KEGG   PATHWAY: rbb04151
Entry
rbb04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Rhinopithecus bieti (black snub-nosed monkey)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
rbb04151  PI3K-Akt signaling pathway
rbb04151

Other DBs
GO: 0043491
Organism
Rhinopithecus bieti (black snub-nosed monkey) [GN:rbb]
Gene
108511984  [KO:K05438]
108511997  [KO:K06856]
108512001  [KO:K06856]
108512065  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
108512076  NRTN; neurturin [KO:K25414]
108512087  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
108512141  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
108512401  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
108512434  PPP2R3A; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha [KO:K11583]
108512498  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108512695  LAMC1; laminin subunit gamma-1 [KO:K05635]
108512733  IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
108512736  LAMC2; laminin subunit gamma-2 [KO:K06246]
108512830  PKN3; serine/threonine-protein kinase N3 isoform X1 [KO:K23692]
108512923  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
108512945  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
108513076  F2R; proteinase-activated receptor 1 isoform X1 [KO:K03914]
108513168  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
108513197  [KO:K02991]
108513309  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
108513498  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
108513507  PIK3R6; LOW QUALITY PROTEIN: phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
108513580  TSC1; hamartin isoform X1 [KO:K07206]
108513587  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
108513599  FGF18; fibroblast growth factor 18 [KO:K04358]
108513636  SOS2; son of sevenless homolog 2 [KO:K03099]
108513682  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X1 [KO:K07826]
108513926  LAMC3; LOW QUALITY PROTEIN: laminin subunit gamma-3 [KO:K06247]
108513979  [KO:K04289]
108514173  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
108514363  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
108514488  PKN2; LOW QUALITY PROTEIN: serine/threonine-protein kinase N2 [KO:K23691]
108514611  ITGA5; integrin alpha-5 [KO:K06484]
108514672  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
108514729  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
108514770  PKN1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
108515073  FGF8; fibroblast growth factor 8 [KO:K04358]
108515100  [KO:K04542]
108515151  RELN; reelin [KO:K06249] [EC:3.4.21.-]
108515330  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
108515538  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
108515579  FGF2; fibroblast growth factor 2 [KO:K18497]
108515581  IL2; interleukin-2 [KO:K05429]
108515625  COMP; cartilage oligomeric matrix protein [KO:K04659]
108515641  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
108515816  EREG; proepiregulin [KO:K09784]
108515817  AREG; LOW QUALITY PROTEIN: amphiregulin [KO:K09782]
108515863  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
108515883  [KO:K04392]
108515958  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
108515975  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
108515989  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
108515999  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
108516025  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
108516053  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
108516076  [KO:K04354]
108516257  YWHAQ; 14-3-3 protein theta [KO:K16197]
108516431  CHAD; chondroadherin [KO:K06248]
108516437  COL1A1; collagen alpha-1(I) chain [KO:K06236]
108516444  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
108516491  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
108516504  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
108516719  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
108516810  [KO:K05855] [EC:2.7.10.2]
108516891  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
108517089  MTCP1; protein p13 MTCP-1 [KO:K16837]
108517177  [KO:K04548]
108517180  COL1A2; LOW QUALITY PROTEIN: collagen alpha-2(I) chain [KO:K06236]
108517188  [KO:K04546]
108517319  FGF7; fibroblast growth factor 7 [KO:K04358]
108517420  ITGB5; integrin beta-5 [KO:K06588]
108517585  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
108517598  OSM; oncostatin-M isoform X1 [KO:K05418]
108517608  EFNA5; ephrin-A5 [KO:K05462]
108517746  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
108517810  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
108517986  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
108518065  BCL2L11; LOW QUALITY PROTEIN: bcl-2-like protein 11 [KO:K16341]
108518621  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
108518653  PPP2CB; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
108518784  IKBKG; NF-kappa-B essential modulator [KO:K07210]
108518844  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
108518846  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
108518925  YWHAG; 14-3-3 protein gamma [KO:K16198]
108518996  CREB3; LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3 [KO:K09048]
108519147  TCL1B; T-cell leukemia/lymphoma protein 1B [KO:K16836]
108519245  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
108519399  TSC2; tuberin isoform X1 [KO:K07207]
108519453  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
108519463  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
108519469  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
108519651  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
108519897  [KO:K06252]
108519898  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
108519975  [KO:K06856]
108519976  [KO:K06856]
108519983  [KO:K06856]
108519992  [KO:K06856]
108520193  YWHAZ; LOW QUALITY PROTEIN: 14-3-3 protein zeta/delta [KO:K16197]
108520396  COL9A1; LOW QUALITY PROTEIN: collagen alpha-1(IX) chain [KO:K08131]
108520463  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
108520474  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
108520515  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
108520828  [KO:K06856]
108520869  SOS1; son of sevenless homolog 1 [KO:K03099]
108520941  IL3RA; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737]
108521318  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
108521438  [KO:K04545]
108521577  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
108521588  ITGB7; integrin beta-7 [KO:K06590]
108521591  NR4A1; nuclear receptor subfamily 4 group A member 1 isoform X1 [KO:K04465]
108521880  AKT1; LOW QUALITY PROTEIN: RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108521978  IL3; interleukin-3 [KO:K04736]
108522039  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
108522153  [KO:K06856]
108522231  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
108522239  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
108522246  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
108522273  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
108522717  [KO:K06237]
108522901  ITGA1; integrin alpha-1 [KO:K06480]
108522903  ITGA2; integrin alpha-2 [KO:K06481]
108523026  [KO:K04447] [EC:2.7.10.2]
108523126  RHEB; GTP-binding protein Rheb [KO:K07208]
108523620  GYS1; glycogen [starch] synthase, muscle isoform X1 [KO:K00693] [EC:2.4.1.11]
108523687  CD19; B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
108523695  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
108523748  KRAS; GTPase KRas isoform X1 [KO:K07827]
108523882  PSPN; persephin [KO:K25416]
108523928  LAMA1; laminin subunit alpha-1 isoform X1 [KO:K05637]
108523953  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
108523982  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
108524131  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
108524248  YWHAE; 14-3-3 protein epsilon [KO:K06630]
108524269  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
108524275  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
108524397  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
108524582  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
108524661  ITGA9; LOW QUALITY PROTEIN: integrin alpha-9 [KO:K06585]
108524775  [KO:K06856]
108525122  [KO:K05414]
108525289  [KO:K05462]
108525752  [KO:K05414]
108526194  IBSP; bone sialoprotein 2 [KO:K06253]
108526207  IL7; interleukin-7 [KO:K05431]
108526259  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
108526281  TNN; tenascin-N [KO:K06252]
108526284  TNR; tenascin-R isoform X1 [KO:K06252]
108526376  GHR; LOW QUALITY PROTEIN: growth hormone receptor [KO:K05080]
108526411  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
108526412  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
108526452  FGF20; fibroblast growth factor 20 [KO:K04358]
108526613  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
108526617  [KO:K06483]
108526765  BRCA1; breast cancer type 1 susceptibility protein [KO:K10605] [EC:2.3.2.27]
108526779  G6PC; glucose-6-phosphatase isoform X1 [KO:K01084] [EC:3.1.3.9]
108526824  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
108526826  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
108526828  EFNA1; ephrin-A1 [KO:K05462]
108526834  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
108526966  THBS1; thrombospondin-1 [KO:K16857]
108527002  LAMB2; laminin subunit beta-2 [KO:K06243]
108527057  COL4A1; LOW QUALITY PROTEIN: collagen alpha-1(IV) chain [KO:K06237]
108527058  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
108527163  ATF2; LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
108527462  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 [KO:K16340] [EC:3.1.3.16]
108527540  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
108527600  YWHAH; 14-3-3 protein eta isoform X1 [KO:K16198]
108527696  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
108527700  LPAR3; LOW QUALITY PROTEIN: lysophosphatidic acid receptor 3 [KO:K04294]
108527702  ITGB6; LOW QUALITY PROTEIN: integrin beta-6 [KO:K06589]
108527784  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
108527794  CSF3; granulocyte colony-stimulating factor [KO:K05423]
108527847  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
108527906  EPOR; erythropoietin receptor [KO:K05079]
108528053  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
108528122  NRAS; GTPase NRas [KO:K07828]
108528126  NGF; beta-nerve growth factor isoform X1 [KO:K02582]
108528336  CDKN1A; LOW QUALITY PROTEIN: cyclin-dependent kinase inhibitor 1 [KO:K06625]
108528490  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
108528695  MET; LOW QUALITY PROTEIN: hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
108528761  MYC; myc proto-oncogene protein [KO:K04377]
108528909  THBS4; thrombospondin-4 [KO:K04659]
108528921  KITLG; kit ligand [KO:K05461]
108529019  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
108529041  TLR2; toll-like receptor 2 [KO:K10159]
108529317  ITGB8; LOW QUALITY PROTEIN: integrin beta-8 [KO:K06591]
108529326  IL6; interleukin-6 isoform X1 [KO:K05405]
108529400  ITGB1; integrin beta-1 [KO:K05719]
108529557  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
108529583  IL4; interleukin-4 isoform X1 [KO:K05430]
108529768  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
108529771  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
108529808  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
108529907  IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
108530054  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
108530219  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
108530235  EFNA2; LOW QUALITY PROTEIN: ephrin-A2 [KO:K05462]
108530261  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
108530294  PRL; prolactin isoform X1 [KO:K05439]
108530341  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
108530403  COL9A2; collagen alpha-2(IX) chain isoform X1 [KO:K08131]
108530611  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
108530673  [KO:K16837]
108530743  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
108530933  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
108531050  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
108531271  RBL2; LOW QUALITY PROTEIN: retinoblastoma-like protein 2 [KO:K16332]
108531442  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
108531452  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
108531541  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 [KO:K05631]
108531591  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
108531834  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
108531842  MYB; transcriptional activator Myb isoform X1 [KO:K09420]
108531858  EIF4E; eukaryotic translation initiation factor 4E isoform X1 [KO:K03259]
108532047  PDGFRB; LOW QUALITY PROTEIN: platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
108532049  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
108532108  IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070]
108532134  TNC; tenascin isoform X1 [KO:K06252]
108532178  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
108532191  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
108532254  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
108532286  FGFR3; LOW QUALITY PROTEIN: fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
108532444  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
108532456  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
108532525  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
108532817  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
108532869  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
108532886  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
108532909  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
108532936  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
108532960  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
108533071  RPS6KB1; LOW QUALITY PROTEIN: ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
108533212  THEM4; acyl-coenzyme A thioesterase THEM4 isoform X1 [KO:K16339] [EC:3.1.2.2]
108533266  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539]
108533372  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
108533395  SGK2; serine/threonine-protein kinase Sgk2 isoform X1 [KO:K13303] [EC:2.7.11.1]
108533442  HSP90AB1; LOW QUALITY PROTEIN: heat shock protein HSP 90-beta [KO:K04079]
108533452  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
108533479  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
108533501  CCND3; LOW QUALITY PROTEIN: G1/S-specific cyclin-D3 [KO:K10152]
108533533  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
108533573  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
108533749  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
108533750  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
108533814  FOXO3; forkhead box protein O3 [KO:K09408]
108534048  VEGFC; vascular endothelial growth factor C [KO:K05449]
108534230  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
108534267  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
108534276  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
108534366  LAMA2; laminin subunit alpha-2 [KO:K05637]
108534554  INSR; LOW QUALITY PROTEIN: insulin receptor [KO:K04527] [EC:2.7.10.1]
108534556  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 isoform X1 [KO:K12230]
108534757  PDGFD; platelet-derived growth factor D [KO:K05450]
108534860  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629]
108534920  PGF; placenta growth factor isoform X1 [KO:K16859]
108535077  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
108535245  LAMA5; LOW QUALITY PROTEIN: laminin subunit alpha-5 [KO:K06240]
108535286  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
108535339  FGF10; fibroblast growth factor 10 [KO:K04358]
108535417  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
108535460  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
108535612  ARTN; LOW QUALITY PROTEIN: artemin [KO:K25415]
108535636  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
108535779  NTF4; neurotrophin-4 [KO:K12457]
108535835  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
108535938  [KO:K06643] [EC:2.3.2.27]
108536033  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
108536070  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
108536133  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
108536240  [KO:K05438]
108536264  [KO:K05438]
108536266  [KO:K05438]
108536269  [KO:K05438]
108536294  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
108536465  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
108536489  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
108536494  FGF6; fibroblast growth factor 6 [KO:K04358]
108536498  FGF23; fibroblast growth factor 23 [KO:K22428]
108536508  VWF; von Willebrand factor [KO:K03900]
108536522  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
108536852  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
108536856  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
108536899  LAMA3; laminin subunit alpha-3 [KO:K06240]
108536940  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
108536968  IFNA8; LOW QUALITY PROTEIN: interferon alpha-8 [KO:K05414]
108536996  [KO:K05414]
108537061  [KO:K04079]
108537115  [KO:K05414]
108537124  IFNA6; interferon alpha-6 [KO:K05414]
108537207  [KO:K06238]
108537272  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
108537357  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
108537414  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
108537601  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
108537733  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
108537873  FGF22; LOW QUALITY PROTEIN: fibroblast growth factor 22 [KO:K04358]
108538126  EPO; erythropoietin isoform X1 [KO:K05437]
108538179  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
108538195  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
108538219  FGF19; fibroblast growth factor 19 [KO:K22603]
108538230  FGF4; fibroblast growth factor 4 [KO:K04358]
108538240  FGF3; fibroblast growth factor 3 [KO:K04358]
108538244  EIF4E2; LOW QUALITY PROTEIN: eukaryotic translation initiation factor 4E type 2 [KO:K03259]
108538283  FGF9; fibroblast growth factor 9 [KO:K04358]
108538560  [KO:K05414]
108538565  IFNB1; interferon beta [KO:K05415]
108538576  [KO:K11583]
108538610  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
108538668  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
108538728  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
108538745  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
108538749  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
108538753  IRS1; insulin receptor substrate 1 [KO:K16172]
108538800  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
108538856  IL4R; interleukin-4 receptor subunit alpha [KO:K05071]
108539069  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
108539209  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
108539226  INS; insulin isoform X1 [KO:K04526]
108539355  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108539366  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
108539549  LAMB3; laminin subunit beta-3 [KO:K06244]
108539697  VEGFD; vascular endothelial growth factor D [KO:K05449]
108539726  GYS2; glycogen [starch] synthase, liver isoform X1 [KO:K00693] [EC:2.4.1.11]
108539763  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
108539779  COL6A1; LOW QUALITY PROTEIN: collagen alpha-1(VI) chain [KO:K06238]
108539896  CCNE2; LOW QUALITY PROTEIN: G1/S-specific cyclin-E2 [KO:K06626]
108539950  VTN; vitronectin [KO:K06251]
108540349  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
108540465  LAMB1; laminin subunit beta-1 [KO:K05636]
108540484  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
108540493  [KO:K06245]
108540719  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
108540843  [KO:K02991]
108540922  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1 [KO:K01596] [EC:4.1.1.32]
108540980  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
108541026  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
108541175  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
108541757  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
108542034  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
108542054  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
108542298  HSP90AA1; LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha [KO:K04079]
108542315  PDGFA; LOW QUALITY PROTEIN: platelet-derived growth factor subunit A [KO:K04359]
108542326  PPP2R5C; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform [KO:K11584]
108542407  THBS2; thrombospondin-2 [KO:K04659]
108542557  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
108542677  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
108542734  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
108543026  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
108543134  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
108543178  FN1; fibronectin isoform X1 [KO:K05717]
108543389  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
108543519  RELA; transcription factor p65 [KO:K04735]
108543525  HRAS; GTPase HRas isoform X1 [KO:K02833]
108543799  PRLR; prolactin receptor [KO:K05081]
108544148  PTK2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
108544251  HSP90B1; LOW QUALITY PROTEIN: endoplasmin [KO:K09487]
108544296  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
108544524  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
108544549  [KO:K16197]
108544577  FGF16; fibroblast growth factor 16 [KO:K04358]
108544591  PIK3CB; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
108544702  SPP1; osteopontin [KO:K06250]
108544746  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
108544759  FGFR4; LOW QUALITY PROTEIN: fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
108544761  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
108544905  SGK3; LOW QUALITY PROTEIN: serine/threonine-protein kinase Sgk3 [KO:K13304] [EC:2.7.11.1]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
rbb00010  Glycolysis / Gluconeogenesis
rbb04010  MAPK signaling pathway
rbb04012  ErbB signaling pathway
rbb04062  Chemokine signaling pathway
rbb04064  NF-kappa B signaling pathway
rbb04068  FoxO signaling pathway
rbb04110  Cell cycle
rbb04115  p53 signaling pathway
rbb04150  mTOR signaling pathway
rbb04210  Apoptosis
rbb04370  VEGF signaling pathway
rbb04510  Focal adhesion
rbb04620  Toll-like receptor signaling pathway
rbb04630  JAK-STAT signaling pathway
rbb04662  B cell receptor signaling pathway
rbb04910  Insulin signaling pathway
KO pathway
ko04151   

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