Entry Name JAK-STAT signaling pathway - Rhinopithecus bieti (black snub-nosed monkey)
Description The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Other DBs Organism Rhinopithecus bieti (black snub-nosed monkey) [GN:
rbb ]
Gene 108512733 IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069 ]
108514784 IL27RA; interleukin-27 receptor subunit alpha isoform X1 [KO:K19598 ]
108515975 OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057 ]
108516059 STAT2; signal transducer and activator of transcription 2 [KO:K11221 ]
108518318 STAT3; LOW QUALITY PROTEIN: signal transducer and activator of transcription 3 [KO:K04692 ]
108518319 STAT5A; LOW QUALITY PROTEIN: signal transducer and activator of transcription 5A [KO:K11223 ]
108518477 CSF2RB; cytokine receptor common subunit beta isoform X1 [KO:K04738 ]
108518617 CLCF1; cardiotrophin-like cytokine factor 1 isoform X1 [KO:K05421 ]
108519030 PIAS2; E3 SUMO-protein ligase PIAS2 isoform X1 [KO:K16063 ] [EC:2.3.2.-]
108519693 STAT6; signal transducer and activator of transcription 6 isoform X1 [KO:K11225 ]
108520435 FHL1; four and a half LIM domains protein 1 isoform X1 [KO:K14365 ]
108520941 IL3RA; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737 ]
108521977 CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427 ]
108522966 IL22RA2; interleukin-22 receptor subunit alpha-2 isoform X1 [KO:K05139 ]
108522971 IL20RA; interleukin-20 receptor subunit alpha isoform X1 [KO:K05136 ]
108525019 STAM2; LOW QUALITY PROTEIN: signal transducing adapter molecule 2 [KO:K04705 ]
108526942 CISH; LOW QUALITY PROTEIN: cytokine-inducible SH2-containing protein [KO:K04701 ]
108527750 STAM; signal transducing adapter molecule 1 isoform X1 [KO:K04705 ]
108527864 STAT4; signal transducer and activator of transcription 4 isoform X1 [KO:K11222 ]
108527866 STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220 ]
108528336 CDKN1A; LOW QUALITY PROTEIN: cyclin-dependent kinase inhibitor 1 [KO:K06625 ]
108529905 IL15RA; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074 ]
108529907 IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068 ]
108531426 IL20RB; interleukin-20 receptor subunit beta isoform X1 [KO:K05137 ]
108531474 PIAS3; E3 SUMO-protein ligase PIAS3 isoform X1 [KO:K16064 ] [EC:2.3.2.-]
108532108 IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070 ]
108532960 PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
108533266 MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539 ]
108534276 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
108535573 IL5RA; interleukin-5 receptor subunit alpha isoform X1 [KO:K05067 ]
108535636 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
108536390 IL10RA; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134 ]
108536853 IL10RB; interleukin-10 receptor subunit beta isoform X1 [KO:K05135 ]
108537272 CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061 ]
108539355 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
108541175 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
108542167 IL11RA; interleukin-11 receptor subunit alpha isoform X1 [KO:K05056 ]
108542186 CNTFR; LOW QUALITY PROTEIN: ciliary neurotrophic factor receptor subunit alpha [KO:K05059 ]
108542315 PDGFA; LOW QUALITY PROTEIN: platelet-derived growth factor subunit A [KO:K04359 ]
108544591 PIK3CB; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
Reference Authors Harrison DA
Title The Jak/STAT pathway.
Journal Reference Authors Kiu H, Nicholson SE
Title Biology and significance of the JAK/STAT signalling pathways.
Journal Reference Authors Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A, Sanmamed MF, Le Bon A, Melero I
Title Direct effects of type I interferons on cells of the immune system.
Journal Reference Authors Fish EN, Platanias LC
Title Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes.
Journal Reference Authors Ivanenkov YA, Balakin KV, Lavrovsky Y
Title Small molecule inhibitors of NF-kB and JAK/STAT signal transduction pathways as promising anti-inflammatory therapeutics.
Journal Reference Authors O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A
Title The JAK-STAT pathway: impact on human disease and therapeutic intervention.
Journal Reference Authors Zoranovic T, Grmai L, Bach EA
Title Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway.
Journal Reference Authors Ungureanu D, Silvennoinen O
Title SLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling.
Journal Reference Authors Richard AJ, Stephens JM
Title The role of JAK-STAT signaling in adipose tissue function.
Journal Reference Authors Sun Y, Lehmbecker A, Kalkuhl A, Deschl U, Sun W, Rohn K, Tzvetanova ID, Nave KA, Baumgartner W, Ulrich R
Title STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis.
Journal Reference Authors Hirano T, Ishihara K, Hibi M
Title Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors.
Journal Reference Authors Rane SG, Reddy EP
Title Janus kinases: components of multiple signaling pathways.
Journal Reference Authors Heim MH
Title The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus.
Journal Reference Authors Morris R, Kershaw NJ, Babon JJ
Title The molecular details of cytokine signaling via the JAK/STAT pathway.
Journal Reference Authors Tzeng HT, Chyuan IT, Lai JH
Title Targeting the JAK-STAT pathway in autoimmune diseases and cancers: A focus on molecular mechanisms and therapeutic potential.
Journal Reference Authors Salas A, Hernandez-Rocha C, Duijvestein M, Faubion W, McGovern D, Vermeire S, Vetrano S, Vande Casteele N
Title JAK-STAT pathway targeting for the treatment of inflammatory bowel disease.
Journal Related rbb04060 Cytokine-cytokine receptor interaction
KO pathway
