
112916832  NGF; beta-nerve growth factor [KO:K02582]
112924140  INS; insulin [KO:K04526]
112930717  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
112929281  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
112933988  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
112912529  platelet-derived growth factor C [KO:K05450]
112925942  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
112918277  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
112914895  KITLG; kit ligand isoform X1 [KO:K05461]
112914029  VEGFA; vascular endothelial growth factor A [KO:K05448]
112924316  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
112927283  PGF; placenta growth factor isoform X1 [KO:K16859]
112910539  VEGFD; vascular endothelial growth factor D [KO:K05449]
112932844  VEGFC; vascular endothelial growth factor C [KO:K05449]
112925397  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
112917013  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
112934484  ANGPT2; angiopoietin-2 [KO:K05466]
112909898  ANGPT4; angiopoietin-4 [KO:K05467]
112918907  EFNA4; ephrin-A4 [KO:K05462]
112918908  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
112918909  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
112915451  EFNA5; ephrin-A5 [KO:K05462]
112935519  EFNA2; ephrin-A2 [KO:K05462]
112925820  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
112916136  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
112916723  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
112922612  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
112925658  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
112918130  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
112909702  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
112922150  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
112933353  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
112927357  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
112927384  CSF1R; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
112912596  mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
112933391  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
112918641  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
112911875  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
112923722  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
112929871  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
112927571  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
112929784  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
112907448  CRKL; crk-like protein [KO:K04438]
112933059  CRK; adapter molecule crk isoform X1 [KO:K04438]
112927996  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
112915672  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
112929524  CDH1; cadherin-1 [KO:K05689]
112924654  cadherin-1-like [KO:K05689]
112921625  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
112909211  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
112925358  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 [KO:K05629]
112907962  MAGI3; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 isoform X1 [KO:K06112]
112926924  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
112917094  RAPGEF6; rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
112929337  LAT; linker for activation of T-cells family member 1 [KO:K07362]
112933536  FYB1; FYN-binding protein 1 [KO:K17698]
112926290  LCP2; lymphocyte cytosolic protein 2 [KO:K07361]
112917830  SKAP1; src kinase-associated phosphoprotein 1 [KO:K17699]
112928123  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
112920728  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
112908300  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
112909321  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
112926578  PRKD1; serine/threonine-protein kinase D1 isoform X1 [KO:K06070] [EC:2.7.11.13]
112931278  PRKD2; serine/threonine-protein kinase D2 [KO:K06070] [EC:2.7.11.13]
112935304  PRKD3; serine/threonine-protein kinase D3 [KO:K06070] [EC:2.7.11.13]
112925994  DRD2; D(2) dopamine receptor isoform X1 [KO:K04145]
112908382  CNR1; cannabinoid receptor 1 [KO:K04277]
112911158  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
112918267  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
112925393  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X1 [KO:K04630]
112929627  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha [KO:K04534]
112929841  RAP1GAP; rap1 GTPase-activating protein 1 isoform X1 [KO:K17700]
112927236  SIPA1L1; signal-induced proliferation-associated 1-like protein 1 isoform X1 [KO:K17701]
112924255  SIPA1; signal-induced proliferation-associated protein 1 [KO:K08013]
112927345  SIPA1L2; signal-induced proliferation-associated 1-like protein 2 isoform X1 [KO:K17702]
112928310  SIPA1L3; signal-induced proliferation-associated 1-like protein 3 [KO:K17703]
112909905  ID1; DNA-binding protein inhibitor ID-1 [KO:K04680]
112919933  THBS1; thrombospondin-1 [KO:K16857]
112928009  RALGDS; ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732]
112925806  RALA; ras-related protein Ral-A [KO:K07834]
112934326  RALB; ras-related protein Ral-B [KO:K07835]
112910012  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
112929159  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
112920582  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
112931157  APBB1IP; amyloid beta A4 precursor protein-binding family B member 1-interacting protein [KO:K17704]
112930840  TLN1; talin-1 isoform X1 [KO:K06271]
112922522  TLN2; talin-2 isoform X1 [KO:K06271]
112910659  ITGA2B; integrin alpha-IIb [KO:K06476]
112920636  ITGB3; integrin beta-3 [KO:K06493]
112912478  profilin-1-like [KO:K05759]
112908509  PFN4; profilin-4 [KO:K05759]
112924789  PFN1; LOW QUALITY PROTEIN: profilin-1 [KO:K05759]
112924987  profilin-1-like [KO:K05759]
112925529  PFN3; profilin-3 [KO:K05759]
112932759  PFN2; profilin-2 isoform X1 [KO:K05759]
112931355  VASP; vasodilator-stimulated phosphoprotein [KO:K06274]
112923566  ENAH; LOW QUALITY PROTEIN: protein enabled homolog [KO:K05746]
112930234  EVL; ena/VASP-like protein isoform X1 [KO:K23487]
112920888  ACTG1; LOW QUALITY PROTEIN: actin, cytoplasmic 2 [KO:K05692]
112929326  ACTB; LOW QUALITY PROTEIN: actin, cytoplasmic 1 [KO:K05692]
112934640  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 [KO:K12490]
112911519  RHOA; transforming protein RhoA [KO:K04513]
112928171  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
112911273  FARP2; FERM, ARHGEF and pleckstrin domain-containing protein 2 [KO:K06082]
112929847  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
112911843  VAV1; proto-oncogene vav [KO:K05730]
112906971  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
112918233  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
112909492  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
112921564  PARD3; partitioning defective 3 homolog [KO:K04237]
112919260  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
112929426  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
112931916  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
112926173  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
112926694  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
112932947  AFDN; afadin isoform X1 [KO:K05702]
112930473  CTNND1; catenin delta-1 isoform X1 [KO:K05690]
112923880  KRIT1; krev interaction trapped protein 1 isoform X1 [KO:K17705]
112925539  RGS14; regulator of G-protein signaling 14 isoform X1 [KO:K17706]
112914363  RASSF5; ras association domain-containing protein 5 [KO:K08015]
112929237  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
112929270  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
112909536  ITGB2; integrin beta-2 isoform X1 [KO:K06464]
112921568  ITGB1; integrin beta-1 [KO:K05719]
112907060  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
112933694  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
112935545  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
112929340  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
112907501  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
112924977  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
112920749  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
112913931  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
112913932  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
112935862  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
112935863  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
112924665  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
112926217  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
112934961  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
112914774  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
112913170  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
112935820  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
112928376  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112930303  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
112923528  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
112913979  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
112914428  HRAS; GTPase HRas isoform X1 [KO:K02833]
112917213  KRAS; GTPase KRas isoform X1 [KO:K07827]
112916766  NRAS; GTPase NRas [KO:K07828]
112931379  RRAS; ras-related protein R-Ras [KO:K07829]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:11331911
  Authors
Bos JL, de Rooij J, Reedquist KA
  Title
Rap1 signalling: adhering to new models.
  Journal
Nat Rev Mol Cell Biol 2:369-77 (2001)
DOI:10.1038/35073073
Reference
PMID:17383543
  Authors
Minato N, Kometani K, Hattori M
  Title
Regulation of immune responses and hematopoiesis by the Rap1 signal.
  Journal
Adv Immunol 93:229-64 (2007)
DOI:10.1016/S0065-2776(06)93006-5
Reference
PMID:15780587
  Authors
Bos JL
  Title
Linking Rap to cell adhesion.
  Journal
Curr Opin Cell Biol 17:123-8 (2005)
DOI:10.1016/j.ceb.2005.02.009
Reference
PMID:12508104
  Authors
Caron E
  Title
Cellular functions of the Rap1 GTP-binding protein: a pattern emerges.
  Journal
J Cell Sci 116:435-40 (2003)
DOI:10.1242/jcs.00238
Reference
PMID:10579920
  Authors
Zwartkruis FJ, Bos JL
  Title
Ras and Rap1: two highly related small GTPases with distinct function.
  Journal
Exp Cell Res 253:157-65 (1999)
DOI:10.1006/excr.1999.4695
Reference
PMID:14607972
  Authors
Hattori M, Minato N
  Title
Rap1 GTPase: functions, regulation, and malignancy.
  Journal
J Biochem 134:479-84 (2003)
DOI:10.1093/jb/mvg180
Reference
PMID:19159611
  Authors
Pannekoek WJ, Kooistra MR, Zwartkruis FJ, Bos JL
  Title
Cell-cell junction formation: the role of Rap1 and Rap1 guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1788:790-6 (2009)
DOI:10.1016/j.bbamem.2008.12.010
Reference
PMID:19615876
  Authors
Boettner B, Van Aelst L
  Title
Control of cell adhesion dynamics by Rap1 signaling.
  Journal
Curr Opin Cell Biol 21:684-93 (2009)
DOI:10.1016/j.ceb.2009.06.004
Reference
PMID:15803158
  Authors
Xia Z, Storm DR.
  Title
The role of calmodulin as a signal integrator for synaptic plasticity.
  Journal
Nat Rev Neurosci 6:267-76 (2005)
DOI:10.1038/nrn1647
Reference
PMID:17624948
  Authors
Mor A, Dustin ML, Philips MR
  Title
Small GTPases and LFA-1 reciprocally modulate adhesion and signaling.
  Journal
Immunol Rev 218:114-25 (2007)
DOI:10.1111/j.1600-065X.2007.00538.x
Reference
PMID:17624944
  Authors
Burbach BJ, Medeiros RB, Mueller KL, Shimizu Y
  Title
T-cell receptor signaling to integrins.
  Journal
Immunol Rev 218:65-81 (2007)
DOI:10.1111/j.1600-065X.2007.00527.x
Reference
PMID:12765839
  Authors
Stork PJ
  Title
Does Rap1 deserve a bad Rap?
  Journal
Trends Biochem Sci 28:267-75 (2003)
DOI:10.1016/S0968-0004(03)00087-2
Reference
PMID:12351703
  Authors
Banihashemi B, Albert PR
  Title
Dopamine-D2S receptor inhibition of calcium influx, adenylyl cyclase, and mitogen-activated protein kinase in pituitary cells: distinct Galpha and Gbetagamma requirements.
  Journal
Mol Endocrinol 16:2393-404 (2002)
DOI:10.1210/me.2001-0220
Reference
PMID:18363565
  Authors
Banno A, Ginsberg MH
  Title
Integrin activation.
  Journal
Biochem Soc Trans 36:229-34 (2008)
DOI:10.1042/BST0360229
Reference
PMID:19710505
  Authors
Doebele RC, Schulze-Hoepfner FT, Hong J, Chlenski A, Zeitlin BD, Goel K, Gomes S, Liu Y, Abe MK, Nor JE, Lingen MW, Rosner MR
  Title
A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis.
  Journal
Blood 114:4592-600 (2009)
DOI:10.1182/blood-2009-04-217042
Reference
PMID:21402149
  Authors
Breckler M, Berthouze M, Laurent AC, Crozatier B, Morel E, Lezoualc'h F
  Title
Rap-linked cAMP signaling Epac proteins: compartmentation, functioning and disease implications.
  Journal
Cell Signal 23:1257-66 (2011)
DOI:10.1016/j.cellsig.2011.03.007
Related
pathway
vvp04010  MAPK signaling pathway
vvp04014  Ras signaling pathway
vvp04020  Calcium signaling pathway
vvp04151  PI3K-Akt signaling pathway
vvp04510  Focal adhesion
vvp04520  Adherens junction
vvp04660  T cell receptor signaling pathway
vvp04810  Regulation of actin cytoskeleton
KO pathway
ko04015   
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