KEGG   PATHWAY: pmur04510
Entry
pmur04510                   Pathway                                
Name
Focal adhesion - Protobothrops mucrosquamatus (Taiwan habu)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
pmur04510  Focal adhesion
pmur04510

Other DBs
GO: 0005925
Organism
Protobothrops mucrosquamatus (Taiwan habu) [GN:pmur]
Gene
107282605  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
107291014  collagen alpha-1(I) chain [KO:K06236]
107283645  COL1A2; collagen alpha-2(I) chain isoform X1 [KO:K06236]
107288503  COL2A1; collagen alpha-1(II) chain [KO:K19719]
107287766  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
107284270  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
107303140  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
107303151  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
107284271  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
107286669  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
107296179  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
107296188  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
107286071  collagen alpha-6(VI) chain-like [KO:K06238]
107291711  COL6A3; LOW QUALITY PROTEIN: collagen alpha-3(VI) chain [KO:K06238]
107286068  LOW QUALITY PROTEIN: collagen alpha-6(VI) chain [KO:K06238]
107286069  collagen alpha-6(VI) chain [KO:K06238]
114923236  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
107288964  laminin subunit alpha-2 [KO:K05637]
107287708  laminin subunit alpha-2 [KO:K05637]
107285988  LAMA1; laminin subunit alpha-1 [KO:K05637]
107296589  LAMA5; LOW QUALITY PROTEIN: laminin subunit alpha-5 [KO:K06240]
107291296  LAMA3; LOW QUALITY PROTEIN: laminin subunit alpha-3 [KO:K06240]
107298950  laminin subunit alpha-5 [KO:K06240]
107287159  LAMA4; laminin subunit alpha-4 [KO:K06241]
107299685  laminin subunit beta-1 [KO:K05636]
107297531  LAMB2; laminin subunit beta-2 [KO:K06243]
107290603  LAMB3; laminin subunit beta-3 [KO:K06244]
107296988  LAMB4; laminin subunit beta-4 [KO:K06245]
107284987  LAMC1; laminin subunit gamma-1 [KO:K05635]
107284986  LAMC2; laminin subunit gamma-2 [KO:K06246]
107291342  LAMC3; laminin subunit gamma-3 [KO:K06247]
107283731  CHAD; chondroadherin [KO:K06248]
107282817  RELN; reelin [KO:K06249] [EC:3.4.21.-]
107296464  THBS1; thrombospondin-1 [KO:K16857]
107296697  THBS3; thrombospondin-3 [KO:K04659]
107293307  THBS2; thrombospondin-2 [KO:K04659]
107300595  THBS4; thrombospondin-4 [KO:K04659]
107282855  COMP; cartilage oligomeric matrix protein [KO:K04659]
107292554  FN1; fibronectin [KO:K05717]
107290427  SPP1; osteopontin [KO:K06250]
107296963  VTN; vitronectin [KO:K06251]
107293206  tenascin-X [KO:K06252]
107298540  TNC; tenascin [KO:K06252]
107287313  TNR; tenascin-R [KO:K06252]
107287314  TNN; tenascin-N [KO:K06252]
107298567  VWF; von Willebrand factor [KO:K03900]
107290431  IBSP; bone sialoprotein 2 [KO:K06253]
107286757  ITGA1; integrin alpha-1 [KO:K06480]
107286758  ITGA2; integrin alpha-2 [KO:K06481]
107302354  ITGA2B; integrin alpha-IIb [KO:K06476]
107282610  ITGA3; integrin alpha-3 [KO:K06482]
107294224  ITGA4; integrin alpha-4 [KO:K06483]
107288179  ITGA5; integrin alpha-5 [KO:K06484]
107291524  ITGA6; integrin alpha-6 [KO:K06485]
107294928  ITGA7; integrin alpha-7 [KO:K06583]
107283308  ITGA8; integrin alpha-8 [KO:K06584]
107283778  integrin alpha-9 [KO:K06585]
114922299  integrin alpha-9-like [KO:K06585]
107288019  ITGA10; integrin alpha-10 [KO:K06586]
107283939  ITGA11; integrin alpha-11 [KO:K06587]
107297042  ITGAV; integrin alpha-V [KO:K06487]
107284025  ITGB1; integrin beta-1 isoform X2 [KO:K05719]
107303035  ITGB3; integrin beta-3 [KO:K06493]
107290217  ITGB4; integrin beta-4 [KO:K06525]
107295717  integrin beta-5-like [KO:K06588]
107294611  ITGB6; integrin beta-6 [KO:K06589]
107288518  ITGB7; integrin beta-7 [KO:K06590]
107282955  ITGB8; integrin beta-8 [KO:K06591]
107284014  EMP2; epithelial membrane protein 2 [KO:K26256]
107291891  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
107288137  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
107294823  PDGFD; platelet-derived growth factor D [KO:K05450]
107290460  PDGFC; platelet-derived growth factor C [KO:K05450]
107290128  EGF; pro-epidermal growth factor [KO:K04357]
107289460  IGF1; insulin-like growth factor I [KO:K05459]
107291631  snake venom vascular endothelial growth factor toxin [KO:K05448]
107289233  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
107293072  PGF; placenta growth factor [KO:K16859]
107285706  VEGFC; vascular endothelial growth factor C [KO:K05449]
107297173  hepatocyte growth factor-like [KO:K05460]
107298631  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
107294993  platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
107290589  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
107284695  EGFR; epidermal growth factor receptor isoform X2 [KO:K04361] [EC:2.7.10.1]
107282917  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
107294150  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
107296517  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
107285371  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
107303070  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
107288988  EMP1; epithelial membrane protein 1 [KO:K26255]
107287254  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
107291936  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
107284943  ARHGAP5; rho GTPase-activating protein 5 [KO:K13709]
107296007  transforming protein RhoA [KO:K04513]
107288686  RHOA; transforming protein RhoA [KO:K04513]
107288688  transforming protein RhoA isoform X1 [KO:K04513]
107299173  DIAPH1; protein diaphanous homolog 1 [KO:K05740]
107285298  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
107294640  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
107286997  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
107292177  MYL5; myosin light chain 5 [KO:K12753]
107286245  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
107288381  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
107294827  myosin regulatory light chain 2B, cardiac muscle isoform-like [KO:K12756]
107294002  myosin regulatory light chain 2, smooth muscle minor isoform isoform X1 [KO:K12757]
107296378  myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
107282744  myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
107298021  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
107302715  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
107286959  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
107284036  PPP1R12A; protein phosphatase 1 regulatory subunit 12A [KO:K06270]
107284458  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
107299194  protein phosphatase 1 regulatory subunit 12C-like [KO:K17457]
107282540  PPP1R12C; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
107290115  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
107284832  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
107295575  putative PIP5K1A and PSMD4-like protein [KO:K00889] [EC:2.7.1.68]
107294420  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
107282850  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [KO:K00889] [EC:2.7.1.68]
107286753  ACTG1; actin, cytoplasmic 2 [KO:K05692]
107298106  actin, cytoplasmic 1 [KO:K05692]
107283944  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
107288074  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
107285832  ACTN1; alpha-actinin-1 isoform X2 [KO:K05699]
107295483  ACTN4; alpha-actinin-4 [KO:K05699]
107283166  TLN2; LOW QUALITY PROTEIN: talin-2 [KO:K06271]
107287338  TLN1; talin-1 [KO:K06271]
107286711  FLNA; filamin-A [KO:K04437]
107287783  FLNB; filamin-B isoform X1 [KO:K27392]
107288824  PXN; paxillin [KO:K05760]
107288657  ILK; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
107289966  ZYX; zyxin [KO:K06273]
107291638  VASP; LOW QUALITY PROTEIN: vasodilator-stimulated phosphoprotein [KO:K06274]
107287903  VCL; vinculin [KO:K05700]
107298522  PARVB; beta-parvin [KO:K06275]
107293553  PARVA; alpha-parvin [KO:K06275]
107302608  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
107292994  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
107302433  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
107285678  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
107286129  GSK3B; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
107294550  catenin beta-1-like isoform X1 [KO:K02105]
107293683  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
107285104  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
107282442  protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
107288141  protein kinase C gamma type-like [KO:K19663] [EC:2.7.11.13]
107285699  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
107292340  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
107284997  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
107292269  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
107282273  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
107283596  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
107286152  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
107285111  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
107285124  VAV1; proto-oncogene vav [KO:K05730]
107291022  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
107298472  guanine nucleotide exchange factor VAV3 [KO:K05730]
107285491  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
107302789  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
107288862  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
107294968  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
107295917  serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
107291657  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
107285367  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
107290814  serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
107290017  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
107287376  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X2 [KO:K05726]
107295151  CRKL; crk-like protein [KO:K04438]
107298840  crk-like protein [KO:K04438]
107289561  CRK; adapter molecule crk isoform X1 [KO:K04438]
107282724  crk-like protein [KO:K04438]
107285398  dedicator of cytokinesis protein 2-like [KO:K13708]
107288952  dedicator of cytokinesis protein 1 [KO:K13708]
107288945  dedicator of cytokinesis protein 1 [KO:K13708]
107291046  RAPGEF1; rap guanine nucleotide exchange factor 1 [KO:K06277]
107292543  RAP1A; ras-related protein Rap-1A [KO:K04353]
107284411  RAP1B; ras-related protein Rap-1b [KO:K07836]
107294632  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
107293954  MAPK8; mitogen-activated protein kinase 8 isoform X3 [KO:K04440] [EC:2.7.11.24]
107303183  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
107302456  JUN; transcription factor AP-1 [KO:K04448]
107288626  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
107287882  CAV1; caveolin-1 isoform X1 [KO:K06278]
107287881  CAV2; caveolin-2 [KO:K12958]
107284239  caveolin-2 [KO:K12958]
107284237  caveolin-3 [KO:K12959]
107287161  FYN; tyrosine-protein kinase Fyn [KO:K05703] [EC:2.7.10.2]
107296691  SHC1; SHC-transforming protein 1 [KO:K06279]
107298759  SHC-transforming protein 2-like [KO:K17447]
107293823  SHC3; SHC-transforming protein 3 [KO:K17448]
107287682  SHC4; SHC-transforming protein 4 [KO:K17449]
107292723  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
107296218  SOS2; son of sevenless homolog 2 [KO:K03099]
107291909  SOS1; son of sevenless homolog 1 [KO:K03099]
107287923  HRAS; GTPase HRas [KO:K02833]
107295520  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
107283932  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
107282702  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
107293871  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
107293420  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
107297859  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
107285821  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
107293964  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
107286355  inhibitor of apoptosis protein [KO:K16060]
107297409  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
107299065  BAD; bcl2-associated agonist of cell death [KO:K02158]
107301245  bcl2-associated agonist of cell death-like [KO:K02158]
107283580  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
pmur04010  MAPK signaling pathway
pmur04060  Cytokine-cytokine receptor interaction
pmur04070  Phosphatidylinositol signaling system
pmur04110  Cell cycle
pmur04310  Wnt signaling pathway
pmur04512  ECM-receptor interaction
pmur04810  Regulation of actin cytoskeleton
KO pathway
ko04510   
LinkDB

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